MX2018011666A - Combinaciones farmaceuticas para el tratamiento de cancer. - Google Patents
Combinaciones farmaceuticas para el tratamiento de cancer.Info
- Publication number
- MX2018011666A MX2018011666A MX2018011666A MX2018011666A MX2018011666A MX 2018011666 A MX2018011666 A MX 2018011666A MX 2018011666 A MX2018011666 A MX 2018011666A MX 2018011666 A MX2018011666 A MX 2018011666A MX 2018011666 A MX2018011666 A MX 2018011666A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- cancer
- pharmaceutical combinations
- inhibitor
- combination therapies
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 abstract 2
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 abstract 2
- 239000012664 BCL-2-inhibitor Substances 0.000 abstract 1
- 229940123711 Bcl2 inhibitor Drugs 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 229940079156 Proteasome inhibitor Drugs 0.000 abstract 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 abstract 1
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 239000003207 proteasome inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662314356P | 2016-03-28 | 2016-03-28 | |
| PCT/US2017/024618 WO2017172826A1 (en) | 2016-03-28 | 2017-03-28 | Pharmaceutical combinations for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018011666A true MX2018011666A (es) | 2019-07-08 |
Family
ID=59966407
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018011666A MX2018011666A (es) | 2016-03-28 | 2017-03-28 | Combinaciones farmaceuticas para el tratamiento de cancer. |
| MX2022011750A MX2022011750A (es) | 2016-03-28 | 2018-09-25 | Combinaciones farmaceuticas para el tratamiento de cancer. |
| MX2022002318A MX2022002318A (es) | 2016-03-28 | 2018-09-25 | Combinaciones farmaceuticas para el tratamiento de cancer. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022011750A MX2022011750A (es) | 2016-03-28 | 2018-09-25 | Combinaciones farmaceuticas para el tratamiento de cancer. |
| MX2022002318A MX2022002318A (es) | 2016-03-28 | 2018-09-25 | Combinaciones farmaceuticas para el tratamiento de cancer. |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US11135198B2 (enExample) |
| EP (1) | EP3436002B1 (enExample) |
| JP (3) | JP7114478B2 (enExample) |
| KR (5) | KR102494039B1 (enExample) |
| CN (1) | CN109689047B (enExample) |
| AU (4) | AU2017241914B2 (enExample) |
| CA (2) | CA3018932C (enExample) |
| IL (3) | IL295472B2 (enExample) |
| MX (3) | MX2018011666A (enExample) |
| NZ (2) | NZ747404A (enExample) |
| RU (1) | RU2726367C2 (enExample) |
| WO (1) | WO2017172826A1 (enExample) |
| ZA (2) | ZA201806819B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2624981T3 (es) | 2011-07-01 | 2017-07-18 | Dana-Farber Cancer Institute, Inc. | Descubrimiento de una mutación somática en el gen MYD88 en linfoma linfoplasmocitario |
| AU2014361798B2 (en) | 2013-12-13 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| KR102494039B1 (ko) * | 2016-03-28 | 2023-01-30 | 프레시지 바이오싸이언시스, 인크. | 암 치료를 위한 제약학적 조합물 |
| WO2019089641A1 (en) * | 2017-10-31 | 2019-05-09 | Eisai R&D Management Co., Ltd. | Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from bcl2 inhibitors, bcl2/bclxl inhibitors, and bclxl inhibitors and methods of use |
| CN108186642B (zh) * | 2018-01-11 | 2019-11-08 | 广西师范大学 | 一种协同起作用治疗肺癌的药物组合物 |
| CN108261414B (zh) * | 2018-01-11 | 2019-09-06 | 广西师范大学 | 一种治疗肺癌的药物组合物 |
| JP2021534114A (ja) * | 2018-08-14 | 2021-12-09 | エムイーアイ ファーマ，インク． | 併用療法 |
| WO2020092615A1 (en) * | 2018-11-01 | 2020-05-07 | Oregon Health & Science University | Treatments for venetoclax-resistant and venetoclax-sensitive acute myeloid leukemia |
| EP3952861A4 (en) | 2019-04-11 | 2023-01-11 | MEI Pharma, Inc. | VORUCICLIB POLYMORPHS AND PROCESSES FOR THEIR PRODUCTION AND USE |
| EP4041239B1 (en) * | 2019-10-08 | 2025-09-03 | Dana-Farber Cancer Institute, Inc. | A pyrrazolopyrimidine derivative as a hck inhibitor for use in therapy, in particular myd88 mutated diseases |
| CN115666574A (zh) * | 2020-05-07 | 2023-01-31 | 里科瑞尔姆Ip控股有限责任公司 | 组合 |
| CN117043159A (zh) * | 2020-11-19 | 2023-11-10 | 梅制药公司 | Kras突变型癌症的治疗 |
| JP2024500288A (ja) * | 2020-11-19 | 2024-01-09 | メイ ファーマ，インク． | Ｋｒａｓ変異癌の治療 |
| CN113018357A (zh) * | 2021-02-08 | 2021-06-25 | 湖南农业大学 | 茶多酚和帕博西尼联合在制备治疗乳腺癌的制剂中的用途 |
| WO2022217133A1 (en) * | 2021-04-10 | 2022-10-13 | Mei Pharma, Inc. | Voruciclib dosing regimens and methods of treatment including the same |
| WO2024239512A1 (zh) * | 2023-05-22 | 2024-11-28 | 劲方医药科技(上海)有限公司 | 药物组合及其在治疗癌症中的用途 |
| WO2025217307A1 (en) | 2024-04-09 | 2025-10-16 | Revolution Medicines, Inc. | Methods for predicting response to a ras(on) inhibitor and combination therapies |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2219867A1 (en) * | 1997-10-31 | 1999-04-30 | Jiangping Wu | The use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock |
| AR031130A1 (es) | 2000-09-20 | 2003-09-10 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| US7271193B2 (en) | 2002-07-08 | 2007-09-18 | Nicholas Piramal India, Ltd. | Inhibitors of cyclin-dependent kinases and their use |
| TWI331034B (en) | 2002-07-08 | 2010-10-01 | Piramal Life Sciences Ltd | Inhibitors of cyclin-dependent kinases and their use |
| US7973161B2 (en) | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
| WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| US7642260B2 (en) | 2003-11-13 | 2010-01-05 | Abbott Laboratories, Inc. | Apoptosis promoters |
| US7767684B2 (en) | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
| CN101006065B (zh) | 2004-06-17 | 2012-07-11 | 英菲尼蒂发现公司 | 抑制bcl蛋白与结合伴侣的相互作用的化合物和方法 |
| US7842815B2 (en) | 2004-06-17 | 2010-11-30 | Infinity Pharmaceuticals, Inc. | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners |
| US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
| TWI337608B (en) | 2005-05-12 | 2011-02-21 | Abbott Lab | Apoptosis promoters |
| EP1888543B1 (en) | 2005-05-24 | 2012-08-01 | Abbott Laboratories | Apoptosis promoters |
| US20090142337A1 (en) * | 2006-05-08 | 2009-06-04 | Astex Therapeutics Limited | Pharmaceutical Combinations of Diazole Derivatives for Cancer Treatment |
| EP2046738B1 (en) | 2006-06-21 | 2014-06-11 | Piramal Enterprises Limited | Enantiomerically pure flavone derivatives for the treatment of proliferative disorders and processes for their preparation |
| US8822526B2 (en) * | 2007-05-15 | 2014-09-02 | Piramal Enterprises Limited | Synergistic pharmaceutical combination for the treatment of cancer |
| US9259399B2 (en) * | 2007-11-07 | 2016-02-16 | Cornell University | Targeting CDK4 and CDK6 in cancer therapy |
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| CN102325531B (zh) | 2008-12-19 | 2014-04-02 | 健泰科生物技术公司 | 化合物和使用方法 |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| MX2013005661A (es) * | 2010-11-19 | 2013-09-13 | Piramal Entpr Ltd | Combinacion farmaceutica de paclitaxel y un inhibidor cdk (quinasa dependiente de ciclina). |
| TW201300105A (zh) * | 2011-05-31 | 2013-01-01 | Piramal Life Sciences Ltd | 治療頭頸鱗狀細胞癌之相乘藥物組合物 |
| WO2014018668A2 (en) * | 2012-07-24 | 2014-01-30 | Genoa Pharmaceuticals, Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| US9241941B2 (en) * | 2012-09-20 | 2016-01-26 | Memorial Sloan-Kettering Cancer Center | Methods for treatment of lymphomas with mutations in cell cycle genes |
| JP6347793B2 (ja) | 2013-01-16 | 2018-06-27 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | Ｂｃｌ−２／Ｂｃｌ−ｘＬ阻害薬およびそれを使用した治療方法 |
| KR20150131276A (ko) * | 2013-03-14 | 2015-11-24 | 오닉스 세라퓨틱스, 인크. | 디펩타이드 및 트리펩타이드 에폭시 케톤 프로테이스 억제제 |
| AU2014296032A1 (en) * | 2013-07-31 | 2016-03-17 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| US10314842B2 (en) | 2013-12-02 | 2019-06-11 | Cornell University | Methods for treating B cell proliferative disorders |
| ES2818110T3 (es) * | 2014-02-28 | 2021-04-09 | Merck Sharp & Dohme | Tratamiento del cáncer con una combinación que comprende dinaciclib |
| WO2015181737A1 (en) * | 2014-05-28 | 2015-12-03 | Piramal Enterprises Limited | Pharmaceutical combination for the treatment of cancer |
| US20170231986A1 (en) | 2014-08-11 | 2017-08-17 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a BCL-2 Inhibitor |
| US9637488B2 (en) * | 2015-01-29 | 2017-05-02 | Fuqiang Ruan | Heterocyclic compounds as inhibitors of class I PI3KS |
| KR102494039B1 (ko) * | 2016-03-28 | 2023-01-30 | 프레시지 바이오싸이언시스, 인크. | 암 치료를 위한 제약학적 조합물 |
-
2017
- 2017-03-28 KR KR1020217021031A patent/KR102494039B1/ko active Active
- 2017-03-28 RU RU2018137687A patent/RU2726367C2/ru active
- 2017-03-28 EP EP17776498.2A patent/EP3436002B1/en active Active
- 2017-03-28 IL IL295472A patent/IL295472B2/en unknown
- 2017-03-28 AU AU2017241914A patent/AU2017241914B2/en active Active
- 2017-03-28 KR KR1020237037917A patent/KR20230156443A/ko active Pending
- 2017-03-28 NZ NZ747404A patent/NZ747404A/en unknown
- 2017-03-28 KR KR1020237019958A patent/KR102599512B1/ko active Active
- 2017-03-28 KR KR1020237002852A patent/KR102545392B1/ko active Active
- 2017-03-28 CA CA3018932A patent/CA3018932C/en active Active
- 2017-03-28 NZ NZ757763A patent/NZ757763A/en unknown
- 2017-03-28 IL IL312398A patent/IL312398A/en unknown
- 2017-03-28 CA CA3103604A patent/CA3103604C/en active Active
- 2017-03-28 JP JP2018550790A patent/JP7114478B2/ja active Active
- 2017-03-28 KR KR1020187030575A patent/KR102275758B1/ko active Active
- 2017-03-28 MX MX2018011666A patent/MX2018011666A/es unknown
- 2017-03-28 WO PCT/US2017/024618 patent/WO2017172826A1/en not_active Ceased
- 2017-03-28 CN CN201780032783.3A patent/CN109689047B/zh active Active
- 2017-03-28 US US16/089,276 patent/US11135198B2/en active Active
-
2018
- 2018-09-17 IL IL261824A patent/IL261824B2/en unknown
- 2018-09-25 MX MX2022011750A patent/MX2022011750A/es unknown
- 2018-09-25 MX MX2022002318A patent/MX2022002318A/es unknown
- 2018-10-12 ZA ZA2018/06819A patent/ZA201806819B/en unknown
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2019
- 2019-05-28 US US16/423,216 patent/US20190275004A1/en not_active Abandoned
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2020
- 2020-02-20 AU AU2020201247A patent/AU2020201247B2/en active Active
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2021
- 2021-06-03 US US17/337,952 patent/US12171744B2/en active Active
- 2021-07-09 US US17/371,774 patent/US12121508B2/en active Active
- 2021-10-08 ZA ZA2021/07579A patent/ZA202107579B/en unknown
- 2021-11-23 AU AU2021273532A patent/AU2021273532B2/en active Active
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2022
- 2022-07-27 JP JP2022119166A patent/JP7416872B2/ja active Active
-
2023
- 2023-12-28 JP JP2023223257A patent/JP2024038227A/ja active Pending
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2024
- 2024-01-11 AU AU2024200194A patent/AU2024200194A1/en active Pending
- 2024-10-21 US US18/921,886 patent/US20250221961A1/en active Pending
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