JP2020097557A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
- Publication number
- JP2020097557A JP2020097557A JP2018237357A JP2018237357A JP2020097557A JP 2020097557 A JP2020097557 A JP 2020097557A JP 2018237357 A JP2018237357 A JP 2018237357A JP 2018237357 A JP2018237357 A JP 2018237357A JP 2020097557 A JP2020097557 A JP 2020097557A
- Authority
- JP
- Japan
- Prior art keywords
- polyoxyethylene
- sulfosuccinic acid
- polyoxypropylene block
- block copolymer
- oral composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 229920001400 block copolymer Polymers 0.000 claims abstract description 37
- 239000004094 surface-active agent Substances 0.000 claims abstract description 29
- -1 polyoxyethylene Polymers 0.000 claims description 108
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 70
- 229920001451 polypropylene glycol Polymers 0.000 claims description 41
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 15
- 210000000214 mouth Anatomy 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 6
- 125000004417 unsaturated alkyl group Chemical group 0.000 claims description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 16
- 239000000194 fatty acid Substances 0.000 description 16
- 229930195729 fatty acid Natural products 0.000 description 16
- JMGZBMRVDHKMKB-UHFFFAOYSA-L disodium;2-sulfobutanedioate Chemical compound [Na+].[Na+].OS(=O)(=O)C(C([O-])=O)CC([O-])=O JMGZBMRVDHKMKB-UHFFFAOYSA-L 0.000 description 13
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
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- 239000007787 solid Substances 0.000 description 7
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- 230000002195 synergetic effect Effects 0.000 description 6
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- 235000021317 phosphate Nutrition 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
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- 239000003381 stabilizer Substances 0.000 description 2
- 229910001631 strontium chloride Inorganic materials 0.000 description 2
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- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 description 1
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
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- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
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- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
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- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
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- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
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- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229960000414 sodium fluoride Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- SLBXZQMMERXQAL-UHFFFAOYSA-M sodium;1-dodecoxy-4-hydroxy-1,4-dioxobutane-2-sulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O SLBXZQMMERXQAL-UHFFFAOYSA-M 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- FVRNDBHWWSPNOM-UHFFFAOYSA-L strontium fluoride Chemical compound [F-].[F-].[Sr+2] FVRNDBHWWSPNOM-UHFFFAOYSA-L 0.000 description 1
- 229910001637 strontium fluoride Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- XJPBRODHZKDRCB-UHFFFAOYSA-N trans-alpha-ocimene Natural products CC(=C)CCC=C(C)C=C XJPBRODHZKDRCB-UHFFFAOYSA-N 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Abstract
Description
上記口腔用組成物において、前記ポリオキシエチレン・ポリオキシプロピレンブロック共重合体の含有量が8〜35質量%であることが好ましい。
本実施形態の口腔用組成物は、(A)スルホコハク酸系界面活性剤と、(B)ポリオキシプロピレン鎖の両末端にポリオキシエチレン鎖が結合した構造のポリオキシエチレン・ポリオキシプロピレンブロック共重合体とを含有する。
モノアルキルスルホコハク酸及びその塩の具体例としては、スルホコハク酸モノラウリル2ナトリウムが挙げられる。
香料の具体例としては、アネトール、オイゲノール、リナロール、メントール、カルボン、リモネン、ウインターグリーン、サリチル酸メチル、シオネール、チモール、丁字油、ユーカリ油、ローズマリー油、セージ油、レモン油、オレンジ油、オシメン油、シトロネロール、各種香料の水溶性香料等が挙げられる。
界面活性剤としては、例えば、ポリオキシエチレン・ポリオキシプロピレンブロック共重合体以外の非イオン性界面活性剤、スルホコハク酸系界面活性剤以外のアニオン性界面活性剤、両性界面活性剤が挙げられる。
増粘剤の具体例としては、ポリアクリル酸ナトリウム、カラギーナン、カルボキシメチルセルロースナトリウム、アルギン酸ナトリウム、キサンタンガム、ヒドロキシエチルセルロース、ヒドロキシプロピルメチルセルロース、メチルセルロース、アルギン酸プロピレングリコールエステル等が挙げられる。
pH調整剤の具体例としては、クエン酸、リンゴ酸、乳酸、酒石酸、酢酸、リン酸、ピロリン酸、並びにこれらのカリウム塩、ナトリウム塩及びアンモニウム塩等の各種塩、水酸化ナトリウム等が挙げられる。口腔用組成物は、pH調整剤を配合することにより、pHが5〜11、特に6〜9の範囲になるように調整されていることが好ましい。口腔用組成物中におけるpH調整剤の配合量は、本発明の効果を妨げない範囲で適宜設定することができる。
上記構成によれば、スルホコハク酸系界面活性剤及びポリオキシエチレン・ポリオキシプロピレンブロック共重合体を単独で使用した場合と比較して、相乗的なステイン除去効果が得られる。したがって、歯牙に付着したステインを効果的に除去できる。
(3)ポリオキシエチレン・ポリオキシプロピレンブロック共重合体の含有量が8〜35質量%である。上記構成によれば、高いステイン除去効果が得られる。
(A)スルホコハク酸系界面活性剤及び(B)ポリオキシエチレン・ポリオキシプロピレンブロック共重合体を含有する口腔用組成物と、(A)スルホコハク酸系界面活性剤及び(B)ポリオキシエチレン・ポリオキシプロピレンブロック共重合体の一方を他の成分に異ならせた口腔用組成物とを調製し、それらのステイン除去効果を評価した。
表4〜7に示す処方で試験例1〜17の口腔用組成物を調製した。表4〜7の「配合欄」の数値は質量%であり、全体として100質量%になるように調製した。本試験では、スルホコハク酸系界面活性剤としてスルホコハク酸ナトリウムを用いるとともに、下記のポリオキシエチレン・ポリオキシプロピレンブロック共重合体B,Cを用いた。なお、各表中においては、ポリオキシエチレン・ポリオキシプロピレンブロック共重合体を「共重合体」と省略して記載している。
ポリオキシエチレン・ポリオキシプロピレンブロック共重合体C(共重合体C):POE(116)PO(66)、EO比率60%(BASF社製PluracareL1220)を用いた。
直径1cmのハイドロキシアパタイト(HAP)ディスクを歯のモデルとして用いた。HAPディスクをイオン交換水に2分間、浸漬させた後、2時間、自然乾燥させることにより付着前HAPディスクを得た。蛍光分光濃度計(コニカミノルタジャパン社製FD−5)を用いて、付着前HAPディスクの色差(L*値、a*値、b*値)を測定し、得られた各測定値をL* 0、a* 0、b* 0とした。
ΔE2={(L* 2−L* 0)2+(a* 2−a* 0)2+(b* 2−b* 0)2}1/2 …(2)
ΔE(%)=100−(ΔE2/ΔE1)×100 …(3)
(B)ポリオキシエチレン・ポリオキシプロピレンブロック共重合体の種類を異ならせた口腔用組成物を調製し、それらのステイン除去効果を評価した。
表8及び表9に示す処方で試験例18〜28の口腔用組成物を調製した。表8及び表9の「配合欄」の数値は質量%であり、全体として100質量%になるように調製した。得られた試験例18〜28について、試験1と同様にして、ステイン除去率を算出した。その結果を表8及び表9の「除去率」欄に示す。本試験では、スルホコハク酸系界面活性剤としてスルホコハク酸ナトリウムを用いるとともに、下記のポリオキシエチレン・ポリオキシプロピレンブロック共重合体A〜Eを用いた。ポリオキシエチレン・ポリオキシプロピレンブロック共重合体A〜Eの構成は、表8及び表9の「共重合体の種類」欄に記載するとおりである。
ポリオキシエチレン・ポリオキシプロピレンブロック共重合体B(共重合体B):ADEKA社製アデカプルロニックL−64
ポリオキシエチレン・ポリオキシプロピレンブロック共重合体C(共重合体C):BASF社製PluracareL1220
ポリオキシエチレン・ポリオキシプロピレンブロック共重合体D(共重合体D):日油社製ユニルーブ70DP−950B
ポリオキシエチレン・ポリオキシプロピレンブロック共重合体E(共重合体E):日油社製プロノン#208
Claims (4)
- スルホコハク酸系界面活性剤と、
ポリオキシプロピレン鎖の両末端にポリオキシエチレン鎖が結合した構造のポリオキシエチレン・ポリオキシプロピレンブロック共重合体とを含有する口腔用組成物。 - 前記スルホコハク酸系界面活性剤は、スルホコハク酸及びその塩、炭素数8〜18の飽和又は不飽和のアルキル基を有するモノアルキルスルホコハク酸及びその塩、炭素数8〜18の飽和又は不飽和のアルキル基を有し、エチレンオキサイドの平均付加モル数が1〜7であるポリオキシエチレンモノアルキルスルホコハク酸及びその塩から選ばれる少なくとも一種である請求項1に記載の口腔用組成物。
- 前記スルホコハク酸系界面活性剤の含有量が0.01〜5質量%である請求項1又は請求項2に記載の口腔用組成物。
- 前記ポリオキシエチレン・ポリオキシプロピレンブロック共重合体の含有量が8〜35質量%である請求項1〜3のいずれか一項に記載の口腔用組成物。
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JP2007137773A (ja) * | 2005-11-14 | 2007-06-07 | Sunstar Inc | 泡沫状フッ素塗布剤 |
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JP2000319148A (ja) * | 1999-04-30 | 2000-11-21 | Sunstar Inc | 口腔用組成物 |
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