JP2019531745A - 主要組織適合遺伝子複合体e分子によって拘束されるt細胞を誘発するサイトメガロウイルスベクター - Google Patents

主要組織適合遺伝子複合体e分子によって拘束されるt細胞を誘発するサイトメガロウイルスベクター Download PDF

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JP2019531745A
JP2019531745A JP2019520801A JP2019520801A JP2019531745A JP 2019531745 A JP2019531745 A JP 2019531745A JP 2019520801 A JP2019520801 A JP 2019520801A JP 2019520801 A JP2019520801 A JP 2019520801A JP 2019531745 A JP2019531745 A JP 2019531745A
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vector
cmv
mhc
antigen
cell
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JP2019531745A5 (cg-RX-API-DMAC7.html
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ネルソン、ジェイ
マルーリ、ダニエル
ピッカー、ルイス
ハンコック、ミーガン
サチャ、ジョナー
フルー、クラウス
ハンセン、スコット
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オレゴン ヘルス アンド サイエンス ユニバーシティ
オレゴン ヘルス アンド サイエンス ユニバーシティ
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Publication of JP2019531745A publication Critical patent/JP2019531745A/ja
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JP2019520801A 2016-10-18 2017-10-18 主要組織適合遺伝子複合体e分子によって拘束されるt細胞を誘発するサイトメガロウイルスベクター Pending JP2019531745A (ja)

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PCT/US2017/057106 WO2018075591A1 (en) 2016-10-18 2017-10-18 Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023507142A (ja) * 2019-12-16 2023-02-21 オレゴン ヘルス アンド サイエンス ユニバーシティ 多重特異性t細胞受容体

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2772265T1 (en) 2010-05-14 2018-06-29 Oregon Health & Science University HCMV AND RHCMV RECOMBINANT VECTORS AND THEIR APPLICATIONS
SI2691530T1 (en) 2011-06-10 2018-08-31 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
ES2696703T3 (es) 2013-03-05 2019-01-17 Univ Oregon Health & Science Vectores de citomegalovirus que permiten el control del direccionamiento de los linfocitos T
CA3113595A1 (en) 2014-07-16 2016-01-21 Oregon Health & Science University Human cytomegalovirus comprising exogenous antigens
KR20170136512A (ko) 2015-02-10 2017-12-11 오레곤 헬스 앤드 사이언스 유니버시티 넌-캐노니컬 cd8+ t 세포 반응 생성에 유용한 방법 및 조성물
CA3005136A1 (en) 2015-11-20 2017-05-26 Oregon Health & Science University Cmv vectors comprising microrna recognition elements
CA3040303A1 (en) * 2016-10-18 2018-04-26 Oregon Health & Science University Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules
US10632186B1 (en) 2019-03-21 2020-04-28 21C Bio Vaccine to pathogenic immune activation cells during infections
EP3941517A1 (en) 2019-03-21 2022-01-26 21C Bio Vaccine to pathogenic immune activation cells during infections
US11077185B2 (en) 2019-03-21 2021-08-03 21C Bio Vaccine to pathogenic immune activation cells during infections
WO2020247859A2 (en) * 2019-06-07 2020-12-10 Oregon Health & Science University Tumor-associated antigen-specific t cell responses
CN113950334B (zh) * 2019-06-07 2025-01-28 俄勒冈健康与科学大学 乙型肝炎病毒特异性t细胞应答
US20220307054A1 (en) * 2019-08-20 2022-09-29 Oregon Health & Science University Modulation of t cell responses by ul18 of human cytomegalovirus
MX2022002270A (es) 2019-08-29 2022-03-22 Vir Biotechnology Inc Vacunas contra el virus de la hepatitis b.
EP4396208A1 (en) 2021-08-31 2024-07-10 VIR Biotechnology, Inc. Tuberculosis vaccines
IL310663A (en) 2021-08-31 2024-04-01 Vir Biotechnology Inc Recombinant hcmv vectors and uses thereof
EP4630027A1 (en) 2022-12-09 2025-10-15 DYS-Immune Therapeutics Composite aids vaccine generating anti-hiv specific neutralizing antibodies and/or anti-hiv cytotoxic t cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110188A1 (en) * 2002-07-16 2004-06-10 Gabriele Hahn Novel virus encoded chemokines determine the tissue tropism of human cytomegalovirus (HCMV)
WO2011143653A2 (en) * 2010-05-14 2011-11-17 Oregon Health & Science University Recombinant hcmv and rhcmv vectors and uses thereof
JP2012525141A (ja) * 2009-04-30 2012-10-22 フォンダツィオーネ セントロ サン ラファエレ デル モンテ タボール 遺伝子ベクター
WO2016011293A1 (en) * 2014-07-16 2016-01-21 Oregon Health & Science University Human cytomegalovirus comprising exogenous antigens

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
DE3853139T2 (de) 1987-06-26 1995-06-14 Syntro Corp Rekombinanter, fremde gene enthaltender menschlicher cytomegalovirus und seine verwendung.
US5273876A (en) 1987-06-26 1993-12-28 Syntro Corporation Recombinant human cytomegalovirus containing foreign gene
SG49046A1 (en) 1991-07-05 1998-05-18 American Cyanamid Co Method for identifying non-essential genes of the human cytomegalovirus genome and for screening for inhibitors of human cytomegaloverirus
WO1995003399A2 (en) 1993-07-19 1995-02-02 Cantab Pharmaceuticals Research Limited Production method for preparation of disabled viruses
JPH09512177A (ja) 1994-04-29 1997-12-09 ファルマシア・アンド・アップジョン・カンパニー ネコ免疫不全ウイルスワクチン
US5846806A (en) 1994-07-29 1998-12-08 American Cyanamid Company Identification of a human cytomegalovirus gene region involved in down-regulation of MHC class I heavy chain expression
AU711121B2 (en) 1995-02-21 1999-10-07 Cantab Pharmaceuticals Research Limited Viral preparations, vectors, immunogens, and vaccines
JPH11503024A (ja) 1995-04-04 1999-03-23 セル・ジェネシス・インコーポレイテッド 細胞表面のクラスi mhcタンパク質の低レベルを有する遺伝子学的に修飾された細胞の移植
ES2237800T3 (es) 1996-07-31 2005-08-01 Ortho-Mcneil Pharmaceutical, Inc. Identificacion de genes del citomegalovirus humano implicados en la retro-regulacion de la expresion de las cadenas pesadas de la clase i del cmh.
US20030138454A1 (en) 1997-06-09 2003-07-24 Oxxon Pharmaccines, Ltd. Vaccination method
DE19733364A1 (de) 1997-08-01 1999-02-04 Koszinowski Ulrich H Prof Verfahren zur Klonierung eines großen Virusgenoms
WO1999007869A1 (en) 1997-08-05 1999-02-18 University Of Florida Live recombinant vaccine comprising inefficiently or non-replicating virus
US7204990B1 (en) 2000-11-28 2007-04-17 Medimmune Vaccines, Inc. Attenuation of cytomegalovirus virulence
WO2002062296A2 (en) 2001-02-02 2002-08-15 Chemocentryx, Inc. Methods and compositions useful for stimulating an immune response
WO2002066629A2 (en) 2001-02-21 2002-08-29 Gabriele Hahn Recombinant vector containing infectious human cytomegalovirus genome with preserved wild-type characteristics of clinical isolates
GB0122232D0 (en) 2001-09-14 2001-11-07 Medical Res Council Gene expression
IL160809A0 (en) 2001-09-20 2004-08-31 Glaxo Group Ltd HIV-gag CODON-OPTIMISED DNA VACCINES
US20030118568A1 (en) 2001-12-18 2003-06-26 Board Of Trustees Of The University Of Arkansas Viral stealth technology to prevent T cell-mediated rejection of xenografts
JP2005523942A (ja) 2002-04-30 2005-08-11 アヴィオル セラピューティクス インコーポレイテッド 免疫療法のためのアデノウイルスベクター
US7407744B2 (en) 2003-07-25 2008-08-05 The Regents Of The University Of California Cytomegalovirus gene function and methods for developing antivirals, anti-CMV vaccines, and CMV-based vectors
EP2497831B1 (en) 2004-05-25 2014-07-16 Oregon Health and Science University TB vaccination using HCMV-based vaccine vectors
EP1602676A1 (en) 2004-06-01 2005-12-07 SOLVAY (Société Anonyme) Catalytic compositions
WO2006004661A1 (en) 2004-06-25 2006-01-12 Medimmune Vaccines, Inc. Recombinant human cytomegalovirus and vaccines comprising heterologous antigens
EP1888622A1 (en) 2005-05-23 2008-02-20 Oxxon Therapeutics Ltd. Compositions for inducing an immune response against hepatitis b
BRPI0615400A2 (pt) 2005-08-31 2011-05-17 Genvec Inc vacinas para malária baseadas em vetor adenoviral
US20100142823A1 (en) 2007-03-07 2010-06-10 Ze Wang 2d partially parallel imaging with k-space surrounding neighbors based data reconstruction
CN101990439A (zh) 2007-07-06 2011-03-23 特鲁比昂药品公司 具有置于c末端的特异性结合结构域的结合肽
RU2498991C2 (ru) 2007-10-30 2013-11-20 Дженентек, Инк. Очистка антител с помощью катионообменной хроматографии
CA2754826A1 (en) 2009-03-06 2010-09-10 Mount Sinai School Of Medicine Live attenuated influenza virus vaccines comprising microrna response elements
MX2012007489A (es) 2009-12-23 2012-11-29 4Antibody Ag Miembros enlazadores para citomegalovirus.
EP2529227B1 (en) 2010-01-27 2015-10-07 Oregon Health & Science University Cytomegalovirus-based immunogenic preparations
CA2793959C (en) 2010-03-25 2019-06-04 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
JP2013527758A (ja) 2010-05-05 2013-07-04 ティリオン,クリスティアン ベータヘルペスウイルス感染に対するワクチンおよびその使用
SI2691530T1 (en) 2011-06-10 2018-08-31 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
US20140227708A1 (en) 2011-09-16 2014-08-14 Oregon Health & Science University Methods and kits used in identifying microrna targets
US20130156808A1 (en) 2011-11-22 2013-06-20 Stipan Jonjic Vaccine comprising beta-herpesvirus
CA2890061A1 (en) 2012-12-04 2014-06-12 Merck Sharp & Dohme Corp. Conditional replicating viral vectors
ES2696703T3 (es) 2013-03-05 2019-01-17 Univ Oregon Health & Science Vectores de citomegalovirus que permiten el control del direccionamiento de los linfocitos T
EP3048114A1 (en) 2015-01-22 2016-07-27 Novartis AG Cytomegalovirus antigens and uses thereof
KR20170136512A (ko) 2015-02-10 2017-12-11 오레곤 헬스 앤드 사이언스 유니버시티 넌-캐노니컬 cd8+ t 세포 반응 생성에 유용한 방법 및 조성물
CA3005136A1 (en) 2015-11-20 2017-05-26 Oregon Health & Science University Cmv vectors comprising microrna recognition elements
AU2017280065B2 (en) * 2016-06-22 2021-07-01 International Aids Vaccine Initiative, Inc. Recombinant cytomegalovirus vectors as vaccines for tuberculosis
CA3028002A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
CA3040303A1 (en) 2016-10-18 2018-04-26 Oregon Health & Science University Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110188A1 (en) * 2002-07-16 2004-06-10 Gabriele Hahn Novel virus encoded chemokines determine the tissue tropism of human cytomegalovirus (HCMV)
JP2012525141A (ja) * 2009-04-30 2012-10-22 フォンダツィオーネ セントロ サン ラファエレ デル モンテ タボール 遺伝子ベクター
WO2011143653A2 (en) * 2010-05-14 2011-11-17 Oregon Health & Science University Recombinant hcmv and rhcmv vectors and uses thereof
WO2016011293A1 (en) * 2014-07-16 2016-01-21 Oregon Health & Science University Human cytomegalovirus comprising exogenous antigens

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOCHEM BIOPHYS RES COMMUN., vol. 386, no. 4, JPN6021031935, 2009, pages 549 - 553, ISSN: 0004803568 *
JOURNAL OF CLINICAL INVESTIGATION, vol. 120, no. 10, JPN6021031936, 2010, pages 3641 - 3650, ISSN: 0004572432 *
MOLECULAR AND CELLULAR BIOLOGY, vol. 34, no. 20, JPN6021031932, 2014, pages 3780 - 3787, ISSN: 0004572435 *
ONCOTARGET, vol. 7, no. 24, JPN7021003248, 2 May 2016 (2016-05-02), pages 36614 - 36621, ISSN: 0004572434 *
SCIENCE, vol. 351, no. 6274, JPN6021031937, 12 February 2016 (2016-02-12), pages 714 - 720, ISSN: 0004572431 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023507142A (ja) * 2019-12-16 2023-02-21 オレゴン ヘルス アンド サイエンス ユニバーシティ 多重特異性t細胞受容体

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