JP2019526337A - 繊維強化生体吸収性インプラント及びその製造方法 - Google Patents
繊維強化生体吸収性インプラント及びその製造方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
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- Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Description
[図面の簡単な説明]
[図2] 図1における、後の状態の断面を示す図である。
Claims (10)
- 硬組織及び/又は軟組織を補填又は置換するための生体吸収性インプラント(1)であって、
第1の材料成分から作製され、第2の材料成分と混合された後マトリックス(3)に埋め込まれる、少なくとも1つの強化繊維(2)を含み、
前記第1の材料成分の材料が、絹、キトサン、コラーゲン、ポリカプロラクトン、ポリ(D,L−ラクチド)、ポリ(ラクチド−co−グリコリド)、ポリグリコリド、ポリウレタン、及びポリプロピレンからなる群の少なくとも1つの要素を含み、
前記第2の材料成分が前記少なくとも1つの強化繊維(2)と混合される時点で、前記第2の材料成分が顆粒状形態又は粉末形態で存在することを特徴とする、生体吸収性インプラント(1)。 - 前記マトリックス(3)が、前記第2の材料成分及び少なくとも1つのさらなる材料成分から作製されていることを特徴とする、請求項1に記載の生体吸収性インプラント(1)。
- 前記第2の材料成分が、リン酸塩系セラミック成分を含むことを特徴とする、請求項1又は2に記載の生体吸収性インプラント(1)。
- 繊維(2)の全体が、絹、キトサン、コラーゲン、ポリカプロラクトン、ポリ(D,L−ラクチド)、ポリ(ラクチド−co−グリコリド)、ポリグリコリド、ポリウレタン、及びポリプロピレンからなる群の少なくとも2つの要素を含むことを特徴とする、請求項1〜3のいずれか一項に記載の生体吸収性インプラント(1)。
- 前記繊維(2)が、前記マトリックス(3)と前記繊維(2)との間の相互作用表面を増大させるための少なくとも1つの凸部及び/又は凹部を含むことを特徴とする、請求項1〜4のいずれか一項に記載の生体吸収性インプラント(1)。
- 吸収時間を制御することを可能にする複数の固体粒子が、前記マトリックス(3)に配置され、前記固体粒子が、前記生体吸収性インプラント(1)の質量に対し測定したとき5%〜25%の質量%を有することを特徴とする、請求項1〜5のいずれか一項に記載の生体吸収性インプラント(1)。
- 個々の材料成分の混合が、生成的製作、サブトラクティブ製作、及び3D成形製作によって可能とされることを特徴とする、請求項1〜6のいずれか一項に記載の生体吸収性インプラント(1)。
- 混合時に顆粒又は粉末である前記第2の材料成分の粒子が、所定の時間枠の後に一体的併合形状をとることを特徴とする、請求項1〜7のいずれか一項に記載の生体吸収性インプラント(1)。
- 混合時に顆粒又は粉末である前記第2の材料成分の粒子が、前記生体吸収性インプラント(1)の分解挙動に特異的に影響するために、マグネシウム、カルシウム、ヒドロキシアパタイト、α−及び/又はβ−リン酸三カルシウム、並びに石灰からなる群の少なくとも1つの要素を含むことを特徴とする、請求項1〜8のいずれか一項に記載の生体吸収性インプラント(1)。
- 請求項1〜9のいずれか一項に記載の生体吸収性インプラント(1)を製造するための方法であって、
前記第1の材料成分から前記少なくとも1つの繊維(2)を用意するステップと、
前記第2の材料成分の顆粒状粒子若しくは粉末粒子、又は液状態を用意するステップと、
前記第1の材料成分を前記第2の材料成分と混合して、前記生体吸収性インプラント(1)を得るステップと、
前記生体吸収性インプラント(1)が、置換を受ける前記硬組織及び/又は軟組織に対して相補的な構成となるように、前記生体吸収性インプラント(1)をその形状及び/又は表面性状に関して後処理するステップと
を含む、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102016116387.2 | 2016-09-01 | ||
DE102016116387.2A DE102016116387A1 (de) | 2016-09-01 | 2016-09-01 | Faserverstärktes bioresorbierbares Implantat und Verfahren zu dessen Herstellung |
PCT/EP2017/071129 WO2018041668A1 (de) | 2016-09-01 | 2017-08-22 | Faserverstärktes bioresorbierbares implantat und verfahren zu dessen herstellung |
Publications (1)
Publication Number | Publication Date |
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JP2019526337A true JP2019526337A (ja) | 2019-09-19 |
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JP2019510947A Pending JP2019526337A (ja) | 2016-09-01 | 2017-08-22 | 繊維強化生体吸収性インプラント及びその製造方法 |
Country Status (11)
Country | Link |
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US (1) | US20190192742A1 (ja) |
EP (1) | EP3506954B1 (ja) |
JP (1) | JP2019526337A (ja) |
CN (1) | CN109641080A (ja) |
AU (1) | AU2017318300A1 (ja) |
BR (1) | BR112019003351A2 (ja) |
CA (1) | CA3034145A1 (ja) |
DE (1) | DE102016116387A1 (ja) |
ES (1) | ES2901377T3 (ja) |
RU (1) | RU2019109358A (ja) |
WO (1) | WO2018041668A1 (ja) |
Families Citing this family (1)
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CN114129778B (zh) * | 2021-10-19 | 2022-08-12 | 奥精医疗科技股份有限公司 | 一种通过静电纺丝与静电喷雾相结合制备引导组织再生膜的方法 |
Citations (3)
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JP2008520304A (ja) * | 2004-11-24 | 2008-06-19 | バイオコンポジッツ・リミテッド | 生体吸収性材料 |
US20110280924A1 (en) * | 2010-05-12 | 2011-11-17 | Sunmax Biotechnology Co., Ltd. | Biodegradable filler for restoration of alveolar bones |
WO2012084214A1 (en) * | 2010-12-22 | 2012-06-28 | Geistlich Pharma Ag | Bone substitute material |
Family Cites Families (8)
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US6953594B2 (en) * | 1996-10-10 | 2005-10-11 | Etex Corporation | Method of preparing a poorly crystalline calcium phosphate and methods of its use |
GB9717433D0 (en) | 1997-08-19 | 1997-10-22 | Univ Nottingham | Biodegradable composites |
GB0317192D0 (en) * | 2003-07-19 | 2003-08-27 | Smith & Nephew | High strength bioresorbable co-polymers |
US7901461B2 (en) | 2003-12-05 | 2011-03-08 | Ethicon, Inc. | Viable tissue repair implants and methods of use |
DE602007011671D1 (de) * | 2006-11-30 | 2011-02-10 | Smith & Nephew Inc | Faserverstärktes verbundmaterial |
DE102008004359A1 (de) | 2008-01-15 | 2009-07-16 | Robert Bosch Gmbh | Verfahren zum Betreiben eines Sensorelements zur Bestimmung der Konzentration von Gaskomponenten |
DE102010034471A1 (de) | 2010-08-06 | 2012-02-09 | Aesculap Ag | Faden, insbesondere chirurgischer Faden, ein den Faden umfassendes Implantat sowie ein Verfahren zur Herstellung des Fadens und des Implantats |
WO2015095745A1 (en) * | 2010-10-20 | 2015-06-25 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
-
2016
- 2016-09-01 DE DE102016116387.2A patent/DE102016116387A1/de not_active Withdrawn
-
2017
- 2017-08-22 WO PCT/EP2017/071129 patent/WO2018041668A1/de unknown
- 2017-08-22 EP EP17755187.6A patent/EP3506954B1/de active Active
- 2017-08-22 RU RU2019109358A patent/RU2019109358A/ru unknown
- 2017-08-22 CA CA3034145A patent/CA3034145A1/en not_active Abandoned
- 2017-08-22 ES ES17755187T patent/ES2901377T3/es active Active
- 2017-08-22 JP JP2019510947A patent/JP2019526337A/ja active Pending
- 2017-08-22 BR BR112019003351A patent/BR112019003351A2/pt not_active Application Discontinuation
- 2017-08-22 CN CN201780050787.4A patent/CN109641080A/zh active Pending
- 2017-08-22 AU AU2017318300A patent/AU2017318300A1/en not_active Abandoned
- 2017-11-22 US US16/329,626 patent/US20190192742A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008520304A (ja) * | 2004-11-24 | 2008-06-19 | バイオコンポジッツ・リミテッド | 生体吸収性材料 |
US20110280924A1 (en) * | 2010-05-12 | 2011-11-17 | Sunmax Biotechnology Co., Ltd. | Biodegradable filler for restoration of alveolar bones |
WO2012084214A1 (en) * | 2010-12-22 | 2012-06-28 | Geistlich Pharma Ag | Bone substitute material |
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Publication number | Publication date |
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US20190192742A1 (en) | 2019-06-27 |
WO2018041668A1 (de) | 2018-03-08 |
ES2901377T3 (es) | 2022-03-22 |
DE102016116387A1 (de) | 2018-03-01 |
RU2019109358A3 (ja) | 2020-11-24 |
AU2017318300A1 (en) | 2019-03-21 |
EP3506954A1 (de) | 2019-07-10 |
RU2019109358A (ru) | 2020-10-01 |
EP3506954B1 (de) | 2021-09-29 |
CN109641080A (zh) | 2019-04-16 |
CA3034145A1 (en) | 2018-03-08 |
BR112019003351A2 (pt) | 2019-06-11 |
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