JP2019533713A5 - - Google Patents

Info

Publication number

JP2019533713A5

JP2019533713A5 JP2019524887A JP2019524887A JP2019533713A5 JP 2019533713 A5 JP2019533713 A5 JP 2019533713A5 JP 2019524887 A JP2019524887 A JP 2019524887A JP 2019524887 A JP2019524887 A JP 2019524887A JP 2019533713 A5 JP2019533713 A5 JP 2019533713A5

Authority

JP

Japan

Prior art keywords

composition according

composition

pah

riociguat

sgc

Prior art date

2017-11-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 28
• 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 17
• 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 claims 16
• 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 claims 16
• 229940127293 prostanoid Drugs 0.000 claims 10
• 150000003814 prostanoids Chemical class 0.000 claims 10
• 238000000034 method Methods 0.000 claims 8
• WXXSNCNJFUAIDG-UHFFFAOYSA-N riociguat Chemical group N1=C(N)C(N(C)C(=O)OC)=C(N)N=C1C(C1=CC=CN=C11)=NN1CC1=CC=CC=C1F WXXSNCNJFUAIDG-UHFFFAOYSA-N 0.000 claims 8
• 229960000529 riociguat Drugs 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 229960005032 treprostinil Drugs 0.000 claims 7
• PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 5
• 239000012453 solvate Substances 0.000 claims 5
• 208000026151 Chronic thromboembolic pulmonary hypertension Diseases 0.000 claims 4
• 229960001123 epoprostenol Drugs 0.000 claims 4
• KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 claims 4
• 208000002815 pulmonary hypertension Diseases 0.000 claims 4
• 208000002330 Congenital Heart Defects Diseases 0.000 claims 3
• 208000031886 HIV Infections Diseases 0.000 claims 3
• 208000037357 HIV infectious disease Diseases 0.000 claims 3
• 208000020875 Idiopathic pulmonary arterial hypertension Diseases 0.000 claims 3
• 208000028831 congenital heart disease Diseases 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 230000002008 hemorrhagic effect Effects 0.000 claims 3
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 3
• 230000000414 obstructive effect Effects 0.000 claims 3
• 208000007232 portal hypertension Diseases 0.000 claims 3
• 230000002685 pulmonary effect Effects 0.000 claims 3
• 210000003492 pulmonary vein Anatomy 0.000 claims 3
• 238000010911 splenectomy Methods 0.000 claims 3
• 239000003053 toxin Substances 0.000 claims 3
• 231100000765 toxin Toxicity 0.000 claims 3
• 102000008186 Collagen Human genes 0.000 claims 2
• 108010035532 Collagen Proteins 0.000 claims 2
• 210000004204 blood vessel Anatomy 0.000 claims 2
• 208000001969 capillary hemangioma Diseases 0.000 claims 2
• -1 cicaprostenol Chemical compound 0.000 claims 2
• 238000011260 co-administration Methods 0.000 claims 2
• 229920001436 collagen Polymers 0.000 claims 2
• 229960002240 iloprost Drugs 0.000 claims 2
• HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 claims 2
• 210000003462 vein Anatomy 0.000 claims 2
• LRGRKWVKESEOGZ-PFYMKENHSA-N (1S,5R)-3-[4-[5-methyl-2-[[2-methyl-4-(piperidine-1-carbonyl)phenyl]methoxy]phenyl]-1,3-thiazol-2-yl]-3-azabicyclo[3.2.1]octane-8-carboxylic acid Chemical compound Cc1ccc(OCc2ccc(cc2C)C(=O)N2CCCCC2)c(c1)-c1csc(n1)N1C[C@@H]2CC[C@H](C1)C2C(O)=O LRGRKWVKESEOGZ-PFYMKENHSA-N 0.000 claims 1
• CRQMDXFUKDWARU-UHFFFAOYSA-N 4-[[4-carboxybutyl-[2-[5-fluoro-2-[[4-[4-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid Chemical compound C=1C=C(C(O)=O)C=CC=1CN(CCCCC(=O)O)CCC1=CC(F)=CC=C1OCC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 CRQMDXFUKDWARU-UHFFFAOYSA-N 0.000 claims 1
• LIVYVCAUBHXIMI-UHFFFAOYSA-N 5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-1h-pyrimidin-6-one Chemical compound C1=C(F)C(O)=NC(C2=NN(CC=3C(=CC=CC=3)F)C(C3=NOC=C3)=C2)=N1 LIVYVCAUBHXIMI-UHFFFAOYSA-N 0.000 claims 1
• 229940127280 BAY 41-2272 Drugs 0.000 claims 1
• ATOAHNRJAXSBOR-UHFFFAOYSA-N BAY 41-2272 Chemical compound NC1=NC(C=2C3=CC=CN=C3N(CC=3C(=CC=CC=3)F)N=2)=NC=C1C1CC1 ATOAHNRJAXSBOR-UHFFFAOYSA-N 0.000 claims 1
• AQYFUZRYBJBAGZ-UHFFFAOYSA-N BAY-41-8543 Chemical compound NC1=NC(C=2C3=CC=CN=C3N(CC=3C(=CC=CC=3)F)N=2)=NC(N)=C1N1CCOCC1 AQYFUZRYBJBAGZ-UHFFFAOYSA-N 0.000 claims 1
• 208000005189 Embolism Diseases 0.000 claims 1
• 208000001435 Thromboembolism Diseases 0.000 claims 1
• 229960002890 beraprost Drugs 0.000 claims 1
• CTPOHARTNNSRSR-APJZLKAGSA-N beraprost Chemical compound O([C@H]1C[C@@H](O)[C@@H]([C@@H]21)/C=C/[C@@H](O)C(C)CC#CC)C1=C2C=CC=C1CCCC(O)=O CTPOHARTNNSRSR-APJZLKAGSA-N 0.000 claims 1
• 150000003815 prostacyclins Chemical class 0.000 claims 1
• 239000000021 stimulant Substances 0.000 claims 1
• 208000019553 vascular disease Diseases 0.000 claims 1