JP6959942B2 - タンパク質生成のための脂質代謝のモジュレーション - Google Patents

タンパク質生成のための脂質代謝のモジュレーション Download PDF

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JP6959942B2
JP6959942B2 JP2018557851A JP2018557851A JP6959942B2 JP 6959942 B2 JP6959942 B2 JP 6959942B2 JP 2018557851 A JP2018557851 A JP 2018557851A JP 2018557851 A JP2018557851 A JP 2018557851A JP 6959942 B2 JP6959942 B2 JP 6959942B2
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cell
lmm
cells
nucleic acid
product
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JP2019514399A5 (enExample
JP2019514399A (ja
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バッジ、ジェームズ
マーク スメールズ、クリストファー
ナイト、タンヤ
ヤング、ロバート
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Lonza AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0097—Oxidoreductases (1.) acting on reduced flavodoxin as donor (1.19)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
    • C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2018557851A 2016-05-03 2017-05-03 タンパク質生成のための脂質代謝のモジュレーション Active JP6959942B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662330973P 2016-05-03 2016-05-03
US62/330,973 2016-05-03
PCT/EP2017/060484 WO2017191165A1 (en) 2016-05-03 2017-05-03 Modulation of lipid metabolism for protein production

Publications (3)

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JP2019514399A JP2019514399A (ja) 2019-06-06
JP2019514399A5 JP2019514399A5 (enExample) 2020-06-18
JP6959942B2 true JP6959942B2 (ja) 2021-11-05

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JP2018557851A Active JP6959942B2 (ja) 2016-05-03 2017-05-03 タンパク質生成のための脂質代謝のモジュレーション

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US (3) US10655111B2 (enExample)
EP (1) EP3452608B1 (enExample)
JP (1) JP6959942B2 (enExample)
KR (1) KR102536221B1 (enExample)
CN (1) CN109415748A (enExample)
AU (1) AU2017259010B2 (enExample)
CA (1) CA3023038C (enExample)
EA (1) EA201892503A1 (enExample)
ES (1) ES2938626T3 (enExample)
IL (2) IL294241B2 (enExample)
MX (1) MX2018013499A (enExample)
SG (1) SG11201809626PA (enExample)
WO (1) WO2017191165A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2938626T3 (es) 2016-05-03 2023-04-13 Lonza Ag Modulación del metabolismo de los lípidos para la producción de proteínas
ES2871818T3 (es) * 2018-02-02 2021-11-02 Lonza Ag Métodos de selección celular y modificación del metabolismo celular
US20210324366A1 (en) * 2018-07-11 2021-10-21 Cornell University Supported plant plasma membrane lipid bilayer on-a-chip
CN120795059A (zh) 2018-08-27 2025-10-17 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN113348248B (zh) * 2018-10-24 2024-12-31 思兰克斯有限公司 表达系统、重组细胞及其用途
JP7574206B2 (ja) 2019-03-20 2024-10-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ステロール調節エレメント結合転写因子１（ｓｒｅｂｆ１）阻害剤による上昇した脂質レベルの治療
CN110317799B (zh) * 2019-07-18 2026-04-03 江南大学 一种人源岩藻糖转移酶8的原核表达方法及其产品
US20220403398A1 (en) 2019-11-14 2022-12-22 Lonza Ltd Methods of cell selection
CN115029307A (zh) * 2022-07-28 2022-09-09 吉林大学 一种延缓MSCs衰老的方法
WO2026062080A1 (en) 2024-09-17 2026-03-26 Ares Trading S.A. Cell having increased secretion capabilities and method of use

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
JP3614866B2 (ja) 1997-06-12 2005-01-26 リサーチ コーポレイション テクノロジーズ，インコーポレイティド 人工抗体ポリペプチド
EP1235842A4 (en) 1999-10-15 2003-04-23 Univ Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
AU2001275474A1 (en) 2000-06-12 2001-12-24 Akkadix Corporation Materials and methods for the control of nematodes
AU2002321989A1 (en) 2001-02-02 2002-12-03 Bayer Corporation Methods of modulating surfactant phospholipid production
JP2007500016A (ja) * 2003-06-11 2007-01-11 バイオジェン・アイデック・エムエイ・インコーポレイテッド 培養においてタンパク質生成を増大させるための方法
JP4783359B2 (ja) 2004-04-16 2011-09-28 ディーエスエム アイピー アセッツ ビー．ブイ． 真菌細胞において遺伝子を発現させるための真菌プロモーター
EP1915394B1 (en) * 2005-05-20 2021-01-27 Lonza Biologics plc. High-level expression of recombinant antibody in a mammalian host cell
US20080182249A1 (en) * 2006-09-01 2008-07-31 Fox Brian G Expression systems for mammalian and mycobacterial desaturases
EP2209891A1 (en) 2007-11-13 2010-07-28 Boehringer Ingelheim Pharma GmbH & Co. KG Improving the secretory capacity in host cells
US8809559B2 (en) * 2008-11-18 2014-08-19 Commonwelath Scientific And Industrial Research Organisation Enzymes and methods for producing omega-3 fatty acids
HUE043103T2 (hu) * 2013-02-01 2019-08-28 Selexis Sa Fokozott transzgén expresszió és processzálás
CN105849265B (zh) * 2013-08-06 2021-03-26 英国龙沙生物医药股份有限公司 用于产生供生产重组蛋白的哺乳动物生产细胞的物品和方法
ES2938626T3 (es) * 2016-05-03 2023-04-13 Lonza Ag Modulación del metabolismo de los lípidos para la producción de proteínas

Also Published As

Publication number Publication date
CA3023038A1 (en) 2017-11-09
BR112018072434A2 (pt) 2019-02-19
EA201892503A1 (ru) 2019-09-30
US10655111B2 (en) 2020-05-19
US11434474B2 (en) 2022-09-06
EP3452608A1 (en) 2019-03-13
IL294241B2 (en) 2023-10-01
AU2017259010A1 (en) 2018-11-22
US20200231944A1 (en) 2020-07-23
AU2017259010B2 (en) 2021-04-22
WO2017191165A1 (en) 2017-11-09
KR20190003651A (ko) 2019-01-09
EP3452608B1 (en) 2022-11-30
CN109415748A (zh) 2019-03-01
KR102536221B1 (ko) 2023-05-23
CA3023038C (en) 2023-03-14
SG11201809626PA (en) 2018-11-29
ES2938626T3 (es) 2023-04-13
JP2019514399A (ja) 2019-06-06
IL262646A (en) 2018-12-31
IL294241B1 (en) 2023-06-01
IL294241A (en) 2022-08-01
IL262646B (en) 2022-08-01
MX2018013499A (es) 2019-09-11
US20230047838A1 (en) 2023-02-16
US20170321194A1 (en) 2017-11-09

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