AU2017284186A1 - Compositions for biological systems and methods for preparing and using the same - Google Patents

Compositions for biological systems and methods for preparing and using the same Download PDF

Info

Publication number
AU2017284186A1
AU2017284186A1 AU2017284186A AU2017284186A AU2017284186A1 AU 2017284186 A1 AU2017284186 A1 AU 2017284186A1 AU 2017284186 A AU2017284186 A AU 2017284186A AU 2017284186 A AU2017284186 A AU 2017284186A AU 2017284186 A1 AU2017284186 A1 AU 2017284186A1
Authority
AU
Australia
Prior art keywords
composition
volume
cells
interleukin
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2017284186A
Other languages
English (en)
Inventor
Christopher D. Jones
Roshan Patel
Nathan Quintanar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smart Surgical Inc
Original Assignee
Smart Surgical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smart Surgical Inc filed Critical Smart Surgical Inc
Publication of AU2017284186A1 publication Critical patent/AU2017284186A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
AU2017284186A 2016-06-13 2017-06-12 Compositions for biological systems and methods for preparing and using the same Abandoned AU2017284186A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662349633P 2016-06-13 2016-06-13
US62/349,633 2016-06-13
US15/619,467 2017-06-10
US15/619,467 US10426796B2 (en) 2016-06-13 2017-06-10 Compositions for biological systems and methods for preparing and using the same
PCT/US2017/037055 WO2017218427A1 (en) 2016-06-13 2017-06-12 Compositions for biological systems and methods for preparing and using the same

Publications (1)

Publication Number Publication Date
AU2017284186A1 true AU2017284186A1 (en) 2019-01-03

Family

ID=60572084

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017284186A Abandoned AU2017284186A1 (en) 2016-06-13 2017-06-12 Compositions for biological systems and methods for preparing and using the same

Country Status (9)

Country Link
US (4) US10426796B2 (https=)
EP (1) EP3468570A4 (https=)
JP (1) JP2019521113A (https=)
KR (1) KR20190018677A (https=)
CN (1) CN109562130A (https=)
AU (1) AU2017284186A1 (https=)
CA (1) CA3026575A1 (https=)
MX (1) MX2018015388A (https=)
WO (1) WO2017218427A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10456423B2 (en) * 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
CN108823160B (zh) * 2018-07-25 2020-08-21 广州赛莱拉干细胞科技股份有限公司 一种脐带间充质干细胞原代培养基及其原代培养方法
CN109628406B (zh) * 2019-01-03 2021-02-26 北京贝来生物科技有限公司 一种治疗自身免疫疾病的间充质干细胞及其制备方法和应用
CN114452285B (zh) * 2022-02-17 2022-11-25 中国中医科学院中药研究所 一种il-17a拮抗剂在治疗糖尿病溃疡中的用途

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525519A (en) 1992-01-07 1996-06-11 Middlesex Sciences, Inc. Method for isolating biomolecules from a biological sample with linear polymers
ES2157260T3 (es) 1993-06-04 2001-08-16 Biotime Inc Solucion semejante a plasma.
US5543316A (en) 1994-04-20 1996-08-06 Diacrin, Inc. Injectable culture medium for maintaining viability of myoblast cells
JPH11322618A (ja) * 1998-05-13 1999-11-24 Asahi Medical Co Ltd 有核細胞分離回収方法及び有核細胞含有液
JP4061775B2 (ja) * 1998-05-21 2008-03-19 ニプロ株式会社 アルブミン含有腹膜透析液
US6153582A (en) 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
US6899889B1 (en) 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US7020845B1 (en) * 1999-11-15 2006-03-28 Gottfurcht Elliot A Navigating internet content on a television using a simplified interface and a remote control
US7274368B1 (en) * 2000-07-31 2007-09-25 Silicon Graphics, Inc. System method and computer program product for remote graphics processing
CN100553636C (zh) * 2000-08-04 2009-10-28 Dmi生物科学公司 二酮基哌嗪和包含它们的组合物的使用方法
DK1349918T3 (da) 2000-12-06 2014-11-10 Anthrogenesis Corp Fremgangsmåde til indsamling af stamceller fra moderkagen
IL158171A0 (en) 2001-04-10 2004-03-28 Bioergonomics Inc Compositions and methods for cell separation
US20030099621A1 (en) * 2001-11-29 2003-05-29 Robert Chow Stem cell screening and transplantation therapy for HIV infection
US7771716B2 (en) * 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US20110280838A1 (en) 2007-12-27 2011-11-17 Advanced Technologies And Regenerative Medicine, Llc Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells
CA2581424A1 (en) 2004-03-09 2005-09-22 Gang Xu Methods for generating insulin-producing cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
US7670596B2 (en) 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
JP2007536936A (ja) 2004-05-14 2007-12-20 ベクトン・ディキンソン・アンド・カンパニー 幹細胞集団および使用方法
WO2007019678A1 (en) * 2005-08-12 2007-02-22 University Health Network Methods and devices for lymphatic targeting
SE529040C2 (sv) * 2006-01-18 2007-04-17 Bows Pharmaceuticals Ag Förfarande för framställning av en dextranmatris för kontrollerad frisättning av insulin
CA2646491A1 (en) 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
US9598673B2 (en) * 2006-05-19 2017-03-21 Creative Medical Health Treatment of disc degenerative disease
WO2007134461A1 (en) * 2006-05-24 2007-11-29 Titan Medical Inc. Snaking robotic arm with movable shapers
WO2008034803A1 (en) 2006-09-18 2008-03-27 Medizinische Universität Graz Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics
US8465733B2 (en) * 2007-11-02 2013-06-18 Jcr Pharmaceuticals Co., Ltd. Pharmaceutical composition containing human mesenchymal stem cell
US20090229463A1 (en) 2008-02-15 2009-09-17 Coalstar Industries, Inc. Apparatus and processes for production of coke and activated carbon from coal products
HU0800134D0 (en) * 2008-02-26 2008-04-28 Semmelweis Egyetem Procedure for producing mineralized bone composition
CA2724839A1 (en) 2008-05-21 2009-11-26 Bioe Llc Differentiation of multi-lineage progenitor cells to pancreatic cells
US20120093782A1 (en) * 2009-05-13 2012-04-19 Grove Robert I Enhanced Hematopoietic Stem Cell Engraftment
US9168442B2 (en) * 2009-09-21 2015-10-27 Thomas M. Covino Gaming surface and game styled after american football
EP2483392B1 (en) 2009-09-23 2015-11-11 Davinci Biosciences LLC Umbilical cord lining stem cells and methods and material for isolating and culturing same
CA2802203A1 (en) * 2010-06-10 2011-12-15 Aastrom Biosciences, Inc. Compositions and methods of treating no-option critical limb ischemia (cli)
US20130323712A1 (en) 2010-11-25 2013-12-05 Kaneka Corporation Method and material for separating leukocytes or mononuclear cells
CA2774383A1 (en) 2011-06-22 2012-12-22 Shaf Keshavjee Repaired organ and method for making the same
WO2013134464A1 (en) * 2012-03-07 2013-09-12 Children's Medical Center Corporation Tissue constructs and uses thereof
SG11201407768QA (en) 2012-04-24 2015-01-29 Brigham & Womens Hospital Generating pluripotent cells de novo
CN104094557A (zh) * 2012-05-30 2014-10-08 株式会社东芝 铁路车辆用传送装置、铁路车辆、控制方法以及控制程序
US9283084B1 (en) 2012-07-24 2016-03-15 Thomas E. O'Hara Spinal fusion cage and vertebral body clamp
CN102920734A (zh) * 2012-11-14 2013-02-13 青岛奥克生物开发有限公司 一种间充质干细胞注射液及其制备方法和在制备治疗溃疡性结肠炎药物中的应用
AU2013364097A1 (en) * 2012-12-18 2015-07-02 Robert Chow Blood cell preparations and related methods (GEN 8)
SG11201505965TA (en) 2013-01-31 2015-09-29 Ajinomoto Kk Culture method for stable undifferentiated proliferation of pluripotent stem cells
SG11201505715RA (en) * 2013-02-01 2015-08-28 Ampio Pharmaceuticals Inc Methods for producing diketopiperazines and compositions containing diketopiperazines
US9241959B2 (en) 2013-03-13 2016-01-26 Mingqi TANG Kits and methods for processing stem cells from bone marrow or umbilical cord blood
SG11201507515YA (en) 2013-03-15 2015-10-29 Marcus Kare Torleif Larsson Cells, methods and apparatuses for umbilical cord blood collection and isolation of cells
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
BR112015020469A2 (pt) * 2013-03-15 2020-01-28 Ampio Pharmaceuticals Inc Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
KR20220044384A (ko) 2013-10-03 2022-04-07 안트로제네시스 코포레이션 사람 태반으로부터의 세포 및 조혈 세포를 사용한 치료
US9238984B2 (en) * 2014-02-03 2016-01-19 Caterpillar, Inc. Exhaust emission prediction system and method
US20170319747A1 (en) * 2014-10-31 2017-11-09 Kyoto University Three-dimensional culture method using biodegradable polymer and culture substrate enabling cell transplantation
CN115777690A (zh) * 2014-11-14 2023-03-14 日本赤十字社 脐带血以及末梢血的冻结保存方法以及冻结保存用溶液
IL297773B2 (en) * 2014-11-17 2024-07-01 Adicet Bio Inc Engineered gamma delta t-cells
TWI548748B (zh) 2015-04-16 2016-09-11 台灣尖端先進生技醫藥股份有限公司 造血幹／先驅細胞之體外放大培養方法及其立即可使用之組成物
KR20180021736A (ko) 2015-06-15 2018-03-05 바이탈 쎄러피스, 인코포레이티드 세포의 항아폽토시스, 생존, 또는 증식을 유도하기 위한 조성물 및 방법

Also Published As

Publication number Publication date
KR20190018677A (ko) 2019-02-25
US10363271B2 (en) 2019-07-30
EP3468570A1 (en) 2019-04-17
JP2019521113A (ja) 2019-07-25
CA3026575A1 (en) 2017-12-21
US20190328789A1 (en) 2019-10-31
US10213463B2 (en) 2019-02-26
EP3468570A4 (en) 2020-01-01
US20170354683A1 (en) 2017-12-14
MX2018015388A (es) 2019-04-29
US10426796B2 (en) 2019-10-01
US20170354684A1 (en) 2017-12-14
WO2017218427A1 (en) 2017-12-21
CN109562130A (zh) 2019-04-02
US20180264041A1 (en) 2018-09-20

Similar Documents

Publication Publication Date Title
Kraus et al. Mesenchymal stem cells and bone regeneration
Cassano et al. Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration
US20190328789A1 (en) Compositions for biological systems and methods for preparing and using the same
Muschler et al. Selective retention of bone marrow-derived cells to enhance spinal fusion.
Muschler et al. Spine fusion using cell matrix composites enriched in bone marrow-derived cells.
Udehiya et al. Comparison of autogenic and allogenic bone marrow derived mesenchymal stem cells for repair of segmental bone defects in rabbits
EP3074507B1 (en) Methods of mediating macrophage phenotypes
Siebrecht et al. Platelet concentrate increases bone ingrowth into porous hydroxyapatite
US20160074479A1 (en) Methods of treating spinal disorders using autologous protein solutions
Yoon et al. Synergistic action of IL-8 and bone marrow concentrate on cartilage regeneration through upregulation of chondrogenic transcription factors
US11369640B2 (en) Compositions for biological systems and methods for preparing and using the same
EP1760144A2 (en) Cartilage and bone repair composition
Seebach et al. Cell-based therapy by autologous bone marrow-derived mononuclear cells for bone augmentation of plate-stabilized proximal humeral fractures: a multicentric, randomized, open phase IIa study
Findikcioglu et al. Effect of platelet-rich plasma and fibrin glue on healing of critical-size calvarial bone defects
Murray et al. Biologics in orthopaedics: concepts and controversies
Sumarta et al. Human umbilical cord mesenchymal stem cells over platelet rich fibrin scaffold for mandibular cartilage defects regenerative medicine
AU2018281936A1 (en) Compositions for biological systems and methods for preparing and using the same
Leung et al. Osteochondral tissue engineering for osteoarthritis using infrapatellar fat-pad derived mesenchymal stem cells
Ernat et al. A Review of Bone Marrow Aspirate Concentrate and Its Use in Primary Osteoarthritis of the Knee
EP3423071B1 (en) Chondrocyte proliferation
US20190224239A1 (en) Heat-exposed platelet lysate compositions, and methods for preparing and using same
Sundberg et al. Mesenchymal stem cells and spinal arthrodesis
Kunze et al. Bone Marrow Aspirate and Bone Marrow Concentrate for the Treatment of Knee Osteoarthritis: Do They Work and Are They Safe?
EP2974753A1 (en) Bone regenerating biomaterials with selected cells from peripheral blood
Karli et al. Biologic and Cellular Therapies in the Clinical Setting: Standardization and Collaboration

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted