JP2019528287A - ナノエマルション及び改質層状複水酸化物を含む経皮デリバリー用組成物 - Google Patents
ナノエマルション及び改質層状複水酸化物を含む経皮デリバリー用組成物 Download PDFInfo
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Abstract
Description
炭酸イオン含有ZnAl−LDHは、以下のように共沈法(co-precipitation)により合成した。0.2MのZn(NO3)2と0.1MのAl(NO3)3の混合溶液に最終pHが7.0程度になるまで1MのNa2CO3溶液を徐々に添加した。混合溶液を約70℃のオーブンに1日保管後、ろ過し、蒸溜水とエタノールで洗浄し、真空ポンプを用いて乾燥した。合成されたc−LDHの式は以下の通りである:
[Zn4Al2(OH)12]CO3・xH2O。
100gのZnAl−カーボネートLDHと3gのステアリン酸を100mLの蒸溜水に溶解し、その混合溶液を80℃で2時間撹拌した。得られた混合物をろ過し、蒸溜水とエタノールで洗浄し、真空ポンプを用いて乾燥した。
CaCl2とドデシル硫酸ナトリウムをモル比1:1で混合し、沈殿させてドデシル硫酸カルシウムの一次物質を得た。得られた一次物質とAl(NO3)3をモル比2:1で混合し、約50重量%のNaOHを添加して溶液のpHを13に調整した。反応溶液を水熱反応器に導入し、85℃で1日反応させた。沈殿物をろ過し、熱蒸溜水で洗浄し、真空ポンプを利用して乾燥した。また、反応溶液をフラスコに入れ、合成のために約85℃で撹拌し、合成のために超音波装置も利用した。合成されたDS−LDHの式は以下の通りである:
[Ca2Al(OH)6]硫酸ドデシルxH2O。
LDHナノシートを製造するために、得られたc−LDHを硝酸イオンで置換し、60℃ホルムアミド溶液中で約4日間撹拌した。DS−LDHナノシートの製造のために、得られたLDHナノシート溶液100mLに約1gのドデシル硫酸ナトリウムを加えた後、約1時間撹拌し、得られた沈殿物を遠心分離機で洗浄した。
Claims (37)
- 1)活性成分、飽和レシチン、フィトステリル/ベヘニル/オクチルドデシル ラウロイル グルタメート、ポリオール及び水を含むナノエマルション;及び
2)改質層状複水酸化物;
を含む経皮デリバリー用組成物。 - 前記ナノエマルションが、1〜40重量%の活性成分、0.1〜20重量%の飽和レシチン、0.1〜20重量%のフィトステリル/ベヘニル/オクチルドデシル ラウロイル グルタメート、2〜70重量%のポリオール及び10〜80重量%の水を含む、請求項1に記載の経皮デリバリー用組成物。
- 前記ナノエマルションが、5〜30重量%の活性成分、0.2〜15重量%の飽和レシチン、0.2〜15重量%のフィトステリル/ベヘニル/オクチルドデシル ラウロイル グルタメート、3〜65重量%のポリオール及び15〜75重量%の水を含む、請求項2に記載の経皮デリバリー用組成物。
- 前記活性成分が、保湿剤、美白剤、抗シワ剤、UVブロック剤、育毛促進剤、ビタミン又はその誘導体、アミノ酸又はペプチド、抗炎症剤、ざ瘡治療剤、殺菌剤、女性ホルモン、角質溶解剤及び天然物からなる群から一つ以上選択される、請求項1に記載の経皮デリバリー用組成物。
- 前記保湿剤が、クレアチン、ポリグルタミン酸、乳酸ナトリウム、ヒドロプロリン、2−ピロリドン−5−カルボン酸ナトリウム、ヒアルロン酸、ヒアルロン酸ナトリウム、セラミド、フィトステリル、コレステロール、シトステロール、プルラン及びプロテオグリカンからなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記美白剤が、アルブチン及びアルブチン誘導体、コウジ酸、ビサボロール、ナイアシンアミド、ビタミンC及びビタミンC誘導体、プラセンタ及びアラントインからなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記抗シワ剤が、レチノール、レチノール誘導体、アデノシン、甘草エキス、紅参エキス及び朝鮮人参エキスからなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記UVブロック剤が、ベンゾフェノン誘導体、パラアミノ安息香酸誘導体、メトキシ桂皮酸誘導体及びサリチル酸誘導体からなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記育毛促進剤が、血行促進剤又は毛包刺激剤である、請求項4に記載の経皮デリバリー用組成物
- 前記血行促進剤が、センブリエキス、セファランチン、ビタミンE及びその誘導体ならびにγ−オリザノールからなる群から一つ以上選択される、請求項9に記載の経皮デリバリー用組成物。
- 前記毛包刺激剤が、トウガラシチンキ、生姜チンキ、カンタリスチンキ及びニコチン酸ベンジルエステルからなる群から一つ以上選択される、請求項9に記載の経皮デリバリー用組成物。
- 前記ビタミン又はその誘導体が、ビタミンA及びその誘導体、ビタミンB1、ビタミンB2、ビタミンB6、ビタミンE及びその誘導体、ビタミンD、ビタミンH、ビタミンK、パントテン酸及びその誘導体、ビオチン、パンテノール、コエンザイムQ10ならびにイデベノンからなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記アミノ酸又はペプチドが、システイン、メチオニン、セリン、リシン、トリプトファン、アミノ酸エキス、上皮細胞成長因子(EGF)、インスリン様成長因子(IGF)、繊維芽細胞増殖因子(FGF)、トリペプチド−1銅、トリペプチド−29、トリペプチド−1、アセチル ヘキサペプチド−8、ニコチノイル トリペプチド−35、ヘキサペプチド−12、ヘキサペプチド−9、パルミトイル ペンタペプチド−4、パルミトイル テトラペプチド−7、パルミトイル トリペプチド−29、パルミトイル トリペプチド−1、ノナペプチド−7、トリペプチド−10 シトルリン、sh−ポリペプチド−15、パルミトイル トリペプチド−5、ジアミノプロピオノイル トリペプチド−33及びr−スパイダーポリペプチド−1からなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記抗炎症剤が、β−グリチルレチン酸、グリチルレチン酸誘導体、アミノカプロン酸、ヒドロコルチゾン、β−グルカン及び甘草からなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記ざ瘡治療剤が、エストラジオール、エストロゲン、エチニル エストラジオール、トリクロサン及びアゼライン酸からなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記殺菌剤が、塩化ベンザルコニウム、塩化ベンゼトニウム及びハロカルバンからなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記女性ホルモンが、エストラジオール、エチニル エストラジオール及びイソフラボンからなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記角質溶解剤が、硫黄、サリチル酸、AHA、BHA及びレゾルシンからなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記天然物が、マンサクエキス、オドリコソウエキス、フタバムグラエキス、ショウヨウダイオウエキス、甘草エキス、アロエエキス、カモミールエキス、ローズヒップエキス、セイヨウトチノキエキス、朝鮮人参エキス、ヘチマエキス、キュウリエキス、アマノリエキス、ワカメエキス、ダイコンイモエキス、カタツムリエキス、ナガイモエキス、ヒノキチオール及びβ−カロテンからなる群から一つ以上選択される、請求項4に記載の経皮デリバリー用組成物。
- 前記ポリオールが、グリセリン、ソルビトール、キシリトール、エリスリトール、フルクトース、ラクトース、マンニトール、ブドウ糖、ショ糖、マルトース、マルチトール及びエチレン グリコールからなる群から一つ以上選択される、請求項1に記載の経皮デリバリー用組成物。
- 前記ナノエマルションがさらに植物油を含む、請求項1に記載の経皮デリバリー用組成物。
- 前記ナノエマルションが、植物油を10〜30重量%で含む、請求項21に記載の経皮デリバリー用組成物。
- 前記植物油が、オリーブ油、マカダミア油、ヒマワリ種子油、カメリア油、ヒマシ油、ホホバ油、アーモンド油、杏子油、グリーンティ油、メドウフォーム種子油、アルガン油及びそれらの混合物からなる群から選択される、請求項21に記載の経皮デリバリー用組成物。
- 前記改質層状複水酸化物が硫酸ドデシルで改質される、請求項1に記載の経皮デリバリー用組成物。
- 前記硫酸ドデシルで改質された層状複水酸化物がナノシートの形態である、請求項24に記載の経皮デリバリー用組成物。
- 前記改質層状複水酸化物の層状複水酸化物が下記式を有する、請求項1に記載の経皮デリバリー用組成物:
[M2+ 1-x M3+ x(OH)2]x+(An-)x/n・mH2O
(式中、M2+とM3+は金属カチオンであり、An-はアニオンであり、0.2≦x≦0.33であり、mは0.5〜4である。) - M2+は、Ca2+, Mg2+, Zn2+, Ni2+, Mn2+, Co2+又はFe2+であり、
M3+は、Al3+, Cr3+, Mn3+, Fe3+, Ga3+, Co3+又はNi3+ であり、
An-は、OH-, F-, Cl-, Br-, I-, NO3 -, CO3 2-又はSO4 2-である、請求項26に記載の経皮デリバリー用組成物。 - 30〜70重量%のナノエマルション及び30〜70重量%の改質層状複水酸化物を含む、請求項1に記載の経皮デリバリー用組成物。
- 40〜60重量%のナノエマルション及び40〜60重量%の改質層状複水酸化物を含む、請求項28に記載の経皮デリバリー用組成物。
- 請求項1〜29のいずれか1項に記載の経皮デリバリー用組成物を含むパーソナルケア組成物。
- 経皮デリバリー用組成物を1〜60重量%で含む請求項30に記載のパーソナルケア組成物。
- 前記パーソナルケア組成物が、スキンケア組成物、ボディケア組成物又はヘアケア組成物である、請求項30に記載のパーソナルケア組成物。
- i)活性成分、飽和レシチン、フィトステリル/ベヘニル/オクチルドデシル ラウロイル グルタメート、ポリオール及び水を混合しナノエマルションを製造する工程、及び
ii)前記工程i)で製造されたナノエマルションを改質層状複水酸化物と混合して、複合体を形成する工程
を含む、経皮デリバリー用組成物の製造方法。 - 前記工程i)において、1〜40重量%の活性成分、0.1〜20重量%の飽和レシチン、0.1〜20重量%のフィトステリル/ベヘニル/オクチルドデシル ラウロイル グルタメート、2〜70重量%のポリオール及び10〜80重量%の水を混合する、請求項33に記載の経皮デリバリー用組成物の製造方法。
- 前記活性成分が、保湿剤、美白剤、抗シワ剤、UVブロック剤、育毛促進剤、ビタミン又はその誘導体、アミノ酸又はペプチド、抗炎症剤、ざ瘡治療剤、殺菌剤、女性ホルモン、角質溶解剤及び天然物からなる群から一つ以上選択される、請求項33に記載の経皮デリバリー用組成物の製造方法。
- 前記改質層状複水酸化物が硫酸ドデシルで改質される、請求項33に記載の経皮デリバリー用組成物の製造方法。
- 前記工程ii)において、30〜70重量%のナノエマルション及び30〜70重量%の改質層状複水酸化物を混合する、請求項33に記載の経皮デリバリー用組成物の製造方法。
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