SG11201600872UA - Means and methods for the generation of mammalian producer cells for the production of recombinant proteins - Google Patents

Means and methods for the generation of mammalian producer cells for the production of recombinant proteins

Info

Publication number
SG11201600872UA
SG11201600872UA SG11201600872UA SG11201600872UA SG11201600872UA SG 11201600872U A SG11201600872U A SG 11201600872UA SG 11201600872U A SG11201600872U A SG 11201600872UA SG 11201600872U A SG11201600872U A SG 11201600872UA SG 11201600872U A SG11201600872U A SG 11201600872UA
Authority
SG
Singapore
Prior art keywords
generation
production
methods
recombinant proteins
producer cells
Prior art date
Application number
SG11201600872UA
Inventor
Marc Feary
James Rance
Robert Young
Elizabeth C Sayer
Christopher Mark Smales
Original Assignee
Lonza Biologics Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Biologics Plc filed Critical Lonza Biologics Plc
Publication of SG11201600872UA publication Critical patent/SG11201600872UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • C12N2310/141MicroRNAs, miRNAs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00Production
    • C12N2330/50Biochemical production, i.e. in a transformed host cell
    • C12N2330/51Specially adapted vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201600872UA 2013-08-06 2014-07-30 Means and methods for the generation of mammalian producer cells for the production of recombinant proteins SG11201600872UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13179342 2013-08-06
PCT/EP2014/066352 WO2015018703A1 (en) 2013-08-06 2014-07-30 Means and methods for the generation of mammalian producer cells for the production of recombinant proteins

Publications (1)

Publication Number Publication Date
SG11201600872UA true SG11201600872UA (en) 2016-03-30

Family

ID=48914165

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201600872UA SG11201600872UA (en) 2013-08-06 2014-07-30 Means and methods for the generation of mammalian producer cells for the production of recombinant proteins

Country Status (9)

Country Link
US (1) US10669541B2 (en)
EP (1) EP3030656B1 (en)
JP (1) JP6676526B2 (en)
CN (1) CN105849265B (en)
ES (1) ES2698610T3 (en)
HK (1) HK1221977A1 (en)
SG (1) SG11201600872UA (en)
TW (1) TWI646194B (en)
WO (1) WO2015018703A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110914413A (en) 2017-02-17 2020-03-24 隆萨有限公司 Mammalian cell producing adeno-associated virus
JP7467119B2 (en) 2017-02-17 2024-04-15 ロンザ リミテッド Multi-site SSI cells for difficult-to-express proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009545309A (en) * 2006-08-04 2009-12-24 ダブリン シティ ユニバーシティ Method for producing a recombinant biologic
WO2012052872A2 (en) * 2010-10-17 2012-04-26 Yeda Research And Development Co. Ltd. Methods and compositions for the treatment of insulin-associated medical conditions
CN102784398B (en) * 2011-05-16 2014-06-18 南京大学 Composition comprising endostatin adopted as delivery system and chemically-synthesized RNA interference molecule, and application thereof

Also Published As

Publication number Publication date
JP2016532445A (en) 2016-10-20
TW201522631A (en) 2015-06-16
EP3030656A1 (en) 2016-06-15
US10669541B2 (en) 2020-06-02
JP6676526B2 (en) 2020-04-08
ES2698610T3 (en) 2019-02-05
EP3030656B1 (en) 2018-08-22
TWI646194B (en) 2019-01-01
CN105849265A (en) 2016-08-10
WO2015018703A1 (en) 2015-02-12
CN105849265B (en) 2021-03-26
US20160177300A1 (en) 2016-06-23
HK1221977A1 (en) 2017-06-16

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