JP2019537588A5 - - Google Patents
Info
- Publication number
- JP2019537588A5 JP2019537588A5 JP2019522962A JP2019522962A JP2019537588A5 JP 2019537588 A5 JP2019537588 A5 JP 2019537588A5 JP 2019522962 A JP2019522962 A JP 2019522962A JP 2019522962 A JP2019522962 A JP 2019522962A JP 2019537588 A5 JP2019537588 A5 JP 2019537588A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- independently selected
- phenyl
- hydroxy
- alkyl
- Prior art date
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610970314 | 2016-10-28 | ||
| CN201610970314.3 | 2016-10-28 | ||
| CN201710044000 | 2017-01-21 | ||
| CN201710044000.5 | 2017-01-21 | ||
| PCT/CN2017/108100 WO2018077246A1 (zh) | 2016-10-28 | 2017-10-27 | 用作神经营养因子酪氨酸激酶受体抑制剂的氨基吡唑并嘧啶化合物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2019537588A JP2019537588A (ja) | 2019-12-26 |
| JP2019537588A5 true JP2019537588A5 (https=) | 2022-01-21 |
| JPWO2018077246A5 JPWO2018077246A5 (https=) | 2022-01-21 |
| JP7046940B2 JP7046940B2 (ja) | 2022-04-04 |
Family
ID=62024344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522962A Active JP7046940B2 (ja) | 2016-10-28 | 2017-10-27 | 神経栄養因子チロシンキナーゼ受容体阻害剤として用いられるアミノピラゾロピリミジン化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10829492B2 (https=) |
| EP (1) | EP3533796B1 (https=) |
| JP (1) | JP7046940B2 (https=) |
| KR (1) | KR102616249B1 (https=) |
| CN (1) | CN109890820B (https=) |
| AU (1) | AU2017348826B2 (https=) |
| CA (1) | CA3041942C (https=) |
| DK (1) | DK3533796T3 (https=) |
| ES (1) | ES2896943T3 (https=) |
| HU (1) | HUE057733T2 (https=) |
| MX (1) | MX380283B (https=) |
| PL (1) | PL3533796T3 (https=) |
| PT (1) | PT3533796T (https=) |
| RU (1) | RU2764523C2 (https=) |
| WO (1) | WO2018077246A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11286264B2 (en) * | 2017-07-28 | 2022-03-29 | Turning Point Therapeutics, Inc. | Macrocyclic compounds and uses thereof |
| DK3674307T3 (da) | 2017-08-23 | 2023-09-11 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Makrocyklus indeholdende aminopyrazol og pyrimidin og farmaceutisk sammensætning og anvendelse deraf |
| CN108794370A (zh) * | 2018-07-31 | 2018-11-13 | 上海弈柯莱生物医药科技有限公司 | 一种拉罗替尼中间体的制备方法 |
| CA3122136A1 (en) * | 2018-12-07 | 2021-06-11 | Betta Pharmaceuticals Co., Ltd | Tyrosine kinase inhibitors, compositions and methods there of |
| JP7209415B2 (ja) | 2019-03-19 | 2023-01-20 | セントラル チャイナ ノーマル ユニバーシティ | ピラゾロピリミジン化合物、医薬組成物、及びその使用 |
| CN112979654B (zh) * | 2019-12-16 | 2024-03-19 | 赛诺哈勃药业（成都）有限公司 | 杂芳基稠环化合物、其制备方法及应用 |
| TW202214635A (zh) * | 2020-06-11 | 2022-04-16 | 大陸商貝達藥業股份有限公司 | 酪氨酸激酶抑制劑的鹽型、晶型、藥物組合物及其用途 |
| CN111620881B (zh) * | 2020-07-08 | 2023-03-31 | 浙江合聚生物医药有限公司 | 拉罗替尼衍生物及其制备方法和应用 |
| CN113563343B (zh) * | 2020-07-27 | 2022-05-24 | 杭州邦顺制药有限公司 | 取代的吡唑并[1,5-a]嘧啶化合物及其用途 |
| CN112010860B (zh) * | 2020-08-05 | 2023-03-10 | 南京纳丁菲医药科技有限公司 | 苄氧基吡唑并嘧啶化合物和药物组合物及其应用 |
| CN114437075B (zh) * | 2020-11-03 | 2026-01-30 | 上海瑶琪生物科技有限公司 | 用作ntrk激酶抑制剂的化合物及其应用 |
| CN113200963A (zh) * | 2021-03-31 | 2021-08-03 | 广东石油化工学院 | N-(吡咯基)-3-吡唑基胺及其制备方法 |
| JP7840066B2 (ja) * | 2021-05-03 | 2026-04-03 | ジェービーケーラボ カンパニー リミテッド | ２，６－ジクロロ－４－（４－（４－ヒドロキシシクロヘキシルアミノ）－７ｈ－ピロロ［２，３－ｄ］ピリミジン－５－イル）フェノールを活性成分として含有する、がんを予防、緩和、または処置するための医薬組成物 |
| CN117751121A (zh) * | 2021-07-30 | 2024-03-22 | 正大天晴药业集团股份有限公司 | 氨基吡唑并嘧啶化合物的晶体 |
| WO2023011616A1 (zh) * | 2021-08-06 | 2023-02-09 | 正大天晴药业集团股份有限公司 | 氨基吡唑并嘧啶化合物在治疗trk激酶介导的肿瘤中的用途 |
| CN117088800B (zh) * | 2023-08-18 | 2024-05-28 | 龙曦宁（上海）医药科技有限公司 | 一种5-甲基吡咯烷-3-醇盐酸盐的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10356579A1 (de) | 2003-12-04 | 2005-07-07 | Merck Patent Gmbh | Aminderivate |
| WO2009140128A2 (en) | 2008-05-13 | 2009-11-19 | Irm Llc | Compounds and compositions as kinase inhibitors |
| RU2509078C2 (ru) | 2008-07-01 | 2014-03-10 | Дженентек, Инк. | Бициклические гетероциклы в качестве ингибиторов киназы мек |
| PT2350075E (pt) | 2008-09-22 | 2014-06-09 | Array Biopharma Inc | Compostos imidazo[1,2b]piridazina substituídos como inibidores da trk cinase |
| AR074052A1 (es) * | 2008-10-22 | 2010-12-22 | Array Biopharma Inc | Compuestos pirazolo{1,5-a}pirimidina sustituida como inhibidores de trk cinasa |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| WO2012034095A1 (en) * | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
| WO2013028263A1 (en) | 2011-08-24 | 2013-02-28 | Glaxosmithkline Llc | Pyrazolopyrimidine derivatives as pi3 kinase inhibitors |
| KR20140105508A (ko) * | 2011-12-12 | 2014-09-01 | 닥터 레디스 레보러터리즈 리미티드 | 트로포미오신 수용체 키나제(Trk) 억제제인 치환된 피라졸로[1,5-a]피리딘 |
| MX362181B (es) | 2013-02-19 | 2019-01-08 | Ono Pharmaceutical Co | Compuesto inhibidor de cinasa del receptor de tropomiosina (trk). |
| WO2014143242A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CN104650092B (zh) * | 2013-11-16 | 2017-11-10 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| DK3077397T3 (da) * | 2013-12-06 | 2019-12-16 | Vertex Pharma | 2-amino-6-fluor-n-[5-fluor-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamidforbindelse anvendelig som atr-kinase-inhibitor, dens fremstilling, forskellige faste former og radiomarkerede derivater deraf |
| CA2971024C (en) | 2014-12-15 | 2023-09-26 | Handok Inc. | Fused ring heteroaryl compounds and their use as trk inhibitors |
-
2017
- 2017-10-27 AU AU2017348826A patent/AU2017348826B2/en active Active
- 2017-10-27 KR KR1020197015241A patent/KR102616249B1/ko active Active
- 2017-10-27 WO PCT/CN2017/108100 patent/WO2018077246A1/zh not_active Ceased
- 2017-10-27 PT PT178634101T patent/PT3533796T/pt unknown
- 2017-10-27 HU HUE17863410A patent/HUE057733T2/hu unknown
- 2017-10-27 JP JP2019522962A patent/JP7046940B2/ja active Active
- 2017-10-27 MX MX2019004847A patent/MX380283B/es unknown
- 2017-10-27 PL PL17863410T patent/PL3533796T3/pl unknown
- 2017-10-27 ES ES17863410T patent/ES2896943T3/es active Active
- 2017-10-27 US US16/345,679 patent/US10829492B2/en active Active
- 2017-10-27 DK DK17863410.1T patent/DK3533796T3/da active
- 2017-10-27 RU RU2019114600A patent/RU2764523C2/ru active
- 2017-10-27 CA CA3041942A patent/CA3041942C/en active Active
- 2017-10-27 CN CN201780064022.6A patent/CN109890820B/zh active Active
- 2017-10-27 EP EP17863410.1A patent/EP3533796B1/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019537588A5 (https=) | ||
| RU2019114600A (ru) | Соединение аминопиразолопиримидина, используемое в качестве ингибитора тирозинкиназного рецептора нейротрофического фактора | |
| JP2009542721A5 (https=) | ||
| JPWO2018077246A5 (https=) | ||
| JP2015529192A5 (https=) | ||
| AR040230A1 (es) | Indol, azaindol, y heterociclos relacionados de 4-alquenil piperidina | |
| AR104963A1 (es) | Derivados de 2-(pirazolopiridin-3-il)pirimidina como inhibidores de jak | |
| HRP20220414T1 (hr) | Inhibitori lizin specifične demetilaze-1 | |
| JP2016517878A5 (https=) | ||
| JP2019519586A5 (https=) | ||
| JP2016503009A5 (https=) | ||
| JP2017525737A5 (https=) | ||
| JP2009542723A5 (https=) | ||
| JP2013501720A5 (https=) | ||
| JP2017521407A5 (https=) | ||
| HRP20140953T1 (hr) | Morfolino pirimidini i njihova uporaba za lijeäśenje | |
| JP2014516074A5 (https=) | ||
| JP2014511869A5 (https=) | ||
| NO20063468L (no) | Triazolforbindelser og deres anvendelse som metabotrofe glutamatreseptorantagonister | |
| EA201070871A1 (ru) | Бициклические производные азабициклических карбоксамидов, их получение и их применение в терапии | |
| HRP20141093T1 (hr) | Triazolopirimidini | |
| RU2013147744A (ru) | Дозированная лекарственная форма для перорального применения | |
| JP2018514544A5 (https=) | ||
| JP2008513500A5 (https=) | ||
| JPWO2018158365A5 (https=) |