JP2019528760A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019528760A5 JP2019528760A5 JP2019517047A JP2019517047A JP2019528760A5 JP 2019528760 A5 JP2019528760 A5 JP 2019528760A5 JP 2019517047 A JP2019517047 A JP 2019517047A JP 2019517047 A JP2019517047 A JP 2019517047A JP 2019528760 A5 JP2019528760 A5 JP 2019528760A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cells
- modified
- population
- unnatural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 16
- 102000006306 Antigen Receptors Human genes 0.000 claims 8
- 108010083359 Antigen Receptors Proteins 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 108091008874 T cell receptors Proteins 0.000 claims 6
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 6
- 102000008579 Transposases Human genes 0.000 claims 6
- 108010020764 Transposases Proteins 0.000 claims 6
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 3
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 3
- 102100033467 L-selectin Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 230000006052 T cell proliferation Effects 0.000 claims 2
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 claims 2
- 229940031578 diisopropyl adipate Drugs 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- LXOFYPKXCSULTL-UHFFFAOYSA-N 2,4,7,9-tetramethyldec-5-yne-4,7-diol Chemical compound CC(C)CC(C)(O)C#CC(C)(O)CC(C)C LXOFYPKXCSULTL-UHFFFAOYSA-N 0.000 claims 1
- 230000008265 DNA repair mechanism Effects 0.000 claims 1
- 230000004568 DNA-binding Effects 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 229930182558 Sterol Natural products 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- MGWAVDBGNNKXQV-UHFFFAOYSA-N diisobutyl phthalate Chemical compound CC(C)COC(=O)C1=CC=CC=C1C(=O)OCC(C)C MGWAVDBGNNKXQV-UHFFFAOYSA-N 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- BYTFESSQUGDMQQ-UHFFFAOYSA-N octadecanehydrazide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NN BYTFESSQUGDMQQ-UHFFFAOYSA-N 0.000 claims 1
- FATBGEAMYMYZAF-KTKRTIGZSA-N oleamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(N)=O FATBGEAMYMYZAF-KTKRTIGZSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- FATBGEAMYMYZAF-UHFFFAOYSA-N oleicacidamide-heptaglycolether Natural products CCCCCCCCC=CCCCCCCCC(N)=O FATBGEAMYMYZAF-UHFFFAOYSA-N 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 150000003432 sterols Chemical class 0.000 claims 1
- 235000003702 sterols Nutrition 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020168576A JP7610948B2 (ja) | 2016-09-30 | 2020-10-05 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
| JP2021156988A JP2021191312A (ja) | 2016-09-30 | 2021-09-27 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
| JP2024076779A JP2024096417A (ja) | 2016-09-30 | 2024-05-09 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402707P | 2016-09-30 | 2016-09-30 | |
| US62/402,707 | 2016-09-30 | ||
| US201762502508P | 2017-05-05 | 2017-05-05 | |
| US62/502,508 | 2017-05-05 | ||
| US201762553058P | 2017-08-31 | 2017-08-31 | |
| US62/553,058 | 2017-08-31 | ||
| US201762556309P | 2017-09-08 | 2017-09-08 | |
| US62/556,309 | 2017-09-08 | ||
| PCT/US2017/054799 WO2018064681A1 (en) | 2016-09-30 | 2017-10-02 | Modified stem cell memory t cells, methods of making and methods of using same |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020168576A Division JP7610948B2 (ja) | 2016-09-30 | 2020-10-05 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
| JP2021156988A Division JP2021191312A (ja) | 2016-09-30 | 2021-09-27 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019528760A JP2019528760A (ja) | 2019-10-17 |
| JP2019528760A5 true JP2019528760A5 (cg-RX-API-DMAC7.html) | 2020-11-12 |
Family
ID=60245180
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517047A Pending JP2019528760A (ja) | 2016-09-30 | 2017-10-02 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
| JP2020168576A Active JP7610948B2 (ja) | 2016-09-30 | 2020-10-05 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
| JP2021156988A Pending JP2021191312A (ja) | 2016-09-30 | 2021-09-27 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
| JP2024076779A Pending JP2024096417A (ja) | 2016-09-30 | 2024-05-09 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020168576A Active JP7610948B2 (ja) | 2016-09-30 | 2020-10-05 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
| JP2021156988A Pending JP2021191312A (ja) | 2016-09-30 | 2021-09-27 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
| JP2024076779A Pending JP2024096417A (ja) | 2016-09-30 | 2024-05-09 | 改変された幹細胞メモリーｔ細胞、その作製方法およびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3519561A1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP2019528760A (cg-RX-API-DMAC7.html) |
| KR (4) | KR102588469B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110199015A (cg-RX-API-DMAC7.html) |
| AU (4) | AU2017337147A1 (cg-RX-API-DMAC7.html) |
| CA (3) | CA3105873A1 (cg-RX-API-DMAC7.html) |
| IL (3) | IL287286B (cg-RX-API-DMAC7.html) |
| SG (2) | SG10202007963SA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018064681A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
| CN110199015A (zh) * | 2016-09-30 | 2019-09-03 | 波赛达治疗公司 | 修饰干细胞记忆t细胞、其制造方法与使用方法 |
| EP3555273B1 (en) | 2016-12-16 | 2024-05-22 | B-Mogen Biotechnologies, Inc. | ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS |
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| EP3351263A1 (en) | 2017-01-20 | 2018-07-25 | Universitätsklinikum Hamburg-Eppendorf | Pharmaceutical preparation for treating or preventing tissue adhesion |
| ES3008982T3 (en) | 2017-08-18 | 2025-03-25 | Neutrolis Inc | Engineered dnase enzymes and use in therapy |
| US20210015866A1 (en) * | 2018-03-23 | 2021-01-21 | La Jolla Institute For Allergy And Immunology | Tissue resident memory cell profiles, and uses thereof |
| US11760983B2 (en) | 2018-06-21 | 2023-09-19 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| EP3864147A4 (en) | 2018-10-08 | 2022-07-06 | Neutrolis, Inc. | DNASE ENZYME ENGINEERING FOR MANUFACTURING AND THERAPY |
| US10988746B2 (en) | 2018-10-08 | 2021-04-27 | Neutrolis, Inc. | Manufacturing and engineering of DNASE enzymes for therapy |
| US11058724B2 (en) * | 2018-10-08 | 2021-07-13 | Neutrolis, Inc. | Methods of using DNASE1-like 3 in therapy |
| US11352613B2 (en) | 2019-02-04 | 2022-06-07 | Neutrolis, Inc. | Engineered human extracellular DNASE enzymes |
| WO2020168362A1 (en) | 2019-02-15 | 2020-08-20 | Crispr Therapeutics Ag | Gene editing for hemophilia a with improved factor viii expression |
| AU2020261411B2 (en) * | 2019-04-26 | 2025-10-02 | Allogene Therapeutics, Inc. | Methods of manufacturing allogeneic car T cells |
| CN113710284A (zh) * | 2019-06-05 | 2021-11-26 | 克里斯珀医疗股份公司 | 具有改善的因子viii表达的血友病a基因编辑 |
| CN110358734B (zh) | 2019-06-13 | 2020-08-25 | 首都医科大学宣武医院 | 以Tcm为主要效应成分的CAR-T制备方法及其应用 |
| BR112022011339A2 (pt) * | 2019-12-11 | 2022-10-04 | Myeloid Therapeutics Inc | Composições de células terapêuticas e métodos para fabricação e usos das mesmas |
| CA3171369A1 (en) * | 2020-02-28 | 2021-09-02 | Wisconsin Alumni Research Foundation | Nonviral generation of genome edited chimeric antigen receptor t cells |
| WO2021183946A2 (en) | 2020-03-13 | 2021-09-16 | The Johns Hopkins University | Selectable marker proteins, expression vectors, engineered cells and extracellular vesicles for the production of virus-like particles for therapeutic and prophylactic applications |
| CA3158133A1 (en) | 2020-04-28 | 2021-11-04 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| US20240060090A1 (en) * | 2021-02-23 | 2024-02-22 | Poseida Therapeutics, Inc. | Genetically modified induced pluripotent stem cells and methods of use thereof |
| CN114990061B (zh) * | 2022-06-30 | 2023-08-29 | 河南省人民医院 | 一种诱导扩增中央记忆性t细胞的培养方法 |
| WO2025221789A1 (en) | 2024-04-16 | 2025-10-23 | Poseida Therapeutics, Inc. | Compositions and methods for use in car/tcr cell therapies |
| CN118272305B (zh) * | 2024-04-29 | 2025-04-08 | 深圳泽医细胞治疗集团有限公司 | 一种免疫细胞的培养基及其应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5266491A (en) | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
| US5580734A (en) | 1990-07-13 | 1996-12-03 | Transkaryotic Therapies, Inc. | Method of producing a physical map contigous DNA sequences |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5733761A (en) | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| AU7082694A (en) * | 1994-05-10 | 1995-11-29 | Kitasato Institute, The | Hematopoietic stem cell proliferation accelerator |
| US6218185B1 (en) | 1996-04-19 | 2001-04-17 | The United States Of America As Represented By The Secretary Of Agriculture | Piggybac transposon-based genetic transformation system for insects |
| US6835394B1 (en) | 1999-12-14 | 2004-12-28 | The Trustees Of The University Of Pennsylvania | Polymersomes and related encapsulating membranes |
| US7105343B1 (en) | 2000-10-31 | 2006-09-12 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector Piggybac |
| US6962810B2 (en) | 2000-10-31 | 2005-11-08 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac |
| IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
| WO2004016731A2 (en) * | 2002-08-19 | 2004-02-26 | Gamida-Cell Ltd. | Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures |
| WO2010099296A1 (en) | 2009-02-26 | 2010-09-02 | Transposagen Biopharmaceuticals, Inc. | Hyperactive piggybac transposases |
| WO2010140298A1 (ja) * | 2009-06-02 | 2010-12-09 | パナソニック株式会社 | 無線通信装置及び無線通信方法 |
| US8808748B2 (en) | 2010-04-20 | 2014-08-19 | Vindico NanoBio Technology Inc. | Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and methods of using the same |
| EP2661275B1 (en) | 2011-01-07 | 2019-01-02 | Poseida Therapeutics, Inc. | Compositions and methods for delivery of high-affinity oxygen binding agents to tumors |
| PT3434775T (pt) * | 2011-06-07 | 2020-04-08 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh | Proteína que tem atividade de nuclease, proteínas de fusão e utilizações das mesmas |
| JP6850528B2 (ja) * | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| EP2975942B1 (en) * | 2013-03-21 | 2018-08-08 | Sangamo Therapeutics, Inc. | Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases |
| WO2014186469A2 (en) * | 2013-05-14 | 2014-11-20 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| US20170335281A1 (en) * | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| CA3246595A1 (en) * | 2014-04-09 | 2025-07-08 | Dna Twopointo Inc. | Enhanced polynucleotide constructs for eukaryotic gene expression |
| CA2954414A1 (en) * | 2014-07-15 | 2016-01-21 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| EP3177713B1 (en) | 2014-08-08 | 2020-08-05 | Poseida Therapeutics, Inc. | Compositions and their use for inducing nanoparticle-mediated microvascular embolization of tumors |
| BR112017004270B1 (pt) * | 2014-09-04 | 2023-03-07 | Stemcell Technologies Inc | Método de ativação de células t ou células nk |
| EP3018200A1 (en) * | 2014-11-07 | 2016-05-11 | Fondazione Matilde Tettamanti e Menotti de Machi Onlus | Improved method for the generation of genetically modified cells |
| WO2016090111A1 (en) | 2014-12-05 | 2016-06-09 | Vindico NanoBio Technology Inc. | Compositions and methods for inducing nanoparticle-mediated microvascular embolization of tumors |
| RU2021118125A (ru) * | 2014-12-29 | 2022-04-06 | Новартис Аг | Способы получения экспрессирующих химерный антигенный рецептор клеток |
| ES2886599T3 (es) * | 2015-06-17 | 2021-12-20 | Poseida Therapeutics Inc | Composiciones y métodos para dirigir proteínas a loci específicos en el genoma |
| US20170000743A1 (en) | 2015-07-02 | 2017-01-05 | Vindico NanoBio Technology Inc. | Compositions and Methods for Delivery of Gene Editing Tools Using Polymeric Vesicles |
| US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
| CN110199015A (zh) * | 2016-09-30 | 2019-09-03 | 波赛达治疗公司 | 修饰干细胞记忆t细胞、其制造方法与使用方法 |
-
2017
- 2017-10-02 CN CN201780073874.1A patent/CN110199015A/zh active Pending
- 2017-10-02 AU AU2017337147A patent/AU2017337147A1/en not_active Abandoned
- 2017-10-02 EP EP17794119.2A patent/EP3519561A1/en active Pending
- 2017-10-02 KR KR1020207026327A patent/KR102588469B1/ko active Active
- 2017-10-02 JP JP2019517047A patent/JP2019528760A/ja active Pending
- 2017-10-02 KR KR1020197011671A patent/KR20190063468A/ko not_active Ceased
- 2017-10-02 CA CA3105873A patent/CA3105873A1/en not_active Abandoned
- 2017-10-02 SG SG10202007963SA patent/SG10202007963SA/en unknown
- 2017-10-02 KR KR1020237007633A patent/KR102757155B1/ko active Active
- 2017-10-02 SG SG11201901959YA patent/SG11201901959YA/en unknown
- 2017-10-02 IL IL287286A patent/IL287286B/en unknown
- 2017-10-02 KR KR1020257001336A patent/KR20250011252A/ko active Pending
- 2017-10-02 WO PCT/US2017/054799 patent/WO2018064681A1/en not_active Ceased
- 2017-10-02 CA CA3154236A patent/CA3154236C/en active Active
- 2017-10-02 CA CA3036926A patent/CA3036926C/en active Active
-
2019
- 2019-03-04 IL IL265157A patent/IL265157B/en active IP Right Grant
-
2020
- 2020-08-25 IL IL276907A patent/IL276907B/en unknown
- 2020-09-01 AU AU2020227020A patent/AU2020227020B2/en active Active
- 2020-10-05 JP JP2020168576A patent/JP7610948B2/ja active Active
-
2021
- 2021-09-27 JP JP2021156988A patent/JP2021191312A/ja active Pending
-
2022
- 2022-09-23 AU AU2022235633A patent/AU2022235633B2/en active Active
-
2024
- 2024-05-09 JP JP2024076779A patent/JP2024096417A/ja active Pending
-
2025
- 2025-04-29 AU AU2025203005A patent/AU2025203005A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019528760A5 (cg-RX-API-DMAC7.html) | ||
| Tsvetkov | Worldview model as the result of education | |
| EP4427809A3 (en) | Altering gene expression in car-t cells and uses thereof | |
| JP2013176400A5 (cg-RX-API-DMAC7.html) | ||
| IL287286B (en) | Differentiated stem cell memory t cells, methods for their preparation and methods for using them | |
| MX395574B (es) | Metodo y composiciones para inmunoterapia celular. | |
| JP2013501505A5 (cg-RX-API-DMAC7.html) | ||
| EA201891212A1 (ru) | Адресная дезорганизация клеточного рецептора гкгс | |
| JP2017512484A5 (cg-RX-API-DMAC7.html) | ||
| EA201890772A1 (ru) | Способ высокоуровневого и стабильного переноса генов в лимфоцитах | |
| HK1216894A1 (zh) | 多價結合蛋白組合物 | |
| NZ705675A (en) | Engineered transgene integration platform (etip) for gene targeting and trait stacking | |
| MX367170B (es) | Enriquecimiento de la clasificacion de las celulas activadas por fluorescencia (facs) para generar plantas. | |
| EP4303232A3 (en) | Chimeric antigen receptor and methods of use thereof | |
| EP4458419A3 (en) | Methods for expanding antigen-specific car-t cells, compositions and uses related thereto | |
| CY1123348T1 (el) | Μεθοδος για την παρασκευη ενισχυμενων πολυδυναμων βλαστοκυτταρων απο μεσεγχυματικα βλαστοκυτταρα με τη χρηση κλασματος φλοροταννινης | |
| Plekhanova et al. | The development of mass media in the modern information society | |
| JP2019534684A5 (cg-RX-API-DMAC7.html) | ||
| Sikorskaya | Noosferic aspects of networked collaborations among vocational educational institutions in Russia | |
| PL415351A1 (pl) | Sposób namnażania in vitro komórek T regulatorowych (Treg) | |
| Khairetdinov et al. | Vibroseismoacoustic method in studying of geophysical fields interaction in ground atmosphere | |
| Karpenko et al. | Some aspects of musically-elucidative activity with students in the conditions of higher educational establishment | |
| MARJUNO et al. | DIVERSITY AND ABUNDANCE OF BEETLES (COLEOPTERA) IN THE VILLAGE OF LUKSAGU, NORTH TINANGKUNG DISTRICT AND ITS UTILIZATIONASA LEARNING MEDIA | |
| Kornienko | PRINCIPLES OF FORMING OF SYSTEM OF ECONOMIC ANALYSIS ARE IN MANAGEMENT ENTERPRISE | |
| Metelitsa | AN ANALYSIS OF DIFFICULTIES READING ACADEMIC ARTCILES OF STUDENTS OF TECHNICAL SPECIALISATIONS AND ATTEMPTS TO SOLVE THEM |