JP2019523253A - グルコキナーゼ活性化剤およびその使用方法 - Google Patents
グルコキナーゼ活性化剤およびその使用方法 Download PDFInfo
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- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- QKSQWQOAUQFORH-UHFFFAOYSA-N tert-butyl n-[(2-methylpropan-2-yl)oxycarbonylimino]carbamate Chemical compound CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C QKSQWQOAUQFORH-UHFFFAOYSA-N 0.000 description 1
- NYMXQKNNEPFDPR-UHFFFAOYSA-N tert-butyl n-[4-(chloromethyl)-1,3-thiazol-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=NC(CCl)=CS1 NYMXQKNNEPFDPR-UHFFFAOYSA-N 0.000 description 1
- PVNUIRUAPVSSOK-UHFFFAOYSA-N tert-butylimino(tripyrrolidin-1-yl)-$l^{5}-phosphane Chemical compound C1CCCN1P(N1CCCC1)(=NC(C)(C)C)N1CCCC1 PVNUIRUAPVSSOK-UHFFFAOYSA-N 0.000 description 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000002076 thermal analysis method Methods 0.000 description 1
- 238000001931 thermography Methods 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960002277 tolazamide Drugs 0.000 description 1
- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
- 229960005371 tolbutamide Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960004394 topiramate Drugs 0.000 description 1
- CMSGWTNRGKRWGS-NQIIRXRSSA-N torcetrapib Chemical compound COC(=O)N([C@H]1C[C@@H](CC)N(C2=CC=C(C=C21)C(F)(F)F)C(=O)OCC)CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 CMSGWTNRGKRWGS-NQIIRXRSSA-N 0.000 description 1
- 229950004514 torcetrapib Drugs 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- NFACJZMKEDPNKN-UHFFFAOYSA-N trichlorfon Chemical compound COP(=O)(OC)C(O)C(Cl)(Cl)Cl NFACJZMKEDPNKN-UHFFFAOYSA-N 0.000 description 1
- 229960004813 trichlormethiazide Drugs 0.000 description 1
- LMJSLTNSBFUCMU-UHFFFAOYSA-N trichlormethiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)Cl)NS2(=O)=O LMJSLTNSBFUCMU-UHFFFAOYSA-N 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 229960004699 valsartan Drugs 0.000 description 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229960001254 vildagliptin Drugs 0.000 description 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
- 229960001729 voglibose Drugs 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229940111503 welchol Drugs 0.000 description 1
- JOLJIIDDOBNFHW-UHFFFAOYSA-N xanomeline Chemical compound CCCCCCOC1=NSN=C1C1=CCCN(C)C1 JOLJIIDDOBNFHW-UHFFFAOYSA-N 0.000 description 1
- 229950006755 xanomeline Drugs 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229960002769 zofenopril Drugs 0.000 description 1
- IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 description 1
- 229960002911 zonisamide Drugs 0.000 description 1
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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Abstract
Description
本願は、本明細書中での引用によりその全体が本明細書の一部を構成する、米国仮出願第62/365520号(出願日:2016年7月22日)の利益を請求するものである。
本発明は、酵素グルコキナーゼの活性化剤であり、従って酵素グルコキナーゼによって活性化される疾患または障害、例えば糖尿病の処置に有用であると考えられる新規ホスホネート化合物、そのエナンチオマー、プロドラッグ、ジアステレオマーまたは塩、並びにそのような化合物を用いて、酵素グルコキナーゼによって活性化される疾患または障害、例えば糖尿病、特にII型糖尿病を処置する方法に関する。
主に膵臓のβ−細胞や肝臓の実質細胞にみられる酵素グルコキナーゼ(GK)は、グルコース代謝の第1段階である、グルコースからグルコース−6−リン酸への変換を触媒する。グルコキナーゼはまた、全身のグルコースホメオスタシスにおいて重要な役割を果たしている膵臓のβ−細胞や肝臓の実質細胞における、グルコース代謝の律速酵素である。
(a)医薬特性(即ち、溶解度、浸透性、持続放出製剤への適合性);
(b)用量要件(例えば、より低い用量および/または1日1回の投薬);
(c)血中濃度のピーク−トラフ特性(peak-to-trough characteristics)を小さくする要素(即ち、クリアランスおよび/または分布容積);
(d)受容体における活性薬物の濃度を増大させる要素(即ち、タンパク質結合、分布容積、代謝安定性);
(e)臨床での薬物間相互作用の傾向を減少させる要素(シトクロムP450酵素の阻害または誘導(CYP 2D6阻害など)、本明細書の一部を構成するDresser, G.K. et al., Clin. Pharmacokinet. 38:41-57 (2000)を参照);
(f)有害な副作用の潜在性を小さくする要素(例えば、キナーゼレセプターを超える薬理学的選択性、潜在的な化学的もしくは代謝的反応性、限定されたCNSへの浸透、イオンチャネル選択性)。上記の薬理学的特性の望ましい組合せを有する化合物を見出すことが特に望ましい。
本発明の一態様によれば、式Iを有する化合物、3−(((1S)−1−(メトキシメチル)プロピル)オキシ)−5−((6−(メチルスルホニル)−3−ピリジニル)オキシ)−N−(4−((2−オキシド−1,3,2−ジオキサホスフィナン−2−イル)メチル)−1,3−チアゾール−2−イル)ベンズアミド、ならびにそのすべての立体異性体、そのプロドラッグ、およびその薬学的に許容される塩が提供される。
本発明によれば、式Iを有する化合物3−(((1S)−1−(メトキシメチル)プロピル)オキシ)−5−((6−(メチルスルホニル)−3−ピリジニル)オキシ)−N−(4−((2−オキシド−1,3,2−ジオキサホスフィナン−2−イル)メチル)−1,3−チアゾール−2−イル)ベンズアミド、およびそのすべての立体異性体、そのプロドラッグ、その薬学的に許容される塩が提供される。
さらに別の実施形態では、本発明の化合物は、式Iの化合物のナトリウム塩またはカリウム塩である。
さらに別の実施形態では、本発明の化合物は、式Iの化合物のナトリウム塩である。
さらに別の実施形態では、本発明の化合物は、式Iの化合物のカリウム塩である。
さらに他の実施形態では、本発明の化合物は、式Iの化合物の結晶形、好ましくはN−1型またはP−2型、より好ましくはN−1型である。
一実施形態では、結晶形は、実質的に純粋な結晶形である。
格子定数(cell dimensions):
a = 8.0531(2)
b = 13.5078(3)
c = 13.7063(3)
α = 73.091(1)
β = 88.186(1)
γ = 89.881(1)
空間群:P1
分子/非対称単位(Molecules/asymmetric unit)(Z’):2
密度(計算値、g/cm3):1.425
本発明の化合物は、光学活性体、またはラセミ体として単離することができる。例えば、ラセミ体の分割による、または光学活性な出発物質からの合成による光学活性体の製造方法は、当分野で周知である。具体的な立体化学もしくは異性体が特に示されていない限り、構造の全てのキラル体、ジアステレオマー体、およびラセミ体が意図される。
a) Wermuth, C.G. et al., The Practice of Medicinal Chemistry, Chapter 31, Academic Press (1996);
b) Design of Prodrugs, Bundgaard, H. ed., Elsevier (1985);
c) Bundgaard, H., Chapter 5, “Design and Application of Prodrugs,” A Textbook of Drug Design and Development, pp. 113-191, Krosgaard-Larsen, P. et al., eds., Harwood Academic Publishers (1991);および
d) Testa, B. et al., Hydrolysis in Drug and Prodrug Metabolism, Wiley-VCH (2003)に記載されている。これら引用文献は、引用により本明細書の一部を構成する。
DMAP ジメチルアミノピリジン
DMF N,N−ジメチルホルムアミド
EDAC 3-エチル-3’-(ジメチルアミノ)プロピル-カルボジイミド塩酸塩
(または1-(3-ジメチルアミノプロピル)-3-エチルカルボジイミド塩酸塩)
Et2O ジエチルエーテル
EtOH エタノール
EtOAc 酢酸エチル
equiv. 当量
g グラム
h 時間
HOBT ヒドロキシベンゾトリアゾール
HPLC 高速液体クロマトグラフィー
i-Pr2EtN ジ(イソプロピル)エチルアミン
LCMS 液体クロマトグラフィー質量分析法
MeOH メタノール
min 分
mL ミリリットル
mmol ミリモル
NaHMDS ナトリウムビス(トリメチルシリル)アミド
rt 反応時間
THF テトラヒドロフラン
3−(((1S)−1−(メトキシメチル)プロピル)オキシ)−5−((6−(メチルスルホニル)−3−ピリジニル)オキシ)−N−(4−((2−オキシド−1,3,2−ジオキサホスフィナン−2−イル)メチル)−1,3−チアゾール−2−イル)ベンズアミド
中間体1A:(2R)−1−メトキシ−2−ブタノール
1H NMR (400 MHz, CDCl3)δ3.78-3.66 (m, 1H), 3.42 (dd, J=9.3, 2.8 Hz, 1H), 3.39 (s, 3H), 3.25 (dd, J=9.3, 7.7 Hz, 1H), 1.54-1.42 (m, 2H), 0.97 (t, J=7.4 Hz, 3H); 13C NMR (100 MHz, CDCl3)δ76.62 , 71.0, 58.5, 25.7, 9.5; [α]21.9 D (EtOH, 27.46 mg/mL) = +6.41°;C5H12O2に関する分析計算値:C, 57.66%; H, 11.61%, 実測値:C, 57.78%; H, 11.19%.
HPLC(YMC CombiScreen ODS-A S-5μ4.6×50mmカラム、220nmで検出;流速=4mL/分;4分かけて0%Bから100%Bまでの連続勾配+100%Bで1分間維持;ここで、A=90:10:0.2 H2O:MeOH:H3PO4およびB=10:90:0.2 H2O:MeOH:H3PO4) 98.7%, rt = 1.75 min; [M + H]+ = 237.99; 1H NMR (300 MHz, CDCl3)δ8.76 (dd, J=2.2, 0.7 Hz, 1H), 8.08 (dd, J = 8.4, 2.2 Hz, 1H), 7.95 (d, J = 8.1 Hz, 1H), 3.20 (s, 3H); 13C NMR (75 MHz; CDCl3)δ156.21, 151.1, 140.8, 125.51, 124.82, 122.4, 40.0; C6H6BrNO2Sに関する分析計算値:C, 30.52; H, 2.56; N, 5.93; 実測値:C, 30.52%; H, 2.56%; N, 5.93%.
1H NMR (400 MHz, CDCl3)δ7.06 (d, J=676.1 Hz, 1H), 4.20-4.37 (m, 4H), 2.04-2.20 (m, 1H), 1.60-1.71 (m, 1H); 13C NMR (100 MHz, CDCl3)δ67.2 (d, J=6.9 Hz), 26.0 (d, J=8.4 Hz); 31P NMR (160 MHz, CDCl3)δ4.4 (d, J=668.8 Hz);C3H7O3Pに関する分析計算値:C, 29.52%; H, 5.78%; 実測値:C, 29.37%; H, 5.78%.
DMF(160mL)中の中間体1K(23.08g、73.4mmol)の撹拌懸濁液に、i−Pr2EtN(15.8g、122mmol)を加え、反応混合物を70℃に加熱した。中間体1F(24.2g、61.2mmol)、HOBT水和物(10.78g、70.4mmol)およびEDAC(16.42g、86mmol)を70℃の反応混合物に添加した。反応混合物を80℃で25分間撹拌した。反応混合物を室温に冷却し、EtOAc(600mL)で希釈し、H2O(250mL)、飽和NaHCO3水溶液(2×250mL)、1N HCl水溶液(250mL)およびブライン(250mL)で順次洗浄し、Na 2SO4で乾燥し、減圧濃縮して、白色の泡状物(40g)を得た。白色の泡状物をEtOH(350mL)から再結晶して、実施例1(34.4g、収率92%)を白色の固体として得た。分析用HPLC(YMC CombiScreen ODS-A S-5μ4.6×50mmカラム、220nmで検出;流速=4mL/分;4分かけて0%Bから100%Bまでの連続勾配+100%Bで1分間維持;ここで、A=90:10:0.2 H2O:MeOH:H3PO4 および B = 10:90:0.2 H2O:MeOH:H3PO4) 99.6%, rt = 2.57 min; >99.0% ee (SFC; Chiralcel OJ-H, 0.46 x 25 cm, 5 μmカラム、220nmにて検出、流速=3 mL/minイソラクチック80/20 CO2/MeCN:iPrOH (1:1) 移動相; 150 barsの圧力); [M + H]+ = 612.2; 1H NMR (400 MHz, CDCl3)δ11.74 (br. s, 1H), 8.51 (d, 1H), 8.09 (d, 1H), 7.61-7.68 (m, 1H), 7.54 (m, 1H), 7.46-7.50 (m, 1H), 6.93 (m, 1H), 6.87 (d, 1H), 4.46-4.58 (m, 1H), 4.28-4.41 (m, 2H), 4.03-4.19 (m, 2H), 3.69 (d, 2H), 3.58-3.62 (m, 2H), 3.39 (s, 3H), 3.24 (s, 3H), 1.89-1.97 (m, 2H), 1.71-1.83 (m, 2H), 1.60-1.71 (m, 1H), 1.00 (m, 3H); 13C NMR (100 MHz, CD3OD)δ166.0, 162.2, 160.2, 158.3, 157.6, 153.3, 142.4, 142.2, 136.8, 127.2, 124.3, 113.6, 113.0, 112.8, 112.4, 80.4, 75.1, 69.3, 59.6, 40.8, 29.1, 28.1, 27.5, 25.3, 9.9; 31P NMR (160 MHz, CD3OD)δ21.11; [α]21.9 D (MeCN, 4.19 mg/mL) = -18.4°;C25H30N3O9PS2に関する分析計算値:C, 49.10%; H, 4.95%; N, 6.86%; 実測値:C, 49.09%; H, 4.96%; N, 6.87%.
3−(((1S)−1−(メトキシメチル)プロピル)オキシ)−5−((6−(メチルスルホニル)−3−ピリジニル)オキシ)−N−(4−((2−オキシド−1,3,2−ジオキサホスフィナン−2−イル)メチル)−1,3−チアゾール−2−イル)ベンズアミドのナトリウム塩
中間体2A:ナトリウム,4−ペンチルフェノラート (Int-2A)
4−ペンチルフェノール(3.604g、21.94mmol)を、マグネチックスターラーとアルゴン導入口を備えた100mLの一ツ口ナシ形フラスコ中のMeOH(10mL)に溶解した。MeOH(24mL)と水(6mL)の混合物中のNaOH(0.878g、21.94mmol)の溶液を加えた。反応混合物を室温で15分間撹拌した。反応混合物を減圧濃縮して半固体とし、これを減圧下100℃で一晩乾燥させて白色の固形物を得た。白色の固形物を石油エーテル(40mL)でスラリー化し、スラリーを濾過し、フィルターケーキを石油エーテル(2×10mL)で洗浄した。フィルターケーキを減圧乾燥して、中間体2A(3.9424g、収率96%)を白色の固体として得た。
1H NMR (400MHz, DMSO-d6)δ6.52 (d, J=8.3 Hz, 2H), 5.99 (d, J=8.2 Hz, 2H), 2.25 (t, J=7.4 Hz, 2H), 1.41 (quin, J=7.4 Hz, 2H), 1.33-1.15 (m, 4H), 0.84 (t, J=6.9 Hz, 3H).
実施例1(11.024g、18.02mmol)を、マグネチックスターラー、還流冷却器およびアルゴン導入口を備えた250mLの一ツ口フラスコ中のTHF(50mL)に溶解した。THF(12.50mL)中の中間体2A(3.36g、18.02mmol)の溶液を加え、混合物を室温で1時間撹拌した。混合物を、撹拌しているEt2O(1000mL)にゆっくり加え、得られたスラリーを濾過した。フィルターケーキをEt2O(3×100mL)で洗浄し、減圧乾燥して、実施例2(11.3166g、収率99%)を灰白色のアモルファス固体として得た。
1H NMR (400MHz, DMSO-d6)δ8.59 (d, J=2.7 Hz, 1H), 8.05 (d, J=8.8 Hz, 1H), 7.62 (dd, J=8.2, 2.7 Hz, 1H), 7.58 (s, 1H), 7.37 (s, 1H), 6.81 (t, J=2.5 Hz, 1H), 6.42 (d, J=3.8 Hz, 1H), 4.46 (s, 1H), 4.39-4.19 (m, 4H), 3.54-3.49 (m, 2H), 3.34-3.22 (m, 8H), 2.08-1.93 (m, 1H), 1.74-1.57 (m, 3H), 0.93 (t, J=7.4 Hz, 3H).
3−(((1S)−1−(メトキシメチル)プロピル)オキシ)−5−((6−(メチルスルホニル)−3−ピリジニル)オキシ)−N−(4−((2−オキシド−1,3,2−ジオキサホスフィナン−2−イル)メチル)−1,3−チアゾール−2−イル)ベンズアミドのカリウム塩
実施例1(0.2g、0.327mmol)を、マグネチックスターラーおよびアルゴン導入口を備えた25mLの一ツ口ナシ型フラスコ中のTHF(比:16.00、容積:8mL)に溶解した。カリウム4−ペンチルフェノレート(0.066g、0.327mmol)のTHF溶液(比:1.000、容量:0.5mL)を加え、混合物を室温で2時間撹拌した。混合物を、撹拌しているEt2O(100mL)に滴加した。得られたスラリーを濾過し、フィルターケーキをEt2O(3×1mL)で洗浄し、減圧乾燥して、実施例3(0.1927g、収率91%)を淡黄色のアモルファス固形物として得た。
1H NMR (400 MHz, DMSO-d6)δppm 8.60 (1 H, d, J=2.75 Hz), 8.05 (1 H, d, J=8.79 Hz), 7.63 (1 H, dd, J=8.79, 2.75 Hz), 7.57 (1 H, s), 7.37 (1 H, s), 6.83 (1 H, br. s.), 6.46 (1 H, br. s.), 4.43-4.52 (1 H, m), 4.21-4.38 (4 H, m), 3.52 (2 H, d, J=5.50 Hz), 3.21-3.34 (8 H, m), 1.92-2.07 (1 H, m), 1.59-1.73 (3 H, m), 0.93 (3 H, t, J=7.42 Hz).
3−(((1S)−1−(メトキシメチル)プロピル)オキシ)−5−((6−(メチルスルホニル)−3−ピリジニル)オキシ)−N−(4−((2−オキシド−1,3,2−ジオキサホスフィナン−2−イル)メチル)−1,3−チアゾール−2−イル)ベンズアミドの結晶形
以下に記載するとおり、3−(((1S)−1−(メトキシメチル)プロピル)オキシ)−5−((6−(メチルスルホニル)−3−ピリジニル)オキシ)−N−(4−((2−オキシド−1,3,2−ジオキサホスフィナン−2−イル)メチル)−1,3−チアゾール−2−イル)ベンズアミド,遊離塩基の結晶形を調製し、特徴付けを行った。
単結晶データ
データをBruker-Nonius(BRUKER AXS, Inc., 5465 East Cheryl Parkway, Madison, WI 53711 USA)CAD4連続回折計で収集した。単位格子パラメータを、25高反射の実験用回折計の最小二乗分析を通じて得た。強度を、θ−2θ可変走査法による恒温でのCuKα照射(λ=1.5418Å)を用いて測定し、ローレンツ偏光因子についてのみ補正した。バックグラウンド計数を、走査時間の半分について走査の極地(extremes of the scan)で収集した。あるいは、単結晶データを、CuKα照射(λ=1.5418Å)を用いてBruker-Nonius Kappa CCD2000システムで収集した。測定した強度データのインデックス化および処理を、Collect program suiteにおけるHKL2000ソフトウェアパッケージ(Otwinowski, Z. & Minor, W. (1997) in Macromolecular Crystallography, eds. Carter, W.C. Jr & Sweet, R.M. (Academic, NY), Vol. 276, pp.307-326.)で行った。あるいは、単結晶データを、CuKα照射(λ=1.5418Å)を用いてBruker-AXS APEX2 CCD システムで収集した。測定した強度データのインデックス化および処理を、APEX2ソフトウェアパッケージ/プログラムスイート (APEX2 Data collection and processing user interface: APEX2 User Manual, v1.27; BRUKER AXS, Inc., 5465 East Cheryl Parkway Madison, WI 53711 USA)で行った。
PXRDデータはBruker C2 GADDSを用いて得た。照射はCuKα(40KV、40mA)であった。試料と検出器の距離は15cmであった。粉末試料を直径1mm以下の密閉したガラスキャピラリーに入れた;キャピラリーはデータ収集中に回転させた。データを3≦2θ≦35°で、少なくとも1000秒間の試料曝露時間で収集した。生じた二次元の回折弧を積分して、3〜35°2θの範囲の範囲で0.02°2θのステップサイズを用いて、伝統的な一次元PXRDパターンを作成した。
DSC実験は、TA Instruments(登録商標)モデルQ1000または2920で行った。試料(約2〜6mg)をアルミニウムパン内で秤量し、100分の1ミリグラムまで正確に記録し、DSCに移した。装置に窒素ガスを50mL/分でパージした。データは、室温〜300℃で、10℃/分の加熱速度で収集した。プロットは、吸熱ピークが下を向くように行った。
TGA実験は、TA Instruments(登録商標)モデルQ500または2950で行った。試料(約10〜30mg)を、予め重さを量ってある白金パンに入れた。試料の重量を正確に測定し、装置によって1000分の1ミリグラムまで記録した。加熱炉を、100mL/分で窒素ガスを用いてパージした。データは、加熱速度10℃/分で、室温〜300℃の間で収集した。
結晶形調製、PXRD、DSCおよびTGAキャラクタリゼーション
実施例4a、N−1型;実施例1の粗製物(20.77g)を無水エタノール(各回175mL)から2回再結晶化させて、N−1型物質(16.0g;73%)を白色の結晶性固体として得た。無水エタノール溶液中で実施例1から無色の針状結晶として結晶を成長させた。N−1型は、典型的には約166℃の吸熱開始を有するDSCサーモグラムによって特徴付けられた。より高い温度では他のことが起こり得る。N−1型は、単結晶構造データから作成された模擬パターンと一致するPXRDパターンによって特徴付けられた。N−1型はまた、重量減少が約275℃まで無視できるTGA曲線によって特徴付けられ、単結晶構造と一致した。
格子定数(Cell dimensions):
a=8.0531(2)
b=13.5078(3)
c=13.7063(3)
α=73.091(1)
β=88.186(1)
γ=89.881(1)
空間群:P1
分子/非対称単位(Molecules/asymmetric unit)(Z’):2
密度(計算値、g/cm3):1.425
ジクロロメタン(28L、11体積)、続いて粗製の実施例1(2.53kg、1.0当量)を周囲温度で30Lの反応器に添加した。得られた混合物を10分間撹拌して溶解させ、酸化アルミニウム(2.82kg、6.7当量)を加えた。添加が完了したら、反応混合物を30分間撹拌した。この後、反応混合物を3kgのセライトベッドで濾過した後、セライトベッドをジクロロメタン(30.4L、12体積)で洗浄した。合わせた濾液を減圧濃縮した後、丁寧に濾過した(polish filtered)エタノール(6L)を加えた。添加後、得られた混合物を低温(55℃未満)下で濃縮して濃縮混合物(7L、3体積)を得た。丁寧に濾過したエタノール(30L、12体積)を濃縮混合物に添加し、得られた混合物を60℃〜65℃に加熱した。所定の温度に達したら、実施例4aの種結晶(12.5g)を加え、反応混合物を60〜65℃で30分間撹拌した。反応混合物を25℃に冷却し、4時間撹拌した。次いで、反応混合物を遠心分離機で濾過し、エタノール(5L)で洗浄した後、1時間スピン乾燥させた。得られた物質を65℃で6時間減圧乾燥して実施例4a(2.27kg)を得た。
粗製の実施例1(50mg)を75℃で無水EtOH(15体積当量)に溶解した。溶解が完了したら、溶液を20℃に冷却し、これを1時間以上4時間以下の間維持して、実施例4aを白色の結晶質固体として得た。
中間体5A−ヨードメチルブチレート
アルゴン下で、DMF(5mL)中の実施例1(0.2g、0.327mmol)の溶液に、Cs2CO3(0.266g、0.817mmol;加熱しながら減圧乾燥させた)およびN,O−ビス(トリメチルシリル)アセトアミド(0.333g、1.64mmol)を順次に加えた後、DMF(1mL)中の中間体5A(0.112g、0.490mmol)の溶液を滴加した。反応混合物を室温で30分間撹拌した後、分析用HPLCおよびLC/MSにより反応が完了したと判断した。次に反応混合物を水(15mL)に注ぎ入れ、EtOAc(2×15mL)で抽出し;合わせた有機抽出物を乾燥し(MgSO4)、減圧濃縮して黄色の油状物を得た。この物質をCH3CN(2mL)に溶解し、分取HPLC[Luna−5μ C−18(2)100A − 30×250mmカラム、220nmで検出;流速=40mL/分;25分かけて0%Bから100%Bまでの連続勾配+100%Bで5分間維持)ここでA=90:10 H2O:MeCNおよびB=10:90 H2O:MeCN]により精製した。早く溶出する生成物1(保持時間19.1分)を減圧濃縮して白色の固体を得た。遅く溶出する生成物2(保持時間19.6分)も減圧濃縮して白色の固体を得た。早く溶出する生成物1(不純)をCH3CN(2mL)に溶解し、分取HPLC[Luna−5μ C−18(2)100A − 30×250mmカラム、220nmで検出;流速=40mL/分。25分かけて0%Bから100%Bへの連続勾配+100%Bで5分間維持;ここで、A=90:10 H2O:MeCNおよびB=10:90 H2O:MeCN]で実施例6(19mg;収率8%)を白色の固体として得た。分析用HPLC[Luna−5μ C−18(2)100A−2.0×50mmカラム、220nmで検出;流速=0.8mL/分;4分かけて0%Bから100%Bへの連続勾配+100%Bでの1分間維持、ここで、A=90:10:0.1 H2O:MeCN:CF3CO2HおよびB=10:90:0.1 H2O:MeCN:CF3CO2H]。保持時間=3.60分、純度100%;[M+H]+ =712.2;1H NMR (400 MHz, CDCl3)δ8.49 (d, J=2.2 Hz, 1H), 8.07 (d, J=8.2 Hz, 1H), 7.50 (dd, J=8.5, 2.5 Hz, 1H), 7.08 (s, 1H), 7.06 (d, J=3.8 Hz, 1H), 6.89 (s, 1H), 6.86 (s, 1H), 6.07 (s, 2H), 4.55 - 4.42 (m, 2H), 4.40 - 4.24 (m, 4H), 3.59 - 3.52 (m, 2H), 3.41 (d, J=20.3 Hz, 3H), 3.36 (s, 3H), 3.23 (s, 3H), 2.29 (t, J=7.4 Hz, 2H), 2.19 - 2.07 (m, 1H), 1.95 - 1.83 (m, 1H), 1.78 - 1.68 (m, 2H), 1.67 - 1.56 (m, 2H), 0.98 (t, J=7.4 Hz, 3H), 0.93 (t, J=7.4 Hz, 3H).
中間体6A
Ar下、MeCN(10mL)中の中間体6B(0.393g、0.595mmol)の溶液に、酪酸(0.163mL、1.79mmol)およびK2CO3(0.329g、2.38mmol)を順次に加えた。反応混合物を60℃で3時間撹拌した後、分析用HPLCおよびLC/MSは反応が完了したことを示した。反応混合物を室温に冷却し、濾過し、残った固体をMeCN(2mL)で洗浄し、合わせた濾液を減圧濃縮して約2mLの体積にした。この粗製物を分取HPLC[Phen Luna AXIA−5μC−18−30×100mmカラム、220nmで検出;流速=40mL/分;20分かけて10%Bから75%Bへの連続勾配+100%Bで2分間維持;ここで、A=90:10 H2O:MeCNおよびB=10:90 H2O:MeCN]により2回精製して実施例6(277mg、収率64%)を白色の固形物として得た。分析用HPLC(Sunfire C18 3.5μM、3.0×150mmカラム、220および254nmで検出;流速=1mL/分;12分かけて10%Bから100%Bまでの連続勾配+100%Bで3分間維持);ここで、A=95:5:0.05 H2O:MeCN:CF3CO2HおよびB=5:95:0.05 H2O:MeCN:CF3CO2H)。保持時間= 9.62分。純度=98%。[M + H]+=712.0、1H NMR (400MHz, CDCl3)δ8.49 (d, J = 2.2 Hz, 1H), 8.07 (d, J = 8.2 Hz, 1H), 7.50 (dd, J = 8.5, 2.5 Hz, 1H), 7.08 (s, 1H), 7.06 (d, J = 3.8 Hz, 1H), 6.89 (s, 1H), 6.86 (s, 1H), 6.07 (s, 2H), 4.55 - 4.42 (m, 2H), 4.40 - 4.24 (m, 4H), 3.59 - 3.52 (m, 2H), 3.41 (d, J = 20.3 Hz, 3H), 3.36 (s, 3H), 3.23 (s, 3H), 2.29 (t, J =7 .4 Hz, 2H), 2.19 - 2.07 (m, 1H), 1.95 - 1.83 (m, 1H), 1.78 - 1.68 (m, 2H), 1.67 - 1.56 (m, 2H), 0.98 (t, J = 7.4 Hz, 3H), 0.93 (t, J =7 .4 Hz, 3H).
中間体7A
1H NMR (400 MHz, CDCl3) δ 5.63 (d, J = 14.8 Hz, 2H), 1.54 - 1.49 (s, 18H); 31P NMR (162 MHz, CDCl3) δ -11.94 (s).
AcOH:水(6.25mLの4:1混合物)中の中間体7C(177mg、0.212mmol)の溶液を、Ar下、60℃で2時間撹拌した後、分析用HPLCおよびLC/MSは、反応が完了したことを示した。揮発性物質を減圧留去して透明な油状物を得、これをMeOH(4mL)に溶解し、分取HPLC[XBridge Prep Phenyl -5μ OBD - 19 x 100 mmカラム、220 nmで検出;流速=20mL/分;20分かけて0%Bから75%Bへの連続勾配+100%Bで5分間維持;ここで、A=90:10:0.1 H2O:MeOH:CF3CO2HおよびB=10:90:0.1 H2O:MeOH:CF3CO2H]により2回精製して、実施例7(77mg、収率48%)を白色の固形物として得た。分析用HPLC[Luna−5μ C−18(2)100A−2.0×50mmカラム、220nmで検出;流速=0.8mL/分;4分かけて0%Bから100%Bへの連続的勾配+100%Bで1分間維持;ここで、A=90:10:0.1 H2O:MeCN:CF3CO2HおよびB=10:90:0.1 H2O:MeCN:CF3CO2H];保持時間=3.02分、純度99.7%;[M+H]+=722.0, 1H NMR (400 MHz, CDCl3) δ 8.45 (d, J = 2.7 Hz, 1H), 8.01 (d, J = 8.2 Hz, 1H), 7.66 (s, 1H), 7.56 (s, 1H), 7.50 (dd, J = 8.8, 2.7 Hz, 1H), 6.92 (d, J = 3.8 Hz, 1H), 6.89 (t, J = 2.2 Hz, 1H), 6.13 (d, J = 11.0 Hz, 2H), 4.51 - 4.30 (m, 5H), 3.64 - 3.54 (m, 4H), 3.37 (s, 3H), 3.17 (s, 3H), 2.11 - 1.99 (m, 1H), 1.98 - 1.87 (m, 1H), 1.79 - 1.65 (m, 2H), 0.97 (t, J = 7.4 Hz, 3H), 31P NMR (162 MHz, CDCl3)δ17.4 (s), -0.65 (s).
分析用HPLC(Sunfire C18 3.5μM、3.0×150mmカラム、220および254nmで検出;流速= 1mL/分;15分かけて10%Bから100%Bへの連続勾配+100%Bで3分間維持、ここでA =95:5:0.05 H2O:MeCN: CF3CO2HおよびB = 5:95:0.05 H2O: MeCN:CF3CO2H);保持時間=9.17分;純度=97%;[M+H]+ = 728.3. 1H NMR (500 MHz, CDCl3)δ8.50 (d, J = 2.20 Hz, 1H), 8.08 (d, J = 8.25 Hz, 1H), 7.50 (dd, J = 2.75, 8.80 Hz, 1H), 7.09 (m, 1H), 7.04 (d, J = 3.85 Hz, 1H), 6.90 (m, 1H), 6.87 (m, 1H), 6.10 (s, 2H), 4.86 (m, 1H), 4.43-4.50 (m, 2H), 4.37 (m, 1H), 4.22-4.31 (m, 2H), 3.57 (m, 2H), 3.44 (d, J = 20.63 Hz, 2H), 3.37 (s, 3H), 3.24 (s, 3H), 2.09 (m, 1H), 1.84 (m, 1H), 1.74 (M, 2H), 1.29 (d, J = 6.33 Hz, 6H), 0.99 (t, J = 7.43 Hz, 3H). 31P NMR (202.45 MHz, CDCl3)δ18.66.
分析用HPLC(Sunfire C18 3.5μM、3.0×150mmカラム、220および254nmで検出;流速= 1mL/分;15分かけて10%Bから100%Bへの連続勾配+100%Bで3分間維持、ここでA =95:5:0.05 H2O:MeCN: CF3CO2HおよびB = 5:95:0.05 H2O: MeCN:CF3CO2H);保持時間=9.35分;分析純度=98.5%;[M+H]+ = 728.3. 1H NMR (500 MHz, CDCl3)δ8.47 (d, J = 2.20 Hz, 1H), 8.00 (d, J = 8.79 Hz, 1H), 7.82 (s, 1H), 7.60 (s, 1H), 7.42 (dd, J = 2.75, 8.79 Hz, 1H), 6.82 (m, 1H), 6.56 (d, J = 4.40 Hz, 1H), 6.39 (s, 2H), 4.80-4.86 (m, 1H), 4.49-4.58 (m, 2H), 4.46 (m, 1H), 4.24-4.33 (m, 2H), 3.57 (m, 2H), 3.50 (d, J = 20.34 Hz, 2H), 3.36 (s, 3H), 3.19 (s, 3H), 2.01 (m, 1H), 1.74 (m, 2H), 1.74 (M, 2H), 1.24 (d, J = 6.05 Hz, 6H), 0.97 (t, J = 7.15 Hz, 3H).
本発明の化合物、そのエナンチオマー、プロドラッグ、ジアステレオマーまたは塩は、グルコキナーゼを活性化する。グルコキナーゼの活性化における本発明の化合物、そのエナンチオマー、プロドラッグ、ジアステレオマーまたは塩の試験に使用することができるアッセイは、米国特許第6,320,050号、同第6,384,200号、同第6,610,846号、WO 04/052869、およびCastellano, A.L. et al., “Glucokinase activating ureas”, Bioorg. Med. Chem. Letters, 15:1501-1504 (2005), and Grimsby, J., et al., “Allosteric Activators of Glucokinase:Potential Role in Diabetes Therapy”, Science, 301:370-373 (2003)等に開示されているように、当分野において知られている。
本発明の化合物、そのエナンチオマー、プロドラッグ、ジアステレオマーまたは塩を以下のアッセイにおいて試験し、グルコキナーゼの活性化剤であることを示した。
ヒトグルコキナーゼ(GK)の酵素活性は、GK、ATPおよびグルコースを個別の期間インキュベートした後、EDTA(エチレンジアミン四酢酸)でクエンチすることにより測定した。G6Pデヒドロゲナーゼを用いて検出アッセイを行い、チオNAD(チオ−ニコチンアミドアデニンジヌクレオチド)からチオNADH(チオ−ジヒドロニコチンアミドアデニンジヌクレオチド)への変換を405nmの波長で測定することにより、生成物のグルコース−6−ホスフェート(G6P)の相対量を測定した。この「脱共役(uncoupled)」酵素反応は、GK「タンデム」アッセイとして示される。本化合物によるGKの活性化は、このアッセイを用いて評価することができる。5および12mMのグルコースで、0〜100μMの濃度範囲の活性化剤化合物を用いて、以下に記載のGKタンデムアッセイ方法に従った。透明底の384ウェル黒色マイクロタイタープレート中で、ヒト全長グルコキナーゼ(GK, 15 nM)を5または12mMのグルコースとインキュベートした。GK反応を開始させるため、マグネシウム−ATP(最終濃度3mM)を、バッファー(最終バッファー条件:pH 7.1、1mMジチオスレイトールおよび5%DMSOを含有する25mM HEPESバッファー)中のGKに添加した。総反応容量は20μLとした。反応を10分間行った後、5μLのEDTA(最終45mM)でクエンチした。次いで、検出反応の成分であるチオNADおよびG6PDH(グルコース−6−リン酸デヒドロゲナーゼ)(各々、最終濃度650μMおよび3.33ユニット)を、25μLの容量中に一緒に添加した(総体積が50μLになるように)。SPECTRAMAX(登録商標) Plus 384吸光プレートリーダー(Molecular Devices)において405nmで吸光度測定を行った。吸光度を読み取り、バックグラウンドのグルコース−6−ホスフェートレベルを減じ、その後、対照の活性に対する百分率として活性化を計算した。対照の活性は、ビークル(DMSO)の存在下でGKを用い、バックグラウンドのグルコース−6−ホスフェートを減じることにより、決定した。バックグラウンドのグルコース−6−ホスフェートは、ATPによる反応の開始の前にEDTAでGKを先にクエンチすることにより決定した。
全長ヒト肝臓GK(未標識)は、Mookhtiar et al. (1)に記載の通り、BL21 STAR (DE3)pLysS細胞(Invitrogen)において25℃で発現させた。Lange (2)に記載(わずかに改変して)のとおり、タンパク質を実質的に精製した。簡単に言うと、3回の凍結および解凍を介して細胞ペレットを溶解させ、15000gで遠心分離して清澄化し、40〜65%の(NH4)2SO4で沈殿させた。得られたペレットをバッファー中に再懸濁させ、透析し、Q-Sepharose(登録商標)(Sigma)カラムに直接アプライし、次いで、直線的な100−600mM KClグラジエントで溶離した。GK含有画分をプールし、25mM Hepes pH 7.2/1mM MgCl2/1mM EDTA/0.1M KCl/1mM DTTに対して終夜透析した後、10%グリセロールを添加した同一のバッファーで再び透析した。
1. Mookhtiar, K.A. et al., “Heterologous expression and characterization of rat liver glucokinase regulatory protein”, Diabetes, 45:1670-1677 (1996).
2. Lange, A.J. et al., “Expression and site-directed mutagenesis of hepatic glucokinase”, Biochem. J., 277:159-163 (1991).
実験の前に高脂肪食(kcalの60%が脂肪由来)を26週間与えた雄のDIO(食餌誘導性肥満)C57BL/6Jマウスを用いて、経口ブドウ糖負荷試験を行った。実験に用いる前に、マウスを終夜絶食させた。試験化合物またはビークル(1)40%PEG 400+10%クレモフォア+50%水、または2)10%ジメチルアセトアミド+10%エタノール+10%クレモフォア+70%水のいずれか)を、ブドウ糖溶液の経口投与の60分前に、経口で、2g/kg体重の用量で与えた(経口ブドウ糖負荷試験;OGTT)。ブドウ糖の投与前および投与後の異なる時点(2時間の経時変化)で採取した尾部採血サンプルから、血糖値を測定した。血糖の時間曲線を作成し、0〜120分の曲線下面積(ΔAUC)のベースラインからの変化を算出した(ブドウ糖投与時を0時間とする)。
薬物動態(PK)スクリーニング試験を、当業者に知られている方法によって行った。例えば、試験化合物を、PEG400/Cremphor EL/水(40/10/50)ビークル中の溶液として、10mg/kgの用量で雄のC57 Black6j(C57Bl6J)マウスに経口投与した(各時点でN=3)。PK試験の前にマウスを一晩絶食させた。投与後0.5時間、1時間、2時間、および4時間で血液サンプルを心臓出血により採取した。血液サンプル(約0.2mL)にK2EDTAを加え、4℃にて遠心分離(1500〜2000×g)して血漿を得た。投与から1時間後に肝臓サンプル(N=3)を採取した。肝臓組織を3倍容量の水でホモジナイズして均一なホモジネートを形成した。LC/MS/MSで分析する前に、血漿と肝臓の両方のサンプルを−20℃で保存した。血漿AUCは、線形台形法および対数台形法を用いて計算した。肝臓対血漿(L/P)比は、各マウスについて、肝臓中の総濃度を血漿中濃度で割ることによって計算した。3匹のマウスのL/P比の平均を標準偏差と共に報告した。
A.有用性
本発明の化合物は、酵素グルコキナーゼの活性の増強剤としての活性を有し、したがって、グルコキナーゼ活性に関連する疾患の治療において使用することができる。
本発明は、活性成分として、治療上有効量の本発明の化合物を、医薬用の担体または希釈剤を組み合わせて含有する医薬組成物をその範囲に含む。場合により、本発明の化合物は、1以上の他の治療剤(例えば、抗糖尿病薬または他の医薬的に活性な物質)と組み合わせて用いることができる。
本開示の化合物は、錠剤、カプセル剤(各々の製剤には、徐放または持続放出製剤が含まれる)、丸剤、散剤、顆粒剤、エリキシル剤、チンキ剤、懸濁剤、シロップ剤および乳剤等の経口製剤で投与することができる。また、医薬の分野で当業者に周知のあらゆる剤型を用いて、静脈内(ボーラスまたは吸入)、腹腔内、皮下、または筋肉内の形態で投与することができる。単独で投与することもできるが、一般に、選択した投与経路や標準的な製薬実務に基づいて選択された医薬用担体とともに投与される。
単位カプセル剤の多くは、標準的なツーピース型(two-piece)硬ゼラチンカプセル剤に、100ミリグラムの粉末化された活性成分、150ミリグラムの乳糖、50ミリグラムのセルロース、および6ミリグラムのステアリン酸マグネシウムをそれぞれ充填することによって製造することができる。
大豆油、綿実油またはオリーブ油などの可消化油中の活性成分の混合物を調製し、容積移送式ポンプ(positive displacement pump)によりゼラチン内に注入して、100ミリグラムの活性成分を含有する軟ゼラチンカプセル剤を形成することができる。このカプセル剤は、洗浄し乾燥される。
錠剤は、慣用の方法により、用量単位が100ミリグラムの活性成分、0.2ミリグラムのコロイド性二酸化ケイ素、5ミリグラムのステアリン酸マグネシウム、275ミリグラムの微結晶セルロース、11ミリグラムのデンプンおよび98.8ミリグラムの乳糖となるよう調製することができる。嗜好性を高め、または吸収を遅延するために適当なコーティングが施されてもよい。
スプレー乾燥された分散剤は、当業者に公知の方法によって経口投与用に調製することができる。
注射による投与に適した非経口組成物は、10体積%のプロピレングリコールおよび水中で1.5重量%の活性成分を攪拌することによって調製することができる。溶液は、塩化ナトリウムを用いて等張とし、滅菌される。
水性の懸濁剤を、経口投与用に、各5mLが、100mgの微粉化した活性成分、200mgのカルボキシメチルセルロースナトリウム、5mgの安息香酸ナトリウム、1.0gのソルビトール溶液、U.S.P.、および0.025mLのバニリンを含有するよう調製することができる。
Claims (15)
- 塩である、請求項1に記載の化合物。
- ナトリウム塩またはカリウム塩である、請求項1または2に記載の化合物。
- ナトリウム塩である、請求項1〜3のいずれかに記載の化合物。
- カリウム塩である、請求項1〜3のいずれかに記載の化合物。
- 前記化合物の結晶形である、請求項1〜5のいずれかに記載の化合物。
- 結晶形がN−1型またはP−2型である、請求項6に記載の化合物。
- 結晶形がN−1型である、請求項6に記載の化合物。
- 結晶形が実質的に純粋な結晶形である、請求項6〜8のいずれか一項記載の化合物。
- 化合物の結晶形が、下記と実質的に等しい単位格子パラメータによって特徴付けられる、請求項8に記載の化合物。
格子定数:
a=8.0531(2)
b=13.5078(3)
c=13.7063(3)
α=73.091(1)
β=88.186(1)
γ=89.881(1)
空間群:P1
分子/非対称単位(Z’):2
密度(計算値、g/cm3):1.425 - 請求項1〜11のいずれかに記載の化合物および薬学的に許容される担体を含む医薬組成物。
- 少なくとも1つの他の種類の治療剤をさらに含有する、請求項12に記載の医薬組成物。
- 糖尿病、高血糖、耐糖能異常、インスリン抵抗性、高インスリン血症、網膜症、ニューロパシー、腎症、創傷治癒遅延、アテローム性動脈硬化症およびその続発症、心機能異常、心筋虚血、卒中、メタボリックシンドローム、高血圧、肥満、脂質異常症、高脂血症、高トリグリセリド血症、高コレステロール血症、低HDL、高LDL、非心臓性虚血、感染症、癌、血管再狭窄、膵炎、神経変性疾患、脂質障害、認知障害および認知症、骨疾患、HIVプロテアーゼ関連リポジストロフィーまたは緑内障の治療のための医薬の製造における請求項1〜11のいずれかに記載の化合物またはその薬学的に許容される塩の使用。
- 糖尿病、高血糖、耐糖能異常、インスリン抵抗性、高インスリン血症、網膜症、ニューロパシー、腎症、創傷治癒遅延、アテローム性動脈硬化症およびその続発症、心機能異常、心筋虚血、卒中、メタボリックシンドローム、高血圧、肥満、脂質異常症、高脂血症、高トリグリセリド血症、高コレステロール血症、低HDL、高LDL、非心臓性虚血、感染症、癌、血管再狭窄、膵炎、神経変性疾患、脂質障害、認知障害および認知症、骨疾患、HIVプロテアーゼ関連リポジストロフィーまたは緑内障の治療における使用のための請求項1〜11のいずれかに記載の化合物またはその製薬上許容される塩。
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EP3487862A1 (en) | 2019-05-29 |
JP7072557B2 (ja) | 2022-05-20 |
CN109715637A (zh) | 2019-05-03 |
US20190233449A1 (en) | 2019-08-01 |
KR20190033571A (ko) | 2019-03-29 |
WO2018017910A1 (en) | 2018-01-25 |
US10604541B2 (en) | 2020-03-31 |
MA45714A (fr) | 2019-05-29 |
CN109715637B (zh) | 2022-04-05 |
KR102513342B1 (ko) | 2023-03-22 |
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