JP2019529415A5 - - Google Patents
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- Publication number
- JP2019529415A5 JP2019529415A5 JP2019514720A JP2019514720A JP2019529415A5 JP 2019529415 A5 JP2019529415 A5 JP 2019529415A5 JP 2019514720 A JP2019514720 A JP 2019514720A JP 2019514720 A JP2019514720 A JP 2019514720A JP 2019529415 A5 JP2019529415 A5 JP 2019529415A5
- Authority
- JP
- Japan
- Prior art keywords
- administered
- combination drug
- imo
- cancer
- weeks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 201000011510 cancer Diseases 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 11
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 10
- 238000002560 therapeutic procedure Methods 0.000 claims description 10
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims description 8
- 208000021039 metastatic melanoma Diseases 0.000 claims description 8
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 7
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims description 7
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims description 7
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 7
- 229960002621 pembrolizumab Drugs 0.000 claims description 7
- 229960005386 ipilimumab Drugs 0.000 claims description 6
- 230000002601 intratumoral effect Effects 0.000 claims description 5
- 229960003301 nivolumab Drugs 0.000 claims description 4
- 201000001441 melanoma Diseases 0.000 claims description 3
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims description 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 2
- 102000008096 B7-H1 Antigen Human genes 0.000 claims description 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 claims description 2
- 208000037819 metastatic cancer Diseases 0.000 claims description 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims description 2
- 238000010254 subcutaneous injection Methods 0.000 claims description 2
- 239000007929 subcutaneous injection Substances 0.000 claims description 2
- 229940000425 combination drug Drugs 0.000 claims 21
- 239000000556 agonist Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 33
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 description 8
- 206010060862 Prostate cancer Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 206010041067 Small cell lung cancer Diseases 0.000 description 2
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 description 2
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 description 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 description 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 102000017578 LAG3 Human genes 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 description 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 description 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 230000005746 immune checkpoint blockade Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021170043A JP2022009200A (ja) | 2016-09-15 | 2021-10-18 | がん治療用ｔｌｒ９アゴニストを用いた免疫調節 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662394845P | 2016-09-15 | 2016-09-15 | |
| US62/394,845 | 2016-09-15 | ||
| US201762486738P | 2017-04-18 | 2017-04-18 | |
| US62/486,738 | 2017-04-18 | ||
| PCT/US2017/051742 WO2018053242A1 (en) | 2016-09-15 | 2017-09-15 | Immune modulation with tlr9 agonists for cancer treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021170043A Division JP2022009200A (ja) | 2016-09-15 | 2021-10-18 | がん治療用ｔｌｒ９アゴニストを用いた免疫調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019529415A JP2019529415A (ja) | 2019-10-17 |
| JP2019529415A5 true JP2019529415A5 (https=) | 2020-11-05 |
| JP7200093B2 JP7200093B2 (ja) | 2023-01-06 |
Family
ID=61620152
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514720A Active JP7200093B2 (ja) | 2016-09-15 | 2017-09-15 | がん治療用ｔｌｒ９アゴニストを用いた免疫調節 |
| JP2021170043A Pending JP2022009200A (ja) | 2016-09-15 | 2021-10-18 | がん治療用ｔｌｒ９アゴニストを用いた免疫調節 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021170043A Pending JP2022009200A (ja) | 2016-09-15 | 2021-10-18 | がん治療用ｔｌｒ９アゴニストを用いた免疫調節 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US10463686B2 (https=) |
| EP (1) | EP3512499A4 (https=) |
| JP (2) | JP7200093B2 (https=) |
| KR (1) | KR20190096936A (https=) |
| CN (1) | CN110114057A (https=) |
| AU (1) | AU2017325981A1 (https=) |
| CA (1) | CA3036978A1 (https=) |
| IL (2) | IL292658A (https=) |
| MX (1) | MX2019002925A (https=) |
| WO (1) | WO2018053242A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3024936B1 (en) | 2013-07-25 | 2019-09-04 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| MX2019002925A (es) | 2016-09-15 | 2019-09-05 | Idera Pharmaceuticals Inc | Modulacion inmune con agonistas de tlr9 para el tratamiento del cancer. |
| JP7066696B2 (ja) | 2016-10-11 | 2022-05-13 | アジェナス インコーポレイテッド | 抗ｌａｇ－３抗体及びその使用方法 |
| LT3618863T (lt) | 2017-05-01 | 2023-10-10 | Agenus Inc. | Anti-tigit antikūnai ir jų panaudojimo būdai |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| JP7173993B2 (ja) | 2017-05-19 | 2022-11-17 | ウーシー バイオロジクス（シャンハイ）カンパニー リミテッド | 細胞傷害性ｔリンパ球関連タンパク質４（ｃｔｌａ－４）に対する新規モノクローナル抗体 |
| AU2019362056A1 (en) * | 2018-10-18 | 2021-05-27 | Idera Pharmaceuticals, Inc. | TLR9 modulators for treating cancer |
| US20210371865A1 (en) * | 2018-11-01 | 2021-12-02 | Faron Pharmaceuticals Oy | Tlr9 agonists for use in downregulating clever-i expression on alternatively activated macrophages |
| CA3122773A1 (en) | 2018-12-26 | 2020-07-02 | Xilio Development, Inc. | Anti-ctla4 antibodies and methods of use thereof |
| US20230072809A1 (en) * | 2020-03-09 | 2023-03-09 | Dynavax Technologies Corporation | Active booster immunization against tetanus, diphtheria and pertussis |
| US20230374523A1 (en) * | 2020-09-22 | 2023-11-23 | Trisalus Life Sciences, Inc. | Cancer therapy using toll-like receptor agonists |
| AR125753A1 (es) | 2021-05-04 | 2023-08-09 | Agenus Inc | Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2314693A3 (en) | 1999-08-13 | 2012-11-28 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| US20040214783A1 (en) | 2002-05-08 | 2004-10-28 | Terman David S. | Compositions and methods for treatment of neoplastic disease |
| US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| KR100881923B1 (ko) | 2000-12-27 | 2009-02-04 | 다이나박스 테크놀로지 코퍼레이션 | 면역자극 폴리뉴클레오티드 및 그것의 사용 방법 |
| US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| JP5102959B2 (ja) * | 2002-12-23 | 2012-12-19 | ダイナバックス テクノロジーズ コーポレイション | 免疫刺激配列オリゴヌクレオチド及びその使用方法 |
| MXPA05013658A (es) | 2003-06-11 | 2006-03-02 | Hybridon Inc | Oligonucleotidos inmunomoduladores estabilizados. |
| MXPA06000619A (es) | 2003-07-15 | 2006-04-11 | Hybridon Inc | Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion. |
| CN100482673C (zh) | 2003-07-15 | 2009-04-29 | 艾德拉药物股份有限公司 | 使用免疫刺激性寡核苷酸和/或免疫子化合物结合细胞因子和/或化疗剂或放射治疗对免疫系统的协同刺激作用 |
| US7498425B2 (en) | 2004-06-15 | 2009-03-03 | Idera Pharmaceuticals, Inc. | Immunostimulatory oligonucleotide multimers |
| JP4942646B2 (ja) | 2004-06-15 | 2012-05-30 | イデラ ファーマシューティカルズ インコーポレイテッド | 免疫賦活オリゴヌクレオチドマルチマー |
| KR20080030656A (ko) | 2005-07-07 | 2008-04-04 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 암 치료를 위한 항-ＣＴＬＡ-4 항체 및 ＣｐＧ-모티프-함유합성 올리고데옥시뉴클레오티드의 조합 요법 |
| NZ568211A (en) | 2005-11-04 | 2011-11-25 | Novartis Vaccines & Diagnostic | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| US7470674B2 (en) | 2005-11-07 | 2008-12-30 | Idera Pharmaceuticals, Inc. | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
| MX2008008279A (es) | 2005-12-20 | 2009-03-04 | Idera Pharmaceuticals Inc | Actividad inmunoestimuladora de oligonucleotidos inmunoestimuladores palindromicos que contienen diferentes longitudes de segmentos palindromicos. |
| US20080031887A1 (en) | 2006-06-30 | 2008-02-07 | Joseph Lustgarten | Conjugates for inducing targeted immune responses and methods of making and using same |
| CN101610671A (zh) | 2006-12-12 | 2009-12-23 | 艾德拉药物股份有限公司 | 合成的tlr9激动剂 |
| KR20100053598A (ko) | 2007-08-01 | 2010-05-20 | 이데라 파마슈티칼즈, 인코포레이티드 | Ｔｌｒ９의 신규한 합성 효능제 |
| EP2391718A2 (en) | 2009-01-30 | 2011-12-07 | Idera Pharmaceuticals, Inc. | Novel synthetic agonists of tlr9 |
| US20130142815A1 (en) | 2010-02-09 | 2013-06-06 | Georiga Health Sciences Univ. Research Inst., Inc. | Alpha-methyl-tryptophan as an inhibitor of indoleamine dioxygenase |
| EP2569633B1 (en) | 2010-05-14 | 2016-02-10 | The General Hospital Corporation | Compositions and methods of identifying tumor specific neoantigens |
| FR2975600B1 (fr) * | 2011-05-24 | 2013-07-05 | Assist Publ Hopitaux De Paris | Agents pour le traitement de tumeurs |
| EP2758080B1 (en) * | 2011-09-19 | 2018-03-07 | The Johns Hopkins University | Cancer immunotherapy |
| WO2014047085A2 (en) | 2012-09-20 | 2014-03-27 | Rongfu Wang | Prostate-specific tumor antigen and uses thereof |
| EA201690746A1 (ru) | 2013-10-25 | 2016-12-30 | Фармасайкликс Элэлси | Лечение с применением ингибиторов тирозинкиназы брутона и иммунотерапии |
| IL292510A (en) | 2013-11-05 | 2022-06-01 | Cognate Bioservices Inc | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
| WO2016030863A1 (en) | 2014-08-29 | 2016-03-03 | Glaxosmithkline Intellectual Property Development Limited | Compounds and methods for treating viral infections |
| JP6991857B2 (ja) * | 2014-10-10 | 2022-01-13 | イデラ ファーマシューティカルズ インコーポレイテッド | Ｔｌｒ９アゴニストをチェックポイント阻害剤と共に用いるがんの治療 |
| EP4523756A3 (en) * | 2015-02-13 | 2025-05-28 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| KR102779525B1 (ko) | 2015-05-29 | 2025-03-12 | 다이나박스 테크놀로지 코퍼레이션 | 폐암을 치료하기 위한 폴리뉴클레오티드 Toll-유사 수용체 9 아고니스트의 폐내 투여 |
| KR20180014009A (ko) | 2015-05-29 | 2018-02-07 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 cpg-c 유형 올리고뉴클레오티드의 조합 |
| MX2019002925A (es) | 2016-09-15 | 2019-09-05 | Idera Pharmaceuticals Inc | Modulacion inmune con agonistas de tlr9 para el tratamiento del cancer. |
-
2017
- 2017-09-15 MX MX2019002925A patent/MX2019002925A/es unknown
- 2017-09-15 CN CN201780067972.4A patent/CN110114057A/zh active Pending
- 2017-09-15 WO PCT/US2017/051742 patent/WO2018053242A1/en not_active Ceased
- 2017-09-15 CA CA3036978A patent/CA3036978A1/en active Pending
- 2017-09-15 AU AU2017325981A patent/AU2017325981A1/en not_active Abandoned
- 2017-09-15 IL IL292658A patent/IL292658A/en unknown
- 2017-09-15 EP EP17851589.6A patent/EP3512499A4/en not_active Withdrawn
- 2017-09-15 KR KR1020197010562A patent/KR20190096936A/ko not_active Ceased
- 2017-09-15 US US15/705,631 patent/US10463686B2/en not_active Expired - Fee Related
- 2017-09-15 JP JP2019514720A patent/JP7200093B2/ja active Active
-
2019
- 2019-03-14 IL IL265370A patent/IL265370B/en unknown
- 2019-08-30 US US16/557,630 patent/US10772907B2/en not_active Expired - Fee Related
- 2019-08-30 US US16/557,597 patent/US10835550B2/en not_active Expired - Fee Related
-
2020
- 2020-09-14 US US17/020,355 patent/US20210052625A1/en not_active Abandoned
- 2020-10-21 US US17/076,677 patent/US11224611B2/en not_active Expired - Fee Related
-
2021
- 2021-10-18 JP JP2021170043A patent/JP2022009200A/ja active Pending
- 2021-12-06 US US17/543,341 patent/US20220088054A1/en not_active Abandoned
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