JP2020011936A - 皮膚外用ジェル製剤 - Google Patents
皮膚外用ジェル製剤 Download PDFInfo
- Publication number
- JP2020011936A JP2020011936A JP2018136912A JP2018136912A JP2020011936A JP 2020011936 A JP2020011936 A JP 2020011936A JP 2018136912 A JP2018136912 A JP 2018136912A JP 2018136912 A JP2018136912 A JP 2018136912A JP 2020011936 A JP2020011936 A JP 2020011936A
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- Granted
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Classifications
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Abstract
Description
また、ジ長鎖型カチオン界面活性剤は水に溶けにくく、析出しやすいという問題があるため、ジェル状製剤に調製する場合でも、経時的な析出に対処する必要がある。
(a)下記式(I)で表されるジ長鎖型カチオン界面活性剤、
〔式(I)中、R1は、それぞれ独立に、炭素原子数が12〜22で、二重結合を0〜3個有するアルキル基を表し;R2は、それぞれ独立に、炭素原子数が1〜3で、二重結合をもたないアルキル基を表し;Yはハロゲン原子、メトサルフェート、またはメトホスフェートを表す。〕
(b)前記(a)成分が可溶な油分
(c)低級アルコール
(d)水溶性増粘剤
(e)水
を含有してなる、皮膚外用ジェル製剤を提供する。
本発明の製剤に配合される(a)ジ長鎖型カチオン界面活性剤(以下、単に「(a)成分」と称する場合がある)は、下記式(I)で表されるジ長鎖型カチオン界面活性剤が好ましく用いられる。
式(I)中、R1は、それぞれ独立に、炭素原子数が12〜22で、二重結合を0〜3個有するアルキル基を表し;R2は、それぞれ独立に、炭素原子数が1〜3で、二重結合をもたないアルキル基を表し;Yはハロゲン原子、メトサルフェート、またはメトホスフェートを表す。
本発明の製剤に配合される(b)前記(a)成分が可溶な油分(以下、単に「(b)成分」と称する場合がある)は、前記(a)成分を溶解することができる油分である。ここで、「(a)成分を溶解する」とは、1gの(a)ジ長鎖型カチオン界面活性剤を100gの油分と混合して加熱溶解し、常温に24時間静置した後でも析出や濁りを生じずに安定である油分を指す。
本発明の製剤に配合される(c)低級アルコール(以下、単に「(c)成分」と称する場合がある)は、化粧料に通常使用可能な、炭素原子数1〜3の一価の低級アルコールである。具体的には、メタノール、エタノール、n−プロパノール、イソプロピルアルコール等が挙げられる。(c)成分は清涼感向上、保存安定性向上、微細な微粒子形成等に寄与する。
本発明の製剤に配合される(d)水溶性増粘剤(以下、単に「(d)成分」と称する場合がある)は、化粧料に通常使用可能な水溶性増粘剤であって、具体的には、限定するものではないが、例として、アラビアガム、トラガガントガム、ガラクタン、グアガム、カラギーナン、ペクチン、クインスシード(マルメロ)抽出物、褐藻粉末およびカンテン等の植物系高分子、キサンタンガム、デキストランおよびプルラン等の微生物系高分子、コラーゲン、カゼイン、アルブミンおよびゼラチン等の動物系高分子、デンプン、カルボキシメチルデンプンおよびメチルヒドロキシデンプン等のデンプン類、メチルセルロース、ニトロセルロース、エチルセルロース、メチルヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、セルロース硫酸塩、ヒドロキシプロピルセルロース、カルボキシメチルセルロース、結晶セルロースおよびセルロース末等のセルロース類、ポリビニルアルコール、ポリビニルメチルエーテル、ポリビニルピロリドンおよびカルボキシビニルポリマー等のビニル系高分子、ポリアクリル酸およびその塩およびポリアクリルイミド等のアクリル系高分子、アクリル酸・メタクリル酸アルキル共重合体、アクリレーツ/アクリル酸アルキルクロスポリマー、PEG−240/デシルテトラデセス−20/ヘキサメチレンジイソシアネート共重合体等の疎水変性ポリエーテルウレタン、グリチルリチン酸やアルギン酸およびその塩等が挙げられる。本発明の(d)成分として、これらから選択される1種を単独で、あるいは2種以上を組み合わせて用いることができる。例えば、カルボキシビニルポリマー、PEG−240/デシルテトラデセス−20/ヘキサメチレンジイソシアネート共重合体およびアクリレーツ/アクリル酸アルキル(C10−30)クロスポリマーから選択される1種又は2種以上を用いることが好ましい。
本発明の製剤に配合される(e)水(以下、単に「(e)成分」と称する場合がある)は特に限定されないが、イオン交換水、精製水、自然水が挙げられる。
(e)成分の配合量は、製剤全量に対して30〜95質量%であり、好ましくは、40〜90質量%である。
ただし、本発明の製剤において界面活性剤を配合する場合には、製剤のべたつきを抑制する観点から、(a)成分以外の界面活性剤の配合量が、製剤全量に対して1質量%以下とすることが好ましい。
本発明の製剤には、上記成分の他に、本発明の効果を損なわない範囲内で通常化粧料に用いられる他の成分、例えば、水溶性高分子、粉末成分、紫外線防御剤、各種水性溶媒、油溶性薬剤、精油、保湿剤、酸化防止剤、金属封鎖剤、pH調整剤、香料、防腐剤等を必要に応じて適宜配合することができる。
1gのジステアリルジモニウムクロリドを100gの下記表1に示す油分と混合して加熱溶解し、常温に24時間静置した後の状態を確認した。評価結果を表1に併せて示す。なお、均一透明を保ったものを○とし、濁りや析出があったものを×とした。
下記表2に示す組成を有するジェル製剤を常法に従って調製し、下記評価方法に従って乳化安定性を調べた。評価結果を表2に併せて示す。
調製した試料を30℃で1日間静置した後、BH形粘度計(ロータNo.6、10回転、1分)により粘度(mPa・s)を測定した。本発明の製剤においては、5,000〜100,000mPa・sであることが好ましい。
試料調製後の水滴の乳化粒子径を、顕微鏡にて測定した。平均乳化粒子は小さいほど乳化安定性が良く、10μmを超えると長期保管により分離が見られる傾向が高くなる。本願発明の製剤においては、平均乳化粒子が0.1〜20μmであることが好ましい。
調製した試料を0℃、25℃で7日間静置した後、配合成分の析出の有無を目視または顕微鏡にて評価した。
Claims (8)
- (a)下記式(I)で表されるジ長鎖型カチオン界面活性剤
〔式(I)中、R1は、それぞれ独立に、炭素原子数が12〜22で、二重結合を0〜3個有するアルキル基を表し;R2は、それぞれ独立に、炭素原子数が1〜3で、二重結合をもたないアルキル基を表し;Yはハロゲン原子、メトサルフェート、またはメトホスフェートを表す。〕
(b)前記(a)成分が可溶な油分
(c)低級アルコール
(d)水溶性増粘剤
(e)水
を含有してなる、皮膚外用ジェル製剤。 - 前記(a)成分以外の界面活性剤の配合量が1質量%以下である、請求項1に記載の皮膚外用ジェル製剤。
- 前記(a)成分が、塩化ジステアリルジメチルアンモニウムである、請求項1又は2に記載の皮膚外用ジェル製剤。
- 前記(b)成分が、高級アルコール、ヒドロキシ基を有するエステル油、モノグリセリド、ジグリセリド、モノアルキルグリセリルエーテル、モノアルケニルグリセリルエーテル、ジアルキルグリセリルエーテル、およびジアルケニルグリセリルエーテルからなる群から選択される1種以上である、請求項1から3のいずれか一項に記載の皮膚外用ジェル製剤。
- 前記(b)成分が高級アルコールである場合に、(c)低級アルコールの配合量が10〜60質量%である、請求項1から4のいずれか一項に記載の皮膚外用ジェル製剤。
- (d)水溶性増粘剤が、カルボキシビニルポリマー、PEG−240/デシルテトラデセス−20/ヘキサメチレンジイソシアネート共重合体およびアクリレーツ/アクリル酸アルキル(C10−30)クロスポリマーから選択される1種又は2種以上である、請求項1から5のいずれか一項に記載の皮膚外用ジェル製剤。
- 指等で塗布して使用するための、請求項1から6のいずれか一項に記載の皮膚外用ジェル製剤。
- 微粒子付着防止用である、請求項1から7のいずれか一項に記載の皮膚外用ジェル製剤。
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PCT/JP2019/026935 WO2020017371A1 (ja) | 2018-07-20 | 2019-07-08 | 皮膚外用ジェル製剤 |
EP19838311.9A EP3824871A4 (en) | 2018-07-20 | 2019-07-08 | SKIN PREPARATION IN GEL FORM FOR EXTERNAL USE |
CN201980048193.9A CN112512488B (zh) | 2018-07-20 | 2019-07-08 | 皮肤外用凝胶制剂 |
US17/260,821 US20210267862A1 (en) | 2018-07-20 | 2019-07-08 | Skin gel preparation for external use |
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