JP2019519221A5 - - Google Patents
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- JP2019519221A5 JP2019519221A5 JP2018560974A JP2018560974A JP2019519221A5 JP 2019519221 A5 JP2019519221 A5 JP 2019519221A5 JP 2018560974 A JP2018560974 A JP 2018560974A JP 2018560974 A JP2018560974 A JP 2018560974A JP 2019519221 A5 JP2019519221 A5 JP 2019519221A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- appendix
- protein
- acid sequence
- viral vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021194601A JP7315284B2 (ja) | 2016-05-20 | 2021-11-30 | 加齢関連疾患及び症状の遺伝子治療法 |
| JP2023044658A JP2023078338A (ja) | 2016-05-20 | 2023-03-20 | 加齢関連疾患及び症状の遺伝子治療法 |
| JP2025028446A JP2025078652A (ja) | 2016-05-20 | 2025-02-25 | 加齢関連疾患及び症状の遺伝子治療法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662339182P | 2016-05-20 | 2016-05-20 | |
| US62/339,182 | 2016-05-20 | ||
| US201662421665P | 2016-11-14 | 2016-11-14 | |
| US62/421,665 | 2016-11-14 | ||
| PCT/US2017/033815 WO2017201527A2 (en) | 2016-05-20 | 2017-05-22 | Gene therapy methods for age-related diseases and conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021194601A Division JP7315284B2 (ja) | 2016-05-20 | 2021-11-30 | 加齢関連疾患及び症状の遺伝子治療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519221A JP2019519221A (ja) | 2019-07-11 |
| JP2019519221A5 true JP2019519221A5 (https=) | 2020-08-27 |
| JP7632835B2 JP7632835B2 (ja) | 2025-02-19 |
Family
ID=60326179
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560974A Active JP7632835B2 (ja) | 2016-05-20 | 2017-05-22 | 加齢関連疾患及び症状の遺伝子治療法 |
| JP2021194601A Active JP7315284B2 (ja) | 2016-05-20 | 2021-11-30 | 加齢関連疾患及び症状の遺伝子治療法 |
| JP2023044658A Pending JP2023078338A (ja) | 2016-05-20 | 2023-03-20 | 加齢関連疾患及び症状の遺伝子治療法 |
| JP2025028446A Pending JP2025078652A (ja) | 2016-05-20 | 2025-02-25 | 加齢関連疾患及び症状の遺伝子治療法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021194601A Active JP7315284B2 (ja) | 2016-05-20 | 2021-11-30 | 加齢関連疾患及び症状の遺伝子治療法 |
| JP2023044658A Pending JP2023078338A (ja) | 2016-05-20 | 2023-03-20 | 加齢関連疾患及び症状の遺伝子治療法 |
| JP2025028446A Pending JP2025078652A (ja) | 2016-05-20 | 2025-02-25 | 加齢関連疾患及び症状の遺伝子治療法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12281154B2 (https=) |
| EP (1) | EP3458585A4 (https=) |
| JP (4) | JP7632835B2 (https=) |
| CN (2) | CN117535350A (https=) |
| AU (2) | AU2017268469C1 (https=) |
| BR (1) | BR112018073861A2 (https=) |
| CA (1) | CA3025020A1 (https=) |
| MX (3) | MX2018014256A (https=) |
| WO (1) | WO2017201527A2 (https=) |
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| US11208443B2 (en) * | 2017-02-14 | 2021-12-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | NAF-1 derived peptides and uses thereof |
| EP4653536A3 (en) * | 2017-03-17 | 2026-02-25 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression |
| EP3630160A1 (en) * | 2017-05-24 | 2020-04-08 | Universitat Autònoma De Barcelona | Viral expression construct comprising a fibroblast growth factor 21 (fgf21) coding sequence |
| IL270882B2 (en) | 2017-05-24 | 2024-02-01 | Univ Barcelona Autonoma | Viral expression vectors containing the coding sequence for FIBROBLAST GROWTH FACTOR 21 (FGF21 |
| US12297272B2 (en) | 2017-08-15 | 2025-05-13 | Eianco US inc. | IgG Fc variants for veterinary use |
| KR20200077534A (ko) * | 2017-10-20 | 2020-06-30 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 이종 단백질 생성을 위한 인공 분비 펩티드 |
| WO2019113061A1 (en) * | 2017-12-06 | 2019-06-13 | Klogene Therapeutics, Inc. | Compositions and methods for modulating gene expression |
| BR112021003174A2 (pt) * | 2018-08-30 | 2021-05-11 | Research Institute At Nationwide Children's Hospital | terapia gênica para o tratamento de galactosemia |
| US20210388053A1 (en) * | 2018-10-18 | 2021-12-16 | Kindred Biosciences, Inc. | Fc Variants with Altered Binding to Neonatal Fc Receptor (FCRN) for Veterinary Use |
| WO2020106351A1 (en) * | 2018-11-21 | 2020-05-28 | Klogenix Llc | Increasing gene expression |
| CA3120923A1 (en) * | 2018-11-26 | 2020-06-04 | Universitat Autonoma De Barcelona | Fibroblast growth factor 21 (fgf21) gene therapy |
| JP7585237B2 (ja) | 2019-05-23 | 2024-11-18 | クリスティアナ ケア ジーン エディティング インスティテュート，インコーポレーテッド | がんを処置するためのバリアントｎｒｆ２の遺伝子ノックアウト |
| KR20220030945A (ko) | 2019-05-23 | 2022-03-11 | 크리스티아나 케어 헬스 서비시즈 인코포레이티드 | 암의 치료를 위한 nrf2의 유전자 녹아웃 |
| CN114207135A (zh) | 2019-06-11 | 2022-03-18 | 夏尔人类遗传性治疗公司 | 用于治疗由失调的血浆激肽释放酶介导的疾病的抗体的腺相关病毒载体递送 |
| US10653731B1 (en) * | 2019-07-15 | 2020-05-19 | Vigene Biosciences Inc. | Recombinantly-modified adeno-associated virus (rAAV) having improved packaging efficiency |
| KR102281858B1 (ko) | 2019-09-11 | 2021-07-26 | 주식회사 쎌바이오텍 | 유산균 유래 p8 단백질의 발현 컨스트럭트를 포함하는 대장 질환의 치료 또는 예방용 조성물 |
| AU2020346062A1 (en) * | 2019-09-13 | 2022-03-24 | Rutgers, The State University Of New Jersey | AAV-compatible laminin-linker polymerization proteins |
| WO2021081280A1 (en) | 2019-10-23 | 2021-04-29 | Shire Human Genetic Therapies, Inc. | Adeno-associated virus vectors based gene therapy for hereditary angioedema |
| CN110894508B (zh) * | 2019-10-31 | 2021-08-06 | 内蒙古大学 | 一种调控白色脂肪棕色化的基因Adra1a的应用 |
| US20230024183A1 (en) * | 2019-12-05 | 2023-01-26 | President And Fellows Of Harvard College | Methods for Treating Osteoarthritis |
| JP7588466B2 (ja) * | 2020-01-22 | 2024-11-22 | 旭化成メディカル株式会社 | パルボウイルスの生産方法 |
| EP4142758A4 (en) * | 2020-04-28 | 2025-02-26 | President and Fellows of Harvard College | High efficiency gene delivery system |
| CN116033915A (zh) * | 2020-05-13 | 2023-04-28 | 利索基因公司 | 用于治疗gm1神经节苷脂贮积症及其它病症的组合物和方法 |
| KR20230017845A (ko) * | 2020-05-26 | 2023-02-06 | 유니버시타트 아우토노마 데 바르셀로나 | 중추 신경계 장애에 대한 섬유아세포 성장 인자 21(fgf21) 유전자 요법 |
| CN114181944B (zh) * | 2020-09-14 | 2023-10-03 | 中国科学院动物研究所 | 突变基因及构建短肢性侏儒症小型猪模型的方法和用途 |
| WO2022115739A2 (en) * | 2020-11-30 | 2022-06-02 | Cellular Longevity, Inc. | Lnp and liposome compositions for longevity in mammals and methods of using the same |
| WO2022130014A1 (en) | 2020-12-16 | 2022-06-23 | Takeda Pharmaceutical Company Limited | Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein |
| KR102590276B1 (ko) * | 2021-01-04 | 2023-10-16 | 부산대학교 산학협력단 | 조직 특이적 발현을 위한 융합 프로모터 및 이의 용도 |
| CN113444730A (zh) * | 2021-03-17 | 2021-09-28 | 昆明市延安医院 | 一种原发性肝细胞klotho基因转导干细胞筛选构建方法 |
| CN113088531B (zh) * | 2021-03-25 | 2023-10-17 | 四川省药品检验研究院(四川省医疗器械检测中心) | 牛源性成分定量分析标准质粒、制备及检测方法及应用 |
| WO2022221291A2 (en) * | 2021-04-12 | 2022-10-20 | University Of Florida Research Foundation Incorporated | Compositions and methods for treating obesity |
| JP2022169389A (ja) * | 2021-04-27 | 2022-11-09 | 国立大学法人北海道大学 | イヌＴＧＦ－β受容体ＩＩ |
| US12564646B2 (en) * | 2021-06-16 | 2026-03-03 | BioViva USA, Inc. | Treatment of age-related cognitive decline using genetically modified viral vectors |
| US20230018934A1 (en) * | 2021-07-16 | 2023-01-19 | Genflow Biosciences Srl | Method of in vivo administration of the coding sequence of the sirt6 gene via adeno-associated virus |
| EP4408482A4 (en) * | 2021-09-29 | 2025-11-12 | Sirt6 Ltd | METHOD OF TREATING A DISEASE |
| CN114921480A (zh) * | 2022-06-09 | 2022-08-19 | 国科宁波生命与健康产业研究院 | 一种骨细胞Terc基因敲除小鼠模型的构建方法 |
| WO2024064796A2 (en) * | 2022-09-21 | 2024-03-28 | Rejuvenate Bio | Gene therapy methods for arrhythmogenic cardiomyopathy |
| WO2024064785A2 (en) * | 2022-09-21 | 2024-03-28 | Rejuvenate Bio | Gene therapy methods for familial partial lipodystrophy |
| WO2024064784A2 (en) * | 2022-09-21 | 2024-03-28 | Rejuvenate Bio | Gene therapy methods for treating mitral valve disease |
| CN116790610B (zh) * | 2023-05-18 | 2024-09-20 | 四川大学 | 一种治疗骨科疾病的基因及以aav为载体的基因治疗药物 |
| WO2025109173A1 (en) | 2023-11-22 | 2025-05-30 | Advantage Therapeutics, Inc. | Nucleic acid encoding klotho for use in therapeutic and non-therapeutic methods for reducing body weight |
| EP4566618A1 (en) * | 2023-12-06 | 2025-06-11 | ADvantage Therapeutics, Inc. | Nucleic acid encoding klotho for use in therapeutic and non-therapeutic methods for reducing body weight |
| WO2026002276A1 (zh) * | 2024-06-28 | 2026-01-02 | 艾码生物科技(南京)有限公司 | 靶向tgfb的rna干扰方法、核酸及其应用 |
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| US5824655A (en) * | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
| NZ500284A (en) | 1997-04-18 | 2001-09-28 | Biogen Inc | Type II TGF-beta receptor fusion proteins |
| US7622300B2 (en) * | 1998-06-03 | 2009-11-24 | Kappes John C | Trans-lentiviral vector particles and transduction of eukaryotic cells therewith |
| US7419829B2 (en) * | 2000-10-06 | 2008-09-02 | Oxford Biomedica (Uk) Limited | Vector system |
| WO2003059396A1 (en) | 2002-01-11 | 2003-07-24 | Sergei Zolotukhin | Adiponectin gene therapy |
| US8158589B2 (en) * | 2003-08-22 | 2012-04-17 | Proyecto Biomedicine Cima, S.L. | Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1) |
| EP1812450A2 (en) * | 2004-11-10 | 2007-08-01 | Eli Lilly And Company | Tgf-beta inhibitors |
| FR2879204B1 (fr) * | 2004-12-15 | 2007-02-16 | Lab Francais Du Fractionnement | Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b. |
| BRPI0608376A8 (pt) * | 2005-04-22 | 2018-10-16 | Lilly Co Eli | composição de ligação, método de uso de uma composição de ligação, e, kit de detecção |
| DE102005061840A1 (de) * | 2005-12-23 | 2007-06-28 | Merck Patent Gmbh | Triazolderivate |
| US20070292922A1 (en) | 2006-03-31 | 2007-12-20 | Cell Genesys, Inc. | Regulated expression of recombinant proteins from adeno-associated viral vectors |
| NZ575804A (en) * | 2006-09-13 | 2012-01-12 | Univ Columbia | Undercarboxylated/uncarboxylated osteocalcin increases beta-cell proliferation, insulin secretion, insulin sensitivity, glucose tolerance and decreases fat mass |
| WO2008157367A1 (en) * | 2007-06-15 | 2008-12-24 | Genzyme Corporation | Fusion proteins containing two tgf-beta binding domains of tgf-beta type ii receptor |
| US8236557B2 (en) * | 2008-05-28 | 2012-08-07 | University Of Missouri-Columbia | Hybrid-AAV vectors to deliver large gene expression cassette |
| JO3096B1 (ar) * | 2008-11-07 | 2017-03-15 | Imclone Llc | الأجسام المضادة لمستقبل ii مضاد tgfb |
| CA3253628A1 (en) * | 2010-03-05 | 2025-11-29 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| AR083445A1 (es) * | 2010-10-14 | 2013-02-27 | Univ Mie | siARN CONTRA LA FIBROSIS |
| ES2423798T3 (es) * | 2010-11-19 | 2013-09-24 | Universitätsklinikum Freiburg | Hidrogeles de PEG disolubles sensibles a estímulos biofuncionalizados |
| EP2548570A1 (en) * | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
| MX2014002260A (es) * | 2011-08-31 | 2014-08-18 | Amgen Inc | Factor de crecimiento de fibroblasto 21 para usar en el tratamiento de diabetes tipo 1. |
| TWI593708B (zh) * | 2011-09-26 | 2017-08-01 | 諾華公司 | 治療代謝病症之融合蛋白質 |
| TWI614031B (zh) | 2011-11-03 | 2018-02-11 | 國立陽明大學 | 防止皮膚老化相關症狀的醫藥組合物及其使用方法 |
| WO2013111081A1 (en) | 2012-01-24 | 2013-08-01 | Bar-Ilan University | Treatment of disease by modulation of sirt6 |
| CN103665166A (zh) * | 2012-09-03 | 2014-03-26 | 福又达生物科技股份有限公司 | 犬融合干扰素 |
| US20160120959A1 (en) | 2013-03-14 | 2016-05-05 | The Board Of Regents Of The University Of Oklahoma | Use of Klotho Nucleic Acids or Proteins for Treatment of Diabetes and Diabetes-Related Conditions |
| AU2015243535A1 (en) * | 2014-04-08 | 2016-11-03 | University Of Southern California | Polypeptide compositions with Type VII collagen fibronectin Type Ill- like repeats and treatment methods for wound closure and healing |
| KR20150135148A (ko) * | 2014-05-23 | 2015-12-02 | 주식회사 제넥신 | Pd-l1 융합 단백질 및 이의 용도 |
| CN114805532A (zh) * | 2014-10-24 | 2022-07-29 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
| KR20160088656A (ko) * | 2015-01-16 | 2016-07-26 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| WO2017024407A1 (en) * | 2015-08-11 | 2017-02-16 | The Royal Institution For The Advancement Of Learning/Mcgill University | Peptidic tgf-beta antagonists |
-
2017
- 2017-05-22 MX MX2018014256A patent/MX2018014256A/es unknown
- 2017-05-22 CN CN202311189446.9A patent/CN117535350A/zh active Pending
- 2017-05-22 AU AU2017268469A patent/AU2017268469C1/en active Active
- 2017-05-22 US US16/302,865 patent/US12281154B2/en active Active
- 2017-05-22 BR BR112018073861-1A patent/BR112018073861A2/pt active Search and Examination
- 2017-05-22 WO PCT/US2017/033815 patent/WO2017201527A2/en not_active Ceased
- 2017-05-22 JP JP2018560974A patent/JP7632835B2/ja active Active
- 2017-05-22 CA CA3025020A patent/CA3025020A1/en active Pending
- 2017-05-22 EP EP17800329.9A patent/EP3458585A4/en active Pending
- 2017-05-22 CN CN201780058862.1A patent/CN109844124B/zh active Active
-
2018
- 2018-11-20 MX MX2025014039A patent/MX2025014039A/es unknown
- 2018-11-20 MX MX2022000085A patent/MX2022000085A/es unknown
-
2021
- 2021-11-30 JP JP2021194601A patent/JP7315284B2/ja active Active
-
2023
- 2023-03-20 JP JP2023044658A patent/JP2023078338A/ja active Pending
-
2024
- 2024-09-23 AU AU2024219991A patent/AU2024219991A1/en active Pending
- 2024-11-11 US US18/942,898 patent/US20250122267A1/en active Pending
-
2025
- 2025-02-25 JP JP2025028446A patent/JP2025078652A/ja active Pending
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