|
WO2008097926A2
(en)
*
|
2007-02-02 |
2008-08-14 |
Yale University |
Transient transfection with rna
|
|
US10155038B2
(en)
|
2007-02-02 |
2018-12-18 |
Yale University |
Cells prepared by transient transfection and methods of use thereof
|
|
US9249423B2
(en)
|
2007-02-02 |
2016-02-02 |
Yale University |
Method of de-differentiating and re-differentiating somatic cells using RNA
|
|
US8450112B2
(en)
*
|
2008-04-09 |
2013-05-28 |
Maxcyte, Inc. |
Engineering and delivery of therapeutic compositions of freshly isolated cells
|
|
PH12013501201A1
(en)
*
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
JP5989016B2
(ja)
*
|
2011-06-24 |
2016-09-07 |
国立大学法人九州大学 |
Nk細胞の増幅方法
|
|
JP5572863B2
(ja)
*
|
2011-06-24 |
2014-08-20 |
国立大学法人九州大学 |
Nk細胞の増幅方法
|
|
CN103946952A
(zh)
|
2011-09-16 |
2014-07-23 |
宾夕法尼亚大学董事会 |
用于治疗癌症的rna改造的t细胞
|
|
US9272002B2
(en)
|
2011-10-28 |
2016-03-01 |
The Trustees Of The University Of Pennsylvania |
Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
|
|
EP2828290B1
(en)
|
2012-03-23 |
2018-08-15 |
The United States of America, represented by the Secretary, Department of Health and Human Services |
Anti-mesothelin chimeric antigen receptors
|
|
EP4282419A1
(en)
|
2012-12-20 |
2023-11-29 |
Purdue Research Foundation |
Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
|
|
US10144770B2
(en)
|
2013-10-17 |
2018-12-04 |
National University Of Singapore |
Chimeric receptors and uses thereof in immune therapy
|
|
US10611837B2
(en)
|
2014-04-10 |
2020-04-07 |
Seattle Children's Hospital |
Transgene genetic tags and methods of use
|
|
WO2016095934A2
(en)
*
|
2014-12-14 |
2016-06-23 |
El Abd Hisham Mohamed Magdy |
A novel genetic device to engineer cell behavior
|
|
WO2016123578A1
(en)
|
2015-01-30 |
2016-08-04 |
The Regents Of The University Of California |
Protein delivery in primary hematopoietic cells
|
|
US12577289B2
(en)
|
2015-06-30 |
2026-03-17 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Surrogate co-receptors for t cells and methods of use
|
|
US11059880B2
(en)
|
2015-06-30 |
2021-07-13 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Redirected cells with MHC chimeric receptors and methods of use in immunotherapy
|
|
IL315940A
(en)
|
2015-07-28 |
2024-11-01 |
Univ Pennsylvania |
Altered monocytes/macrophages expressing chimeric antigen receptors and their uses
|
|
AU2016306209B2
(en)
|
2015-08-07 |
2023-07-06 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Bispecific CAR T-cells for solid tumor targeting
|
|
AU2016361451B2
(en)
|
2015-11-27 |
2024-01-25 |
Cartherics Pty. Ltd. |
Genetically modified cells and uses thereof
|
|
EP3439675A4
(en)
|
2016-04-08 |
2019-12-18 |
Purdue Research Foundation |
METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY
|
|
US11293021B1
(en)
|
2016-06-23 |
2022-04-05 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments, and systems
|
|
US11408005B2
(en)
|
2016-12-12 |
2022-08-09 |
Seattle Children's Hospital |
Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells
|
|
US11649288B2
(en)
|
2017-02-07 |
2023-05-16 |
Seattle Children's Hospital |
Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
|
|
WO2018160622A1
(en)
|
2017-02-28 |
2018-09-07 |
Endocyte, Inc. |
Compositions and methods for car t cell therapy
|
|
EP3612210A4
(en)
|
2017-04-19 |
2021-01-27 |
Board Of Regents, The University Of Texas System |
MANIPULATED ANTIGEN RECEPTORS EXPRESSING IMMUNE CELLS
|
|
WO2018232356A1
(en)
|
2017-06-15 |
2018-12-20 |
The Regents Of The University Of California |
Targeted non-viral dna insertions
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
JP2020530979A
(ja)
|
2017-06-30 |
2020-11-05 |
インスクリプタ, インコーポレイテッド |
自動細胞処理方法、モジュール、機器及びシステム
|
|
JP2020530280A
(ja)
*
|
2017-07-03 |
2020-10-22 |
トルク セラピューティクス, インコーポレイテッド |
免疫刺激性融合分子およびその使用
|
|
US10738327B2
(en)
|
2017-08-28 |
2020-08-11 |
Inscripta, Inc. |
Electroporation cuvettes for automation
|
|
CN111065399B
(zh)
|
2017-09-01 |
2023-11-28 |
Gpb科学有限公司 |
使用微流体制备治疗活性细胞的方法
|
|
JP6985508B2
(ja)
|
2017-09-30 |
2021-12-22 |
インスクリプタ, インコーポレイテッド |
フロースルーエレクトロポレーション機器編成
|
|
JP7101419B2
(ja)
|
2017-10-27 |
2022-07-15 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
内因性t細胞受容体の標的置換
|
|
WO2019090355A1
(en)
*
|
2017-11-06 |
2019-05-09 |
Children's National Medical Center |
Cells expressing antibodies and methods of treatment using the same
|
|
EP3735255A4
(en)
*
|
2018-01-05 |
2021-09-22 |
Maxcyte, Inc. |
CHRONIC CANCER TREATMENT BY CARS
|
|
US11311576B2
(en)
|
2018-01-22 |
2022-04-26 |
Seattle Children's Hospital |
Methods of use for CAR T cells
|
|
US12312416B2
(en)
|
2018-02-06 |
2025-05-27 |
Seattle Children's Hospital |
Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors
|
|
BR112020016176A2
(pt)
*
|
2018-02-09 |
2022-02-22 |
Immatics Us Inc |
Métodos de transdução de uma célula t, célula t transduzida geneticamente, composição farmacêutica, métodos de preparação de uma população de células t e uso da célula t
|
|
US12473336B2
(en)
|
2018-02-21 |
2025-11-18 |
Board Of Regents, The University Of Texas System |
Methods for activation and expansion of natural killer cells and uses thereof
|
|
AU2019225174B2
(en)
|
2018-02-23 |
2025-11-20 |
Endocyte, Inc. |
Sequencing method for CAR T cell therapy
|
|
US10443031B1
(en)
|
2018-03-29 |
2019-10-15 |
Inscripta, Inc. |
Methods for controlling the growth of prokaryotic and eukaryotic cells
|
|
WO2019200004A1
(en)
|
2018-04-13 |
2019-10-17 |
Inscripta, Inc. |
Automated cell processing instruments comprising reagent cartridges
|
|
US10858761B2
(en)
|
2018-04-24 |
2020-12-08 |
Inscripta, Inc. |
Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
|
|
WO2019209926A1
(en)
|
2018-04-24 |
2019-10-31 |
Inscripta, Inc. |
Automated instrumentation for production of peptide libraries
|
|
US10557216B2
(en)
|
2018-04-24 |
2020-02-11 |
Inscripta, Inc. |
Automated instrumentation for production of T-cell receptor peptide libraries
|
|
CA3108767A1
(en)
|
2018-06-30 |
2020-01-02 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
WO2020014235A1
(en)
|
2018-07-09 |
2020-01-16 |
The Regents Of The University Of California |
Gene targets for t-cell-based immunotherapy
|
|
US11142740B2
(en)
|
2018-08-14 |
2021-10-12 |
Inscripta, Inc. |
Detection of nuclease edited sequences in automated modules and instruments
|
|
US10532324B1
(en)
|
2018-08-14 |
2020-01-14 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
JP7456638B2
(ja)
|
2018-08-14 |
2024-03-27 |
ソティオ,リミティド ライアビリティ カンパニー |
クレブス回路を調節するトランス代謝分子と組み合わせたキメラ抗原受容体ポリペプチド、及び、それらの治療的使用
|
|
WO2020081149A2
(en)
|
2018-08-30 |
2020-04-23 |
Inscripta, Inc. |
Improved detection of nuclease edited sequences in automated modules and instruments
|
|
KR20210056377A
(ko)
*
|
2018-09-07 |
2021-05-18 |
소티오, 엘엘씨 |
세포내 락테이트 농도를 조절하는 트랜스 대사 분자와 조합된 키메라 수용체 폴리펩타이드 및 이의 치료 용도
|
|
EP3868783A4
(en)
*
|
2018-10-19 |
2022-01-19 |
Cartexell Inc. |
ANTI-L1CAM ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF AND CHIMERIC ANTIGEN RECEPTOR THEREOF
|
|
WO2020086475A1
(en)
|
2018-10-22 |
2020-04-30 |
Inscripta, Inc. |
Engineered enzymes
|
|
US11214781B2
(en)
|
2018-10-22 |
2022-01-04 |
Inscripta, Inc. |
Engineered enzyme
|
|
CN111349615B
(zh)
*
|
2018-12-24 |
2024-08-13 |
上海细胞治疗集团股份有限公司 |
制备过表达外源基因的细胞的方法
|
|
EP3773918A4
(en)
|
2019-03-05 |
2022-01-05 |
Nkarta, Inc. |
CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
|
|
AU2020247900A1
(en)
|
2019-03-25 |
2021-11-04 |
Inscripta, Inc. |
Simultaneous multiplex genome editing in yeast
|
|
US11001831B2
(en)
|
2019-03-25 |
2021-05-11 |
Inscripta, Inc. |
Simultaneous multiplex genome editing in yeast
|
|
AU2020288623A1
(en)
|
2019-06-06 |
2022-01-06 |
Inscripta, Inc. |
Curing for recursive nucleic acid-guided cell editing
|
|
WO2020257395A1
(en)
|
2019-06-21 |
2020-12-24 |
Inscripta, Inc. |
Genome-wide rationally-designed mutations leading to enhanced lysine production in e. coli
|
|
US10927385B2
(en)
|
2019-06-25 |
2021-02-23 |
Inscripta, Inc. |
Increased nucleic-acid guided cell editing in yeast
|
|
US11203762B2
(en)
|
2019-11-19 |
2021-12-21 |
Inscripta, Inc. |
Methods for increasing observed editing in bacteria
|
|
CA3157131A1
(en)
|
2019-12-10 |
2021-06-17 |
Inscripta, Inc. |
Novel mad nucleases
|
|
US10704033B1
(en)
|
2019-12-13 |
2020-07-07 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
AU2020407048A1
(en)
|
2019-12-18 |
2022-06-09 |
Inscripta, Inc. |
Cascade/dCas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells
|
|
US10689669B1
(en)
|
2020-01-11 |
2020-06-23 |
Inscripta, Inc. |
Automated multi-module cell processing methods, instruments, and systems
|
|
US11225674B2
(en)
|
2020-01-27 |
2022-01-18 |
Inscripta, Inc. |
Electroporation modules and instrumentation
|
|
CN115210252A
(zh)
|
2020-02-04 |
2022-10-18 |
西雅图儿童医院(Dba西雅图儿童研究所) |
抗二硝基苯酚的嵌合抗原受体
|
|
US20210332388A1
(en)
|
2020-04-24 |
2021-10-28 |
Inscripta, Inc. |
Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
|
|
US11787841B2
(en)
|
2020-05-19 |
2023-10-17 |
Inscripta, Inc. |
Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
|
|
EP4161536A4
(en)
|
2020-06-04 |
2024-08-14 |
Carisma Therapeutics Inc. |
Novel constructs for chimeric antigen receptors
|
|
US11299731B1
(en)
|
2020-09-15 |
2022-04-12 |
Inscripta, Inc. |
CRISPR editing to embed nucleic acid landing pads into genomes of live cells
|
|
US11512297B2
(en)
|
2020-11-09 |
2022-11-29 |
Inscripta, Inc. |
Affinity tag for recombination protein recruitment
|
|
AU2021415461A1
(en)
|
2021-01-04 |
2023-08-17 |
Inscripta, Inc. |
Mad nucleases
|
|
EP4274890A4
(en)
|
2021-01-07 |
2024-11-27 |
Inscripta, Inc. |
MAD-NUCLEASES
|
|
US11884924B2
(en)
|
2021-02-16 |
2024-01-30 |
Inscripta, Inc. |
Dual strand nucleic acid-guided nickase editing
|
|
JP2024537991A
(ja)
|
2021-10-14 |
2024-10-18 |
アーセナル バイオサイエンシズ インコーポレイテッド |
共発現されるshRNAと論理ゲートシステムとを有する免疫細胞
|
|
EP4279085A1
(en)
|
2022-05-20 |
2023-11-22 |
Mnemo Therapeutics |
Compositions and methods for treating a refractory or relapsed cancer or a chronic infectious disease
|
|
PE20251319A1
(es)
|
2022-09-13 |
2025-05-16 |
Arsenal Biosciences Inc |
Celulas inmunitarias que coexpresan arnhc de tgfbr
|
|
EP4587570A2
(en)
|
2022-09-16 |
2025-07-23 |
Arsenal Biosciences, Inc. |
Immune cells with combination gene perturbations
|
|
IL322949A
(en)
|
2023-03-03 |
2025-10-01 |
Arsenal Biosciences Inc |
Systems targeting PSMA and CA9
|
|
IL322838A
(en)
|
2023-03-13 |
2025-10-01 |
Arsenal Biosciences Inc |
Synthetic pathway operators
|
|
AU2024260837A1
(en)
|
2023-04-25 |
2025-10-16 |
Arsenal Biosciences, Inc. |
Novel receptors for transcription regulation
|
|
WO2024233494A2
(en)
*
|
2023-05-05 |
2024-11-14 |
Cellfe, Inc. |
Methods and systems for rapid engineering of resting cells
|
|
WO2024259299A1
(en)
|
2023-06-14 |
2024-12-19 |
The Broad Institute, Inc. |
Compositions and methods for identification of vhh antibodies that bind a target antigen
|
|
WO2024259305A1
(en)
|
2023-06-14 |
2024-12-19 |
The Broad Institute, Inc. |
Vhh polypeptides that bind to mesothelin, compositions and methods of use thereof
|
|
WO2025199346A1
(en)
|
2024-03-20 |
2025-09-25 |
Arsenal Biosciences, Inc. |
Antigen binding proteins that bind tmprss4 and methods of use thereof
|
|
WO2026055342A1
(en)
|
2024-09-04 |
2026-03-12 |
Arsenal Biosciences, Inc. |
Synthetic pathway activators
|
|
WO2026076388A1
(en)
|
2024-10-03 |
2026-04-09 |
The Broad Institute, Inc. |
Vhh polypeptides that bind to claudin-18, compositions and methods of use thereof
|