JP2020045296A - M.aerilataを有効成分とする皮膚外用組成物 - Google Patents
M.aerilataを有効成分とする皮膚外用組成物 Download PDFInfo
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- JP2020045296A JP2020045296A JP2018172783A JP2018172783A JP2020045296A JP 2020045296 A JP2020045296 A JP 2020045296A JP 2018172783 A JP2018172783 A JP 2018172783A JP 2018172783 A JP2018172783 A JP 2018172783A JP 2020045296 A JP2020045296 A JP 2020045296A
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- skin
- massilia
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Abstract
Description
本発明の皮膚外用組成物は、バリア機能の向上及び/又はタイトジャンクション構造の形成促進作用を有する。
マッシリア・エリラタを有効成分として含む形態の本発明の皮膚外用組成物は、バリア機能の向上及び/又はタイトジャンクション構造の形成促進作用に優れる。
また、バリア機能の低下及び/又はタイトジャンクション構造形成能の低下により引き起こされる皮膚の状態の予防又は改善に特に有用である。
バリア機能の低下及び/又はタイトジャンクション構造形成能の低下により引き起こされる皮膚の状態としては、乾燥肌、肌荒れ、シワ、色素沈着、タルミなどを挙げることができる。
マッシリア属細菌は上述の皮膚状態の予防又は改善に有効である。
剤型としては、通常知られているローション剤形、乳液剤形、エッセンス剤形、クリーム剤形、粉体含有剤形の何れをも取ることができる。
経口組成物の形態としては、食品組成物又は医薬組成物の形態が挙げられる。
医薬組成物としては、顆粒剤、粉末剤、カプセル剤や、錠剤の形態をとる経口投与医薬品などの実施形態が好適に例示できる。特に好ましくは、食品組成物としての形態である。
後述する試験例に使用したマッシリア・エリラタ(Massilia aerilata)、スタフィロコッカス・エピデルミディス(Staphylococcus epidermidis)、スタフィロコッカス・アウレウス(Staphylococcus aureus)は、いずれも独立行政法人製品評価技術基盤機構から購入した。なお、マッシリア・エリラタは、M.エリラタ KACC 12505の菌株を購入した。
以下の方法により、マッシリア属細菌のバリア機能向上効果を評価した。
まず、正常ヒト表皮角化細胞(NHEK)(クラボウ社製)を12穴トランズウェルプレートに播種(70,000cells/well)した。その後、播種したNHEKを37℃、5%CO2環境下で3日間培養した。3日間の培養後、培養液を高カルシウム培地(1.45mM)に置換した。ここへ、最終的に7,500CFU/wellとなるように培地で濃度を調整した各菌株の懸濁液を添加した。なお、菌株を含まない試料を比較対照として用意した。
以下の方法で、タイトジャンクション構造の形成を可視化し、マッシリア属細菌のタイトジャンクション構造形成促進効果を評価した。
まず、正常ヒト表皮角化細胞(NHEK)(クラボウ社製)を4穴チャンバープレートに播種(30,000cells/well)した。その後、播種したNHEKを37℃、5%CO2環境下で3日間培養した。3日間の培養後、培養液を高カルシウム培地(1.45mM)に置換した。ここへ、最終的に2,300CFU/wellとなるように培地で濃度を調整した各菌株の懸濁液を添加した。なお、菌株を含まない試料を比較対照として用意した。
(1)菌体濃縮液の調製
マッシリア・エリラタの菌株をR2A培地中で好気培養した。次いで、増殖した菌株を生理食塩水で懸濁し、菌体濃縮液(菌体濃度:約4.6×106CFU/mL)とした。調製した菌体濃縮液は、以下に示す処方例の配合材料として使用した。なお、マッシリア・エリラタは、M.エリラタ KACC 12505の菌株を使用した。
表1の処方に従って、本発明の皮膚外用剤である化粧水を調製した。まず、表1に示したAの成分を常温で、Bの成分を60℃に加温して、それぞれ混合した。その後、攪拌下でAにBを徐々に加え、攪拌冷却することで化粧水を得た。
表2の処方に従って、本発明の皮膚外用剤であるエッセンスを調製した。まず、表2に示したA及びBの成分を80℃に加温して、それぞれ混合した。その後、攪拌下でAにBを徐々に加え、攪拌冷却することでエッセンスを得た。
表3の処方に従って、本発明の皮膚外用剤である乳液を調製した。まず、表3に示したA及びBの成分を80℃に加温して、それぞれ混合した。その後、攪拌下でAにBを徐々に加え、攪拌冷却することで乳液を得た。
表4の処方に従って、本発明の皮膚外用剤であるO/Wクリームを調製した。まず、表4に示したA及びBの成分を80℃に加温して、それぞれ混合した。その後、攪拌下でAにBを徐々に加え、攪拌冷却することでO/Wクリームを得た。
表5の処方に従って、本発明の皮膚外用剤であるW/Oクリームを調製した。まず、表5に示したA及びBの成分を80℃に加温して、それぞれ混合した。その後、攪拌下でBにAを徐々に加え、攪拌冷却することでW/Oクリームを得た。
表6の処方に従って、本発明の皮膚外用剤であるO/W UVクリームを調製した。まず、表6に示したA及びBの成分を80℃に加温して、それぞれ混合した。その後、攪拌下でAにBを徐々に加え、攪拌冷却することでO/W UVクリームを得た。
Claims (7)
- マッシリア(Massilia)属細菌を有効成分として含む、皮膚外用組成物。
- 前記マッシリア(Massilia)属細菌がマッシリア・エリラタ(Massilia aerilata)である、請求項1に記載の皮膚外用組成物。
- バリア機能向上及び/又はタイトジャンクション構造形成促進のための、請求項1又は2に記載の皮膚外用組成物。
- 乾燥肌、肌荒れ、シワ、色素沈着、タルミから選ばれる1又は2以上の予防又は改善のための、請求項1〜3の何れか1項に記載の皮膚外用組成物。
- マッシリア(Massilia)属細菌を有効成分とする、バリア機能向上及び/又はタイトジャンクション構造形成促進剤。
- 前記マッシリア(Massilia)属細菌がマッシリア・エリラタ(Massilia aerilata)である、請求項5に記載のバリア機能向上及び/又はタイトジャンクション構造形成促進剤。
- 乾燥肌、肌荒れ、シワ、色素沈着、タルミから選ばれる1又は2以上の予防又は改善のための、請求項5又は6に記載のバリア機能向上及び/又はタイトジャンクション構造形成促進剤。
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