|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
JP2861087B2
(ja)
*
|
1989-08-08 |
1999-02-24 |
三菱化学株式会社 |
Ｎ―アシル‐５‐ピラゾールカルボキサミド類およびこれを有効成分とする殺虫、殺ダニ剤
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
CA2372813A1
(en)
|
1992-02-06 |
1993-08-19 |
L.L. Houston |
Biosynthetic binding protein for cancer marker
|
|
IT1255527B
(it)
*
|
1992-09-29 |
1995-11-09 |
Mini Ricerca Scient Tecnolog |
Pirazolcarbossammidi ad attivita' insetticida ed acaricida
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
CA2218503C
(en)
|
1995-04-20 |
2001-07-24 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
DK0780386T3
(da)
|
1995-12-20 |
2003-02-03 |
Hoffmann La Roche |
Matrixmetalloproteaseinhibitorer
|
|
DE19600097C1
(de)
|
1996-01-03 |
1997-07-31 |
Siemens Ag |
Verfahren und Vorrichtung zur Bestimmung einer Flüssigkeitshöhe mit Hilfe von Ultraschallimpulsen
|
|
NZ331191A
(en)
|
1996-03-05 |
2000-03-27 |
Zeneca Ltd |
4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
AR007855A1
(es)
|
1996-07-13 |
1999-11-24 |
Glaxo Group Ltd |
Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios, uso en medicinay composiciones farmaceuticas que los contienen
|
|
US6391874B1
(en)
|
1996-07-13 |
2002-05-21 |
Smithkline Beecham Corporation |
Fused heterocyclic compounds as protein tyrosine kinase inhibitors
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
EP0922030A1
(en)
|
1996-08-23 |
1999-06-16 |
Pfizer Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
US6077864A
(en)
|
1997-01-06 |
2000-06-20 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
HUP0000852A2
(hu)
|
1997-02-03 |
2001-05-28 |
Pfizer Products Inc. |
Aril-szulfonil-amino-hidroxámsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
NZ336836A
(en)
|
1997-02-11 |
2001-02-23 |
Pfizer |
Arylsulfonyl hydroxamic acid derivatives suitable for a broad range of medicinal treatments
|
|
CA2289102A1
(en)
|
1997-05-07 |
1998-11-12 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
CA2291709A1
(en)
|
1997-05-30 |
1998-12-03 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
TR200000368T2
(tr)
|
1997-08-08 |
2000-07-21 |
Pfizer Products Inc. |
Ariloksiariarilsülfonilamino hidroksamik asit türevleri.
|
|
DE69838172T2
(de)
|
1997-08-22 |
2008-04-10 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
|
AU744939B2
(en)
|
1997-09-26 |
2002-03-07 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
SK6652000A3
(en)
|
1997-11-11 |
2002-05-09 |
Pfizer Prod Inc |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
KR100743287B1
(ko)
|
1998-05-29 |
2007-07-26 |
수젠, 인크. |
피롤기로 치환된 2-인돌리논 단백질 인산화 효소 억제제
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
EP1004578B1
(en)
|
1998-11-05 |
2004-02-25 |
Pfizer Products Inc. |
5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
|
|
JP2002532415A
(ja)
|
1998-12-16 |
2002-10-02 |
ワーナー−ランバート・カンパニー |
Ｍｅｋ阻害剤による関節炎の治療
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
JP2001172261A
(ja)
*
|
1999-12-20 |
2001-06-26 |
Mitsubishi Chemicals Corp |
ピラゾールカルボン酸アミド類、およびこれを有効成分とする殺虫、殺ダニ剤
|
|
HRP20020751B1
(hr)
|
2000-02-15 |
2011-01-31 |
Sugen |
Pirolom supstituirani 2-indolinoni kao inhibitori protein kinaze
|
|
AU7349801A
(en)
|
2000-07-19 |
2002-01-30 |
Warner Lambert Co |
Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
|
|
US6660731B2
(en)
*
|
2000-09-15 |
2003-12-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
AU2001290912A1
(en)
*
|
2000-09-15 |
2002-03-26 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
JP2002363164A
(ja)
*
|
2001-04-06 |
2002-12-18 |
Mitsubishi Chemicals Corp |
ピラゾールカルボキサミド類、その中間体およびこれを有効成分とする有害生物防除剤
|
|
CN1511142A
(zh)
*
|
2001-04-06 |
2004-07-07 |
日本农药株式会社 |
吡唑酰胺衍生物及用于制备该衍生物的中间体、以该衍生物为活性成分的有害生物防治剂
|
|
WO2004078163A2
(en)
|
2003-02-28 |
2004-09-16 |
Transform Pharmaceuticals, Inc. |
Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
|
|
CA2478065C
(en)
|
2002-03-08 |
2013-01-08 |
Eisai Co. Ltd. |
Macrocyclic compounds useful as pharmaceuticals
|
|
SG2013013339A
(en)
|
2002-03-13 |
2014-12-30 |
Array Biopharma Inc |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
|
US20070060589A1
(en)
*
|
2004-12-21 |
2007-03-15 |
Purandare Ashok V |
Inhibitors of protein arginine methyl transferases
|
|
MX2007012463A
(es)
*
|
2005-04-08 |
2007-11-07 |
Pfizer Prod Inc |
Heteroarilamidas[3.1.0]biciclicas como inhibidores del transporte de glicina de tipo i.
|
|
BRPI0609464A2
(pt)
*
|
2005-05-23 |
2010-04-13 |
Japan Tobacco Inc |
composto de pirazol e agente terapêutico para diabetes compreendendo o mesmo
|
|
MX2008002114A
(es)
|
2005-07-21 |
2008-04-17 |
Ardea Biosciences Inc |
Inhibidores de n-(arilamino)-sulfonamida de mek.
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
WO2009025781A1
(en)
|
2007-08-16 |
2009-02-26 |
Beth Israel Deaconess Medical Center |
Activators of pyruvate kinase m2 and methods of treating disease
|
|
JPWO2009028280A1
(ja)
*
|
2007-08-29 |
2010-11-25 |
三井化学アグロ株式会社 |
ピラゾールカルボン酸誘導体及びその製造方法、並びに殺菌剤
|
|
BRPI0816769A2
(pt)
|
2007-09-12 |
2016-11-29 |
Hoffmann La Roche |
combinações de compostos inibidores de fosfoinositida 3-cinase e agentes quimioterapêuticos, e métodos de uso
|
|
WO2009055730A1
(en)
|
2007-10-25 |
2009-04-30 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
ES2620634T3
(es)
|
2008-10-09 |
2017-06-29 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Activadores de piruvato quinasa humana
|
|
US8637550B2
(en)
|
2008-11-17 |
2014-01-28 |
Boehringer Ingelheim International Gmbh |
Heteroaryl diamide compounds useful as MMP-13 inhibitors
|
|
WO2010083246A1
(en)
|
2009-01-15 |
2010-07-22 |
Amgen Inc. |
Fluoroisoquinoline substituted thiazole compounds and methods of use
|
|
JP5756457B2
(ja)
*
|
2009-04-06 |
2015-07-29 |
アジオス ファーマシューティカルズ， インコーポレイテッド |
ピルビン酸キナーゼｍ２調節剤、治療組成物および関連する使用方法
|
|
PL2427441T3
(pl)
|
2009-05-04 |
2017-06-30 |
Agios Pharmaceuticals, Inc. |
Aktywatory PKM2 do stosowania w leczeniu raka
|
|
US8349832B2
(en)
|
2009-09-02 |
2013-01-08 |
Canthera Therapeutics |
Compounds and compositions for treating cancer
|
|
WO2011069298A1
(en)
|
2009-12-11 |
2011-06-16 |
F. Hoffmann-La Roche Ag |
Novel cyclopropane indolinone derivatives
|
|
CN103269706B
(zh)
|
2010-09-30 |
2015-06-24 |
黄奇英 |
抗癌萃取物及化合物
|
|
WO2012056319A1
(en)
|
2010-10-27 |
2012-05-03 |
Dynamix Pharmaceuticals Ltd. |
Sulfonamides for the modulation of pkm2
|
|
US9221792B2
(en)
*
|
2010-12-17 |
2015-12-29 |
Agios Pharmaceuticals, Inc |
N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators
|
|
WO2012088314A1
(en)
|
2010-12-21 |
2012-06-28 |
Agios Pharmaceuticals, Inc. |
Bicyclic pkm2 activators
|
|
TWI549947B
(zh)
|
2010-12-29 |
2016-09-21 |
阿吉歐斯製藥公司 |
治療化合物及組成物
|
|
EP2497775A1
(en)
|
2011-03-11 |
2012-09-12 |
Ruprecht-Karls-Universität Heidelberg |
Ferrocene-based compounds and their use as ROS regulating prodrugs
|
|
WO2012160447A1
(en)
*
|
2011-05-25 |
2012-11-29 |
Dynamix Pharmaceuticals Ltd. |
3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases
|
|
WO2013005157A1
(en)
|
2011-07-05 |
2013-01-10 |
Lupin Limited |
Sulfone derivatives and their use as pkm2 modulators for the treatment of cancer
|
|
EP2909181B1
(en)
*
|
2012-10-16 |
2017-08-09 |
Tolero Pharmaceuticals, Inc. |
Pkm2 modulators and methods for their use
|
|
NZ707778A
(en)
|
2012-11-08 |
2019-03-29 |
Agios Pharmaceuticals Inc |
Therapeutic compounds and compositions and their use as pkm2 modulators
|
|
US9447054B2
(en)
|
2014-01-15 |
2016-09-20 |
Korea Institute Of Radiological & Medical Sciences |
Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient
|