JP2020073561A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020073561A5 JP2020073561A5 JP2020001139A JP2020001139A JP2020073561A5 JP 2020073561 A5 JP2020073561 A5 JP 2020073561A5 JP 2020001139 A JP2020001139 A JP 2020001139A JP 2020001139 A JP2020001139 A JP 2020001139A JP 2020073561 A5 JP2020073561 A5 JP 2020073561A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- oxo
- dihydro
- phenoxyphenyl
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562170547P | 2015-06-03 | 2015-06-03 | |
| US62/170,547 | 2015-06-03 | ||
| US201562271689P | 2015-12-28 | 2015-12-28 | |
| US62/271,689 | 2015-12-28 | ||
| JP2017562758A JP6646072B2 (ja) | 2015-06-03 | 2016-06-02 | チロシンキナーゼ阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562758A Division JP6646072B2 (ja) | 2015-06-03 | 2016-06-02 | チロシンキナーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020073561A JP2020073561A (ja) | 2020-05-14 |
| JP2020073561A5 true JP2020073561A5 (cg-RX-API-DMAC7.html) | 2020-07-09 |
| JP6985433B2 JP6985433B2 (ja) | 2021-12-22 |
Family
ID=56118090
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562758A Active JP6646072B2 (ja) | 2015-06-03 | 2016-06-02 | チロシンキナーゼ阻害剤 |
| JP2020001139A Active JP6985433B2 (ja) | 2015-06-03 | 2020-01-08 | チロシンキナーゼ阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562758A Active JP6646072B2 (ja) | 2015-06-03 | 2016-06-02 | チロシンキナーゼ阻害剤 |
Country Status (33)
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150044271A1 (en) | 2012-02-27 | 2015-02-12 | O-Ray Pharma, Inc. | Solid drug implants for intracochlear delivery of therapeutics for the treatment of otic disorders |
| BR112015003859B1 (pt) | 2012-09-10 | 2023-04-11 | Principia Biopharma Inc. | Composto e/ou sal farmaceuticamente aceitável do mesmo, respectivo uso e composição farmacêutica |
| JP6581506B2 (ja) | 2013-11-29 | 2019-09-25 | 株式会社ダイゾー | 内容物収容容器、それを用いた内容物収容製品、吐出製品および吐出装置 |
| CA2939186C (en) | 2014-02-21 | 2023-03-07 | Principia Biopharma Inc. | Salts and solid form of a btk inhibitor |
| ES2843323T3 (es) | 2014-12-18 | 2021-07-16 | Principia Biopharma Inc | Tratamiento de pénfigo |
| UA124090C2 (uk) * | 2015-06-03 | 2021-07-21 | Прінсіпіа Байофарма Інк. | Інгібітори тирозинкінази |
| WO2016210165A1 (en) | 2015-06-24 | 2016-12-29 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| CN105753863B (zh) * | 2015-09-11 | 2018-07-31 | 东莞市真兴贝特医药技术有限公司 | 氧代二氢咪唑并吡啶类化合物及其应用 |
| WO2017066014A1 (en) | 2015-10-14 | 2017-04-20 | Sunnylife Pharma Inc. | Bruton's tyrosine kinase inhibitors |
| IL293621B2 (en) | 2016-06-29 | 2023-09-01 | Principia Biopharma Inc | Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(oxane-3-yl)piperazine-1-yl)penta-2-ananitrile |
| JP6920411B2 (ja) * | 2016-07-25 | 2021-08-18 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | コリンキナーゼ阻害剤としてのプリン及び３−デアザプリンアナログ |
| EP3585789A1 (en) * | 2017-02-24 | 2020-01-01 | Gilead Sciences, Inc. | Inhibitors of bruton's tyrosine kinase |
| WO2019208805A1 (ja) * | 2018-04-27 | 2019-10-31 | 小野薬品工業株式会社 | Ｂｔｋ阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および／または治療剤 |
| AU2019309727B2 (en) | 2018-07-25 | 2021-12-23 | Novartis Ag | NLRP3 inflammasome inhibitors |
| CA3224985C (en) | 2018-07-31 | 2025-11-18 | Loxo Oncology, Inc. | SPRAY-DRIED DISPERSIONS, FORMULATIONS AND POLYMORPHIES OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE |
| US12077531B2 (en) * | 2018-09-13 | 2024-09-03 | Kissei Pharmaceutical Co., Ltd. | Imidazopyridinone compound |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
| US20210106584A1 (en) | 2019-10-14 | 2021-04-15 | Principia Biopharma Inc. | Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| CN113045484B (zh) * | 2019-12-27 | 2024-01-26 | 南京药石科技股份有限公司 | 一种2-氨基-2-(1-甲基-4-哌啶基)丙烷-1-醇的制备方法 |
| CN113149891B (zh) * | 2020-01-07 | 2024-02-02 | 南京药石科技股份有限公司 | 一种2-氨基-2-（1-甲基-4-哌啶基）乙醇的制备方法 |
| KR20220130179A (ko) | 2020-01-20 | 2022-09-26 | 젠자임 코포레이션 | 재발성 다발성 경화증(rms)에 대한 치료용 티로신 키나제 저해제 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| TW202140484A (zh) | 2020-01-22 | 2021-11-01 | 美商普林斯匹亞生物製藥公司 | ２－［３－［４－胺基－３－（２－氟－４－苯氧基－苯基）－１Ｈ－吡唑并［３，４－ｄ］嘧啶－１－基］哌啶－１－羰基］－４－甲基－４－［４－（氧環丁烷－３－基）哌𠯤－１－基］戊－２－烯腈之晶形 |
| MX2022012248A (es) * | 2020-03-30 | 2022-10-27 | Igia Pharmaceuticals Inc | Formulacion pediatrica de inhibidores de tirosina quinasa. |
| TW202214250A (zh) * | 2020-08-10 | 2022-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｂｔｋ抑制劑治療疾病的用途 |
| CA3185469A1 (en) | 2020-08-14 | 2022-02-17 | Novartis Ag | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof |
| CN116507627A (zh) | 2020-11-02 | 2023-07-28 | 勃林格殷格翰国际有限公司 | 作为egfr抑制剂的经取代1h-吡唑并[4,3-c]吡啶及衍生物 |
| JP2023553930A (ja) * | 2020-12-10 | 2023-12-26 | ジェンザイム・コーポレーション | トレブルチニブの結晶形態、その製造方法、およびその使用 |
| US20240051955A1 (en) * | 2020-12-23 | 2024-02-15 | Genzyme Corporation | 4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof |
| CN116710452A (zh) * | 2020-12-23 | 2023-09-05 | 建新公司 | 4-氨基-3-(4-苯氧基苯基)-1,3-二氢-2h-咪唑并[4,5-c]吡啶-2-酮衍生物及其盐类 |
| EP4313023A1 (en) | 2021-04-02 | 2024-02-07 | Biogen MA Inc. | Combination treatment methods of multiple sclerosis |
| WO2022218430A1 (zh) * | 2021-04-16 | 2022-10-20 | 南京明德新药研发有限公司 | 咪唑并吡啶类化合物及其应用 |
| EP4328226A4 (en) * | 2021-04-23 | 2025-08-27 | Hangzhou Solipharma Co Ltd | CRYSTALLINE FORM, AMORPHOUS FORM OF TOLEBRUTINIB, PREPARATION PROCESS THEREOF AND USE THEREOF |
| EP4342468A4 (en) * | 2021-05-21 | 2025-06-04 | Hangzhou Solipharma Co., Ltd. | Tolbrutinib salt and crystal form thereof, manufacturing process therefor, pharmaceutical composition therefrom and use thereof |
| CA3221129A1 (en) | 2021-06-11 | 2022-12-15 | Minhua Chen | Crystal form of tolebrutinib, preparation method therefor and use thereof |
| WO2023280132A1 (zh) * | 2021-07-06 | 2023-01-12 | 苏州晶云药物科技股份有限公司 | 氧代二氢咪唑并吡啶类化合物的晶型及其制备方法 |
| EP4404937A4 (en) * | 2021-09-24 | 2025-10-15 | Chadwick Donaldson | DRY POWDER FOAMING FORMULATIONS FOR DRUG DELIVERY ACROSS THE MUCOSA |
| US20250145618A1 (en) | 2021-12-21 | 2025-05-08 | Principia Biopharma Inc. | Crystalline Forms of (R)-1-(1-Acryloylpiperidin-3-YL)-4-Amino-3-(4-Phenoxyphenyl)-1H-Imidazo[4,5-C]Pyridin-2(3H)-One and salts Thereof |
| WO2023172663A1 (en) * | 2022-03-09 | 2023-09-14 | Teva Pharmaceuticals International Gmbh | Solid state forms of tolebrutinib and of tolebrutinib salts |
| US20230399313A1 (en) * | 2022-06-10 | 2023-12-14 | Advenchen Pharmaceuticals, LLC | Biological activities of 5-(2-(4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)ethyl)-5-azaspiro[2.4]-heptan-7-ol crystalline, phosphoric acid salt and its enantiomers |
| TW202408491A (zh) * | 2022-06-14 | 2024-03-01 | 美商健臻公司 | 製備托來布替尼的方法 |
| EP4543867A1 (en) * | 2022-06-22 | 2025-04-30 | Principia Biopharma Inc. | Methods of making modified btk inhibitors |
| TW202421141A (zh) | 2022-06-30 | 2024-06-01 | 美商健臻公司 | 用於多發性硬化症及重症肌無力之治療性酪胺酸激酶抑制劑 |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
| US20240173313A1 (en) | 2022-10-11 | 2024-05-30 | Genzyme Corporation | Therapeutic tyrosine kinase inhibitors for multiple sclerosis |
| CN118891260B (zh) * | 2022-11-07 | 2025-07-25 | 天津瑞程健达医药科技有限公司 | 氘代的氨基吡啶衍生物以及包含该化合物的药物组合物 |
| WO2024137604A1 (en) | 2022-12-20 | 2024-06-27 | Genzyme Corporation | Drug formulations of (r)-l-(l-acryloylpiperidin-3-yl)-4-amino-3-(4- phenoxyphenyl)-1h-imidazo[4,5-c]pyridin-2(3h)-one |
| AU2024214470A1 (en) | 2023-02-01 | 2025-09-11 | Principia Biopharma Inc. | Methods of diagnosing and treating multiple sclerosis by detecting a biomarker in the cerebrospinal fluid |
| US20250282777A1 (en) | 2024-03-06 | 2025-09-11 | Principia Biopharma Inc. | Methods of Making Tolebrutinib |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2809918A (en) | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical preparations |
| DE2010416B2 (de) | 1970-03-05 | 1979-03-29 | Hoechst Ag, 6000 Frankfurt | Oral anwendbare Arzneiform mit Retardwirkung |
| US3760984A (en) | 1971-09-29 | 1973-09-25 | Alza Corp | Osmotically powered agent dispensing device with filling means |
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US3952741A (en) | 1975-01-09 | 1976-04-27 | Bend Research Inc. | Controlled release delivery system by an osmotic bursting mechanism |
| US4728512A (en) | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
| US4794001A (en) | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| WO2003037890A2 (en) | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Piperidines |
| US20060045822A1 (en) | 2004-09-01 | 2006-03-02 | Board Of Regents, The University Of Texas System | Plasma polymerization for encapsulating particles |
| EP1797091A2 (en) * | 2004-09-14 | 2007-06-20 | Novartis Vaccines and Diagnostics, Inc. | Imidazoquinoline compounds |
| JP2008530113A (ja) * | 2005-02-11 | 2008-08-07 | コーリー ファーマシューティカル グループ，インコーポレイテッド | オキシムおよびヒドロキシラミン置換イミダゾ［４，５−ｃ］環化合物および方法 |
| CA2653941C (en) | 2006-05-31 | 2013-01-08 | The Regents Of The University Of California | Substituted amino purine derivatives and uses thereof |
| TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| NZ601278A (en) | 2006-09-22 | 2013-09-27 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| CN102713618B (zh) | 2009-09-16 | 2015-07-15 | 新基阿维罗米克斯研究公司 | 蛋白激酶复合物和抑制剂 |
| US7741330B1 (en) * | 2009-10-12 | 2010-06-22 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase |
| BR112012030711B1 (pt) * | 2010-05-31 | 2020-10-13 | Ono Pharmaceutical Co. Ltd | derivado de purinona |
| WO2012158785A1 (en) * | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Azaindole derivatives as tyrosine kinase inhibitors |
| ES2604191T3 (es) * | 2011-05-17 | 2017-03-03 | Principia Biopharma Inc. | Inhibidores de tirosina quinasas |
| MX355728B (es) * | 2011-05-17 | 2018-04-27 | Univ California | Inhibidores de cinasas. |
| BR112014012727B1 (pt) * | 2011-11-29 | 2022-10-25 | Ono Pharmaceutical Co., Ltd | Cloridrato de 6-amino-9-[(3r)-1-(2-butinoil)-3-pirrolidinil]-7-(4-fenoxifenil)-7,9-di-hidro-8h-puri- 8-ona e composição farmacêutica |
| US8501724B1 (en) | 2012-01-31 | 2013-08-06 | Pharmacyclics, Inc. | Purinone compounds as kinase inhibitors |
| WO2013191965A1 (en) | 2012-06-18 | 2013-12-27 | Principia Biopharma Inc. | Reversible covalent pyrrolo- or pyrazolopyrimidines useful for the treatment cancer and autoimmune diseases |
| CN109627239B (zh) | 2012-07-11 | 2021-10-12 | 缆图药品公司 | 成纤维细胞生长因子受体的抑制剂 |
| BR112015003859B1 (pt) * | 2012-09-10 | 2023-04-11 | Principia Biopharma Inc. | Composto e/ou sal farmaceuticamente aceitável do mesmo, respectivo uso e composição farmacêutica |
| US20140142099A1 (en) * | 2012-11-20 | 2014-05-22 | Principia Biopharma Inc. | Purinone Derivatives as Tyrosine Kinase Inhibitors |
| US8957080B2 (en) * | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| UA124090C2 (uk) * | 2015-06-03 | 2021-07-21 | Прінсіпіа Байофарма Інк. | Інгібітори тирозинкінази |
| CN105753863B (zh) | 2015-09-11 | 2018-07-31 | 东莞市真兴贝特医药技术有限公司 | 氧代二氢咪唑并吡啶类化合物及其应用 |
| WO2017066014A1 (en) | 2015-10-14 | 2017-04-20 | Sunnylife Pharma Inc. | Bruton's tyrosine kinase inhibitors |
-
2016
- 2016-06-02 UA UAA201712794A patent/UA124090C2/uk unknown
- 2016-06-02 PH PH1/2021/551681A patent/PH12021551681A1/en unknown
- 2016-06-02 CN CN201680000891.8A patent/CN106459049B/zh active Active
- 2016-06-02 TW TW105117466A patent/TWI732765B/zh active
- 2016-06-02 TN TNP/2017/000501A patent/TN2017000501A1/en unknown
- 2016-06-02 HR HRP20211249TT patent/HRP20211249T1/hr unknown
- 2016-06-02 PH PH1/2017/502203A patent/PH12017502203B1/en unknown
- 2016-06-02 PL PL16728566T patent/PL3303334T3/pl unknown
- 2016-06-02 SI SI201631244T patent/SI3303334T1/sl unknown
- 2016-06-02 HU HUE16728566A patent/HUE055419T2/hu unknown
- 2016-06-02 DK DK16728566.7T patent/DK3303334T3/da active
- 2016-06-02 EP EP22188609.6A patent/EP4112618A1/en active Pending
- 2016-06-02 WO PCT/US2016/035588 patent/WO2016196840A1/en not_active Ceased
- 2016-06-02 MY MYPI2017704576A patent/MY190548A/en unknown
- 2016-06-02 ES ES16728566T patent/ES2878030T3/es active Active
- 2016-06-02 EP EP16728566.7A patent/EP3303334B1/en active Active
- 2016-06-02 KR KR1020247015612A patent/KR20240070721A/ko active Pending
- 2016-06-02 US US15/578,623 patent/US20180162861A1/en not_active Abandoned
- 2016-06-02 EP EP21169631.5A patent/EP3912979A1/en active Pending
- 2016-06-02 MX MX2021006571A patent/MX395007B/es unknown
- 2016-06-02 LT LTEPPCT/US2016/035588T patent/LT3303334T/lt unknown
- 2016-06-02 PT PT167285667T patent/PT3303334T/pt unknown
- 2016-06-02 KR KR1020227035399A patent/KR102666352B1/ko active Active
- 2016-06-02 CA CA2987335A patent/CA2987335A1/en active Pending
- 2016-06-02 CN CN202011284728.3A patent/CN113149983B/zh active Active
- 2016-06-02 PE PE2017002512A patent/PE20180521A1/es unknown
- 2016-06-02 KR KR1020177037609A patent/KR102552653B1/ko active Active
- 2016-06-02 SG SG10201912443XA patent/SG10201912443XA/en unknown
- 2016-06-02 RS RS20211083A patent/RS62290B1/sr unknown
- 2016-06-02 CR CR20170593A patent/CR20170593A/es unknown
- 2016-06-02 HK HK18111674.0A patent/HK1252378A1/zh unknown
- 2016-06-02 TW TW110121130A patent/TWI810582B/zh active
- 2016-06-02 JP JP2017562758A patent/JP6646072B2/ja active Active
- 2016-06-02 EA EA201792529A patent/EA039006B1/ru unknown
- 2016-06-02 MX MX2017015470A patent/MX383213B/es unknown
- 2016-06-02 AU AU2016270973A patent/AU2016270973B2/en active Active
-
2017
- 2017-01-19 US US15/410,716 patent/US9688676B2/en active Active
- 2017-11-27 IL IL255946A patent/IL255946A/en active IP Right Grant
- 2017-12-01 CL CL2017003073A patent/CL2017003073A1/es unknown
- 2017-12-01 DO DO2017000279A patent/DOP2017000279A/es unknown
- 2017-12-15 CO CONC2017/0012947A patent/CO2017012947A2/es unknown
- 2017-12-19 ZA ZA2017/08667A patent/ZA201708667B/en unknown
-
2019
- 2019-07-31 CL CL2019002150A patent/CL2019002150A1/es unknown
-
2020
- 2020-01-08 JP JP2020001139A patent/JP6985433B2/ja active Active
- 2020-05-26 AU AU2020203447A patent/AU2020203447B2/en active Active
- 2020-09-23 US US17/029,184 patent/US20210171526A1/en not_active Abandoned
- 2020-12-07 IL IL279258A patent/IL279258B/en unknown
-
2022
- 2022-10-27 US US17/974,613 patent/US20230151012A1/en not_active Abandoned
-
2024
- 2024-02-13 ZA ZA2024/01324A patent/ZA202401324B/en unknown
- 2024-11-26 US US18/960,997 patent/US20250197402A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020073561A5 (cg-RX-API-DMAC7.html) | ||
| JP6776399B2 (ja) | ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用 | |
| US7642263B2 (en) | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes | |
| JP6218260B2 (ja) | Ｊａｋ阻害剤としてのアミノピリミジニル化合物 | |
| US8329711B2 (en) | Pyridone-substituted-dihydropyrazolopyrimidinone derivative | |
| US7745475B2 (en) | Heteroaryl benzamide derivatives as GLK activators | |
| US20100160286A1 (en) | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes | |
| JP2019504821A5 (cg-RX-API-DMAC7.html) | ||
| JP2009541268A5 (cg-RX-API-DMAC7.html) | ||
| US20190345138A1 (en) | Heterocyclic amides as kinase inhibitors | |
| CN114269432A (zh) | 作为p2x3抑制剂的氨基喹唑啉衍生物 | |
| US20110053910A1 (en) | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes | |
| JP2015500862A5 (cg-RX-API-DMAC7.html) | ||
| TW201725202A (zh) | 新穎經取代吲唑、其製法、包含其之醫藥製劑及其製備藥劑之用途 | |
| HUE026041T2 (en) | Pyrrolo-triazinone derivatives as P13K inhibitors | |
| JP2009513575A5 (cg-RX-API-DMAC7.html) | ||
| US7655652B2 (en) | Imidazolo-5-yl-2-anilinopyrimidines as agents for the inhibition of cell proliferation | |
| CN103288833A (zh) | 作为激酶抑制剂的咪唑并三嗪和咪唑并嘧啶 | |
| RU2014152257A (ru) | Гетероциклильные пиримидиновые аналоги в качестве ингибиторов tyk2 | |
| JP2019523233A5 (cg-RX-API-DMAC7.html) | ||
| JP2009525978A5 (cg-RX-API-DMAC7.html) | ||
| JP6983945B2 (ja) | 自己免疫性疾患の処置 | |
| JP2004508366A5 (cg-RX-API-DMAC7.html) | ||
| JP2019521167A5 (cg-RX-API-DMAC7.html) | ||
| WO2023183768A2 (en) | Small molecule inhibitors of tea domain family members |