JP2021530559A5 - - Google Patents
Info
- Publication number
- JP2021530559A5 JP2021530559A5 JP2021520287A JP2021520287A JP2021530559A5 JP 2021530559 A5 JP2021530559 A5 JP 2021530559A5 JP 2021520287 A JP2021520287 A JP 2021520287A JP 2021520287 A JP2021520287 A JP 2021520287A JP 2021530559 A5 JP2021530559 A5 JP 2021530559A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- hydrogen
- compound
- halogen
- pharmaceutically acceptable
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862688612P | 2018-06-22 | 2018-06-22 | |
| US62/688,612 | 2018-06-22 | ||
| PCT/US2019/038622 WO2019246603A1 (en) | 2018-06-22 | 2019-06-22 | Methods and compositions for inhibition of dihydroorotate dehydrogenase |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021530559A JP2021530559A (ja) | 2021-11-11 |
| JP2021530559A5 true JP2021530559A5 (https=) | 2022-06-30 |
| JPWO2019246603A5 JPWO2019246603A5 (https=) | 2022-06-30 |
| JP7373170B2 JP7373170B2 (ja) | 2023-11-02 |
Family
ID=68984309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021520287A Active JP7373170B2 (ja) | 2018-06-22 | 2019-06-22 | ジヒドロオロト酸デヒドロゲナーゼ阻害のための方法及び組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11312686B2 (https=) |
| EP (2) | EP4438042A3 (https=) |
| JP (1) | JP7373170B2 (https=) |
| KR (1) | KR102821649B1 (https=) |
| CN (1) | CN112672744B (https=) |
| AU (2) | AU2019288813B2 (https=) |
| BR (1) | BR112020026308A2 (https=) |
| CA (1) | CA3103557A1 (https=) |
| ES (1) | ES2994093T3 (https=) |
| IL (1) | IL279586B (https=) |
| MX (1) | MX2021000143A (https=) |
| SG (1) | SG11202012029PA (https=) |
| WO (1) | WO2019246603A1 (https=) |
| ZA (1) | ZA202007620B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3773579A4 (en) | 2018-03-26 | 2022-03-09 | Clear Creek Bio, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE |
| WO2021134045A1 (en) * | 2019-12-26 | 2021-07-01 | Ohio State Innovation Foundation | Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-cd38 therapeutic agent |
| AU2020411507A1 (en) * | 2019-12-26 | 2022-07-14 | Hendrix College | Methods and compositions for inhibition of dihydroorotate dehydrogenase |
| EP4121050A4 (en) * | 2020-03-20 | 2024-04-17 | Clear Creek Bio, Inc. | STABLE POLYMORPHOUS COMPOSITIONS OF BREQUINA SODIUM, METHODS OF USE AND PRODUCTION THEREOF |
| US20210300873A1 (en) | 2020-03-20 | 2021-09-30 | Clear Creek Bio, Inc. | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof |
| CN113943312A (zh) * | 2020-07-17 | 2022-01-18 | 轶诺(浙江)药业有限公司 | 一类肠道裂解型共药及其制备和用途 |
| WO2023278778A1 (en) * | 2021-06-30 | 2023-01-05 | Ohio State Innovation Foundation | Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-cd47-sirpα therapeutic agent |
| CN115896025B (zh) * | 2021-08-20 | 2025-08-26 | 合肥中科普瑞昇生物医药科技有限公司 | 人原代急性髓系白血病细胞的培养基及培养方法 |
| US20250009740A1 (en) * | 2021-11-22 | 2025-01-09 | Ohio State Innovation Foundation | Methods and compositions for targeting alternative metabolism along with flt3 inhibitor-mediated antileukemic actions |
| CN115532290B (zh) * | 2022-10-13 | 2024-04-30 | 浙江昌海制药有限公司 | 一种特定晶面选择性氢化催化剂及其制备方法和应用 |
| WO2025227007A1 (en) * | 2024-04-26 | 2025-10-30 | Ohio State Innovation Foundation | Methods and compositions for inhibition of dihydroorotate dehydrogenase |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2888346A (en) * | 1955-08-22 | 1959-05-26 | Gen Aniline & Film Corp | Ultra-violet absorbing compounds |
| AU2896097A (en) * | 1996-05-10 | 1997-12-05 | Novartis Ag | Use of brequinar and derivatives in chronic rejection of allografts and xenotransplantation |
| JP2003510352A (ja) * | 1999-10-01 | 2003-03-18 | インスティチュート オブ モレキュラー アンド セル バイオロジー | ウイルス媒介性疾病の治療用化合物 |
| US6841561B1 (en) | 1999-10-01 | 2005-01-11 | Institute Of Molecular And Cell Biology | Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases |
| HRPK20041072B3 (hr) * | 2002-05-17 | 2007-07-31 | Aventis Pharma S.A. | Primjena docetaxela/doxorubicina/ciklofosfamida uadjuvantnoj terapiji karcinoma dojke i jajnika |
| EP2948450A4 (en) | 2013-01-28 | 2016-11-09 | Viamet Pharmaceuticals Inc | METALLOENZYMINHIBITORVERBINDUNGEN |
| HRP20181908T1 (hr) | 2013-02-25 | 2019-01-11 | Aurigene Discovery Technologies Limited | Derivati trosupstituiranog benzotriazola kao inhibitori dihidroorotat oksigenaze |
| US20190192501A1 (en) * | 2016-08-23 | 2019-06-27 | Icahn School Of Medicine At Mount Sinai | Methods for treating pten-mutant tumors |
-
2019
- 2019-06-22 WO PCT/US2019/038622 patent/WO2019246603A1/en not_active Ceased
- 2019-06-22 CN CN201980042068.7A patent/CN112672744B/zh active Active
- 2019-06-22 CA CA3103557A patent/CA3103557A1/en active Pending
- 2019-06-22 US US17/253,342 patent/US11312686B2/en active Active
- 2019-06-22 BR BR112020026308-7A patent/BR112020026308A2/pt not_active Application Discontinuation
- 2019-06-22 AU AU2019288813A patent/AU2019288813B2/en active Active
- 2019-06-22 EP EP24181542.2A patent/EP4438042A3/en active Pending
- 2019-06-22 ES ES19822319T patent/ES2994093T3/es active Active
- 2019-06-22 JP JP2021520287A patent/JP7373170B2/ja active Active
- 2019-06-22 SG SG11202012029PA patent/SG11202012029PA/en unknown
- 2019-06-22 KR KR1020217002054A patent/KR102821649B1/ko active Active
- 2019-06-22 MX MX2021000143A patent/MX2021000143A/es unknown
- 2019-06-22 EP EP19822319.0A patent/EP3793562B1/en active Active
-
2020
- 2020-12-07 ZA ZA2020/07620A patent/ZA202007620B/en unknown
- 2020-12-20 IL IL279586A patent/IL279586B/en unknown
-
2021
- 2021-11-10 US US17/523,675 patent/US11999697B2/en active Active
-
2023
- 2023-09-19 AU AU2023233065A patent/AU2023233065B2/en active Active
-
2024
- 2024-04-26 US US18/647,273 patent/US20240294477A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021530559A5 (https=) | ||
| JP2023052094A5 (https=) | ||
| JP2004516314A5 (https=) | ||
| JP2016518434A5 (https=) | ||
| JP2008510691A5 (https=) | ||
| JP2007501859A5 (https=) | ||
| JP2017537940A5 (https=) | ||
| JP2008503515A5 (https=) | ||
| JPWO2019246603A5 (https=) | ||
| JP2012505871A5 (https=) | ||
| RU2015125006A (ru) | Новые аналоги сс-1065 и их конъюгаты | |
| JP2021525787A5 (https=) | ||
| RU2013156074A (ru) | Диазакарбазолы и способы применения | |
| JP2014505017A5 (https=) | ||
| JP2015512943A5 (https=) | ||
| JP2010529994A5 (https=) | ||
| JP2013518036A5 (https=) | ||
| AR061306A1 (es) | Compuestos de pirrolidin-3-1l-piperidina como agonistas de receptores muscarinicos | |
| RU2012135698A (ru) | Способ и композиция | |
| JP2020504184A5 (https=) | ||
| JP2013513607A5 (https=) | ||
| JP2004523478A5 (https=) | ||
| RU2009128970A (ru) | Производные изосорбидмононитрата для лечения кишечных заболеваний | |
| JP2025183283A5 (https=) | ||
| RU2006139140A (ru) | Средства и способы для лечения нарушений свертываемости |