JP2019533017A5 - - Google Patents
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- Publication number
- JP2019533017A5 JP2019533017A5 JP2019540482A JP2019540482A JP2019533017A5 JP 2019533017 A5 JP2019533017 A5 JP 2019533017A5 JP 2019540482 A JP2019540482 A JP 2019540482A JP 2019540482 A JP2019540482 A JP 2019540482A JP 2019533017 A5 JP2019533017 A5 JP 2019533017A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cysteine
- toxin complex
- thiol group
- cytotoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610876568.9 | 2016-10-08 | ||
| CN201610876568 | 2016-10-08 | ||
| PCT/CN2017/104706 WO2018064964A1 (zh) | 2016-10-08 | 2017-09-30 | 半胱氨酸改造的抗体-毒素偶联物及其制备方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019533017A JP2019533017A (ja) | 2019-11-14 |
| JP2019533017A5 true JP2019533017A5 (https=) | 2020-08-20 |
| JP6998386B2 JP6998386B2 (ja) | 2022-02-10 |
Family
ID=61533952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540482A Active JP6998386B2 (ja) | 2016-10-08 | 2017-09-30 | システイン改変抗体－毒素複合体及びその製造方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11484605B2 (https=) |
| EP (1) | EP3524273B1 (https=) |
| JP (1) | JP6998386B2 (https=) |
| KR (2) | KR102480873B1 (https=) |
| CN (3) | CN117398475A (https=) |
| AU (1) | AU2017340314B2 (https=) |
| CA (1) | CA3039559A1 (https=) |
| ES (1) | ES3040239T3 (https=) |
| IL (1) | IL265838B2 (https=) |
| RU (1) | RU2762594C2 (https=) |
| SG (1) | SG11201903084UA (https=) |
| WO (1) | WO2018064964A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018288030B2 (en) * | 2017-06-20 | 2022-02-03 | Systimmune, Inc. | Screening of fixed-point coupling sites of cysteine-modified antibody-toxin conjugate (TDC) |
| CN110872339A (zh) * | 2018-08-30 | 2020-03-10 | 中国人民解放军军事科学院军事医学研究院 | 含有芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途 |
| CA3085001C (en) * | 2019-05-20 | 2021-10-05 | Mabplex International, Ltd. | One-pot process for preparing intermediate of antibody-drug conjugate |
| KR102720758B1 (ko) * | 2021-06-25 | 2024-10-22 | 강원대학교산학협력단 | 주류담배연기 노출 장치 |
| TW202417057A (zh) * | 2022-10-26 | 2024-05-01 | 大陸商同潤生物醫藥(上海)有限公司 | 人源化的l1cam抗體藥物偶聯物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1791565T3 (en) * | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| CL2008001334A1 (es) * | 2007-05-08 | 2008-09-22 | Genentech Inc | Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer. |
| EP2176295B1 (en) * | 2007-07-16 | 2014-11-19 | Genentech, Inc. | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| NZ584514A (en) * | 2007-10-19 | 2012-07-27 | Genentech Inc | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates |
| KR101607346B1 (ko) * | 2008-01-31 | 2016-03-29 | 제넨테크, 인크. | 항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법 |
| CN102770456B (zh) * | 2009-12-04 | 2018-04-06 | 弗·哈夫曼-拉罗切有限公司 | 多特异性抗体、抗体类似物、组合物和方法 |
| EP2953976B1 (en) * | 2013-02-08 | 2021-03-24 | Novartis Ag | Specific sites for modifying antibodies to make immunoconjugates |
| JP6685924B2 (ja) * | 2014-04-11 | 2020-04-22 | メディミューン，エルエルシー | システイン操作抗体を含むコンジュゲート化合物 |
| EP4592311A3 (en) | 2015-02-16 | 2026-02-25 | Lonza Ltd | Antibodies |
| CN106467575B (zh) | 2015-08-18 | 2020-07-31 | 四川百利药业有限责任公司 | 半胱氨酸改造的抗体-毒素偶联物 |
| TWI812873B (zh) | 2015-11-30 | 2023-08-21 | 美商輝瑞股份有限公司 | 用於部位專一性接合之抗體和抗體片段 |
| CN106866822A (zh) | 2016-12-25 | 2017-06-20 | 四川百利药业有限责任公司 | 半胱氨酸改造的抗体‑毒素偶联物 |
-
2017
- 2017-09-29 CN CN202311413663.1A patent/CN117398475A/zh active Pending
- 2017-09-29 CN CN201710910870.6A patent/CN107789630A/zh active Pending
- 2017-09-29 CN CN202410922502.3A patent/CN118846112A/zh active Pending
- 2017-09-30 WO PCT/CN2017/104706 patent/WO2018064964A1/zh not_active Ceased
- 2017-09-30 US US16/339,719 patent/US11484605B2/en active Active
- 2017-09-30 RU RU2019113758A patent/RU2762594C2/ru active
- 2017-09-30 ES ES17857845T patent/ES3040239T3/es active Active
- 2017-09-30 EP EP17857845.6A patent/EP3524273B1/en active Active
- 2017-09-30 AU AU2017340314A patent/AU2017340314B2/en active Active
- 2017-09-30 IL IL265838A patent/IL265838B2/en unknown
- 2017-09-30 CA CA3039559A patent/CA3039559A1/en active Pending
- 2017-09-30 JP JP2019540482A patent/JP6998386B2/ja active Active
- 2017-09-30 SG SG11201903084UA patent/SG11201903084UA/en unknown
- 2017-09-30 KR KR1020197013122A patent/KR102480873B1/ko active Active
- 2017-09-30 KR KR1020227044769A patent/KR102579211B1/ko active Active
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