JP2010529130A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010529130A5 JP2010529130A5 JP2010511206A JP2010511206A JP2010529130A5 JP 2010529130 A5 JP2010529130 A5 JP 2010529130A5 JP 2010511206 A JP2010511206 A JP 2010511206A JP 2010511206 A JP2010511206 A JP 2010511206A JP 2010529130 A5 JP2010529130 A5 JP 2010529130A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- composition
- ray diffraction
- diffraction pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims description 104
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 38
- 208000035475 disorder Diseases 0.000 claims description 38
- 238000002441 X-ray diffraction Methods 0.000 claims description 32
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 27
- 102000004384 Histamine H3 receptors Human genes 0.000 claims description 20
- 108090000981 Histamine H3 receptors Proteins 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 17
- 238000013213 extrapolation Methods 0.000 claims description 14
- 238000002560 therapeutic procedure Methods 0.000 claims description 13
- 208000026935 allergic disease Diseases 0.000 claims description 12
- 208000010877 cognitive disease Diseases 0.000 claims description 12
- 208000028698 Cognitive impairment Diseases 0.000 claims description 10
- 241001465754 Metazoa Species 0.000 claims description 10
- 238000001237 Raman spectrum Methods 0.000 claims description 10
- 238000002835 absorbance Methods 0.000 claims description 10
- 208000024827 Alzheimer disease Diseases 0.000 claims description 6
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 6
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 6
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims description 6
- 206010012289 Dementia Diseases 0.000 claims description 6
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims description 6
- 206010020751 Hypersensitivity Diseases 0.000 claims description 6
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims description 6
- 206010028735 Nasal congestion Diseases 0.000 claims description 6
- 208000008589 Obesity Diseases 0.000 claims description 6
- 208000002193 Pain Diseases 0.000 claims description 6
- 206010062519 Poor quality sleep Diseases 0.000 claims description 6
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 6
- 208000032140 Sleepiness Diseases 0.000 claims description 6
- 206010041349 Somnolence Diseases 0.000 claims description 6
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 6
- 201000010105 allergic rhinitis Diseases 0.000 claims description 6
- 230000007815 allergy Effects 0.000 claims description 6
- 206010015037 epilepsy Diseases 0.000 claims description 6
- 208000013403 hyperactivity Diseases 0.000 claims description 6
- 206010020765 hypersomnia Diseases 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 6
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 201000003631 narcolepsy Diseases 0.000 claims description 6
- 235000020824 obesity Nutrition 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 210000002345 respiratory system Anatomy 0.000 claims description 6
- 201000000980 schizophrenia Diseases 0.000 claims description 6
- 201000002859 sleep apnea Diseases 0.000 claims description 6
- 208000011580 syndromic disease Diseases 0.000 claims description 6
- OHJSZGUPPGWNSH-JQDLGSOUSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r)-1-[2-[4-[4-(3-methoxypropylsulfonyl)phenyl]phenyl]ethyl]-2-methylpyrrolidine Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(S(=O)(=O)CCCOC)=CC=C1C(C=C1)=CC=C1CCN1[C@H](C)CCC1 OHJSZGUPPGWNSH-JQDLGSOUSA-N 0.000 claims description 5
- 230000006735 deficit Effects 0.000 claims description 5
- 230000037007 arousal Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 238000001179 sorption measurement Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- CBSWFXXPFPAFPJ-GDYGQLJFSA-N (z)-but-2-enedioic acid;(2r)-1-[2-[4-[4-(3-methoxypropylsulfonyl)phenyl]phenyl]ethyl]-2-methylpyrrolidine Chemical compound OC(=O)\C=C/C(O)=O.C1=CC(S(=O)(=O)CCCOC)=CC=C1C(C=C1)=CC=C1CCN1[C@H](C)CCC1 CBSWFXXPFPAFPJ-GDYGQLJFSA-N 0.000 claims description 3
- VKBJTEGIYYKTCH-FSRHSHDFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r)-1-[2-[4-[4-(3-methoxypropylsulfonyl)phenyl]phenyl]ethyl]-2-methylpyrrolidine Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(S(=O)(=O)CCCOC)=CC=C1C(C=C1)=CC=C1CCN1[C@H](C)CCC1 VKBJTEGIYYKTCH-FSRHSHDFSA-N 0.000 claims description 3
- CHONWFJBJATGBZ-FSRHSHDFSA-N (2r)-1-[2-[4-[4-(3-methoxypropylsulfonyl)phenyl]phenyl]ethyl]-2-methylpyrrolidine;hydrochloride Chemical compound Cl.C1=CC(S(=O)(=O)CCCOC)=CC=C1C(C=C1)=CC=C1CCN1[C@H](C)CCC1 CHONWFJBJATGBZ-FSRHSHDFSA-N 0.000 claims description 2
- 230000007812 deficiency Effects 0.000 claims 1
- -1 3-methoxy-propan-1-sulfonyl Chemical group 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 150000003235 pyrrolidines Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93379107P | 2007-06-08 | 2007-06-08 | |
| US12452708P | 2008-04-16 | 2008-04-16 | |
| PCT/US2008/007144 WO2008153958A2 (en) | 2007-06-08 | 2008-06-06 | Crystalline forms of (r)-1-{2-[4'- (3-methoxy-propane-1- sulfonyl)-biphenyl-4-yl]-ethyl}-2-methyl-pyrrolidine, and compositions, and methods related thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529130A JP2010529130A (ja) | 2010-08-26 |
| JP2010529130A5 true JP2010529130A5 (cg-RX-API-DMAC7.html) | 2012-08-02 |
Family
ID=40039702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511206A Withdrawn JP2010529130A (ja) | 2007-06-08 | 2008-06-06 | （ｒ）−１−｛２−［４’−（３−メトキシ−プロパン−１−スルホニル）−ビフェニル−４−イル］−エチル｝−２−メチル−ピロリジンの結晶形、およびその組成物ならびにそれに関連する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100292288A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2155668A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010529130A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101801924A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2687721A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008153958A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
| CN101809021B (zh) | 2007-09-11 | 2013-04-24 | 雅培制药有限公司 | 八氢-吡咯并[3,4-b]吡咯n-氧化物 |
| WO2009128907A1 (en) * | 2008-04-16 | 2009-10-22 | Arena Pharmaceuticals, Inc. | Processes useful for the synthesis of (r)-1-{2-[4'-(3-methoxypropane-1-sulfonyl)-biphenyl-4-yl]-ethyl}-2-methyl-pyrrolidine |
| WO2012006205A1 (en) * | 2010-07-09 | 2012-01-12 | Theravance, Inc. | Crystalline form of a 3-phenoxymethylpyrrolidine compound |
| KR101305524B1 (ko) * | 2011-01-26 | 2013-09-06 | 주식회사 바이오랜드 | 신규한 4-ｏ-메틸호노키올 유도체를 유효성분으로 포함하는 치매 치료용 조성물 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| AU2020286003B2 (en) * | 2019-05-24 | 2025-04-24 | Irl 790 Ab | Pharmaceutically acceptable salts of [2-(3-fluoro-5-methane-sulfonylphenoxy)ethyl](propyl)amine and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1735278B1 (en) * | 2004-04-01 | 2010-01-06 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
-
2008
- 2008-06-06 US US12/663,415 patent/US20100292288A1/en not_active Abandoned
- 2008-06-06 CA CA002687721A patent/CA2687721A1/en not_active Abandoned
- 2008-06-06 WO PCT/US2008/007144 patent/WO2008153958A2/en not_active Ceased
- 2008-06-06 CN CN200880102446A patent/CN101801924A/zh active Pending
- 2008-06-06 EP EP08768217A patent/EP2155668A2/en not_active Withdrawn
- 2008-06-06 JP JP2010511206A patent/JP2010529130A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010529130A5 (cg-RX-API-DMAC7.html) | ||
| EA200970386A1 (ru) | Бифенилсульфонильные и фенилгетероарилсульфонильные модуляторы гистаминового н3-рецептора, используемые для лечения ассоциированных с ним расстройств | |
| Permut et al. | Comparison of positional therapy to CPAP in patients with positional obstructive sleep apnea | |
| HRP20192032T1 (hr) | Supstituirani 2-azabicikli i njihova upotreba kao modulatora receptora oreksina | |
| JP6479670B2 (ja) | ７，８−ジヒドロキシフラボンおよび７，８−置換フラボン誘導体、組成物、およびそれらに関連する方法 | |
| ME02275B (me) | Polimorfni oblik rotigotina | |
| CA2676456A1 (en) | Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof | |
| JP2009541216A5 (cg-RX-API-DMAC7.html) | ||
| MX2009012430A (es) | Amidas disustituidas para mejorar las respuestas sinapticas glutamatergicas. | |
| Miano et al. | NREM sleep instability changes following rapid maxillary expansion in children with obstructive apnea sleep syndrome | |
| RU2016105971A (ru) | Применение флекаинида в качестве антиконнексинового средства и способ потенцирования эффектов психотропных лекарственных средств | |
| EA201071083A1 (ru) | Арилсульфонилпиразолинкарбоксамидиновые производные в качестве антагонистов 5-нт | |
| WO2009038752A3 (en) | 3-substituted 1,2,3-triazin-4-one's and 3-substituted 1,3-pyrimidinone's for enhancing glutamatergic synaptic responses | |
| JP2015521642A5 (cg-RX-API-DMAC7.html) | ||
| JP2014503593A (ja) | 閉塞性睡眠時無呼吸を処置するための方法 | |
| WO2009023126A3 (en) | Bicyclic amides for enhancing glutamatergic synaptic responses | |
| JP2012508275A5 (cg-RX-API-DMAC7.html) | ||
| JP2012531402A5 (cg-RX-API-DMAC7.html) | ||
| HRP20141196T1 (hr) | Anhidrirani kristalni oblik orvepitant-maleata | |
| WO2008153958A3 (en) | Crystalline forms of (r)-1-{2-[4'- (3-methoxy-propane-1- sulfonyl)-biphenyl-4-yl]-ethyl}-2-methyl-pyrrolidine, and compositions, and methods related thereto | |
| JP2013537901A5 (cg-RX-API-DMAC7.html) | ||
| JP5600253B2 (ja) | 情動障害の治療のための［２−（６−フルオロ−１ｈ−インドール−３−イルスルファニル）ベンジル］メチルアミン | |
| JP5017268B2 (ja) | 覚醒を改善する方法 | |
| Choi | Treatments for adult obstructive sleep apnea | |
| Singhal et al. | Association of naso-oro-pharyngeal structures with the sleep architecture in suspected obstructive sleep apnea |