JP2019529408A5 - - Google Patents
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- Publication number
- JP2019529408A5 JP2019529408A5 JP2019514208A JP2019514208A JP2019529408A5 JP 2019529408 A5 JP2019529408 A5 JP 2019529408A5 JP 2019514208 A JP2019514208 A JP 2019514208A JP 2019514208 A JP2019514208 A JP 2019514208A JP 2019529408 A5 JP2019529408 A5 JP 2019529408A5
- Authority
- JP
- Japan
- Prior art keywords
- component
- weight
- preliminary preparation
- ethanol
- preparation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 3
- 239000004973 liquid crystal related substance Substances 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 12
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 7
- 229960005032 treprostinil Drugs 0.000 claims 5
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 3
- 239000004615 ingredient Substances 0.000 claims 3
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 239000006184 cosolvent Substances 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 208000003782 Raynaud disease Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 150000001982 diacylglycerols Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 150000003462 sulfoxides Chemical class 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- IQKAWAUTOKVMLE-ZSESPEEFSA-M treprostinil sodium Chemical class [Na+].C1=CC=C(OCC([O-])=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 IQKAWAUTOKVMLE-ZSESPEEFSA-M 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1615754.7A GB201615754D0 (en) | 2016-09-15 | 2016-09-15 | Formulations |
| GB1615754.7 | 2016-09-15 | ||
| GB1621277.1 | 2016-12-14 | ||
| GBGB1621277.1A GB201621277D0 (en) | 2016-12-14 | 2016-12-14 | Formulations |
| PCT/EP2017/073359 WO2018050864A1 (en) | 2016-09-15 | 2017-09-15 | Prostacyclin analogue formulations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019529408A JP2019529408A (ja) | 2019-10-17 |
| JP2019529408A5 true JP2019529408A5 (enExample) | 2020-10-22 |
| JP7527785B2 JP7527785B2 (ja) | 2024-08-05 |
Family
ID=59887281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514208A Active JP7527785B2 (ja) | 2016-09-15 | 2017-09-15 | プロスタサイクリン類似体製剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11369617B2 (enExample) |
| EP (1) | EP3512495B1 (enExample) |
| JP (1) | JP7527785B2 (enExample) |
| KR (1) | KR20190083645A (enExample) |
| CN (1) | CN109715138B (enExample) |
| AU (1) | AU2017328630B2 (enExample) |
| CA (1) | CA3036307A1 (enExample) |
| DK (1) | DK3512495T3 (enExample) |
| ES (1) | ES2933175T3 (enExample) |
| IL (1) | IL265270B (enExample) |
| LT (1) | LT3512495T (enExample) |
| MX (1) | MX390136B (enExample) |
| PL (1) | PL3512495T3 (enExample) |
| PT (1) | PT3512495T (enExample) |
| RU (1) | RU2757903C2 (enExample) |
| SI (1) | SI3512495T1 (enExample) |
| WO (1) | WO2018050864A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109150387B (zh) | 2017-06-16 | 2023-04-28 | 华为技术有限公司 | 发送参考信号的方法、接收参考信号的方法和通信装置 |
| WO2020240018A1 (en) | 2019-05-29 | 2020-12-03 | Camurus Ab | Administration device & regime |
| EP4173614A4 (en) * | 2020-06-30 | 2024-08-14 | Chong Kun Dang Pharmaceutical Corp. | Injectable composition comprising gnrh derivatives |
| JP2023543037A (ja) * | 2020-09-25 | 2023-10-12 | アルゴリズム サイエンシズ，インコーポレイテッド | 血管拡張剤送達のための組成物及び方法 |
| WO2024107096A1 (en) * | 2022-11-14 | 2024-05-23 | Camurus Ab | Treprostinil formulations |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4125255A1 (de) | 1991-07-31 | 1993-02-04 | Knoll Ag | Prostaglandin e (pfeil abwaerts)1(pfeil abwaerts)-formulierung |
| ATE195866T1 (de) | 1993-07-28 | 2000-09-15 | Pharmaderm Lab Ltd | Zweiphasige multilamellare lipidvesikel |
| SE0201659D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| CN102697790A (zh) * | 2003-05-22 | 2012-10-03 | 联合治疗公司 | 化合物和释放前列环素类似物的方法 |
| GB0412530D0 (en) * | 2004-06-04 | 2004-07-07 | Camurus Ab | Formulation |
| RU2390331C2 (ru) * | 2004-06-04 | 2010-05-27 | Камурус Аб | Жидкие депо-препараты |
| KR20070054644A (ko) * | 2004-07-26 | 2007-05-29 | 액테리온 파마슈티칼 리미티드 | 미립자 제형으로 흡입된 일로프로스트에 의한 폐고혈압의치료 |
| CA2594718C (en) * | 2005-01-14 | 2012-01-24 | Camurus Ab | Gnrh analogue formulations |
| CA2609810C (en) | 2005-06-06 | 2012-05-22 | Camurus Ab | Glp-1 analogue formulations |
| CN108283619B (zh) | 2011-05-25 | 2021-09-14 | 卡穆鲁斯公司 | 控制释放肽制剂 |
| JP6092867B2 (ja) | 2011-08-12 | 2017-03-08 | アセンディス ファーマ エー／エス | 担体連結しているトレプロスチニルプロドラッグ |
| KR20140082649A (ko) * | 2011-08-12 | 2014-07-02 | 아센디스 파마 에이에스 | 프로스타사이클린의 서방형 조성물 |
| WO2013038460A1 (ja) | 2011-09-16 | 2013-03-21 | 株式会社日立製作所 | 画像表示システム及びその方法 |
| DK2787974T3 (en) * | 2011-12-05 | 2017-07-17 | Camurus Ab | Robust PEPTID FORMULATIONS WITH CONTROLLED RELEASE |
| EP3791861A1 (en) * | 2012-07-26 | 2021-03-17 | Camurus AB | Opioid formulations |
| AU2013351934B2 (en) * | 2012-11-30 | 2018-03-29 | Insmed Incorporated | Prostacylin compositions and methods for using the same |
| KR101586790B1 (ko) | 2012-12-28 | 2016-01-19 | 주식회사 종근당 | 음이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물 |
| WO2015138423A1 (en) | 2014-03-11 | 2015-09-17 | Insmed Incorporated | Prostacylin compositions and methods for using the same |
| GB201419091D0 (en) | 2014-10-27 | 2014-12-10 | Camurus Ab | Formulations |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
-
2017
- 2017-09-15 LT LTEPPCT/EP2017/073359T patent/LT3512495T/lt unknown
- 2017-09-15 WO PCT/EP2017/073359 patent/WO2018050864A1/en not_active Ceased
- 2017-09-15 SI SI201731280T patent/SI3512495T1/sl unknown
- 2017-09-15 KR KR1020197008219A patent/KR20190083645A/ko not_active Ceased
- 2017-09-15 RU RU2019108832A patent/RU2757903C2/ru active
- 2017-09-15 EP EP17768124.4A patent/EP3512495B1/en active Active
- 2017-09-15 MX MX2019002999A patent/MX390136B/es unknown
- 2017-09-15 AU AU2017328630A patent/AU2017328630B2/en active Active
- 2017-09-15 PT PT177681244T patent/PT3512495T/pt unknown
- 2017-09-15 IL IL265270A patent/IL265270B/en unknown
- 2017-09-15 CA CA3036307A patent/CA3036307A1/en active Pending
- 2017-09-15 CN CN201780056712.7A patent/CN109715138B/zh active Active
- 2017-09-15 DK DK17768124.4T patent/DK3512495T3/da active
- 2017-09-15 PL PL17768124.4T patent/PL3512495T3/pl unknown
- 2017-09-15 US US16/333,448 patent/US11369617B2/en active Active
- 2017-09-15 ES ES17768124T patent/ES2933175T3/es active Active
- 2017-09-15 JP JP2019514208A patent/JP7527785B2/ja active Active
-
2022
- 2022-06-09 US US17/836,120 patent/US20220387445A1/en not_active Abandoned
-
2024
- 2024-11-12 US US18/945,113 patent/US20250319097A1/en active Pending
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