JP2019528307A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019528307A5 JP2019528307A5 JP2019511664A JP2019511664A JP2019528307A5 JP 2019528307 A5 JP2019528307 A5 JP 2019528307A5 JP 2019511664 A JP2019511664 A JP 2019511664A JP 2019511664 A JP2019511664 A JP 2019511664A JP 2019528307 A5 JP2019528307 A5 JP 2019528307A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- diamine
- isopropylsulfonyl
- pyrimidine
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YZVRDSIPTUIXBL-UHFFFAOYSA-N 4-(2-propan-2-ylsulfonylphenyl)-1H-pyrimidine-2,4-diamine Chemical compound CC(C)S(=O)(=O)C1=CC=CC=C1C1(N)C=CN=C(N)N1 YZVRDSIPTUIXBL-UHFFFAOYSA-N 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 17
- 239000011780 sodium chloride Substances 0.000 claims 17
- 239000012453 solvate Substances 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 13
- -1 4-((cis) -2,6-diethyl-1-methyl-1,2,3,6-tetrahydropyridine-4-yl) -2-isopropoxy-5-methylphenyl Chemical group 0.000 claims 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- YWPHBSHEGTZPNS-UHFFFAOYSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1CCN(CC=1)C1CCOCC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1CCN(CC=1)C1CCOCC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C YWPHBSHEGTZPNS-UHFFFAOYSA-N 0.000 claims 2
- ILCXJAPSUFBQHI-YADHBBJMSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@@H](C=1)C)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@@H](C=1)C)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C ILCXJAPSUFBQHI-YADHBBJMSA-N 0.000 claims 2
- FQHDPBMKCKJTSQ-IOWSJCHKSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@@H](C=1)C1CC1)C)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@@H](C=1)C1CC1)C)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C FQHDPBMKCKJTSQ-IOWSJCHKSA-N 0.000 claims 2
- ILCXJAPSUFBQHI-VXKWHMMOSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C ILCXJAPSUFBQHI-VXKWHMMOSA-N 0.000 claims 2
- RNRSZZIBWISOMX-GOTSBHOMSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C)C1COC1)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C)C1COC1)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C RNRSZZIBWISOMX-GOTSBHOMSA-N 0.000 claims 2
- FQHDPBMKCKJTSQ-FIRIVFDPSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C1CC1)C)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C1CC1)C)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C FQHDPBMKCKJTSQ-FIRIVFDPSA-N 0.000 claims 2
- WXMLFRIMSKNYHP-RTWAWAEBSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@@H](C=1)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@@H](C=1)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C WXMLFRIMSKNYHP-RTWAWAEBSA-N 0.000 claims 2
- WXMLFRIMSKNYHP-SFTDATJTSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@H](C=1)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@H](C=1)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C WXMLFRIMSKNYHP-SFTDATJTSA-N 0.000 claims 2
- 206010012818 Diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 208000008968 Lymphoma, Large-Cell, Anaplastic Diseases 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 2
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 208000006265 Renal Cell Carcinoma Diseases 0.000 claims 2
- 201000011231 colorectal cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000005619 esophageal carcinoma Diseases 0.000 claims 2
- 230000002757 inflammatory Effects 0.000 claims 2
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- CVICEEPAFUYBJG-UHFFFAOYSA-N 5-chloro-2,2-difluoro-1,3-benzodioxole Chemical group C1=C(Cl)C=C2OC(F)(F)OC2=C1 CVICEEPAFUYBJG-UHFFFAOYSA-N 0.000 claims 1
- PKLRPVDAVLKMTH-UHFFFAOYSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1CC(N(C(C=1)(C)C)C)(C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1CC(N(C(C=1)(C)C)C)(C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C PKLRPVDAVLKMTH-UHFFFAOYSA-N 0.000 claims 1
- MEOQISVGQSCFTC-UHFFFAOYSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1CCN(CC=1)C1COC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1CCN(CC=1)C1COC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C MEOQISVGQSCFTC-UHFFFAOYSA-N 0.000 claims 1
- RNRSZZIBWISOMX-PKTZIBPZSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@@H](C=1)C)C1COC1)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@@H](C=1)C)C1COC1)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C RNRSZZIBWISOMX-PKTZIBPZSA-N 0.000 claims 1
- NSCRUEJRXPOLMQ-JHOUSYSJSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@@H](C=1)C1CC1)C1COC1)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@@H](C=1)C1CC1)C1COC1)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C NSCRUEJRXPOLMQ-JHOUSYSJSA-N 0.000 claims 1
- NSCRUEJRXPOLMQ-CZNDPXEESA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C1CC1)C1COC1)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C1CC1)C1COC1)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C NSCRUEJRXPOLMQ-CZNDPXEESA-N 0.000 claims 1
- BHUGQFWESOOMNM-VSJLXWSYSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C1CCC1)C1COC1)C1CCC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)C1CCC1)C1COC1)C1CCC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C BHUGQFWESOOMNM-VSJLXWSYSA-N 0.000 claims 1
- ONFQEIWCZKXFPK-UIOOFZCWSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)CC)C1COC1)CC)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N([C@H](C=1)CC)C1COC1)CC)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C ONFQEIWCZKXFPK-UIOOFZCWSA-N 0.000 claims 1
- AQMVMGCAYJJJLL-URLMMPGGSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@@H](C=1)C1CC1)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@@H](C=1)C1CC1)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C AQMVMGCAYJJJLL-URLMMPGGSA-N 0.000 claims 1
- RPIBNKYLOBFIBS-IOWSJCHKSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@@H](C=1)C1CCC1)C1CCC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@@H](C=1)C1CCC1)C1CCC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C RPIBNKYLOBFIBS-IOWSJCHKSA-N 0.000 claims 1
- MEADTBIAKHZGML-RPWUZVMVSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@@H](C=1)CC)CC)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@@H](C=1)CC)CC)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C MEADTBIAKHZGML-RPWUZVMVSA-N 0.000 claims 1
- AQMVMGCAYJJJLL-FQLXRVMXSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@H](C=1)C1CC1)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@H](C=1)C1CC1)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C AQMVMGCAYJJJLL-FQLXRVMXSA-N 0.000 claims 1
- RPIBNKYLOBFIBS-FIRIVFDPSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@H](C=1)C1CCC1)C1CCC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@@H](N[C@H](C=1)C1CCC1)C1CCC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C RPIBNKYLOBFIBS-FIRIVFDPSA-N 0.000 claims 1
- ILCXJAPSUFBQHI-FGZHOGPDSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@@H](C=1)C)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@@H](C=1)C)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C ILCXJAPSUFBQHI-FGZHOGPDSA-N 0.000 claims 1
- RNRSZZIBWISOMX-DHIUTWEWSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@@H](C=1)C)C1COC1)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@@H](C=1)C)C1COC1)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C RNRSZZIBWISOMX-DHIUTWEWSA-N 0.000 claims 1
- FQHDPBMKCKJTSQ-CONSDPRKSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@@H](C=1)C1CC1)C)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@@H](C=1)C1CC1)C)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C FQHDPBMKCKJTSQ-CONSDPRKSA-N 0.000 claims 1
- ILCXJAPSUFBQHI-FCHUYYIVSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@H](C=1)C)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@H](C=1)C)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C ILCXJAPSUFBQHI-FCHUYYIVSA-N 0.000 claims 1
- RNRSZZIBWISOMX-XZOQPEGZSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@H](C=1)C)C1COC1)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@H](C=1)C)C1COC1)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C RNRSZZIBWISOMX-XZOQPEGZSA-N 0.000 claims 1
- FQHDPBMKCKJTSQ-JSOSNVBQSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@H](C=1)C1CC1)C)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N([C@H](C=1)C1CC1)C)C1CC1)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C FQHDPBMKCKJTSQ-JSOSNVBQSA-N 0.000 claims 1
- WXMLFRIMSKNYHP-NHCUHLMSSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N[C@@H](C=1)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N[C@@H](C=1)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C WXMLFRIMSKNYHP-NHCUHLMSSA-N 0.000 claims 1
- WXMLFRIMSKNYHP-LEWJYISDSA-N ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N[C@H](C=1)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C Chemical compound ClC=1C(=NC(=NC=1)NC1=C(C=C(C(=C1)C)C=1C[C@H](N[C@H](C=1)C)C)OC(C)C)NC1=C(C=CC=C1)S(=O)(=O)C(C)C WXMLFRIMSKNYHP-LEWJYISDSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 *C(CC(c(cc1O*)c(*)cc1Nc1ncc(*)c(*(c2c3cccc2)=S3(I*)=O)n1)=C1)(*=C)N(*)C1(*)I Chemical compound *C(CC(c(cc1O*)c(*)cc1Nc1ncc(*)c(*(c2c3cccc2)=S3(I*)=O)n1)=C1)(*=C)N(*)C1(*)I 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022096630A JP2022120151A (ja) | 2016-08-29 | 2022-06-15 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380818P | 2016-08-29 | 2016-08-29 | |
| US62/380,818 | 2016-08-29 | ||
| PCT/US2017/048845 WO2018044767A2 (en) | 2016-08-29 | 2017-08-28 | Aminopyrimidines as alk inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022096630A Division JP2022120151A (ja) | 2016-08-29 | 2022-06-15 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528307A JP2019528307A (ja) | 2019-10-10 |
| JP2019528307A5 true JP2019528307A5 (US07585860-20090908-C00112.png) | 2020-10-01 |
| JP7094566B2 JP7094566B2 (ja) | 2022-07-04 |
Family
ID=59846649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511664A Active JP7094566B2 (ja) | 2016-08-29 | 2017-08-28 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
| JP2022096630A Pending JP2022120151A (ja) | 2016-08-29 | 2022-06-15 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022096630A Pending JP2022120151A (ja) | 2016-08-29 | 2022-06-15 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
Country Status (13)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11478477B2 (en) | 2018-07-31 | 2022-10-25 | Ascentage Pharma (Suzhou) Co., Ltd. | Method for treating cancer by combination of FAK/ALK/ROS1 inhibitor and EGFR inhibitor |
| CN111171033B (zh) * | 2018-11-09 | 2021-11-02 | 天津大学 | 一种嘧啶衍生物及其合成方法和应用 |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| CN110143947B (zh) * | 2019-05-29 | 2021-10-15 | 华东师范大学 | 一种色瑞替尼类似物的制备方法 |
| CN113395968B (zh) * | 2019-06-25 | 2024-03-01 | 苏州亚盛药业有限公司 | 用于治疗疾病的fak抑制剂和btk抑制剂的组合 |
| AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20230381176A1 (en) * | 2020-09-25 | 2023-11-30 | Ascentage Pharma (Suzhou) Co., Ltd. | A pharmaceutical composition and use thereof for treatment of cancer |
| WO2022222932A1 (en) * | 2021-04-19 | 2022-10-27 | Ascentage Pharma (Suzhou) Co., Ltd. | A pharmaceutical combination and use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| WO2005016894A1 (en) | 2003-08-15 | 2005-02-24 | Novartis Ag | 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders |
| CA2538413A1 (en) * | 2003-09-18 | 2005-03-24 | Novartis Ag | 2,4-di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
| AR048927A1 (es) * | 2004-04-07 | 2006-06-14 | Novartis Ag | Compuestos heterociclicos como inhibidores de proteinas de apoptosis (iap); composiciones farmaceuticas que los contienen y su uso en el tratamiento de una enfermedad proliferativa |
| NZ577197A (en) | 2006-12-08 | 2011-02-25 | Irm Llc | Pyrimidine compounds especially 4-phenylamino-2-arylamino-pyrimidine derivatives and compositions as protein kinase inhibitors |
| EA018282B1 (ru) | 2008-04-07 | 2013-06-28 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназы |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| AU2011315831B2 (en) | 2010-10-14 | 2015-01-22 | Takeda Pharmaceutical Company Limited | Methods for inhibiting cell proliferation in EGFR-driven cancers |
| KR101521861B1 (ko) * | 2011-02-02 | 2015-05-21 | 노파르티스 아게 | Ａｌｋ 억제제의 사용 방법 |
| CN104672214B (zh) * | 2013-12-03 | 2019-04-12 | 上海翰森生物医药科技有限公司 | 具有alk抑制活性的化合物及其制备与用途 |
| KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
-
2017
- 2017-08-28 AU AU2017319135A patent/AU2017319135B2/en active Active
- 2017-08-28 NZ NZ751713A patent/NZ751713A/en unknown
- 2017-08-28 CN CN201780057518.0A patent/CN109715620B/zh active Active
- 2017-08-28 CA CA3033223A patent/CA3033223A1/en active Pending
- 2017-08-28 JP JP2019511664A patent/JP7094566B2/ja active Active
- 2017-08-28 MX MX2019002393A patent/MX2019002393A/es unknown
- 2017-08-28 SG SG10201914030UA patent/SG10201914030UA/en unknown
- 2017-08-28 EP EP21212760.9A patent/EP4001273A3/en not_active Withdrawn
- 2017-08-28 EP EP17764949.8A patent/EP3504203B1/en active Active
- 2017-08-28 KR KR1020197007075A patent/KR102530871B1/ko active IP Right Grant
- 2017-08-28 CN CN202210533398.XA patent/CN115043821A/zh active Pending
- 2017-08-28 WO PCT/US2017/048845 patent/WO2018044767A2/en unknown
- 2017-08-28 US US15/559,445 patent/US10709705B2/en active Active
- 2017-08-28 SG SG11201901251SA patent/SG11201901251SA/en unknown
- 2017-08-28 BR BR112019003897-3A patent/BR112019003897A2/pt unknown
-
2019
- 2019-02-04 IL IL264638A patent/IL264638B/en unknown
- 2019-02-27 MX MX2022000376A patent/MX2022000376A/es unknown
-
2020
- 2020-06-29 US US16/914,518 patent/US11110090B2/en active Active
-
2021
- 2021-05-14 AU AU2021203098A patent/AU2021203098B2/en active Active
-
2022
- 2022-06-15 JP JP2022096630A patent/JP2022120151A/ja active Pending
