JP2020100630A5 - - Google Patents
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- Publication number
- JP2020100630A5 JP2020100630A5 JP2020019337A JP2020019337A JP2020100630A5 JP 2020100630 A5 JP2020100630 A5 JP 2020100630A5 JP 2020019337 A JP2020019337 A JP 2020019337A JP 2020019337 A JP2020019337 A JP 2020019337A JP 2020100630 A5 JP2020100630 A5 JP 2020100630A5
- Authority
- JP
- Japan
- Prior art keywords
- ofatumumab
- multiple sclerosis
- during
- administered
- regimen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960002450 ofatumumab Drugs 0.000 claims description 47
- 238000012423 maintenance Methods 0.000 claims description 17
- 201000006417 multiple sclerosis Diseases 0.000 claims description 15
- 208000007118 chronic progressive multiple sclerosis Diseases 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 5
- 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 201000008628 secondary progressive multiple sclerosis Diseases 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 230000000306 recurrent effect Effects 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229940090047 auto-injector Drugs 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 235000017281 sodium acetate Nutrition 0.000 claims 1
- 239000001632 sodium acetate Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 230000003902 lesion Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 206010063401 primary progressive multiple sclerosis Diseases 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374986P | 2016-08-15 | 2016-08-15 | |
| US62/374,986 | 2016-08-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550539A Division JP6851391B2 (ja) | 2016-08-15 | 2017-08-11 | オファツムマブを用いた多発性硬化症の治療レジメンおよび治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020100630A JP2020100630A (ja) | 2020-07-02 |
| JP2020100630A5 true JP2020100630A5 (https=) | 2020-09-24 |
| JP7198786B2 JP7198786B2 (ja) | 2023-01-04 |
Family
ID=59901554
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550539A Active JP6851391B2 (ja) | 2016-08-15 | 2017-08-11 | オファツムマブを用いた多発性硬化症の治療レジメンおよび治療方法 |
| JP2020019337A Active JP7198786B2 (ja) | 2016-08-15 | 2020-02-07 | オファツムマブを用いた多発性硬化症の治療レジメンおよび治療方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550539A Active JP6851391B2 (ja) | 2016-08-15 | 2017-08-11 | オファツムマブを用いた多発性硬化症の治療レジメンおよび治療方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US11161909B2 (https=) |
| EP (5) | EP3497132B1 (https=) |
| JP (2) | JP6851391B2 (https=) |
| KR (2) | KR20190038914A (https=) |
| CN (5) | CN120053638A (https=) |
| AU (2) | AU2017311664C1 (https=) |
| CA (2) | CA3030530C (https=) |
| CY (1) | CY1123350T1 (https=) |
| DE (1) | DE202017007542U1 (https=) |
| DK (2) | DK3497132T3 (https=) |
| ES (2) | ES2954259T3 (https=) |
| FI (1) | FI3733712T3 (https=) |
| HR (2) | HRP20230894T1 (https=) |
| HU (2) | HUE051948T2 (https=) |
| IL (4) | IL302488B2 (https=) |
| LT (2) | LT3497132T (https=) |
| MX (1) | MX388593B (https=) |
| PL (2) | PL3497132T3 (https=) |
| PT (2) | PT3497132T (https=) |
| RS (2) | RS64541B1 (https=) |
| RU (1) | RU2749951C2 (https=) |
| SI (2) | SI3497132T1 (https=) |
| TW (1) | TWI752995B (https=) |
| WO (1) | WO2018033841A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120053638A (zh) * | 2016-08-15 | 2025-05-30 | 诺华股份有限公司 | 使用奥法木单抗治疗多发性硬化的方案和方法 |
| ES2957112T3 (es) | 2019-09-11 | 2024-01-11 | Novartis Ag | Tratamiento del RMS mediante cambio de terapia |
| MX2022003030A (es) | 2019-09-11 | 2022-04-07 | Novartis Ag | Tratamiento de afecciones distintas de la esclerosis multiple en pacientes tratados con ofatumumab. |
| US20230151106A1 (en) * | 2020-04-09 | 2023-05-18 | Novartis Ag | OFATUMUMAB FOR TREATING MS WHILE MAINTAINING SERUM IgG |
| US20240228647A1 (en) * | 2021-04-14 | 2024-07-11 | Novartis Ag | Ofatumumab for treating multiple sclerosis in asian patients |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US4816401A (en) | 1985-09-09 | 1989-03-28 | University Of Rochester | Serum free cell culture medium |
| JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| DE69232137T2 (de) | 1991-11-25 | 2002-05-29 | Enzon Inc | Multivalente antigen-bindende proteine |
| JP2003529361A (ja) | 2000-03-30 | 2003-10-07 | アムジェン インコーポレイテッド | ＣＤ２０／ＩｇＥレセプター様分子およびその使用 |
| EA013564B1 (ru) | 2000-08-03 | 2010-06-30 | Терапеутик Хьюман Поликлоналз Инк. | Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция |
| CN101928344B (zh) | 2002-10-17 | 2014-08-13 | 根马布股份公司 | 抗cd20的人单克隆抗体 |
| US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
| DOP2006000029A (es) | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
| US10155816B2 (en) | 2005-11-28 | 2018-12-18 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
| UA107557C2 (xx) | 2007-07-06 | 2015-01-26 | Композиція антитіла офатумумабу | |
| TW201014605A (en) | 2008-09-16 | 2010-04-16 | Genentech Inc | Methods for treating progressive multiple sclerosis |
| WO2012018704A1 (en) | 2010-08-02 | 2012-02-09 | Sanofi-Aventis U.S. Llc | Use of teriflunomide for treating multiple sclerosis |
| EP2663331A4 (en) | 2011-01-10 | 2015-07-15 | Glaxosmithkline Intellectual Property Man Ltd | NEW USES |
| TWI606064B (zh) * | 2012-02-08 | 2017-11-21 | Ｉｇｍ生物科技公司 | 細胞死亡誘導分子（ｃｄｉｍ）結合蛋白類及彼等之用途 |
| EP2692343A1 (en) | 2012-08-03 | 2014-02-05 | Forward Pharma A/S | Combination therapy for treatment of multiple sclerosis |
| SG11201500499TA (en) | 2012-08-10 | 2015-03-30 | Boehringer Ingelheim Int | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| WO2015162504A1 (en) | 2014-04-23 | 2015-10-29 | Novartis Ag | Novel dosing and uses of ofatumumab |
| EA201692180A1 (ru) | 2014-04-29 | 2017-08-31 | Тева Фармасьютикал Индастриз Лтд. | Лахинимод для лечения пациентов с рецидивирующе-ремиттирующим рассеянным склерозом (рррс) с высоким статусом инвалидизации |
| WO2016123329A2 (en) * | 2015-01-28 | 2016-08-04 | Genentech, Inc. | Gene expression markers and treatment of multiple sclerosis |
| CN106699886A (zh) | 2015-07-13 | 2017-05-24 | 西藏海思科药业集团股份有限公司 | 抗体依赖性细胞介导的细胞毒性(adcc)增强的奥法木抗体 |
| CN120053638A (zh) | 2016-08-15 | 2025-05-30 | 诺华股份有限公司 | 使用奥法木单抗治疗多发性硬化的方案和方法 |
| ES2957112T3 (es) | 2019-09-11 | 2024-01-11 | Novartis Ag | Tratamiento del RMS mediante cambio de terapia |
| MX2022003030A (es) | 2019-09-11 | 2022-04-07 | Novartis Ag | Tratamiento de afecciones distintas de la esclerosis multiple en pacientes tratados con ofatumumab. |
| US20230151106A1 (en) | 2020-04-09 | 2023-05-18 | Novartis Ag | OFATUMUMAB FOR TREATING MS WHILE MAINTAINING SERUM IgG |
| US20240228647A1 (en) | 2021-04-14 | 2024-07-11 | Novartis Ag | Ofatumumab for treating multiple sclerosis in asian patients |
| IL310813A (en) | 2021-08-16 | 2024-04-01 | Novartis Ag | OFATUMUMAB for the treatment of multiple sclerosis in children |
-
2017
- 2017-08-11 CN CN202510270941.5A patent/CN120053638A/zh active Pending
- 2017-08-11 PT PT177688637T patent/PT3497132T/pt unknown
- 2017-08-11 KR KR1020197007454A patent/KR20190038914A/ko not_active Ceased
- 2017-08-11 EP EP17768863.7A patent/EP3497132B1/en active Active
- 2017-08-11 EP EP23172507.8A patent/EP4252847A3/en active Pending
- 2017-08-11 LT LTEP17768863.7T patent/LT3497132T/lt unknown
- 2017-08-11 HU HUE17768863A patent/HUE051948T2/hu unknown
- 2017-08-11 WO PCT/IB2017/054909 patent/WO2018033841A1/en not_active Ceased
- 2017-08-11 RU RU2019107146A patent/RU2749951C2/ru active
- 2017-08-11 MX MX2019001860A patent/MX388593B/es unknown
- 2017-08-11 FI FIEP20180938.1T patent/FI3733712T3/fi active
- 2017-08-11 DE DE202017007542.3U patent/DE202017007542U1/de active Active
- 2017-08-11 EP EP20180938.1A patent/EP3733712B1/en active Active
- 2017-08-11 HR HRP20230894TT patent/HRP20230894T1/hr unknown
- 2017-08-11 CA CA3030530A patent/CA3030530C/en active Active
- 2017-08-11 RS RS20230635A patent/RS64541B1/sr unknown
- 2017-08-11 IL IL302488A patent/IL302488B2/en unknown
- 2017-08-11 AU AU2017311664A patent/AU2017311664C1/en active Active
- 2017-08-11 ES ES20180938T patent/ES2954259T3/es active Active
- 2017-08-11 PL PL17768863T patent/PL3497132T3/pl unknown
- 2017-08-11 CN CN202510270903.XA patent/CN120037367A/zh active Pending
- 2017-08-11 EP EP25225892.6A patent/EP4711008A2/en active Pending
- 2017-08-11 HU HUE20180938A patent/HUE063625T2/hu unknown
- 2017-08-11 ES ES17768863T patent/ES2821924T3/es active Active
- 2017-08-11 DK DK17768863.7T patent/DK3497132T3/da active
- 2017-08-11 PT PT201809381T patent/PT3733712T/pt unknown
- 2017-08-11 CA CA3101514A patent/CA3101514A1/en active Pending
- 2017-08-11 KR KR1020207034140A patent/KR20200136503A/ko not_active Ceased
- 2017-08-11 SI SI201730400T patent/SI3497132T1/sl unknown
- 2017-08-11 CN CN202510270924.1A patent/CN120000782A/zh active Pending
- 2017-08-11 IL IL313932A patent/IL313932A/en unknown
- 2017-08-11 IL IL276890A patent/IL276890B2/en unknown
- 2017-08-11 DK DK20180938.1T patent/DK3733712T3/da active
- 2017-08-11 SI SI201731396T patent/SI3733712T1/sl unknown
- 2017-08-11 EP EP24166956.3A patent/EP4371611A3/en active Pending
- 2017-08-11 HR HRP20201388TT patent/HRP20201388T1/hr unknown
- 2017-08-11 CN CN201780049932.7A patent/CN109641965A/zh active Pending
- 2017-08-11 PL PL20180938.1T patent/PL3733712T3/pl unknown
- 2017-08-11 CN CN202510270961.2A patent/CN120053639A/zh active Pending
- 2017-08-11 US US16/324,619 patent/US11161909B2/en active Active
- 2017-08-11 JP JP2018550539A patent/JP6851391B2/ja active Active
- 2017-08-11 RS RS20201066A patent/RS60807B1/sr unknown
- 2017-08-11 LT LTEP20180938.1T patent/LT3733712T/lt unknown
- 2017-08-15 TW TW106127565A patent/TWI752995B/zh active
-
2019
- 2019-02-12 IL IL264804A patent/IL264804B/en active IP Right Grant
-
2020
- 2020-02-07 JP JP2020019337A patent/JP7198786B2/ja active Active
- 2020-02-17 AU AU2020201112A patent/AU2020201112C1/en active Active
- 2020-09-11 CY CY20201100861T patent/CY1123350T1/el unknown
-
2021
- 2021-10-06 US US17/495,559 patent/US20220081488A1/en not_active Abandoned
-
2023
- 2023-06-08 US US18/331,701 patent/US12570754B2/en active Active
-
2024
- 2024-03-06 US US18/597,624 patent/US12338290B2/en active Active
-
2025
- 2025-05-28 US US19/221,422 patent/US20250289902A1/en active Pending
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