JP2015514535A5 - - Google Patents
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- JP2015514535A5 JP2015514535A5 JP2015507665A JP2015507665A JP2015514535A5 JP 2015514535 A5 JP2015514535 A5 JP 2015514535A5 JP 2015507665 A JP2015507665 A JP 2015507665A JP 2015507665 A JP2015507665 A JP 2015507665A JP 2015514535 A5 JP2015514535 A5 JP 2015514535A5
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- JP
- Japan
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- composition
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 50
- 239000007788 liquid Substances 0.000 claims description 19
- 239000007787 solid Substances 0.000 claims description 17
- 210000000988 bone and bone Anatomy 0.000 claims description 13
- 239000001506 calcium phosphate Substances 0.000 claims description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- 235000011010 calcium phosphates Nutrition 0.000 claims description 7
- 230000006196 deacetylation Effects 0.000 claims description 7
- 238000003381 deacetylation reaction Methods 0.000 claims description 7
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- 229920002101 Chitin Polymers 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- 235000011054 acetic acid Nutrition 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 239000003181 biological factor Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 229940112869 bone morphogenetic protein Drugs 0.000 claims description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 2
- 239000000920 calcium hydroxide Substances 0.000 claims description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- GEKBIENFFVFKRG-UHFFFAOYSA-L disodium;2,3-dihydroxypropyl phosphate Chemical compound [Na+].[Na+].OCC(O)COP([O-])([O-])=O GEKBIENFFVFKRG-UHFFFAOYSA-L 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- 235000013922 glutamic acid Nutrition 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- 230000035876 healing Effects 0.000 claims description 2
- 235000011167 hydrochloric acid Nutrition 0.000 claims description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 230000002188 osteogenic effect Effects 0.000 claims description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 2
- 235000011007 phosphoric acid Nutrition 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 235000019260 propionic acid Nutrition 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 2
- 239000000463 material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010603 microCT Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IS050032 | 2012-04-23 | ||
| IS50032 | 2012-04-23 | ||
| PCT/IS2013/050003 WO2013160917A1 (en) | 2012-04-23 | 2013-04-23 | Self-hardening bioactive cement compositions with partially deacetylated chitin as bone graft substitutes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514535A JP2015514535A (ja) | 2015-05-21 |
| JP2015514535A5 true JP2015514535A5 (enExample) | 2016-06-09 |
| JP6232048B2 JP6232048B2 (ja) | 2017-11-15 |
Family
ID=48485243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015507665A Active JP6232048B2 (ja) | 2012-04-23 | 2013-04-23 | 骨移植片代用材としての部分的に脱アセチル化されたキチンを含む自硬性の生体活性セメント組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9474828B2 (enExample) |
| EP (1) | EP2841114B1 (enExample) |
| JP (1) | JP6232048B2 (enExample) |
| CN (2) | CN104470550A (enExample) |
| DK (1) | DK2841114T3 (enExample) |
| ES (1) | ES2688324T3 (enExample) |
| MX (1) | MX352422B (enExample) |
| PL (1) | PL2841114T3 (enExample) |
| PT (1) | PT2841114T (enExample) |
| WO (1) | WO2013160917A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025526752A (ja) * | 2022-08-11 | 2025-08-15 | ジーニス エイチエフ． | ３ｄプリントされた生体活性スキャホールド |
| KR102673344B1 (ko) * | 2023-09-06 | 2024-06-10 | 주식회사 메디팹 | 체내 이온감응성 조직 수복용 생체재료 제조용 조성물 및 이의 용도 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3881707B2 (ja) * | 1995-07-20 | 2007-02-14 | 学校法人松本歯科大学 | 骨形成促進剤の製造方法及び骨形成促進剤を用いた骨形成組成物の製造方法 |
| DE60003459T2 (de) | 1999-12-09 | 2004-05-06 | Biosyntech Canada Inc., Laval | Mineral-polymer hybrid-zusammensetzung |
| US20030158302A1 (en) | 1999-12-09 | 2003-08-21 | Cyric Chaput | Mineral-polymer hybrid composition |
| IS6085A (is) | 2001-09-26 | 2003-03-27 | Genis Ehf. | Lyfjablanda með kítósan óligómerum |
| WO2004000374A1 (en) * | 2002-06-19 | 2003-12-31 | Dr. H.C. Robert Mathys Stiftung | Hydraulic cement based on calcium phosphate for surgical use |
| WO2004028578A1 (en) | 2002-09-30 | 2004-04-08 | Regen Biotech, Inc. | Composition for stimulating bone-formation and bone consolidation |
| IS7572A (is) | 2004-11-29 | 2006-05-30 | Genis Ehf | Aðferð og efni til lækninga |
| JP5632125B2 (ja) * | 2005-06-14 | 2014-11-26 | ジェニス イーエイチエフ．Ｇｅｎｉｓ ｅｈｆ． | 部分的脱アセチル化キチン誘導体の組成物 |
| US20080181926A1 (en) * | 2006-10-13 | 2008-07-31 | Ndsu Research Foundation | Composites and methods of preparation and use thereof |
| CN101057979B (zh) * | 2007-04-03 | 2010-06-09 | 暨南大学 | 可注射自固化磷酸钙骨组织修复材料及其制备方法与应用 |
-
2013
- 2013-04-23 CN CN201380029068.6A patent/CN104470550A/zh active Pending
- 2013-04-23 EP EP13724891.0A patent/EP2841114B1/en active Active
- 2013-04-23 PT PT13724891T patent/PT2841114T/pt unknown
- 2013-04-23 US US14/396,257 patent/US9474828B2/en active Active
- 2013-04-23 PL PL13724891T patent/PL2841114T3/pl unknown
- 2013-04-23 MX MX2014012728A patent/MX352422B/es active IP Right Grant
- 2013-04-23 JP JP2015507665A patent/JP6232048B2/ja active Active
- 2013-04-23 WO PCT/IS2013/050003 patent/WO2013160917A1/en not_active Ceased
- 2013-04-23 CN CN201710454216.9A patent/CN107320772A/zh active Pending
- 2013-04-23 ES ES13724891.0T patent/ES2688324T3/es active Active
- 2013-04-23 DK DK13724891.0T patent/DK2841114T3/en active
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