JP2019513801A5 - - Google Patents
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- Publication number
- JP2019513801A5 JP2019513801A5 JP2018554492A JP2018554492A JP2019513801A5 JP 2019513801 A5 JP2019513801 A5 JP 2019513801A5 JP 2018554492 A JP2018554492 A JP 2018554492A JP 2018554492 A JP2018554492 A JP 2018554492A JP 2019513801 A5 JP2019513801 A5 JP 2019513801A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotinamide
- release
- pharmaceutical product
- unit dose
- dose pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 56
- 239000011570 nicotinamide Substances 0.000 claims 28
- 229960003966 nicotinamide Drugs 0.000 claims 28
- 235000005152 nicotinamide Nutrition 0.000 claims 28
- 239000000825 pharmaceutical preparation Substances 0.000 claims 27
- 229940127557 pharmaceutical product Drugs 0.000 claims 27
- 239000008185 minitablet Substances 0.000 claims 21
- 230000003111 delayed effect Effects 0.000 claims 18
- 238000013268 sustained release Methods 0.000 claims 16
- 239000012730 sustained-release form Substances 0.000 claims 16
- 239000011159 matrix material Substances 0.000 claims 12
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 12
- 229960004963 mesalazine Drugs 0.000 claims 12
- 230000001419 dependent effect Effects 0.000 claims 9
- 239000002702 enteric coating Substances 0.000 claims 9
- 238000009505 enteric coating Methods 0.000 claims 9
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 5
- 206010009900 Colitis ulcerative Diseases 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 210000001072 colon Anatomy 0.000 claims 4
- 210000003405 ileum Anatomy 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 3
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 2
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 229960003943 hypromellose Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662324415P | 2016-04-19 | 2016-04-19 | |
| US62/324,415 | 2016-04-19 | ||
| PCT/US2017/028063 WO2017184563A1 (en) | 2016-04-19 | 2017-04-18 | Oral pharmaceutical compositions of nicotinamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019513801A JP2019513801A (ja) | 2019-05-30 |
| JP2019513801A5 true JP2019513801A5 (OSRAM) | 2020-05-28 |
| JP7021108B2 JP7021108B2 (ja) | 2022-02-16 |
Family
ID=59227843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554492A Active JP7021108B2 (ja) | 2016-04-19 | 2017-04-18 | ニコチンアミドの経口薬学的組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11622938B2 (OSRAM) |
| EP (1) | EP3445360B1 (OSRAM) |
| JP (1) | JP7021108B2 (OSRAM) |
| KR (1) | KR20180135020A (OSRAM) |
| CN (1) | CN109152772B (OSRAM) |
| AR (1) | AR108233A1 (OSRAM) |
| AU (1) | AU2017252407A1 (OSRAM) |
| BR (1) | BR112018071363A2 (OSRAM) |
| CA (1) | CA3021066C (OSRAM) |
| ES (1) | ES2848575T3 (OSRAM) |
| RU (1) | RU2738114C2 (OSRAM) |
| TW (1) | TW201739455A (OSRAM) |
| WO (1) | WO2017184563A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2876540C (en) | 2012-06-15 | 2022-11-29 | Conaris Research Institute Ag | A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota |
| JP6895752B2 (ja) | 2013-12-13 | 2021-06-30 | コナリス リサーチ インスティチュート アーゲー | ニコチン酸および／またはニコチンアミドを含む、腸内微生物叢を改変することにより血中脂質レベルに有益に影響を及ぼすための医薬組成物 |
| WO2015086838A2 (en) | 2013-12-13 | 2015-06-18 | Conaris Research Institute Ag | A pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation |
| US20210236519A1 (en) * | 2020-01-30 | 2021-08-05 | Atoz Pharmaceuticals Pvt Ltd | Controlled release dosage forms of 5-aminosalicylic acid and process thereof |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791458A (fr) | 1972-07-31 | 1973-05-16 | Merck & Co Inc | Produit microencapsule |
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| DE69420746T2 (de) | 1994-06-02 | 2000-06-29 | Dan Riga | Arzneimittel gegen stress, beeinträchtigung und altwerden und verfahren zu ihrer herstellung |
| WO1998022096A1 (en) | 1996-11-15 | 1998-05-28 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
| GB0007419D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Gmbh | Composition |
| IT1318625B1 (it) | 2000-07-14 | 2003-08-27 | Roberto Valducci | Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente. |
| DE50113344D1 (de) * | 2001-01-31 | 2008-01-17 | Evonik Roehm Gmbh | Multipartikuläre arzneiform, enthaltend mindestens zwei unterschiedlich überzogene pelletformen |
| US8048924B2 (en) | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| US20040185097A1 (en) * | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| BRPI0614021A2 (pt) | 2005-01-21 | 2011-03-01 | Pharmanova Inc | formulações farmacêuticas e métodos de uso |
| EP1935422A1 (en) | 2006-12-20 | 2008-06-25 | PEJO Iserlohn Heilmittel-und Diät-GmbH & Co.KG | Pharmaceutical composition comprising nicotinamide or nicotinic acid |
| US20080286344A1 (en) | 2007-05-16 | 2008-11-20 | Olivia Darmuzey | Solid form |
| EP2276491A4 (en) | 2008-04-25 | 2011-08-17 | Karolinska Inst Innovations Ab | NEW THERAPY FOR THE TREATMENT OF IRRITATION SYNDROME |
| US20110123609A1 (en) | 2008-07-19 | 2011-05-26 | Sunil Shantwan Borude | Multiple unit dosage form of niacin |
| US20120093939A1 (en) | 2008-12-17 | 2012-04-19 | Altheus Therapeutics, Inc. | Oral formulations |
| US20100159001A1 (en) | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
| GB201003734D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Delayed prolonged drug delivery |
| GB201003731D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Immediate/delayed drug delivery |
| EP2468264A1 (en) | 2010-12-27 | 2012-06-27 | Laboratorios Liconsa, S.A. | Oral pharmaceutical tablet for controled release of mesalazine and process for obtaining it |
| US10071058B2 (en) * | 2012-03-07 | 2018-09-11 | Santarus, Inc. | Controlled-release solid dosage forms of mesalamine |
| US20150164920A1 (en) | 2012-03-30 | 2015-06-18 | Laboratorios Del Dr. Esteve S.A. | Controlled release formulation comprising mesalamine |
| CA2876540C (en) * | 2012-06-15 | 2022-11-29 | Conaris Research Institute Ag | A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota |
| US20140178468A1 (en) | 2012-12-24 | 2014-06-26 | Ranbaxy Laboratories Limited | Multiparticulate extended-release composition of mesalamine |
| HK1218856A1 (zh) | 2013-03-15 | 2017-03-17 | Warner Chilcott Company, Llc | 用於减少递送变化性的具有多种剂量单元的美沙拉嗪药物组合物 |
| ES2785399T3 (es) | 2013-06-14 | 2020-10-06 | Conaris Res Institute Ag | Formulación de nicotinamida de liberación prolongada |
| JP6895752B2 (ja) * | 2013-12-13 | 2021-06-30 | コナリス リサーチ インスティチュート アーゲー | ニコチン酸および／またはニコチンアミドを含む、腸内微生物叢を改変することにより血中脂質レベルに有益に影響を及ぼすための医薬組成物 |
| WO2015086838A2 (en) | 2013-12-13 | 2015-06-18 | Conaris Research Institute Ag | A pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation |
| US20170143743A1 (en) | 2014-06-16 | 2017-05-25 | Valpharma International S.P.A. | Formulation for oral administration containing mesalazine |
| US20160045442A1 (en) | 2014-08-13 | 2016-02-18 | Cadila Healthcare Limited | Stable pharmaceutical compositions of mesalamine |
| CN104257669A (zh) | 2014-09-25 | 2015-01-07 | 合肥平光制药有限公司 | 一种用于向肠道递送水杨酸类药物的口服给药组合物 |
| EP3445340A1 (en) | 2016-04-19 | 2019-02-27 | Ferring B.V. | Oral pharmaceutical compositions of mesalazine |
-
2017
- 2017-04-18 BR BR112018071363A patent/BR112018071363A2/pt not_active Application Discontinuation
- 2017-04-18 ES ES17733604T patent/ES2848575T3/es active Active
- 2017-04-18 JP JP2018554492A patent/JP7021108B2/ja active Active
- 2017-04-18 KR KR1020187033390A patent/KR20180135020A/ko not_active Withdrawn
- 2017-04-18 CA CA3021066A patent/CA3021066C/en active Active
- 2017-04-18 AU AU2017252407A patent/AU2017252407A1/en not_active Abandoned
- 2017-04-18 TW TW106112905A patent/TW201739455A/zh unknown
- 2017-04-18 AR ARP170100995A patent/AR108233A1/es unknown
- 2017-04-18 CN CN201780029815.4A patent/CN109152772B/zh active Active
- 2017-04-18 RU RU2018137323A patent/RU2738114C2/ru active
- 2017-04-18 WO PCT/US2017/028063 patent/WO2017184563A1/en not_active Ceased
- 2017-04-18 EP EP17733604.7A patent/EP3445360B1/en active Active
- 2017-04-18 US US16/094,654 patent/US11622938B2/en active Active
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