JP2019514854A5 - - Google Patents
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- JP2019514854A5 JP2019514854A5 JP2018550790A JP2018550790A JP2019514854A5 JP 2019514854 A5 JP2019514854 A5 JP 2019514854A5 JP 2018550790 A JP2018550790 A JP 2018550790A JP 2018550790 A JP2018550790 A JP 2018550790A JP 2019514854 A5 JP2019514854 A5 JP 2019514854A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- inhibitor
- hydroxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 88
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 48
- 239000012664 BCL-2-inhibitor Substances 0.000 claims description 36
- 229940123711 Bcl2 inhibitor Drugs 0.000 claims description 36
- 125000001475 halogen functional group Chemical group 0.000 claims description 36
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 claims description 32
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 32
- 229940079156 Proteasome inhibitor Drugs 0.000 claims description 30
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 30
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 30
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 30
- 239000003207 proteasome inhibitor Substances 0.000 claims description 30
- 125000001424 substituent group Chemical group 0.000 claims description 30
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 16
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 16
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 16
- 206010028980 Neoplasm Diseases 0.000 claims description 15
- 201000011510 cancer Diseases 0.000 claims description 15
- -1 2-chloro-4-trifluoromethylphenyl Chemical group 0.000 claims description 13
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 12
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 12
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 12
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 12
- 229950002736 marizomib Drugs 0.000 claims description 12
- NGWSFRIPKNWYAO-UHFFFAOYSA-N salinosporamide A Natural products N1C(=O)C(CCCl)C2(C)OC(=O)C21C(O)C1CCCC=C1 NGWSFRIPKNWYAO-UHFFFAOYSA-N 0.000 claims description 12
- NGWSFRIPKNWYAO-SHTIJGAHSA-N salinosporamide A Chemical compound C([C@@H]1[C@H](O)[C@]23C(=O)O[C@]2([C@H](C(=O)N3)CCCl)C)CCC=C1 NGWSFRIPKNWYAO-SHTIJGAHSA-N 0.000 claims description 12
- 229960003648 ixazomib Drugs 0.000 claims description 10
- MXAYKZJJDUDWDS-LBPRGKRZSA-N ixazomib Chemical compound CC(C)C[C@@H](B(O)O)NC(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl MXAYKZJJDUDWDS-LBPRGKRZSA-N 0.000 claims description 10
- 229960001183 venetoclax Drugs 0.000 claims description 10
- LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims description 10
- 229960001467 bortezomib Drugs 0.000 claims description 8
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims description 8
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 claims description 8
- 230000002489 hematologic effect Effects 0.000 claims description 8
- QYPJBTMRYKRTFG-UHFFFAOYSA-N (-)-marinopyrrole A Chemical compound OC1=CC=CC=C1C(=O)C1=C(N2C(=CC(Cl)=C2Cl)C(=O)C=2C(=CC=CC=2)O)C(Cl)=C(Cl)N1 QYPJBTMRYKRTFG-UHFFFAOYSA-N 0.000 claims description 6
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 229960002438 carfilzomib Drugs 0.000 claims description 6
- 108010021331 carfilzomib Proteins 0.000 claims description 6
- BLMPQMFVWMYDKT-NZTKNTHTSA-N carfilzomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(C)OC1)NC(=O)CN1CCOCC1)CC1=CC=CC=C1 BLMPQMFVWMYDKT-NZTKNTHTSA-N 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 229950004847 navitoclax Drugs 0.000 claims description 6
- JLYAXFNOILIKPP-KXQOOQHDSA-N navitoclax Chemical compound C([C@@H](NC1=CC=C(C=C1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC1)CC1=C(CCC(C1)(C)C)C=1C=CC(Cl)=CC=1)CSC=1C=CC=CC=1)CN1CCOCC1 JLYAXFNOILIKPP-KXQOOQHDSA-N 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- TZYWCYJVHRLUCT-VABKMULXSA-N N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal Chemical compound CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1 TZYWCYJVHRLUCT-VABKMULXSA-N 0.000 claims description 5
- 201000005787 hematologic cancer Diseases 0.000 claims description 5
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 5
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims description 4
- 229930014124 (-)-epigallocatechin gallate Natural products 0.000 claims description 4
- KUUJEXLRLIPQQJ-HNNXBMFYSA-N (2s)-1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol Chemical compound C([C@H](O)CN1C2=CC=C(Br)C=C2C2=CC(Br)=CC=C21)N1CCNCC1 KUUJEXLRLIPQQJ-HNNXBMFYSA-N 0.000 claims description 4
- CIJUJPVFECBUKG-BDQAORGHSA-N (2s)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-n-methoxy-n-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1([C@]2(CCCN)SC(=NN2C(=O)N(C)OC)C=2C(=CC=C(F)C=2)F)=CC=CC=C1 CIJUJPVFECBUKG-BDQAORGHSA-N 0.000 claims description 4
- NHMUTADCTDDWPV-YFNVTMOMSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C NHMUTADCTDDWPV-YFNVTMOMSA-N 0.000 claims description 4
- CVCLJVVBHYOXDC-IAZSKANUSA-N (2z)-2-[(5z)-5-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indole Chemical compound COC1=C\C(=C/2N=C3C=CC=CC3=C\2)N\C1=C/C=1NC(C)=CC=1C CVCLJVVBHYOXDC-IAZSKANUSA-N 0.000 claims description 4
- WUGANDSUVKXMEC-UHFFFAOYSA-N 2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid Chemical compound C=12C=CC=CC2=C(O)C(SCC(=O)O)=CC=1NS(=O)(=O)C1=CC=C(Br)C=C1 WUGANDSUVKXMEC-UHFFFAOYSA-N 0.000 claims description 4
- SOYCFODXNRVBTI-UHFFFAOYSA-N 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1h-isoquinolin-2-yl]-5-[3-[4-[3-(dimethylamino)prop-1-ynyl]-2-fluorophenoxy]propyl]-1,3-thiazole-4-carboxylic acid Chemical compound FC1=CC(C#CCN(C)C)=CC=C1OCCCC1=C(C(O)=O)N=C(N2CC3=C(C(=O)NC=4SC5=CC=CC=C5N=4)C=CC=C3CC2)S1 SOYCFODXNRVBTI-UHFFFAOYSA-N 0.000 claims description 4
- JWCVUOLQOHIRML-UHFFFAOYSA-N 3,6-dibromo-9-(2-fluoro-3-piperazin-1-ylpropyl)carbazole;dihydrochloride Chemical compound Cl.Cl.C12=CC=C(Br)C=C2C2=CC(Br)=CC=C2N1CC(F)CN1CCNCC1 JWCVUOLQOHIRML-UHFFFAOYSA-N 0.000 claims description 4
- WRLVHADVOGFZOZ-UHFFFAOYSA-N 4-[(2-ethoxyphenyl)diazenyl]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-3-one Chemical compound CCOC1=CC=CC=C1N=NC2=C(NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C WRLVHADVOGFZOZ-UHFFFAOYSA-N 0.000 claims description 4
- HPLNQCPCUACXLM-PGUFJCEWSA-N ABT-737 Chemical compound C([C@@H](CCN(C)C)NC=1C(=CC(=CC=1)S(=O)(=O)NC(=O)C=1C=CC(=CC=1)N1CCN(CC=2C(=CC=CC=2)C=2C=CC(Cl)=CC=2)CC1)[N+]([O-])=O)SC1=CC=CC=C1 HPLNQCPCUACXLM-PGUFJCEWSA-N 0.000 claims description 4
- 101100325758 Arabidopsis thaliana BAM7 gene Proteins 0.000 claims description 4
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims description 4
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 4
- 208000011691 Burkitt lymphomas Diseases 0.000 claims description 4
- 206010007953 Central nervous system lymphoma Diseases 0.000 claims description 4
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims description 4
- 206010052178 Lymphocytic lymphoma Diseases 0.000 claims description 4
- 101150054675 MIM1 gene Proteins 0.000 claims description 4
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims description 4
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims description 4
- PQAPVTKIEGUPRN-UHFFFAOYSA-N N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide Chemical compound CC(C)C1=CC=CC=C1CC1=CC(C(=O)NC=2C=CC(=CC=2)S(=O)(=O)C=2C(=CC=CC=2)C(C)(C)C)=C(O)C(O)=C1O PQAPVTKIEGUPRN-UHFFFAOYSA-N 0.000 claims description 4
- 206010029461 Nodal marginal zone B-cell lymphomas Diseases 0.000 claims description 4
- 108010064641 ONX 0912 Proteins 0.000 claims description 4
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 230000001154 acute effect Effects 0.000 claims description 4
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 4
- 229960002563 disulfiram Drugs 0.000 claims description 4
- 201000003444 follicular lymphoma Diseases 0.000 claims description 4
- 208000026876 intravascular large B-cell lymphoma Diseases 0.000 claims description 4
- 201000007919 lymphoplasmacytic lymphoma Diseases 0.000 claims description 4
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims description 4
- 208000021937 marginal zone lymphoma Diseases 0.000 claims description 4
- 229960004584 methylprednisolone Drugs 0.000 claims description 4
- SWZXEVABPLUDIO-WSZYKNRRSA-N n-[(2s)-3-methoxy-1-[[(2s)-3-methoxy-1-[[(2s)-1-[(2r)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide Chemical compound N([C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)[C@]1(C)OC1)C(=O)C1=CN=C(C)S1 SWZXEVABPLUDIO-WSZYKNRRSA-N 0.000 claims description 4
- 229950006584 obatoclax Drugs 0.000 claims description 4
- 229950005750 oprozomib Drugs 0.000 claims description 4
- 208000016800 primary central nervous system lymphoma Diseases 0.000 claims description 4
- 201000006037 primary mediastinal B-cell lymphoma Diseases 0.000 claims description 4
- 206010062113 splenic marginal zone lymphoma Diseases 0.000 claims description 4
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims description 4
- XMVAWGSQPHFXKU-UHFFFAOYSA-N 7-[5-[[4-[4-(dimethylsulfamoyl)piperazin-1-yl]phenoxy]methyl]-1,3-dimethylpyrazol-4-yl]-1-(2-morpholin-4-ylethyl)-3-(3-naphthalen-1-yloxypropyl)indole-2-carboxylic acid Chemical compound C1CN(S(=O)(=O)N(C)C)CCN1C(C=C1)=CC=C1OCC1=C(C=2C=3N(CCN4CCOCC4)C(C(O)=O)=C(CCCOC=4C5=CC=CC=C5C=CC=4)C=3C=CC=2)C(C)=NN1C XMVAWGSQPHFXKU-UHFFFAOYSA-N 0.000 claims description 3
- SJFBTAPEPRWNKH-CCKFTAQKSA-N delanzomib Chemical compound CC(C)C[C@@H](B(O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)C1=CC=CC(C=2C=CC=CC=2)=N1 SJFBTAPEPRWNKH-CCKFTAQKSA-N 0.000 claims description 3
- 108700002672 epoxomicin Proteins 0.000 claims description 3
- DOGIDQKFVLKMLQ-JTHVHQAWSA-N epoxomicin Chemical compound CC[C@H](C)[C@H](N(C)C(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 DOGIDQKFVLKMLQ-JTHVHQAWSA-N 0.000 claims description 3
- GEZHEQNLKAOMCA-RRZNCOCZSA-N (-)-gambogic acid Chemical compound C([C@@H]1[C@]2([C@@](C3=O)(C\C=C(\C)C(O)=O)OC1(C)C)O1)[C@H]3C=C2C(=O)C2=C1C(CC=C(C)C)=C1O[C@@](CCC=C(C)C)(C)C=CC1=C2O GEZHEQNLKAOMCA-RRZNCOCZSA-N 0.000 claims description 2
- RAYNZUHYMMLQQA-ZEQRLZLVSA-N 2,3,5-trihydroxy-7-methyl-n-[(2r)-2-phenylpropyl]-6-[1,6,7-trihydroxy-3-methyl-5-[[(2r)-2-phenylpropyl]carbamoyl]naphthalen-2-yl]naphthalene-1-carboxamide Chemical compound C1([C@@H](C)CNC(=O)C=2C3=CC(C)=C(C(=C3C=C(O)C=2O)O)C=2C(O)=C3C=C(O)C(O)=C(C3=CC=2C)C(=O)NC[C@H](C)C=2C=CC=CC=2)=CC=CC=C1 RAYNZUHYMMLQQA-ZEQRLZLVSA-N 0.000 claims description 2
- GAQGZEPUTWPXOG-UHFFFAOYSA-N 2-[[6-amino-2-[[4-methyl-2-[[4-methylsulfanyl-2-(pyrrolidine-2-carbonylamino)butanoyl]amino]pentanoyl]amino]hexanoyl]amino]pentanedioic acid Chemical compound OC(=O)CCC(C(O)=O)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCSC)NC(=O)C1CCCN1 GAQGZEPUTWPXOG-UHFFFAOYSA-N 0.000 claims description 2
- 108010090931 Proto-Oncogene Proteins c-bcl-2 Proteins 0.000 claims description 2
- 102000013535 Proto-Oncogene Proteins c-bcl-2 Human genes 0.000 claims description 2
- 102000055102 bcl-2-Associated X Human genes 0.000 claims description 2
- GEZHEQNLKAOMCA-UHFFFAOYSA-N epiisogambogic acid Natural products O1C2(C(C3=O)(CC=C(C)C(O)=O)OC4(C)C)C4CC3C=C2C(=O)C2=C1C(CC=C(C)C)=C1OC(CCC=C(C)C)(C)C=CC1=C2O GEZHEQNLKAOMCA-UHFFFAOYSA-N 0.000 claims description 2
- GEZHEQNLKAOMCA-GXSDCXQCSA-N gambogic acid Natural products C([C@@H]1[C@]2([C@@](C3=O)(C\C=C(/C)C(O)=O)OC1(C)C)O1)[C@H]3C=C2C(=O)C2=C1C(CC=C(C)C)=C1O[C@@](CCC=C(C)C)(C)C=CC1=C2O GEZHEQNLKAOMCA-GXSDCXQCSA-N 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- QALPNMQDVCOSMJ-UHFFFAOYSA-N isogambogic acid Natural products CC(=CCc1c2OC(C)(CC=C(C)C)C=Cc2c(O)c3C(=O)C4=CC5CC6C(C)(C)OC(CC=C(C)/C(=O)O)(C5=O)C46Oc13)C QALPNMQDVCOSMJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 201000003791 MALT lymphoma Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 51
- 0 *C1N(*)CCC1c1c(*)cc(*)c2c1OC(*)=CC2=O Chemical compound *C1N(*)CCC1c1c(*)cc(*)c2c1OC(*)=CC2=O 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 208000003950 B-cell lymphoma Diseases 0.000 description 2
- MRPGRAKIAJJGMM-OCCSQVGLSA-N CN(CC1)[C@@H](CO)[C@@H]1c(c(OC(c(ccc(C(F)(F)F)c1)c1Cl)=C1)c(c(O)c2)C1=O)c2O Chemical compound CN(CC1)[C@@H](CO)[C@@H]1c(c(OC(c(ccc(C(F)(F)F)c1)c1Cl)=C1)c(c(O)c2)C1=O)c2O MRPGRAKIAJJGMM-OCCSQVGLSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022119166A JP7416872B2 (ja) | 2016-03-28 | 2022-07-27 | 癌の治療のための配合剤 |
| JP2023223257A JP2024038227A (ja) | 2016-03-28 | 2023-12-28 | 癌の治療のための配合剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662314356P | 2016-03-28 | 2016-03-28 | |
| US62/314,356 | 2016-03-28 | ||
| PCT/US2017/024618 WO2017172826A1 (en) | 2016-03-28 | 2017-03-28 | Pharmaceutical combinations for the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022119166A Division JP7416872B2 (ja) | 2016-03-28 | 2022-07-27 | 癌の治療のための配合剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514854A JP2019514854A (ja) | 2019-06-06 |
| JP2019514854A5 true JP2019514854A5 (enExample) | 2020-05-07 |
| JP7114478B2 JP7114478B2 (ja) | 2022-08-08 |
Family
ID=59966407
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550790A Active JP7114478B2 (ja) | 2016-03-28 | 2017-03-28 | 癌の治療のための配合剤 |
| JP2022119166A Active JP7416872B2 (ja) | 2016-03-28 | 2022-07-27 | 癌の治療のための配合剤 |
| JP2023223257A Pending JP2024038227A (ja) | 2016-03-28 | 2023-12-28 | 癌の治療のための配合剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022119166A Active JP7416872B2 (ja) | 2016-03-28 | 2022-07-27 | 癌の治療のための配合剤 |
| JP2023223257A Pending JP2024038227A (ja) | 2016-03-28 | 2023-12-28 | 癌の治療のための配合剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US11135198B2 (enExample) |
| EP (1) | EP3436002B1 (enExample) |
| JP (3) | JP7114478B2 (enExample) |
| KR (5) | KR102599512B1 (enExample) |
| CN (1) | CN109689047B (enExample) |
| AU (4) | AU2017241914B2 (enExample) |
| CA (2) | CA3103604C (enExample) |
| IL (3) | IL295472B2 (enExample) |
| MX (3) | MX2018011666A (enExample) |
| NZ (1) | NZ747404A (enExample) |
| RU (1) | RU2726367C2 (enExample) |
| WO (1) | WO2017172826A1 (enExample) |
| ZA (2) | ZA201806819B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2624981T3 (es) | 2011-07-01 | 2017-07-18 | Dana-Farber Cancer Institute, Inc. | Descubrimiento de una mutación somática en el gen MYD88 en linfoma linfoplasmocitario |
| USRE50030E1 (en) | 2013-12-13 | 2024-07-02 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| IL295472B2 (en) * | 2016-03-28 | 2024-10-01 | Presage Biosciences Inc | Pharmaceutical combinations for the treatment of cancer |
| CN111727059A (zh) * | 2017-10-31 | 2020-09-29 | 卫材研究发展管理有限公司 | 包含至少一种剪接体调控剂和至少一种选自BCL2抑制剂、BCL2/BCLxL抑制剂和BCLxL抑制剂的抑制剂的组合及其使用方法 |
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