JP2019524771A5 - - Google Patents
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- Publication number
- JP2019524771A5 JP2019524771A5 JP2019505214A JP2019505214A JP2019524771A5 JP 2019524771 A5 JP2019524771 A5 JP 2019524771A5 JP 2019505214 A JP2019505214 A JP 2019505214A JP 2019505214 A JP2019505214 A JP 2019505214A JP 2019524771 A5 JP2019524771 A5 JP 2019524771A5
- Authority
- JP
- Japan
- Prior art keywords
- dengue
- flavivirus
- virus
- composition according
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 37
- 241000710831 Flavivirus Species 0.000 claims 36
- 208000001490 Dengue Diseases 0.000 claims 16
- 206010012310 Dengue fever Diseases 0.000 claims 16
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 16
- 208000025729 dengue disease Diseases 0.000 claims 16
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 8
- 229930006000 Sucrose Natural products 0.000 claims 8
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 8
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 8
- 239000004202 carbamide Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000005720 sucrose Substances 0.000 claims 8
- 241000725619 Dengue virus Species 0.000 claims 6
- 108091006905 Human Serum Albumin Proteins 0.000 claims 6
- 102000008100 Human Serum Albumin Human genes 0.000 claims 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 150000001408 amides Chemical class 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 5
- 229940098773 bovine serum albumin Drugs 0.000 claims 5
- 239000004475 Arginine Substances 0.000 claims 4
- 241000710815 Dengue virus 2 Species 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 3
- 102000007562 Serum Albumin Human genes 0.000 claims 3
- 108010071390 Serum Albumin Proteins 0.000 claims 3
- 230000002238 attenuated effect Effects 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 241000710842 Japanese encephalitis virus Species 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 241000710888 St. Louis encephalitis virus Species 0.000 claims 2
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims 2
- 241000710886 West Nile virus Species 0.000 claims 2
- 241000710772 Yellow fever virus Species 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 2
- 206010014599 encephalitis Diseases 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 235000013923 monosodium glutamate Nutrition 0.000 claims 2
- 239000002953 phosphate buffered saline Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920005862 polyol Polymers 0.000 claims 2
- 150000003077 polyols Chemical class 0.000 claims 2
- 229940076376 protein agonist Drugs 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 2
- 229940051021 yellow-fever virus Drugs 0.000 claims 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- 241000710781 Flaviviridae Species 0.000 claims 1
- 239000007995 HEPES buffer Substances 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 235000009697 arginine Nutrition 0.000 claims 1
- 239000012888 bovine serum Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 235000006109 methionine Nutrition 0.000 claims 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims 1
- 239000004223 monosodium glutamate Substances 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 1
- 235000011009 potassium phosphates Nutrition 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023009386A JP2023052624A (ja) | 2016-08-03 | 2023-01-25 | 製剤の向上によりフラビウイルスを安定化するための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370611P | 2016-08-03 | 2016-08-03 | |
| US62/370,611 | 2016-08-03 | ||
| PCT/US2017/045375 WO2018027075A1 (en) | 2016-08-03 | 2017-08-03 | Compositions and methods for stabilizing flaviviruses with improved formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023009386A Division JP2023052624A (ja) | 2016-08-03 | 2023-01-25 | 製剤の向上によりフラビウイルスを安定化するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524771A JP2019524771A (ja) | 2019-09-05 |
| JP2019524771A5 true JP2019524771A5 (OSRAM) | 2020-09-10 |
| JP7280179B2 JP7280179B2 (ja) | 2023-05-23 |
Family
ID=59593235
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019505214A Active JP7280179B2 (ja) | 2016-08-03 | 2017-08-03 | 製剤の向上によりフラビウイルスを安定化するための組成物および方法 |
| JP2023009386A Pending JP2023052624A (ja) | 2016-08-03 | 2023-01-25 | 製剤の向上によりフラビウイルスを安定化するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023009386A Pending JP2023052624A (ja) | 2016-08-03 | 2023-01-25 | 製剤の向上によりフラビウイルスを安定化するための組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10835597B2 (OSRAM) |
| EP (1) | EP3493839A1 (OSRAM) |
| JP (2) | JP7280179B2 (OSRAM) |
| KR (2) | KR20230132887A (OSRAM) |
| CN (1) | CN109789200A (OSRAM) |
| AU (2) | AU2017305498B2 (OSRAM) |
| CA (1) | CA3030343A1 (OSRAM) |
| CO (1) | CO2019001448A2 (OSRAM) |
| MX (2) | MX2019001473A (OSRAM) |
| PH (1) | PH12019500003A1 (OSRAM) |
| SG (2) | SG11201811831SA (OSRAM) |
| TW (2) | TW202309276A (OSRAM) |
| WO (1) | WO2018027075A1 (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984357B (zh) * | 2015-06-02 | 2018-01-30 | 长春百克生物科技股份公司 | 不含明胶的疫苗保护剂组合物及流感减毒活疫苗 |
| GEAP202315128A (en) * | 2016-12-23 | 2023-02-10 | Serum Institute Of India Pvt Ltd | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
| US20200390877A1 (en) | 2017-12-07 | 2020-12-17 | Merck Sharp & Dohme Corp. | Formulations of dengue virus vaccine compositions |
| US11738075B2 (en) | 2018-03-20 | 2023-08-29 | National Research Council Of Canada | Method for lyophilizing live vaccine strains of Francisella tularensis |
| KR102649069B1 (ko) | 2018-05-31 | 2024-03-19 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 안면 홍조 개선용 조성물 |
| WO2020027466A1 (ko) | 2018-07-28 | 2020-02-06 | 주식회사 엑소코바이오 | 엑소좀의 동결건조 방법 |
| KR102163806B1 (ko) | 2018-07-30 | 2020-10-07 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물 |
| US11464815B2 (en) * | 2018-09-05 | 2022-10-11 | Takeda Vaccines, Inc. | Dengue vaccine unit dose and administration thereof |
| AU2019393877A1 (en) * | 2018-12-05 | 2021-06-17 | Seres Therapeutics, Inc. | Compositions for stabilizing bacteria and uses thereof |
| MX2022001742A (es) | 2019-08-16 | 2022-04-07 | Takeda Vaccines Inc | Metodos para prevenir el dengue y la hepatitis a. |
| EP4110381A1 (en) * | 2020-02-27 | 2023-01-04 | Takeda Vaccines, Inc. | Method for removing host cell dna from virus preparation |
| CN115023135B (zh) * | 2020-02-28 | 2024-04-19 | 台湾粒线体应用技术股份有限公司 | 线粒体的冷冻保存剂与使用其的线粒体冷冻保存方法 |
| CN113549653B (zh) * | 2020-04-23 | 2024-03-22 | 上海赛比曼生物科技有限公司 | 用于慢病毒载体长期存贮的组合试剂 |
| CN111588859B (zh) * | 2020-06-02 | 2021-09-03 | 成都可恩生物科技有限公司 | 一种冻干保护剂及其应用和冻干苗及其制备方法 |
| CN112501024A (zh) * | 2020-12-03 | 2021-03-16 | 英科新创（苏州）生物科技有限公司 | 一种体外诊断试剂盒通用型质控品保存液 |
| EP4012025A1 (en) * | 2020-12-10 | 2022-06-15 | Univerzita Palackého v Olomouci | Transport medium for samples containing nucleic acids and/or proteins |
| CN113730592B (zh) * | 2021-09-03 | 2023-12-19 | 吉林正业生物制品股份有限公司 | 一种鸭坦布苏病毒病活疫苗冻干保护剂及制备方法和应用 |
| WO2023158989A1 (en) * | 2022-02-15 | 2023-08-24 | Takeda Vaccines, Inc. | Dengue vaccine batch mixing process |
| AU2023365824A1 (en) * | 2022-10-18 | 2025-06-05 | Takeda Vaccines, Inc. | Dengue vaccine formulation |
| WO2025027616A1 (en) * | 2023-08-01 | 2025-02-06 | Serum Institute Of India Private Limited | Freeze-dried viral vaccine compositions and method of manufacturing thereof |
| WO2025072259A1 (en) | 2023-09-25 | 2025-04-03 | Takeda Vaccines, Inc. | Coadministration of tetravalent dengue vaccine with hpv vaccine |
| WO2025122946A1 (en) * | 2023-12-07 | 2025-06-12 | Rovin Richard A | Zika viruses and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005066333A1 (en) * | 2003-12-30 | 2005-07-21 | Aventis Pasteur, Inc. | Stabilizing compositions for recombinant viruses |
| CA2668834C (en) | 2006-11-07 | 2016-10-11 | Sanofi Pasteur Biologics Co. | Stabilization of vaccines by lyophilization |
| SI2144998T1 (sl) * | 2007-04-06 | 2017-05-31 | Takeda Vaccines, Inc. | Postopki in sestavki za žive atenuirane viruse |
| EP2143440A1 (fr) * | 2008-07-09 | 2010-01-13 | Sanofi Pasteur | Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués |
| CN104984357B (zh) * | 2015-06-02 | 2018-01-30 | 长春百克生物科技股份公司 | 不含明胶的疫苗保护剂组合物及流感减毒活疫苗 |
| EP3442571A1 (en) * | 2016-04-13 | 2019-02-20 | Takeda Vaccines, Inc. | Compositions and methods of vaccination against dengue virus in children and young adults |
-
2017
- 2017-08-02 TW TW111118644A patent/TW202309276A/zh unknown
- 2017-08-02 TW TW106126119A patent/TWI766876B/zh active
- 2017-08-03 MX MX2019001473A patent/MX2019001473A/es unknown
- 2017-08-03 SG SG11201811831SA patent/SG11201811831SA/en unknown
- 2017-08-03 CA CA3030343A patent/CA3030343A1/en active Pending
- 2017-08-03 SG SG10201913040SA patent/SG10201913040SA/en unknown
- 2017-08-03 WO PCT/US2017/045375 patent/WO2018027075A1/en not_active Ceased
- 2017-08-03 AU AU2017305498A patent/AU2017305498B2/en active Active
- 2017-08-03 KR KR1020237030300A patent/KR20230132887A/ko not_active Withdrawn
- 2017-08-03 US US16/322,791 patent/US10835597B2/en active Active
- 2017-08-03 CN CN201780047777.5A patent/CN109789200A/zh active Pending
- 2017-08-03 KR KR1020197005623A patent/KR102576789B1/ko active Active
- 2017-08-03 EP EP17751959.2A patent/EP3493839A1/en active Pending
- 2017-08-03 JP JP2019505214A patent/JP7280179B2/ja active Active
-
2019
- 2019-01-03 PH PH12019500003A patent/PH12019500003A1/en unknown
- 2019-02-01 MX MX2022010907A patent/MX2022010907A/es unknown
- 2019-02-19 CO CONC2019/0001448A patent/CO2019001448A2/es unknown
-
2020
- 2020-10-05 US US17/062,923 patent/US11701421B2/en active Active
-
2023
- 2023-01-25 JP JP2023009386A patent/JP2023052624A/ja active Pending
- 2023-02-23 US US18/113,193 patent/US20230263880A1/en active Pending
- 2023-06-14 AU AU2023203715A patent/AU2023203715A1/en active Pending
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