JP2019534044A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019534044A5 JP2019534044A5 JP2019545717A JP2019545717A JP2019534044A5 JP 2019534044 A5 JP2019534044 A5 JP 2019534044A5 JP 2019545717 A JP2019545717 A JP 2019545717A JP 2019545717 A JP2019545717 A JP 2019545717A JP 2019534044 A5 JP2019534044 A5 JP 2019534044A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nos
- amino acid
- antibody
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022087695A JP7455897B2 (ja) | 2016-11-08 | 2022-05-30 | 抗ｐｄ１および抗ｃｔｌａ４抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662419157P | 2016-11-08 | 2016-11-08 | |
| US62/419,157 | 2016-11-08 | ||
| PCT/US2017/060122 WO2018089293A2 (en) | 2016-11-08 | 2017-11-06 | Anti-pd1 and anti-ctla4 antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022087695A Division JP7455897B2 (ja) | 2016-11-08 | 2022-05-30 | 抗ｐｄ１および抗ｃｔｌａ４抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019534044A JP2019534044A (ja) | 2019-11-28 |
| JP2019534044A5 true JP2019534044A5 (enExample) | 2021-02-12 |
Family
ID=60409406
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545717A Pending JP2019534044A (ja) | 2016-11-08 | 2017-11-06 | 抗ｐｄ１および抗ｃｔｌａ４抗体 |
| JP2022087695A Active JP7455897B2 (ja) | 2016-11-08 | 2022-05-30 | 抗ｐｄ１および抗ｃｔｌａ４抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022087695A Active JP7455897B2 (ja) | 2016-11-08 | 2022-05-30 | 抗ｐｄ１および抗ｃｔｌａ４抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11124570B2 (enExample) |
| EP (1) | EP3538137A2 (enExample) |
| JP (2) | JP2019534044A (enExample) |
| CN (2) | CN110312523B (enExample) |
| AU (1) | AU2017356860A1 (enExample) |
| CA (1) | CA3042249A1 (enExample) |
| WO (1) | WO2018089293A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3463451A1 (en) * | 2016-05-26 | 2019-04-10 | Qilu Puget Sound Biotherapeutics Corporation | Mixtures of antibodies |
| CN110312523B (zh) | 2016-11-08 | 2024-04-26 | 齐鲁皮吉特湾生物治疗有限公司 | 抗pd1和抗ctla4抗体 |
| SG11202106898VA (en) * | 2018-12-28 | 2021-07-29 | Transgene Sa | M2-defective poxvirus |
| WO2020180811A1 (en) | 2019-03-04 | 2020-09-10 | Qilu Puget Sound Biotherapeutics Corporation | Anti-sirp-alpha antibodies |
| CN114650867A (zh) | 2019-08-30 | 2022-06-21 | 齐鲁普吉湾生物治疗公司 | 抗cd20抗体、抗cd37抗体及它们的混合物 |
| WO2021225378A1 (ko) * | 2020-05-06 | 2021-11-11 | 고려대학교 산학협력단 | Pd-l1 친화도가 증가된 pd-1 변이체 |
| CN111875697B (zh) * | 2020-08-03 | 2021-10-01 | 杭州皓阳生物技术有限公司 | 一种包含肽标签的融合蛋白 |
| EP4294531A4 (en) * | 2021-02-18 | 2025-07-16 | Qilu Puget Sound Biotherapeutics Corp | COMBINATIONS OF ANTI-PD1 AND ANTI-CTLA4 ANTIBODIES |
| WO2023160517A1 (zh) * | 2022-02-22 | 2023-08-31 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
| WO2023185720A1 (zh) * | 2022-03-28 | 2023-10-05 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
| CN118946366A (zh) * | 2022-04-13 | 2024-11-12 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
| WO2023240086A1 (en) * | 2022-06-07 | 2023-12-14 | Unm Rainforest Innovations | Humanized non-opioid composition and therapies for pain management |
| EP4548929A4 (en) * | 2022-06-28 | 2025-10-15 | Qilu Pharmaceutical Co Ltd | Pharmaceutical composition containing mixed antibodies of anti-CTLA4 and anti-PD1 and therapeutic use thereof |
| US20250381268A1 (en) * | 2022-06-30 | 2025-12-18 | Qilu Pharmaceutical Co., Ltd. | Pharmaceutical composition comprising anti-ctla4 and anti-pd1 antibody mixture and therapeutic use thereof |
| TW202525861A (zh) * | 2023-12-01 | 2025-07-01 | 大陸商齊魯製藥有限公司 | 穩定的混合抗體的藥物組合物 |
| WO2025228542A1 (en) | 2024-05-03 | 2025-11-06 | Genmab B.V. | Method for co-expression of a plurality of antibodies |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07507055A (ja) | 1992-02-26 | 1995-08-03 | アラーガン、インコーポレイテッド | 眼の創傷の治癒における血小板誘導化成長因子の使用 |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| EE05627B1 (et) * | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| DK2112166T3 (en) * | 1998-12-23 | 2019-02-04 | Pfizer | Human monoclonal antibodies to CTLA-4 |
| NZ517202A (en) * | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
| ES2720160T3 (es) | 2005-05-09 | 2019-07-18 | Ono Pharmaceutical Co | Anticuerpos monoclonales humanos contra muerte programada 1(PD-1) y métodos para tratar el cáncer usando anticuerpos dirigidos contra PD-1 solos o junto con otras sustancias inmunoterapéuticas |
| GB0514779D0 (en) | 2005-07-19 | 2005-08-24 | Celltech R&D Ltd | Biological products |
| CA2647282A1 (en) * | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| EP2035456A1 (en) | 2006-06-22 | 2009-03-18 | Novo Nordisk A/S | Production of bispecific antibodies |
| JP5191537B2 (ja) * | 2007-06-18 | 2013-05-08 | エム・エス・ディー・オス・ベー・フェー | ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体 |
| SI2235064T1 (sl) | 2008-01-07 | 2016-04-29 | Amgen Inc. | Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov |
| EP2240204A1 (en) * | 2008-02-04 | 2010-10-20 | Medarex, Inc. | Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof |
| AU2009255357A1 (en) * | 2008-05-29 | 2009-12-10 | Bristol-Myers Squibb Company | Methods for predicting patient response to modulation of the co-stimulatory pathway |
| JO3246B1 (ar) | 2009-09-09 | 2018-03-08 | Regeneron Pharma | اجسام مضادة بشرية ذات ألفة تفاعل عالية مع مستقبل 2 المفعل بالبروتين البشري |
| US8435516B2 (en) * | 2009-10-12 | 2013-05-07 | Pfizer Inc. | Cancer treatment |
| WO2012052230A1 (en) | 2010-10-18 | 2012-04-26 | Mediapharma S.R.L. | Erbb3 binding antibody |
| CN103429619B (zh) | 2011-03-17 | 2017-07-28 | 雷蒙特亚特特拉维夫大学有限公司 | 双特异性和单特异性、不对称抗体和其制备方法 |
| CN202105787U (zh) | 2011-06-03 | 2012-01-11 | 杨自强 | 糠粞分离机 |
| EA026924B1 (ru) | 2011-08-01 | 2017-05-31 | Дженентек, Инк. | Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek |
| CN102851338A (zh) | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| EP2975061A4 (en) | 2013-03-13 | 2017-03-01 | Ibentrus Inc. | Protein in which electrical interaction is introduced within hydrophobic interaction site and preparation method therefor |
| ES2746805T3 (es) * | 2013-12-12 | 2020-03-06 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo de PD-1, fragmento de unión a antígeno del mismo y aplicación médica del mismo |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| EA201891178A1 (ru) * | 2015-12-14 | 2019-01-31 | Макродженикс, Инк. | Биспецифичные молекулы, обладающие иммунореактивностью в отношении pd-1 и ctla-4, и способы их применения |
| CN110312523B (zh) | 2016-11-08 | 2024-04-26 | 齐鲁皮吉特湾生物治疗有限公司 | 抗pd1和抗ctla4抗体 |
-
2017
- 2017-11-06 CN CN201780069181.5A patent/CN110312523B/zh active Active
- 2017-11-06 CA CA3042249A patent/CA3042249A1/en active Pending
- 2017-11-06 CN CN202410423333.9A patent/CN118480125A/zh active Pending
- 2017-11-06 WO PCT/US2017/060122 patent/WO2018089293A2/en not_active Ceased
- 2017-11-06 EP EP17801203.5A patent/EP3538137A2/en active Pending
- 2017-11-06 US US16/347,554 patent/US11124570B2/en active Active
- 2017-11-06 AU AU2017356860A patent/AU2017356860A1/en not_active Abandoned
- 2017-11-06 JP JP2019545717A patent/JP2019534044A/ja active Pending
-
2021
- 2021-09-16 US US17/477,525 patent/US12037397B2/en active Active
-
2022
- 2022-05-30 JP JP2022087695A patent/JP7455897B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019534044A5 (enExample) | ||
| RU2425841C2 (ru) | Получение и анализ полностью человеческих лечебных антител-производных hucal gold, специфичных к человеческому cd38 | |
| JP2018527919A5 (enExample) | ||
| RU2018134065A (ru) | Антитела, специфические к рецептору полиовируса (pvr) человека | |
| JP2017532952A5 (enExample) | ||
| KR102104296B1 (ko) | 종양성 질병들에 대한 치료 | |
| JP2025065211A (ja) | 癌の治療における有効性の増強のためのｐｄ－１阻害剤とｌａｇ－３阻害剤の組み合わせ | |
| FI3459597T3 (fi) | Yksiketjuinen vasta-aine ctla4:lle ja siitä johdettu proteiini | |
| WO2017034916A1 (en) | Pd-l1 ("programmed death-ligand 1") antibodies | |
| JP2017535257A5 (enExample) | ||
| RU2019104980A (ru) | Анти-icos антитела | |
| CN102753195A (zh) | 用于增强抗肿瘤抗体疗法的方法 | |
| JP2018532383A5 (enExample) | ||
| JP2019528683A5 (enExample) | ||
| AU2020363041B2 (en) | Antibodies against the poliovirus receptor (PVR) and uses thereof | |
| AU2020207664A1 (en) | Antibodies specific to human Nectin-2 | |
| CN113412124A (zh) | Baff-r双特异性t细胞衔接子抗体 | |
| JPWO2019165340A5 (enExample) | ||
| CA3062479A1 (en) | Bispecific recombinant protein and use thereof | |
| CN113501879B (zh) | 一种解除肿瘤免疫微环境中免疫抑制的双功能抗体及其应用和制备方法 | |
| IL277899B1 (en) | Methods and compositions for treating yellow fever | |
| JPWO2020144697A5 (enExample) | ||
| JP2026506070A (ja) | 抗ｃｎｔｎ４抗体及びその使用 | |
| CN106963950B (zh) | 用于治疗肿瘤的联合用药物 | |
| AU2015271978B2 (en) | Treatment for neoplastic diseases |