JP2019514399A5 - - Google Patents
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- Publication number
- JP2019514399A5 JP2019514399A5 JP2018557851A JP2018557851A JP2019514399A5 JP 2019514399 A5 JP2019514399 A5 JP 2019514399A5 JP 2018557851 A JP2018557851 A JP 2018557851A JP 2018557851 A JP2018557851 A JP 2018557851A JP 2019514399 A5 JP2019514399 A5 JP 2019514399A5
- Authority
- JP
- Japan
- Prior art keywords
- lmm
- recombinant polypeptide
- cell
- nucleic acid
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 18
- 238000000034 method Methods 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 101710159293 Acyl-CoA desaturase 1 Proteins 0.000 claims 4
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 4
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 4
- 239000003114 blood coagulation factor Substances 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102100028897 Stearoyl-CoA desaturase Human genes 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000023555 blood coagulation Effects 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 230000037356 lipid metabolism Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 229940023143 protein vaccine Drugs 0.000 claims 2
- 102000009822 Sterol Regulatory Element Binding Proteins Human genes 0.000 claims 1
- 108010020396 Sterol Regulatory Element Binding Proteins Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000012092 media component Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330973P | 2016-05-03 | 2016-05-03 | |
| US62/330,973 | 2016-05-03 | ||
| PCT/EP2017/060484 WO2017191165A1 (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514399A JP2019514399A (ja) | 2019-06-06 |
| JP2019514399A5 true JP2019514399A5 (enExample) | 2020-06-18 |
| JP6959942B2 JP6959942B2 (ja) | 2021-11-05 |
Family
ID=58745198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557851A Active JP6959942B2 (ja) | 2016-05-03 | 2017-05-03 | タンパク質生成のための脂質代謝のモジュレーション |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10655111B2 (enExample) |
| EP (1) | EP3452608B1 (enExample) |
| JP (1) | JP6959942B2 (enExample) |
| KR (1) | KR102536221B1 (enExample) |
| CN (1) | CN109415748A (enExample) |
| AU (1) | AU2017259010B2 (enExample) |
| CA (1) | CA3023038C (enExample) |
| EA (1) | EA201892503A1 (enExample) |
| ES (1) | ES2938626T3 (enExample) |
| IL (2) | IL262646B (enExample) |
| MX (1) | MX2018013499A (enExample) |
| SG (1) | SG11201809626PA (enExample) |
| WO (1) | WO2017191165A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017191165A1 (en) | 2016-05-03 | 2017-11-09 | Lonza Ltd | Modulation of lipid metabolism for protein production |
| US12077786B2 (en) * | 2018-02-02 | 2024-09-03 | Lonza Ltd | Methods of cell selection and modifying cell metabolism |
| US20210324366A1 (en) * | 2018-07-11 | 2021-10-21 | Cornell University | Supported plant plasma membrane lipid bilayer on-a-chip |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20230193341A1 (en) * | 2018-10-24 | 2023-06-22 | Selexis Sa | Expression systems, recombinant cells and uses thereof |
| JP7574206B2 (ja) | 2019-03-20 | 2024-10-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ステロール調節エレメント結合転写因子１（ｓｒｅｂｆ１）阻害剤による上昇した脂質レベルの治療 |
| CN110317799B (zh) * | 2019-07-18 | 2026-04-03 | 江南大学 | 一种人源岩藻糖转移酶8的原核表达方法及其产品 |
| WO2021094461A1 (en) | 2019-11-14 | 2021-05-20 | Lonza Ltd | Methods of cell selection |
| CN115029307A (zh) * | 2022-07-28 | 2022-09-09 | 吉林大学 | 一种延缓MSCs衰老的方法 |
| WO2026062080A1 (en) | 2024-09-17 | 2026-03-26 | Ares Trading S.A. | Cell having increased secretion capabilities and method of use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| JP3614866B2 (ja) | 1997-06-12 | 2005-01-26 | リサーチ コーポレイション テクノロジーズ，インコーポレイティド | 人工抗体ポリペプチド |
| EP1235842A4 (en) | 1999-10-15 | 2003-04-23 | Univ Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
| WO2002095008A2 (en) * | 2001-02-02 | 2002-11-28 | Bayer Corporation | Methods of modulating surfactant phospholipid production |
| JP2007500016A (ja) * | 2003-06-11 | 2007-01-11 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 培養においてタンパク質生成を増大させるための方法 |
| CA2560205A1 (en) | 2004-04-16 | 2005-10-27 | Dsm Ip Assets B.V. | Fungal promoters for expressing a gene in a fungal cell |
| US20090215165A1 (en) * | 2005-05-20 | 2009-08-27 | James Rance | High-level expression of recombinant antibody in a mammalian host cell |
| US20080182249A1 (en) * | 2006-09-01 | 2008-07-31 | Fox Brian G | Expression systems for mammalian and mycobacterial desaturases |
| WO2009062789A1 (en) | 2007-11-13 | 2009-05-22 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Improving the secretory capacity in host cells |
| DK2358882T3 (da) * | 2008-11-18 | 2017-11-06 | Commw Scient Ind Res Org | Enzymer og fremgangsmåder til fremstilling af omega-3 fedtsyrer |
| DK2951309T3 (en) * | 2013-02-01 | 2019-04-23 | Selexis Sa | INCREASED TRANSGEN EXPRESSION AND PROCESSING |
| EP3030656B1 (en) * | 2013-08-06 | 2018-08-22 | Lonza Biologics Plc. | Means and methods for the generation of mammalian producer cells for the production of recombinant proteins |
| WO2017191165A1 (en) | 2016-05-03 | 2017-11-09 | Lonza Ltd | Modulation of lipid metabolism for protein production |
-
2017
- 2017-05-03 WO PCT/EP2017/060484 patent/WO2017191165A1/en not_active Ceased
- 2017-05-03 CA CA3023038A patent/CA3023038C/en active Active
- 2017-05-03 EP EP17724770.7A patent/EP3452608B1/en active Active
- 2017-05-03 CN CN201780039286.6A patent/CN109415748A/zh active Pending
- 2017-05-03 AU AU2017259010A patent/AU2017259010B2/en active Active
- 2017-05-03 SG SG11201809626PA patent/SG11201809626PA/en unknown
- 2017-05-03 ES ES17724770T patent/ES2938626T3/es active Active
- 2017-05-03 EA EA201892503A patent/EA201892503A1/ru unknown
- 2017-05-03 IL IL262646A patent/IL262646B/en unknown
- 2017-05-03 MX MX2018013499A patent/MX2018013499A/es unknown
- 2017-05-03 IL IL294241A patent/IL294241B2/en unknown
- 2017-05-03 US US15/585,570 patent/US10655111B2/en active Active
- 2017-05-03 JP JP2018557851A patent/JP6959942B2/ja active Active
- 2017-05-03 KR KR1020187034453A patent/KR102536221B1/ko active Active
-
2020
- 2020-03-13 US US16/818,162 patent/US11434474B2/en active Active
-
2022
- 2022-07-27 US US17/815,465 patent/US20230047838A1/en active Pending
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