JP2019524675A5 - - Google Patents
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- JP2019524675A5 JP2019524675A5 JP2018568310A JP2018568310A JP2019524675A5 JP 2019524675 A5 JP2019524675 A5 JP 2019524675A5 JP 2018568310 A JP2018568310 A JP 2018568310A JP 2018568310 A JP2018568310 A JP 2018568310A JP 2019524675 A5 JP2019524675 A5 JP 2019524675A5
- Authority
- JP
- Japan
- Prior art keywords
- cysteine
- lysine
- peptide
- valine
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 30
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- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 27
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
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| CN110545849A (zh) * | 2017-02-03 | 2019-12-06 | 韩美药品株式会社 | 具有增加的持续性的生理活性物质的缀合物及其应用 |
| WO2020071865A1 (ko) * | 2018-10-04 | 2020-04-09 | 한미약품 주식회사 | 글루카곤 및 이를 포함하는 조합물의 치료학적 용도 |
| KR20200078414A (ko) * | 2018-12-21 | 2020-07-01 | 한미약품 주식회사 | 인슐린 및 글루카곤을 포함하는 약학 조성물 |
| CN110551203B (zh) * | 2019-09-25 | 2023-02-10 | 成都奥达生物科技有限公司 | 一种艾塞那肽类似物 |
| KR20210040818A (ko) * | 2019-10-04 | 2021-04-14 | 한미약품 주식회사 | 글루카곤, 및 glp-1 수용체 및 gip 수용체 이중 작용제를 포함하는 조성물 및 이의 치료학적 용도 |
| CN112898406B (zh) * | 2019-10-12 | 2023-11-10 | 深圳纳福生物医药有限公司 | 不同构型的glp-1类似肽修饰二聚体及其制备方法在治疗ii型糖尿病中的应用 |
| WO2021201654A1 (ko) * | 2020-04-03 | 2021-10-07 | 한미약품 주식회사 | Glp-2 유도체 또는 이의 지속형 결합체를 포함하는 방사선요법, 화학요법, 또는 이들의 조합으로 유발된 점막염의 예방 또는 치료용 약학적 조성물 |
| EP4140496A4 (en) * | 2020-04-20 | 2024-05-22 | Hanmi Pharm. Co., Ltd. | Preventive or therapeutic pharmaceutical composition for hyperlipidemia comprising triple agonist acting on all of glucagon, glp-1 and gip receptors, or conjugate thereof, and preventive or therapeutic method |
| NZ793813A (en) * | 2020-04-29 | 2025-12-19 | Onegene Biotechnology Inc | Novel protein conjugate, and use thereof for preventing or treating nonalcoholic steatohepatitis, obesity and diabetes |
| KR20210144606A (ko) * | 2020-05-22 | 2021-11-30 | 한미약품 주식회사 | 글루카곤 유도체의 지속형 결합체의 액상 제제 |
| WO2021235915A1 (ko) * | 2020-05-22 | 2021-11-25 | 한미약품 주식회사 | 액상 제제 |
| EP4181881A1 (en) | 2020-07-14 | 2023-05-24 | Universität Heidelberg | Oral pharmaceutical compositions comprising lipid conjugates |
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-
2017
- 2017-06-29 EP EP17820559.7A patent/EP3479841A4/en active Pending
- 2017-06-29 WO PCT/KR2017/006922 patent/WO2018004283A2/ko not_active Ceased
- 2017-06-29 TW TW106122465A patent/TWI757305B/zh active
- 2017-06-29 CA CA3029518A patent/CA3029518A1/en active Pending
- 2017-06-29 SG SG11201811697SA patent/SG11201811697SA/en unknown
- 2017-06-29 IL IL263934A patent/IL263934B2/en unknown
- 2017-06-29 TN TNP/2018/000452A patent/TN2018000452A1/en unknown
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- 2017-06-29 UA UAA201900200A patent/UA126662C2/uk unknown
- 2017-06-29 CN CN201780050664.0A patent/CN109641035A/zh active Pending
- 2017-06-29 MX MX2019000019A patent/MX2019000019A/es unknown
- 2017-06-29 BR BR112018077457-0A patent/BR112018077457A2/pt active Search and Examination
- 2017-06-29 JP JP2018568310A patent/JP7208020B2/ja active Active
- 2017-06-29 AU AU2017289014A patent/AU2017289014B2/en active Active
- 2017-06-29 KR KR1020170082862A patent/KR102005457B1/ko active Active
- 2017-06-29 MY MYPI2018002944A patent/MY190855A/en unknown
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2018
- 2018-12-21 PH PH12018502742A patent/PH12018502742A1/en unknown
- 2018-12-21 CL CL2018003754A patent/CL2018003754A1/es unknown
- 2018-12-27 US US16/233,890 patent/US11142559B2/en active Active
- 2018-12-27 DO DO2018000297A patent/DOP2018000297A/es unknown
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2019
- 2019-01-23 ZA ZA2019/00470A patent/ZA201900470B/en unknown
- 2019-03-26 EC ECSENADI201921223A patent/ECSP19021223A/es unknown
- 2019-03-29 CO CONC2019/0003182A patent/CO2019003182A2/es unknown
- 2019-07-24 KR KR1020190089585A patent/KR102395856B1/ko active Active
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2022
- 2022-04-25 JP JP2022071472A patent/JP7399212B2/ja active Active
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