JP2019514925A5 - - Google Patents
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- JP2019514925A5 JP2019514925A5 JP2018556411A JP2018556411A JP2019514925A5 JP 2019514925 A5 JP2019514925 A5 JP 2019514925A5 JP 2018556411 A JP2018556411 A JP 2018556411A JP 2018556411 A JP2018556411 A JP 2018556411A JP 2019514925 A5 JP2019514925 A5 JP 2019514925A5
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- Prior art keywords
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- composition
- Prior art date
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- 239000000203 mixture Substances 0.000 claims 18
- 239000000902 placebo Substances 0.000 claims 10
- 229940068196 placebo Drugs 0.000 claims 10
- 230000000250 revascularization Effects 0.000 claims 5
- 206010002388 Angina unstable Diseases 0.000 claims 4
- 208000007814 Unstable Angina Diseases 0.000 claims 4
- 230000003111 delayed effect Effects 0.000 claims 4
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 4
- 231100001160 nonlethal Toxicity 0.000 claims 4
- DLSWIYLPEUIQAV-UHFFFAOYSA-N Semaglutide Chemical compound CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(O)=O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(C)(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CCCNC(N)=N)C(=O)NCC(O)=O DLSWIYLPEUIQAV-UHFFFAOYSA-N 0.000 claims 2
- 230000001934 delay Effects 0.000 claims 2
- 229950011186 semaglutide Drugs 0.000 claims 2
- 108010060325 semaglutide Proteins 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 230000007211 cardiovascular event Effects 0.000 claims 1
- 238000011866 long-term treatment Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16167458 | 2016-04-28 | ||
| EP16167458.5 | 2016-04-28 | ||
| EP16188262 | 2016-09-12 | ||
| EP16188262.6 | 2016-09-12 | ||
| PCT/EP2017/060160 WO2017186896A1 (en) | 2016-04-28 | 2017-04-28 | Semaglutide in cardiovascular conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514925A JP2019514925A (ja) | 2019-06-06 |
| JP2019514925A5 true JP2019514925A5 (https=) | 2020-06-18 |
| JP7221694B2 JP7221694B2 (ja) | 2023-02-14 |
Family
ID=58668875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018556411A Active JP7221694B2 (ja) | 2016-04-28 | 2017-04-28 | 心血管状態におけるセマグルチド |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US12569543B2 (https=) |
| EP (1) | EP3448416B1 (https=) |
| JP (1) | JP7221694B2 (https=) |
| KR (3) | KR102778218B1 (https=) |
| CN (1) | CN109069589B (https=) |
| AU (2) | AU2017256774B2 (https=) |
| BR (1) | BR112018072020A2 (https=) |
| CA (1) | CA3022535A1 (https=) |
| CL (1) | CL2018003045A1 (https=) |
| DK (1) | DK3448416T3 (https=) |
| ES (1) | ES2928007T3 (https=) |
| HR (1) | HRP20221150T1 (https=) |
| HU (1) | HUE060040T2 (https=) |
| IL (1) | IL262390B1 (https=) |
| MA (1) | MA44762A (https=) |
| MX (1) | MX2018012700A (https=) |
| MY (1) | MY202967A (https=) |
| PH (1) | PH12018502274B1 (https=) |
| PL (1) | PL3448416T3 (https=) |
| RS (1) | RS63630B1 (https=) |
| RU (1) | RU2768283C2 (https=) |
| SI (1) | SI3448416T1 (https=) |
| WO (1) | WO2017186896A1 (https=) |
| ZA (2) | ZA202507394B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3022535A1 (en) | 2016-04-28 | 2017-11-02 | Novo Nordisk A/S | Semaglutide in cardiovascular conditions |
| KR102665710B1 (ko) | 2017-08-24 | 2024-05-14 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 그 용도 |
| SG11202103137WA (en) * | 2018-10-26 | 2021-04-29 | Novo Nordisk As | Stable semaglutide compositions and uses thereof |
| ES2994462T3 (en) * | 2018-12-21 | 2025-01-24 | Novo Nordisk As | Process of spray drying of glp-1 peptide |
| JP7761567B2 (ja) | 2020-02-18 | 2025-10-28 | ノヴォ ノルディスク アー／エス | 医薬製剤 |
| CN114699510B (zh) * | 2021-12-29 | 2024-07-16 | 浙江湃肽生物有限公司 | 一种司美格鲁肽微针阵列及其制备方法 |
| CN119317635A (zh) * | 2022-06-08 | 2025-01-14 | 载度思生命科学有限公司 | 用于2型糖尿病和体重管理的可重复使用的多剂量可变剂量的单一笔式注射器 |
| CN117462654A (zh) * | 2023-09-28 | 2024-01-30 | 武汉大学人民医院（湖北省人民医院） | 司美格鲁肽在制备预防或治疗心肌重构的药物中的应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003002136A2 (en) * | 2001-06-28 | 2003-01-09 | Novo Nordisk A/S | Stable formulation of modified glp-1 |
| WO2003084563A1 (en) | 2002-04-04 | 2003-10-16 | Novo Nordisk A/S | Glp-1 agonist and cardiovascular complications |
| DK3300721T4 (da) | 2003-11-20 | 2025-03-03 | Novo Nordisk As | Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger |
| TWI362392B (en) * | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| NZ598170A (en) | 2009-10-02 | 2014-06-27 | Boehringer Ingelheim Int | Pharmaceutical compositions comprising bi-1356 and metformin |
| KR20240090632A (ko) | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CN102946875A (zh) * | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
| WO2011161161A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Diabetes therapy |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| SI2651398T1 (en) * | 2010-12-16 | 2018-04-30 | Novo Nordisk A/S | SOLID COMPOSITIONS CONTAINING GLP-1 AGONIST AND SOL N- (8- (2-HYDROXYBENZOIL) AMINO) CAPRICULATE ACIDS |
| US20130035281A1 (en) * | 2011-02-09 | 2013-02-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| JP6126097B2 (ja) | 2011-09-06 | 2017-05-10 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１誘導体 |
| US20130172244A1 (en) | 2011-12-29 | 2013-07-04 | Thomas Klein | Subcutaneous therapeutic use of dpp-4 inhibitor |
| JP6218811B2 (ja) | 2012-05-14 | 2017-10-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| JP6224084B2 (ja) | 2012-05-14 | 2017-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| JP6374862B2 (ja) | 2012-05-24 | 2018-08-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 自己免疫性糖尿病、特に、ｌａｄａの治療に使用するためのｄｐｐ−４阻害剤としてのキサンチン誘導体 |
| WO2014066992A1 (en) | 2012-11-02 | 2014-05-08 | Mansoor Husain | Methods for inhibiting platelet aggregation using glp-1 receptor agonists |
| WO2014124860A1 (en) | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Specific pde4b-inhibitors for the treatment of diabetes mellitus |
| EP3744327A1 (en) | 2013-03-15 | 2020-12-02 | Boehringer Ingelheim International GmbH | Use of linagliptin in cardio- and renoprotective antidiabetic therapy |
| CN105722526B (zh) | 2013-11-15 | 2020-12-08 | 诺和诺德股份有限公司 | 选择性pyy化合物及其用途 |
| US8969371B1 (en) | 2013-12-06 | 2015-03-03 | Orexigen Therapeutics, Inc. | Compositions and methods for weight loss in at risk patient populations |
| CR20170456A (es) | 2015-04-07 | 2018-06-13 | Intercept Pharmaceuticals Inc | Composiciones farmacéuticas para terapias combinadas |
| US9968659B2 (en) | 2016-03-04 | 2018-05-15 | Novo Nordisk A/S | Liraglutide in cardiovascular conditions |
| CA3022535A1 (en) * | 2016-04-28 | 2017-11-02 | Novo Nordisk A/S | Semaglutide in cardiovascular conditions |
-
2017
- 2017-04-28 CA CA3022535A patent/CA3022535A1/en active Pending
- 2017-04-28 RU RU2018140900A patent/RU2768283C2/ru active
- 2017-04-28 PH PH1/2018/502274A patent/PH12018502274B1/en unknown
- 2017-04-28 WO PCT/EP2017/060160 patent/WO2017186896A1/en not_active Ceased
- 2017-04-28 ES ES17721109T patent/ES2928007T3/es active Active
- 2017-04-28 CN CN201780026303.2A patent/CN109069589B/zh active Active
- 2017-04-28 DK DK17721109.1T patent/DK3448416T3/da active
- 2017-04-28 MX MX2018012700A patent/MX2018012700A/es unknown
- 2017-04-28 PL PL17721109.1T patent/PL3448416T3/pl unknown
- 2017-04-28 BR BR112018072020-8A patent/BR112018072020A2/pt unknown
- 2017-04-28 KR KR1020227036550A patent/KR102778218B1/ko active Active
- 2017-04-28 JP JP2018556411A patent/JP7221694B2/ja active Active
- 2017-04-28 MY MYPI2018703725A patent/MY202967A/en unknown
- 2017-04-28 SI SI201731219T patent/SI3448416T1/sl unknown
- 2017-04-28 KR KR1020187033310A patent/KR20180135012A/ko not_active Ceased
- 2017-04-28 MA MA044762A patent/MA44762A/fr unknown
- 2017-04-28 KR KR1020257007151A patent/KR20250038818A/ko active Pending
- 2017-04-28 RS RS20220901A patent/RS63630B1/sr unknown
- 2017-04-28 HR HRP20221150TT patent/HRP20221150T1/hr unknown
- 2017-04-28 EP EP17721109.1A patent/EP3448416B1/en active Active
- 2017-04-28 AU AU2017256774A patent/AU2017256774B2/en active Active
- 2017-04-28 US US16/097,032 patent/US12569543B2/en active Active
- 2017-04-28 HU HUE17721109A patent/HUE060040T2/hu unknown
-
2018
- 2018-10-15 IL IL262390A patent/IL262390B1/en unknown
- 2018-10-25 CL CL2018003045A patent/CL2018003045A1/es unknown
-
2024
- 2024-10-04 AU AU2024227113A patent/AU2024227113A1/en active Pending
-
2025
- 2025-01-15 US US19/023,039 patent/US20250288649A1/en active Pending
- 2025-05-02 US US19/197,677 patent/US20250262281A1/en active Pending
- 2025-09-03 ZA ZA2025/07394A patent/ZA202507394B/en unknown
- 2025-09-03 ZA ZA2025/07395A patent/ZA202507395B/en unknown
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