JP2019521113A5 - - Google Patents
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- JP2019521113A5 JP2019521113A5 JP2018564394A JP2018564394A JP2019521113A5 JP 2019521113 A5 JP2019521113 A5 JP 2019521113A5 JP 2018564394 A JP2018564394 A JP 2018564394A JP 2018564394 A JP2018564394 A JP 2018564394A JP 2019521113 A5 JP2019521113 A5 JP 2019521113A5
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- interleukin
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- cells
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- 239000000203 mixture Substances 0.000 claims 120
- 238000000034 method Methods 0.000 claims 68
- 210000005087 mononuclear cell Anatomy 0.000 claims 40
- 102000009027 Albumins Human genes 0.000 claims 30
- 108010088751 Albumins Proteins 0.000 claims 30
- 239000012867 bioactive agent Substances 0.000 claims 25
- 210000004027 cell Anatomy 0.000 claims 23
- 210000004700 fetal blood Anatomy 0.000 claims 23
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 20
- 210000000130 stem cell Anatomy 0.000 claims 17
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 15
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 12
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- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 6
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 4
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- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 3
- 108700012434 CCL3 Proteins 0.000 claims 3
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- 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims 3
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- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 3
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- 102000006992 Interferon-alpha Human genes 0.000 claims 3
- 108010047761 Interferon-alpha Proteins 0.000 claims 3
- 102000008070 Interferon-gamma Human genes 0.000 claims 3
- 108010074328 Interferon-gamma Proteins 0.000 claims 3
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 3
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 3
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 3
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- 229940053128 nerve growth factor Drugs 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 3
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 claims 2
- 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 claims 2
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- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 claims 2
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- 108010002335 Interleukin-9 Proteins 0.000 claims 2
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- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 102000004058 Leukemia inhibitory factor Human genes 0.000 claims 2
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- 102000008072 Lymphokines Human genes 0.000 claims 2
- 108010074338 Lymphokines Proteins 0.000 claims 2
- 102100035194 Placenta growth factor Human genes 0.000 claims 2
- BPKIGYQJPYCAOW-FFJTTWKXSA-I calcium;potassium;disodium;(2s)-2-hydroxypropanoate;dichloride;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].C[C@H](O)C([O-])=O BPKIGYQJPYCAOW-FFJTTWKXSA-I 0.000 claims 2
- 230000000959 cryoprotective effect Effects 0.000 claims 2
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 2
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662349633P | 2016-06-13 | 2016-06-13 | |
| US62/349,633 | 2016-06-13 | ||
| US15/619,467 | 2017-06-10 | ||
| US15/619,467 US10426796B2 (en) | 2016-06-13 | 2017-06-10 | Compositions for biological systems and methods for preparing and using the same |
| PCT/US2017/037055 WO2017218427A1 (en) | 2016-06-13 | 2017-06-12 | Compositions for biological systems and methods for preparing and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019521113A JP2019521113A (ja) | 2019-07-25 |
| JP2019521113A5 true JP2019521113A5 (https=) | 2020-07-30 |
Family
ID=60572084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564394A Pending JP2019521113A (ja) | 2016-06-13 | 2017-06-12 | 生体システム用の組成物並びに組成物を調製及び使用する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10426796B2 (https=) |
| EP (1) | EP3468570A4 (https=) |
| JP (1) | JP2019521113A (https=) |
| KR (1) | KR20190018677A (https=) |
| CN (1) | CN109562130A (https=) |
| AU (1) | AU2017284186A1 (https=) |
| CA (1) | CA3026575A1 (https=) |
| MX (1) | MX2018015388A (https=) |
| WO (1) | WO2017218427A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10456423B2 (en) * | 2016-06-13 | 2019-10-29 | SMART SURGICAL, Inc. | Compositions for biological systems and methods for preparing and using the same |
| CN108823160B (zh) * | 2018-07-25 | 2020-08-21 | 广州赛莱拉干细胞科技股份有限公司 | 一种脐带间充质干细胞原代培养基及其原代培养方法 |
| CN109628406B (zh) * | 2019-01-03 | 2021-02-26 | 北京贝来生物科技有限公司 | 一种治疗自身免疫疾病的间充质干细胞及其制备方法和应用 |
| CN114452285B (zh) * | 2022-02-17 | 2022-11-25 | 中国中医科学院中药研究所 | 一种il-17a拮抗剂在治疗糖尿病溃疡中的用途 |
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2017
- 2017-06-10 US US15/619,467 patent/US10426796B2/en not_active Expired - Fee Related
- 2017-06-12 AU AU2017284186A patent/AU2017284186A1/en not_active Abandoned
- 2017-06-12 CA CA3026575A patent/CA3026575A1/en active Pending
- 2017-06-12 WO PCT/US2017/037055 patent/WO2017218427A1/en not_active Ceased
- 2017-06-12 CN CN201780049575.4A patent/CN109562130A/zh active Pending
- 2017-06-12 JP JP2018564394A patent/JP2019521113A/ja active Pending
- 2017-06-12 EP EP17813877.2A patent/EP3468570A4/en not_active Withdrawn
- 2017-06-12 KR KR1020197000781A patent/KR20190018677A/ko not_active Abandoned
- 2017-06-12 MX MX2018015388A patent/MX2018015388A/es unknown
- 2017-08-11 US US15/675,542 patent/US10213463B2/en not_active Expired - Fee Related
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2018
- 2018-05-24 US US15/988,855 patent/US10363271B2/en not_active Expired - Fee Related
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2019
- 2019-07-09 US US16/506,528 patent/US20190328789A1/en not_active Abandoned
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