JP2019514651A5 - - Google Patents

Info

Publication number

JP2019514651A5

JP2019514651A5 JP2019508159A JP2019508159A JP2019514651A5 JP 2019514651 A5 JP2019514651 A5 JP 2019514651A5 JP 2019508159 A JP2019508159 A JP 2019508159A JP 2019508159 A JP2019508159 A JP 2019508159A JP 2019514651 A5 JP2019514651 A5 JP 2019514651A5

Authority

JP

Japan

Prior art keywords

injectable biomaterial

bone

affected area

solid

injectable

Prior art date

2017-04-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000012620 biological material Substances 0.000 claims 30
• 210000000988 bone and bone Anatomy 0.000 claims 24
• 239000007787 solid Substances 0.000 claims 12
• 239000007788 liquid Substances 0.000 claims 10
• 239000000470 constituent Substances 0.000 claims 9
• 238000000034 method Methods 0.000 claims 7
• 230000001054 cortical effect Effects 0.000 claims 6
• 239000011575 calcium Substances 0.000 claims 3
• 150000001720 carbohydrates Chemical class 0.000 claims 3
• 235000014633 carbohydrates Nutrition 0.000 claims 3
• 239000013078 crystal Substances 0.000 claims 3
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229910052588 hydroxylapatite Inorganic materials 0.000 claims 2
• 201000008482 osteoarthritis Diseases 0.000 claims 2
• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 2
• 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
• 229910052586 apatite Inorganic materials 0.000 claims 1
• 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
• ZBZJARSYCHAEND-UHFFFAOYSA-L calcium;dihydrogen phosphate;hydrate Chemical compound O.[Ca+2].OP(O)([O-])=O.OP(O)([O-])=O ZBZJARSYCHAEND-UHFFFAOYSA-L 0.000 claims 1
• 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
• 230000006378 damage Effects 0.000 claims 1
• 238000011065 in-situ storage Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229910052751 metal Inorganic materials 0.000 claims 1
• 239000002184 metal Substances 0.000 claims 1
• 229910001463 metal phosphate Inorganic materials 0.000 claims 1
• 239000003002 pH adjusting agent Substances 0.000 claims 1
• 230000000149 penetrating effect Effects 0.000 claims 1
• VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims 1
• 239000011148 porous material Substances 0.000 claims 1
• 229940010747 sodium hyaluronate Drugs 0.000 claims 1
• YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1