JP2019519574A5 - - Google Patents
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- Publication number
- JP2019519574A5 JP2019519574A5 JP2018568338A JP2018568338A JP2019519574A5 JP 2019519574 A5 JP2019519574 A5 JP 2019519574A5 JP 2018568338 A JP2018568338 A JP 2018568338A JP 2018568338 A JP2018568338 A JP 2018568338A JP 2019519574 A5 JP2019519574 A5 JP 2019519574A5
- Authority
- JP
- Japan
- Prior art keywords
- conhch
- compound
- och
- group
- nhch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 5
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000000260 trans-2-phenylcyclopropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@@]1([H])* 0.000 claims 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- -1 2-(4-fluorophenyl)ethyl Chemical group 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 230000028996 humoral immune response Effects 0.000 claims 2
- 150000004678 hydrides Chemical class 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001145 hydrido group Chemical group *[H] 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- LCDCPQHFCOBUEF-UHFFFAOYSA-N pyrrolidine-1-carboxamide Chemical group NC(=O)N1CCCC1 LCDCPQHFCOBUEF-UHFFFAOYSA-N 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 125000006353 oxyethylene group Chemical group 0.000 description 2
- 210000001616 monocyte Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662356314P | 2016-06-29 | 2016-06-29 | |
| US62/356,314 | 2016-06-29 | ||
| PCT/US2017/040028 WO2018005812A1 (en) | 2016-06-29 | 2017-06-29 | Diprovocims: a new and potent class of tlr agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519574A JP2019519574A (ja) | 2019-07-11 |
| JP2019519574A5 true JP2019519574A5 (https=) | 2020-08-06 |
| JP6964298B2 JP6964298B2 (ja) | 2021-11-10 |
Family
ID=60787607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568338A Active JP6964298B2 (ja) | 2016-06-29 | 2017-06-29 | ジプロボシム：新規かつ強力なクラスのｔｌｒアゴニスト |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11040959B2 (https=) |
| EP (1) | EP3445758B1 (https=) |
| JP (1) | JP6964298B2 (https=) |
| KR (1) | KR102522730B1 (https=) |
| CN (1) | CN109641878B (https=) |
| AU (1) | AU2017290238B2 (https=) |
| BR (1) | BR112018077397A2 (https=) |
| CA (1) | CA3026178C (https=) |
| IL (1) | IL263388B (https=) |
| WO (1) | WO2018005812A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113164445A (zh) * | 2018-08-02 | 2021-07-23 | 得克萨斯系统大学评议会 | Tlr1/2激动剂地普罗考姆的佐剂作用协同增效检查点抑制性抗体以消除疾病 |
| JP2023527792A (ja) | 2020-05-27 | 2023-06-30 | アキシャル セラピューティクス，インク． | Ｔｌｒ２調節剤化合物、医薬組成物、及びそれらの使用 |
| US20250367166A1 (en) * | 2022-04-29 | 2025-12-04 | The Scripps Research Institute | Next generation diprovocims that activate the innate and adaptive immune response |
| US20260091126A1 (en) * | 2022-09-20 | 2026-04-02 | The Curators Of The University Of Missouri | Amino acid-modified lipids for rna delivery |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1418905T3 (da) | 2001-08-08 | 2007-09-10 | Pentraxin Therapeutics Ltd | Terapeutisk middel til depletering af en uönsket proteinpopulation fra plasma |
| WO2005016235A2 (en) * | 2003-04-14 | 2005-02-24 | The Regents Of The University Of California | Combined use of impdh inhibitors with toll-like receptor agonists |
| PE20071079A1 (es) | 2005-11-15 | 2007-12-16 | Cytokinetics Inc | Compuestos de piperidina como inhibidores de la proliferacion celular |
| AU2011232421B2 (en) | 2010-03-23 | 2015-08-13 | Novartis Ag | Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| EP2958889B1 (en) | 2013-02-25 | 2017-03-22 | The Scripps Research Institute | Neoseptins: small molecule adjuvants |
| US9918959B2 (en) | 2014-08-06 | 2018-03-20 | The Board Of Regents Of The University Of Texas System | TLR-independent small molecule adjuvants |
-
2017
- 2017-06-29 KR KR1020197002820A patent/KR102522730B1/ko active Active
- 2017-06-29 BR BR112018077397A patent/BR112018077397A2/pt unknown
- 2017-06-29 EP EP17821259.3A patent/EP3445758B1/en active Active
- 2017-06-29 CN CN201780040830.9A patent/CN109641878B/zh active Active
- 2017-06-29 CA CA3026178A patent/CA3026178C/en active Active
- 2017-06-29 WO PCT/US2017/040028 patent/WO2018005812A1/en not_active Ceased
- 2017-06-29 JP JP2018568338A patent/JP6964298B2/ja active Active
- 2017-06-29 US US16/303,043 patent/US11040959B2/en active Active
- 2017-06-29 AU AU2017290238A patent/AU2017290238B2/en active Active
-
2018
- 2018-11-29 IL IL263388A patent/IL263388B/en active IP Right Grant
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