JP2019536770A5 - - Google Patents
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- JP2019536770A5 JP2019536770A5 JP2019524074A JP2019524074A JP2019536770A5 JP 2019536770 A5 JP2019536770 A5 JP 2019536770A5 JP 2019524074 A JP2019524074 A JP 2019524074A JP 2019524074 A JP2019524074 A JP 2019524074A JP 2019536770 A5 JP2019536770 A5 JP 2019536770A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- item
- heteroalkyl
- amino
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000003839 salts Chemical class 0.000 claims description 53
- 125000000217 alkyl group Chemical group 0.000 claims description 40
- 229910052739 hydrogen Inorganic materials 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 28
- -1 selenoalkyl Chemical group 0.000 claims description 24
- 125000003342 alkenyl group Chemical group 0.000 claims description 19
- 125000003118 aryl group Chemical group 0.000 claims description 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 19
- 150000002431 hydrogen Chemical class 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- 125000002252 acyl group Chemical group 0.000 claims description 14
- 125000000304 alkynyl group Chemical group 0.000 claims description 13
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 13
- 125000003277 amino group Chemical group 0.000 claims description 12
- 125000001475 halogen functional group Chemical group 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 10
- 125000000524 functional group Chemical group 0.000 claims description 10
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 9
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- 150000003573 thiols Chemical class 0.000 claims description 8
- 108091023037 Aptamer Proteins 0.000 claims description 6
- 125000005018 aryl alkenyl group Chemical group 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 150000004665 fatty acids Chemical class 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 125000001188 haloalkyl group Chemical group 0.000 claims description 6
- 239000002773 nucleotide Substances 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 108091033319 polynucleotide Proteins 0.000 claims description 6
- 239000002157 polynucleotide Substances 0.000 claims description 6
- 102000040430 polynucleotide Human genes 0.000 claims description 6
- 239000007790 solid phase Substances 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- 229940124530 sulfonamide Drugs 0.000 claims description 6
- 150000003456 sulfonamides Chemical class 0.000 claims description 6
- 125000004423 acyloxy group Chemical group 0.000 claims description 5
- 125000003282 alkyl amino group Chemical group 0.000 claims description 5
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 5
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims description 5
- 125000004414 alkyl thio group Chemical group 0.000 claims description 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 125000006684 polyhaloalkyl group Polymers 0.000 claims description 5
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 5
- 108010043958 Peptoids Proteins 0.000 claims description 4
- 239000011324 bead Substances 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 239000002777 nucleoside Substances 0.000 claims description 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 3
- 125000004001 thioalkyl group Chemical group 0.000 claims description 3
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
- 125000005041 acyloxyalkyl group Chemical group 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 125000005353 silylalkyl group Chemical group 0.000 claims description 2
- 238000000034 method Methods 0.000 description 34
- 150000001875 compounds Chemical class 0.000 description 13
- 238000003776 cleavage reaction Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000007017 scission Effects 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical group CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229940100198 alkylating agent Drugs 0.000 description 3
- 239000002168 alkylating agent Substances 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010511 deprotection reaction Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 239000012808 vapor phase Substances 0.000 description 2
- VODKOOOHHCAWFR-UHFFFAOYSA-N 2-iodoacetonitrile Chemical compound ICC#N VODKOOOHHCAWFR-UHFFFAOYSA-N 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical group C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000012346 acetyl chloride Substances 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- 230000002152 alkylating effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 125000003435 aroyl group Chemical group 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000008049 diazo compounds Chemical group 0.000 description 1
- 150000002081 enamines Chemical class 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- 125000005545 phthalimidyl group Chemical group 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662419861P | 2016-11-09 | 2016-11-09 | |
| US62/419,861 | 2016-11-09 | ||
| PCT/US2017/060721 WO2018089554A1 (en) | 2016-11-09 | 2017-11-08 | Pre-assembled, protected, chemically stable, chemoselective linkers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019536770A JP2019536770A (ja) | 2019-12-19 |
| JP2019536770A5 true JP2019536770A5 (cg-RX-API-DMAC7.html) | 2020-12-17 |
Family
ID=62109408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019524074A Withdrawn JP2019536770A (ja) | 2016-11-09 | 2017-11-08 | 予め会合され、保護され、化学的に安定した、官能基選択的リンカー |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12037311B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3538536A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2019536770A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20190082871A (cg-RX-API-DMAC7.html) |
| CN (2) | CN116514861A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017359448A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3043373A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018089554A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017223116A2 (en) | 2016-06-20 | 2017-12-28 | Healthtell Inc. | Methods for differential diagnosis of autoimmune diseases |
| US11774446B2 (en) | 2016-06-20 | 2023-10-03 | Cowper Sciences Inc. | Methods for diagnosis and treatment of autoimmune diseases |
| CA3043329A1 (en) | 2016-11-09 | 2018-05-17 | Healthtell Inc. | Coatings with tunable amine density |
| KR20190082871A (ko) | 2016-11-09 | 2019-07-10 | 헬스텔 인크. | 선조립되고, 보호되고, 화학적으로 안정한, 화학선택적 링커 |
| EP3538893A4 (en) | 2016-11-11 | 2020-09-23 | Healthtell Inc. | PROCESSES FOR IDENTIFYING CANDIDATE BIOMARKERS |
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| CN110187122A (zh) * | 2012-09-05 | 2019-08-30 | 亚利桑那州评议委员会,亚利桑那州法人团体,代理和代表亚利桑那州立大学 | 发现治疗靶标的方法 |
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| PT3177640T (pt) | 2014-08-08 | 2020-08-31 | Univ Leland Stanford Junior | Agentes pd-1 de alta afinidade e métodos de utilização |
| AU2016251857B2 (en) | 2015-04-23 | 2020-09-10 | F. Hoffmann-La Roche Ag | Method and composition for peptide cyclization and protease treatment |
| US10094825B2 (en) | 2015-07-30 | 2018-10-09 | The Florida International University Board Of Trustees | Predictive biomarkers for detection of organ damage in autoimmune illnesses and other diseases |
| EP3436825A4 (en) | 2016-04-01 | 2020-03-18 | Healthtell Inc. | NETWORK-BASED PEPTIDE BANKS FOR THE CHARACTERIZATION OF THERAPEUTIC ANTIBODIES |
| CA3043329A1 (en) | 2016-11-09 | 2018-05-17 | Healthtell Inc. | Coatings with tunable amine density |
| KR20190082871A (ko) | 2016-11-09 | 2019-07-10 | 헬스텔 인크. | 선조립되고, 보호되고, 화학적으로 안정한, 화학선택적 링커 |
| KR20200031613A (ko) | 2017-06-19 | 2020-03-24 | 헬스텔 인크. | 감별 진단을 위한 면역서명 |
| EP3749676A4 (en) | 2018-02-09 | 2021-12-22 | Healthtell Inc. | NETWORK BASED CYCLIC PEPTIDE BANKS |
| CN113677691A (zh) | 2018-11-14 | 2021-11-19 | 库博科学公司 | 选择功能界面模拟物的方法及其组合物 |
-
2017
- 2017-11-08 KR KR1020197016417A patent/KR20190082871A/ko not_active Withdrawn
- 2017-11-08 JP JP2019524074A patent/JP2019536770A/ja not_active Withdrawn
- 2017-11-08 CA CA3043373A patent/CA3043373A1/en not_active Abandoned
- 2017-11-08 CN CN202310471997.8A patent/CN116514861A/zh active Pending
- 2017-11-08 CN CN201780077556.2A patent/CN110072870A/zh active Pending
- 2017-11-08 EP EP17870322.9A patent/EP3538536A4/en not_active Withdrawn
- 2017-11-08 US US16/348,484 patent/US12037311B2/en active Active
- 2017-11-08 WO PCT/US2017/060721 patent/WO2018089554A1/en not_active Ceased
- 2017-11-08 AU AU2017359448A patent/AU2017359448A1/en not_active Abandoned
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