JP2019528810A5 - - Google Patents
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- JP2019528810A5 JP2019528810A5 JP2019500495A JP2019500495A JP2019528810A5 JP 2019528810 A5 JP2019528810 A5 JP 2019528810A5 JP 2019500495 A JP2019500495 A JP 2019500495A JP 2019500495 A JP2019500495 A JP 2019500495A JP 2019528810 A5 JP2019528810 A5 JP 2019528810A5
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- Prior art keywords
- disease
- disease material
- flow path
- blood
- targeting ligand
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- 239000000463 material Substances 0.000 claims description 112
- 201000010099 disease Diseases 0.000 claims description 87
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 87
- 239000003446 ligand Substances 0.000 claims description 41
- 239000008280 blood Substances 0.000 claims description 35
- 210000004369 blood Anatomy 0.000 claims description 35
- 230000008685 targeting Effects 0.000 claims description 31
- 239000013060 biological fluid Substances 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 15
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022129921A JP2022176962A (ja) | 2016-07-07 | 2022-08-17 | 疾患材料の検出、捕捉、または除去のための流体デバイス |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359322P | 2016-07-07 | 2016-07-07 | |
| US62/359,322 | 2016-07-07 | ||
| US201662407767P | 2016-10-13 | 2016-10-13 | |
| US62/407,767 | 2016-10-13 | ||
| US201762454235P | 2017-02-03 | 2017-02-03 | |
| US62/454,235 | 2017-02-03 | ||
| US201762478904P | 2017-03-30 | 2017-03-30 | |
| US62/478,904 | 2017-03-30 | ||
| PCT/US2017/041038 WO2018009756A1 (en) | 2016-07-07 | 2017-07-07 | Fluidic device for the detection, capture, or removal of a disease material |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022129921A Division JP2022176962A (ja) | 2016-07-07 | 2022-08-17 | 疾患材料の検出、捕捉、または除去のための流体デバイス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019528810A JP2019528810A (ja) | 2019-10-17 |
| JP2019528810A5 true JP2019528810A5 (https=) | 2020-08-13 |
Family
ID=60912299
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500495A Withdrawn JP2019528810A (ja) | 2016-07-07 | 2017-07-07 | 疾患材料の検出、捕捉、または除去のための流体デバイス |
| JP2022129921A Pending JP2022176962A (ja) | 2016-07-07 | 2022-08-17 | 疾患材料の検出、捕捉、または除去のための流体デバイス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022129921A Pending JP2022176962A (ja) | 2016-07-07 | 2022-08-17 | 疾患材料の検出、捕捉、または除去のための流体デバイス |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11154861B2 (https=) |
| EP (1) | EP3482203A4 (https=) |
| JP (2) | JP2019528810A (https=) |
| CN (1) | CN109791146A (https=) |
| CA (1) | CA3030138A1 (https=) |
| WO (1) | WO2018009756A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3735281B1 (en) * | 2018-01-05 | 2024-11-27 | Path Ex, Inc. | Device for the capture and removal of disease material from fluids |
| EP3870969A4 (en) * | 2018-10-24 | 2022-07-27 | Path Ex, Inc. | PROCESS FOR RECOVERING AND ISOLATION OF DISEASE MATERIAL FROM FLOWING MATERIAL |
| CN109082368A (zh) * | 2018-10-29 | 2018-12-25 | 上海理工大学 | 循环肿瘤细胞分选、富集及检测用多级微流控芯片装置 |
| WO2020102533A1 (en) * | 2018-11-15 | 2020-05-22 | Massachusetts Institute Of Technology | Multi-dimensional double spiral device and methods of use thereof |
| WO2021063708A1 (en) * | 2019-09-30 | 2021-04-08 | Hemotune Ag | Assembly for extracorporeal treatment of body fluids |
| KR20210043207A (ko) * | 2019-10-11 | 2021-04-21 | 주식회사 싸이토딕스 | 비편향적 순환종양세포 연속 분리 장치 및 방법 |
| WO2021144769A1 (en) | 2020-01-17 | 2021-07-22 | Wynnvision, Llc | Antimicrobial silicones |
| US20210237064A1 (en) * | 2020-01-31 | 2021-08-05 | Astrin Biosciences, Inc. | Biological Fluid Filtration System |
| US20230381393A1 (en) * | 2022-05-27 | 2023-11-30 | Actorius Innovations Research Co | Devices and methods for recovering disease-causing toxic constituents in the blood |
| CN115107285B (zh) * | 2022-06-16 | 2024-04-02 | 乾德生物医疗技术(重庆)有限公司 | 血液净化装置的制造方法 |
| WO2024038432A1 (en) * | 2022-08-13 | 2024-02-22 | Adrian Paz | Circulating tumor cells collection and therapy system |
| CN117050764B (zh) * | 2023-09-11 | 2024-04-05 | 华南理工大学 | 一种抗生素菌渣多步热解制备高含量可燃气体的方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001087486A2 (en) * | 2000-05-15 | 2001-11-22 | Tecan Trading Ag | Microfluidics devices and methods for performing cell based assays |
| US20020164816A1 (en) | 2001-04-06 | 2002-11-07 | California Institute Of Technology | Microfluidic sample separation device |
| JP4110806B2 (ja) | 2002-03-14 | 2008-07-02 | 東レ株式会社 | 体外循環用毒素吸着材 |
| DE102004040785B4 (de) * | 2004-08-23 | 2006-09-21 | Kist-Europe Forschungsgesellschaft Mbh | Mikrofluidisches System zur Isolierung biologischer Partikel unter Verwendung der immunomagnetischen Separation |
| GB2472927B (en) | 2005-04-05 | 2011-05-04 | Gen Hospital Corp | Microfluidic Cell Capture on Micro-Corrugated Surface |
| CN100420947C (zh) | 2005-05-30 | 2008-09-24 | 孙东旭 | 用单一捕获剂定量检测特异性分析物的方法及其试剂盒 |
| JP2007268490A (ja) | 2006-03-31 | 2007-10-18 | Fujifilm Corp | マイクロデバイス及びそれを用いた触媒反応方法 |
| US10052571B2 (en) * | 2007-11-07 | 2018-08-21 | Palo Alto Research Center Incorporated | Fluidic device and method for separation of neutrally buoyant particles |
| WO2009009408A2 (en) * | 2007-07-06 | 2009-01-15 | Applied Biosystems Inc. | Devices and methods for the detection of analytes |
| WO2009012340A2 (en) | 2007-07-16 | 2009-01-22 | California Institute Of Technology | Microfluidic devices, methods and systems for detecting target molecules |
| US20100075340A1 (en) | 2008-09-22 | 2010-03-25 | Mehdi Javanmard | Electrical Detection Of Biomarkers Using Bioactivated Microfluidic Channels |
| GB0902316D0 (en) * | 2009-02-12 | 2009-04-01 | Univ Nottingham | Pathogen detector assay, method and kit |
| WO2010129532A2 (en) * | 2009-05-05 | 2010-11-11 | Trustees Of Boston University | Method and device for rapid detection of bacterial antibiotic resistance/susceptibility |
| FR2950699A1 (fr) | 2009-09-29 | 2011-04-01 | Centre Nat Rech Scient | Dispositif a usage unique pour la detection de particules d'interet, telles que des entites biologiques, systeme de detection comprenant ledit dispositif et procede de mise en oeuvre |
| US9458489B2 (en) * | 2010-03-04 | 2016-10-04 | Massachusetts Institute Of Technology | Microfluidics sorter for cell detection and isolation |
| US20140154703A1 (en) * | 2011-01-06 | 2014-06-05 | Alison Skelley | Circulating tumor cell capture on a microfluidic chip incorporating both affinity and size |
| US10130946B2 (en) * | 2011-09-30 | 2018-11-20 | The Regents Of The University Of Michigan | System for detecting rare cells |
| WO2013049636A1 (en) | 2011-09-30 | 2013-04-04 | The Regents Of The University Of Michigan | System for detecting rare cells |
| WO2014046621A1 (en) | 2012-09-21 | 2014-03-27 | Massachusetts Institute Of Technology | Micro-fluidic device and uses thereof |
| CN104345153B (zh) * | 2013-07-30 | 2017-05-10 | 香港中文大学 | 微阵列基底、微阵列、微流体系统及其制备方法 |
| SG11201700733TA (en) | 2014-07-30 | 2017-02-27 | Univ Case Western Reserve | Biochips to diagnose hemoglobin disorders and monitor blood cells |
| WO2016040850A1 (en) * | 2014-09-11 | 2016-03-17 | Oregon State University | Microfluidic device for removal of constituents from blood |
| US10228313B2 (en) * | 2014-10-24 | 2019-03-12 | Massachusetts Institute Of Technology | System and method for multiplexed affinity purification of proteins and cells |
| WO2019241794A1 (en) * | 2018-06-16 | 2019-12-19 | Hacker Kevin Jay | Microorganism identification and characterization |
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2017
- 2017-07-07 WO PCT/US2017/041038 patent/WO2018009756A1/en not_active Ceased
- 2017-07-07 CN CN201780055162.7A patent/CN109791146A/zh active Pending
- 2017-07-07 US US16/315,732 patent/US11154861B2/en active Active
- 2017-07-07 CA CA3030138A patent/CA3030138A1/en active Pending
- 2017-07-07 EP EP17824950.4A patent/EP3482203A4/en active Pending
- 2017-07-07 JP JP2019500495A patent/JP2019528810A/ja not_active Withdrawn
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2021
- 2021-09-01 US US17/464,103 patent/US11883821B2/en active Active
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2022
- 2022-08-17 JP JP2022129921A patent/JP2022176962A/ja active Pending
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