CA3023038C - Modulation of lipid metabolism for protein production - Google Patents
Modulation of lipid metabolism for protein production Download PDFInfo
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- 241001430294 unidentified retrovirus Species 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 229950000449 vanucizumab Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0097—Oxidoreductases (1.) acting on reduced flavodoxin as donor (1.19)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Zoology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
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| US201662330973P | 2016-05-03 | 2016-05-03 | |
| US62/330,973 | 2016-05-03 | ||
| PCT/EP2017/060484 WO2017191165A1 (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
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| CA3023038A1 CA3023038A1 (en) | 2017-11-09 |
| CA3023038C true CA3023038C (en) | 2023-03-14 |
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| CA3023038A Active CA3023038C (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
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| CN (1) | CN109415748A (enExample) |
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| EA (1) | EA201892503A1 (enExample) |
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| WO2020014483A1 (en) * | 2018-07-11 | 2020-01-16 | Cornell University | Supported plant plasma membrane lipid bilayer on-a-chip |
| IL280880B2 (en) | 2018-08-27 | 2025-04-01 | Regeneron Pharma | Using Raman Spectroscopy in Downstream Purification |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020084528A1 (en) * | 2018-10-24 | 2020-04-30 | Selexis Sa | Expression systems, recombinant cells and uses thereof |
| US11504390B2 (en) | 2019-03-20 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (SREBF1) inhibitors |
| CN110317799A (zh) * | 2019-07-18 | 2019-10-11 | 江南大学 | 一种人源岩藻糖转移酶8的原核表达方法及其产品 |
| KR20220097910A (ko) | 2019-11-14 | 2022-07-08 | 론자 리미티드 | 세포 선택 방법 |
| CN115029307A (zh) * | 2022-07-28 | 2022-09-09 | 吉林大学 | 一种延缓MSCs衰老的方法 |
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| EP0985039B1 (en) | 1997-06-12 | 2008-02-20 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
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| CN102286483B (zh) | 2004-04-16 | 2014-06-04 | 中化帝斯曼制药有限公司荷兰公司 | 用于在真菌细胞中表达基因的真菌启动子 |
| CA2606576A1 (en) * | 2005-05-20 | 2006-11-23 | Lonza Biologics Plc. | High-level expression of recombinant antibody in a mammalian host cell |
| US20080182249A1 (en) * | 2006-09-01 | 2008-07-31 | Fox Brian G | Expression systems for mammalian and mycobacterial desaturases |
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| CA3015426C (en) * | 2008-11-18 | 2020-01-14 | Commonwealth Scientific And Industrial Research Organisation | Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases |
| ES2717175T3 (es) * | 2013-02-01 | 2019-06-19 | Selexis Sa | Expresión mejorada de transgenes y procesamiento |
| CN105849265B (zh) * | 2013-08-06 | 2021-03-26 | 英国龙沙生物医药股份有限公司 | 用于产生供生产重组蛋白的哺乳动物生产细胞的物品和方法 |
| JP6959942B2 (ja) | 2016-05-03 | 2021-11-05 | ロンザ リミテッドLonza Limited | タンパク質生成のための脂質代謝のモジュレーション |
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2017
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- 2017-05-03 IL IL294241A patent/IL294241B2/en unknown
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2022
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Also Published As
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| BR112018072434A2 (pt) | 2019-02-19 |
| JP2019514399A (ja) | 2019-06-06 |
| US20200231944A1 (en) | 2020-07-23 |
| KR20190003651A (ko) | 2019-01-09 |
| US10655111B2 (en) | 2020-05-19 |
| IL262646B (en) | 2022-08-01 |
| EP3452608A1 (en) | 2019-03-13 |
| WO2017191165A1 (en) | 2017-11-09 |
| CN109415748A (zh) | 2019-03-01 |
| IL294241A (en) | 2022-08-01 |
| JP6959942B2 (ja) | 2021-11-05 |
| IL294241B2 (en) | 2023-10-01 |
| ES2938626T3 (es) | 2023-04-13 |
| US11434474B2 (en) | 2022-09-06 |
| IL294241B1 (en) | 2023-06-01 |
| AU2017259010A1 (en) | 2018-11-22 |
| MX2018013499A (es) | 2019-09-11 |
| IL262646A (en) | 2018-12-31 |
| SG11201809626PA (en) | 2018-11-29 |
| EP3452608B1 (en) | 2022-11-30 |
| CA3023038A1 (en) | 2017-11-09 |
| US20230047838A1 (en) | 2023-02-16 |
| AU2017259010B2 (en) | 2021-04-22 |
| US20170321194A1 (en) | 2017-11-09 |
| KR102536221B1 (ko) | 2023-05-23 |
| EA201892503A1 (ru) | 2019-09-30 |
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