JP2019523220A5 - - Google Patents
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- Publication number
- JP2019523220A5 JP2019523220A5 JP2018561017A JP2018561017A JP2019523220A5 JP 2019523220 A5 JP2019523220 A5 JP 2019523220A5 JP 2018561017 A JP2018561017 A JP 2018561017A JP 2018561017 A JP2018561017 A JP 2018561017A JP 2019523220 A5 JP2019523220 A5 JP 2019523220A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- amino acids
- antimicrobial
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 235000018417 cysteine Nutrition 0.000 claims description 3
- 239000004475 Arginine Substances 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 229940024606 amino acid Drugs 0.000 claims 16
- 235000001014 amino acid Nutrition 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 16
- 102000044503 Antimicrobial Peptides Human genes 0.000 claims 14
- 108700042778 Antimicrobial Peptides Proteins 0.000 claims 14
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims 12
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 4
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims 3
- 108091035707 Consensus sequence Proteins 0.000 claims 2
- 229930028154 D-arginine Natural products 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 239000000562 conjugate Substances 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 150000008574 D-amino acids Chemical class 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical group OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 229960003121 arginine Drugs 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 229940021745 d- arginine Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 235000009697 arginine Nutrition 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 150000001484 arginines Chemical class 0.000 description 1
- 150000001945 cysteines Chemical group 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662342415P | 2016-05-27 | 2016-05-27 | |
| US62/342,415 | 2016-05-27 | ||
| PCT/US2017/034489 WO2017205631A1 (en) | 2016-05-27 | 2017-05-25 | Modified antimicrobial peptide derived from an arginine-rich domain |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2019523220A JP2019523220A (ja) | 2019-08-22 |
| JP2019523220A5 true JP2019523220A5 (enExample) | 2020-07-02 |
| JP7161263B2 JP7161263B2 (ja) | 2022-10-26 |
| JP7161263B6 JP7161263B6 (ja) | 2023-03-20 |
Family
ID=60411947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561017A Active JP7161263B6 (ja) | 2016-05-27 | 2017-05-25 | アルギニンリッチドメインに由来する改変抗微生物ペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20190144510A1 (enExample) |
| EP (1) | EP3464329A4 (enExample) |
| JP (1) | JP7161263B6 (enExample) |
| KR (1) | KR102530478B1 (enExample) |
| CN (1) | CN109641938A (enExample) |
| AU (1) | AU2017270201A1 (enExample) |
| BR (1) | BR112018074478A2 (enExample) |
| CA (1) | CA3024873A1 (enExample) |
| IL (1) | IL263086A (enExample) |
| MX (1) | MX2018014490A (enExample) |
| SG (1) | SG11201809928VA (enExample) |
| TW (1) | TWI635095B (enExample) |
| WO (1) | WO2017205631A1 (enExample) |
| ZA (1) | ZA201807763B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202317598A (zh) * | 2021-09-01 | 2023-05-01 | 美商艾姆麥克斯治療股份有限公司 | 具有抗微生物活性的胜肽 |
| KR102544102B1 (ko) * | 2021-11-05 | 2023-06-19 | 주식회사 레메디 | 상처 치료 및 항염증 활성을 가지는 펩타이드 및 이의 용도 |
| US11713341B1 (en) | 2022-06-17 | 2023-08-01 | Vestaron Corporation | Antimicrobial NCR13 variant peptides |
| CN116947974B (zh) * | 2023-07-25 | 2025-03-11 | 武汉大学人民医院（湖北省人民医院） | 一种来源于中药美洲大蠊的多聚精氨酸修饰肽及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060595A (en) * | 1996-09-03 | 2000-05-09 | The General Hospital Corporation | Inhibition of viral replication |
| US6399570B1 (en) * | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
| PL201419B1 (pl) | 2002-12-04 | 2009-04-30 | Inst Biotechnologii I Antybiot | Białko chimeryczne, sekwencja, konstrukt, komórka roślinna, sposób otrzymywania białka chimerycznego, transgenicznej rośliny, transgeniczna roślina |
| WO2014124047A1 (en) * | 2013-02-06 | 2014-08-14 | Academia Sinica | Antimicrobial peptides derived from hepatitis b virus core protein arginine-rich domain |
-
2017
- 2017-05-25 CA CA3024873A patent/CA3024873A1/en not_active Abandoned
- 2017-05-25 MX MX2018014490A patent/MX2018014490A/es unknown
- 2017-05-25 BR BR112018074478-6A patent/BR112018074478A2/pt not_active IP Right Cessation
- 2017-05-25 US US16/303,464 patent/US20190144510A1/en not_active Abandoned
- 2017-05-25 CN CN201780032261.3A patent/CN109641938A/zh active Pending
- 2017-05-25 AU AU2017270201A patent/AU2017270201A1/en not_active Abandoned
- 2017-05-25 WO PCT/US2017/034489 patent/WO2017205631A1/en not_active Ceased
- 2017-05-25 KR KR1020187035660A patent/KR102530478B1/ko active Active
- 2017-05-25 SG SG11201809928VA patent/SG11201809928VA/en unknown
- 2017-05-25 EP EP17803588.7A patent/EP3464329A4/en active Pending
- 2017-05-25 JP JP2018561017A patent/JP7161263B6/ja active Active
- 2017-05-26 TW TW106117731A patent/TWI635095B/zh active
-
2018
- 2018-11-18 IL IL263086A patent/IL263086A/en unknown
- 2018-11-19 ZA ZA2018/07763A patent/ZA201807763B/en unknown
-
2020
- 2020-07-17 US US16/932,372 patent/US12084479B2/en active Active
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