JP2019518732A5 - - Google Patents
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- Publication number
- JP2019518732A5 JP2019518732A5 JP2018558728A JP2018558728A JP2019518732A5 JP 2019518732 A5 JP2019518732 A5 JP 2019518732A5 JP 2018558728 A JP2018558728 A JP 2018558728A JP 2018558728 A JP2018558728 A JP 2018558728A JP 2019518732 A5 JP2019518732 A5 JP 2019518732A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- formula
- sleep
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 230000001788 irregular Effects 0.000 claims 8
- 230000008454 sleep-wake cycle Effects 0.000 claims 8
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 2
- 229920004142 LEXAN™ Polymers 0.000 claims 2
- 239000004418 Lexan Substances 0.000 claims 2
- 230000027288 circadian rhythm Effects 0.000 claims 2
- 230000008451 emotion Effects 0.000 claims 2
- MUGXRYIUWFITCP-PGRDOPGGSA-N (1r,2s)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-n-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide Chemical compound CC1=NC(C)=NC=C1OC[C@]1(C=2C=C(F)C=CC=2)[C@H](C(=O)NC=2N=CC(F)=CC=2)C1 MUGXRYIUWFITCP-PGRDOPGGSA-N 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 1
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims 1
- 206010062519 Poor quality sleep Diseases 0.000 claims 1
- 206010041349 Somnolence Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 230000036626 alertness Effects 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 229950003528 lemborexant Drugs 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 230000000422 nocturnal effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021084719A JP7150096B2 (ja) | 2016-05-12 | 2021-05-19 | 概日リズム睡眠障害群を治療する方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662335599P | 2016-05-12 | 2016-05-12 | |
| US201662335611P | 2016-05-12 | 2016-05-12 | |
| US62/335,599 | 2016-05-12 | ||
| US62/335,611 | 2016-05-12 | ||
| US201662413976P | 2016-10-27 | 2016-10-27 | |
| US62/413,976 | 2016-10-27 | ||
| US201662414599P | 2016-10-28 | 2016-10-28 | |
| US201662414606P | 2016-10-28 | 2016-10-28 | |
| US62/414,599 | 2016-10-28 | ||
| US62/414,606 | 2016-10-28 | ||
| PCT/US2017/032228 WO2017197160A1 (en) | 2016-05-12 | 2017-05-11 | Methods of treating circadian rhythm sleep disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021084719A Division JP7150096B2 (ja) | 2016-05-12 | 2021-05-19 | 概日リズム睡眠障害群を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019518732A JP2019518732A (ja) | 2019-07-04 |
| JP2019518732A5 true JP2019518732A5 (cg-RX-API-DMAC7.html) | 2020-06-18 |
| JP6888026B2 JP6888026B2 (ja) | 2021-06-16 |
Family
ID=58745465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558728A Active JP6888026B2 (ja) | 2016-05-12 | 2017-05-11 | 概日リズム睡眠障害群を治療する方法 |
| JP2021084719A Active JP7150096B2 (ja) | 2016-05-12 | 2021-05-19 | 概日リズム睡眠障害群を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021084719A Active JP7150096B2 (ja) | 2016-05-12 | 2021-05-19 | 概日リズム睡眠障害群を治療する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11096941B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3454859B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6888026B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102511855B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109640998A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2017264871B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3022068A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2904625T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL291791B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX379318B (cg-RX-API-DMAC7.html) |
| MY (1) | MY199382A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2763493C2 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201809527UA (cg-RX-API-DMAC7.html) |
| TW (1) | TWI795359B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017197160A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201807903B (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201809527UA (en) * | 2016-05-12 | 2018-11-29 | Eisai R&D Man Co Ltd | Methods of treating circadian rhythm sleep disorders |
| WO2020263253A1 (en) * | 2019-06-26 | 2020-12-30 | Moline Margaret | Lemborexant for treating sleep issues |
| MX2021016090A (es) * | 2019-06-26 | 2022-02-03 | Eisai R&D Man Co Ltd | Lemborexant para el tratamiento de problemas del sueño. |
| JP2022538170A (ja) * | 2019-06-26 | 2022-08-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 睡眠問題の治療のためのレンボレキサント |
| CA3151634A1 (en) * | 2019-09-13 | 2021-03-18 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating insomnia |
| US20240010629A1 (en) * | 2019-12-11 | 2024-01-11 | Teva Czech Industries S.R.O | Solid state form of lemborexant |
| MX2022008260A (es) * | 2020-01-16 | 2022-08-04 | Eisai R&D Man Co Ltd | Sustancia farmacologica de lemborexant y composicion medicinal que la comprende. |
| CN111450076A (zh) * | 2020-05-25 | 2020-07-28 | 安徽省逸欣铭医药科技有限公司 | 一种Lemborexant软胶囊组合物及其制备方法 |
| CN114159568B (zh) * | 2020-09-11 | 2025-08-01 | 北京原基华毅生物科技有限公司 | Sik抑制剂在制备用于预防和/或治疗睡眠障碍的药物中的应用 |
| JP2024527024A (ja) * | 2021-07-26 | 2024-07-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患に伴う不規則睡眠・覚醒リズム障害及び概日リズム睡眠障害を治療する方法における使用のためのレンボレキサント |
| CN116421605B (zh) * | 2022-01-04 | 2024-08-02 | 中国科学院脑科学与智能技术卓越创新中心 | Isx-9在治疗衰老相关的昼夜节律幅度下降和睡眠障碍方面的应用 |
| KR20250070087A (ko) * | 2022-09-23 | 2025-05-20 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신경변성 질병과 관련된 신경변성의 감소 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06009377A (es) * | 2004-02-20 | 2007-03-07 | Lifescape Biosciences Inc | Composiciones y metodos para regulacion del sueno. |
| WO2008026149A1 (en) * | 2006-08-28 | 2008-03-06 | Actelion Pharmaceuticals Ltd | 1,4,5,6, 7,8-hexahydro-i^1s-triaza-azulene derivatives as orexin receptor antagonists |
| MX2013003218A (es) | 2010-09-22 | 2013-06-28 | Eisai R&D Man Co Ltd | Compuestos de ciclopropano. |
| CA2863413A1 (en) * | 2012-02-07 | 2013-08-15 | Eolas Therapeutics, Inc. | Substituted prolines / piperidines as orexin receptor antagonists |
| CN107810006B (zh) * | 2014-10-23 | 2021-03-30 | 卫材R&D管理有限公司 | 用于治疗失眠的组合物 |
| SG11201809527UA (en) * | 2016-05-12 | 2018-11-29 | Eisai R&D Man Co Ltd | Methods of treating circadian rhythm sleep disorders |
-
2017
- 2017-05-11 SG SG11201809527UA patent/SG11201809527UA/en unknown
- 2017-05-11 ES ES17725084T patent/ES2904625T3/es active Active
- 2017-05-11 AU AU2017264871A patent/AU2017264871B2/en active Active
- 2017-05-11 RU RU2018143809A patent/RU2763493C2/ru active
- 2017-05-11 KR KR1020187035708A patent/KR102511855B1/ko active Active
- 2017-05-11 KR KR1020237009013A patent/KR20230043227A/ko not_active Ceased
- 2017-05-11 CA CA3022068A patent/CA3022068A1/en active Pending
- 2017-05-11 WO PCT/US2017/032228 patent/WO2017197160A1/en not_active Ceased
- 2017-05-11 JP JP2018558728A patent/JP6888026B2/ja active Active
- 2017-05-11 MX MX2018013663A patent/MX379318B/es unknown
- 2017-05-11 EP EP17725084.2A patent/EP3454859B1/en active Active
- 2017-05-11 IL IL291791A patent/IL291791B2/en unknown
- 2017-05-11 MY MYPI2018002456A patent/MY199382A/en unknown
- 2017-05-11 US US16/300,335 patent/US11096941B2/en active Active
- 2017-05-11 CN CN201780039758.8A patent/CN109640998A/zh active Pending
- 2017-05-11 EP EP21208238.2A patent/EP4056180A1/en active Pending
- 2017-05-12 TW TW106115904A patent/TWI795359B/zh active
-
2018
- 2018-11-06 IL IL262803A patent/IL262803B/en unknown
- 2018-11-22 ZA ZA2018/07903A patent/ZA201807903B/en unknown
-
2021
- 2021-05-19 JP JP2021084719A patent/JP7150096B2/ja active Active
- 2021-07-27 US US17/443,650 patent/US20210353625A1/en active Pending
-
2023
- 2023-05-31 AU AU2023203418A patent/AU2023203418A1/en not_active Abandoned
-
2025
- 2025-07-10 AU AU2025205336A patent/AU2025205336A1/en active Pending
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