JP2019513800A5 - - Google Patents
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- Publication number
- JP2019513800A5 JP2019513800A5 JP2018554489A JP2018554489A JP2019513800A5 JP 2019513800 A5 JP2019513800 A5 JP 2019513800A5 JP 2018554489 A JP2018554489 A JP 2018554489A JP 2018554489 A JP2018554489 A JP 2018554489A JP 2019513800 A5 JP2019513800 A5 JP 2019513800A5
- Authority
- JP
- Japan
- Prior art keywords
- mesalazine
- release
- unit dose
- pharmaceutical product
- dose pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 22
- 229960004963 mesalazine Drugs 0.000 claims 22
- 239000000825 pharmaceutical preparation Substances 0.000 claims 19
- 229940127557 pharmaceutical product Drugs 0.000 claims 19
- 239000008185 minitablet Substances 0.000 claims 16
- 230000003111 delayed effect Effects 0.000 claims 12
- 238000013268 sustained release Methods 0.000 claims 11
- 239000012730 sustained-release form Substances 0.000 claims 11
- 239000011159 matrix material Substances 0.000 claims 6
- 230000001419 dependent effect Effects 0.000 claims 5
- 239000002702 enteric coating Substances 0.000 claims 5
- 238000009505 enteric coating Methods 0.000 claims 5
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 5
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 238000007922 dissolution test Methods 0.000 claims 2
- 239000012156 elution solvent Substances 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 210000003405 ileum Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229960003943 hypromellose Drugs 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662324416P | 2016-04-19 | 2016-04-19 | |
| US62/324,416 | 2016-04-19 | ||
| PCT/US2017/028067 WO2017184566A1 (en) | 2016-04-19 | 2017-04-18 | Oral pharmaceutical compositions of mesalazine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019513800A JP2019513800A (ja) | 2019-05-30 |
| JP2019513800A5 true JP2019513800A5 (OSRAM) | 2020-06-25 |
Family
ID=59298513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554489A Pending JP2019513800A (ja) | 2016-04-19 | 2017-04-18 | メサラジンの経口薬学的組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10874617B2 (OSRAM) |
| EP (1) | EP3445340A1 (OSRAM) |
| JP (1) | JP2019513800A (OSRAM) |
| KR (1) | KR102381586B1 (OSRAM) |
| CN (1) | CN109310642B (OSRAM) |
| AR (1) | AR108231A1 (OSRAM) |
| AU (1) | AU2017252410A1 (OSRAM) |
| BR (1) | BR112018071370A2 (OSRAM) |
| CA (1) | CA3021071A1 (OSRAM) |
| MX (1) | MX387731B (OSRAM) |
| RU (1) | RU2744576C2 (OSRAM) |
| TW (1) | TW201740932A (OSRAM) |
| WO (1) | WO2017184566A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITUA20162293A1 (it) * | 2016-04-05 | 2017-10-05 | Sofar Spa | Processo per formulazioni solide di mesalazina |
| BR112018071363A2 (pt) | 2016-04-19 | 2019-02-05 | Ferring Bv | composições farmacêuticas orais de nicotinamida |
| TR201722039A2 (tr) * | 2017-12-27 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Mesalazi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari |
| IT201800011120A1 (it) | 2018-12-14 | 2020-06-14 | Dpl Pharma S P A | Composizioni farmaceutiche orali solide per la somministrazione di mesalazina o suoi derivati |
| JP2022531012A (ja) * | 2019-05-03 | 2022-07-05 | アゾーラ セラピューティクス，インコーポレイテッド | インジゴ及び／又はインジゴ誘導体を含む組成物並びにその使用の方法 |
| US20210236519A1 (en) * | 2020-01-30 | 2021-08-05 | Atoz Pharmaceuticals Pvt Ltd | Controlled release dosage forms of 5-aminosalicylic acid and process thereof |
| US20220125733A1 (en) * | 2020-10-23 | 2022-04-28 | Atoz Pharmaceuticals Pvt Ltd | Nongranulated compressed tablets of mesalamine, and process of preparation thereof |
| EP4382099A1 (en) * | 2022-12-05 | 2024-06-12 | ADD Advanced Drug Delivery Technologies, Ltd. | Drug loaded modified release pellets |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1246382B (it) * | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
| IT1318625B1 (it) | 2000-07-14 | 2003-08-27 | Roberto Valducci | Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente. |
| CA2359812C (en) * | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
| DE50113344D1 (de) * | 2001-01-31 | 2008-01-17 | Evonik Roehm Gmbh | Multipartikuläre arzneiform, enthaltend mindestens zwei unterschiedlich überzogene pelletformen |
| US8048924B2 (en) | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| US20040185097A1 (en) | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| US20080286344A1 (en) | 2007-05-16 | 2008-11-20 | Olivia Darmuzey | Solid form |
| EP2367421A4 (en) | 2008-12-17 | 2013-03-13 | Altheus Therapeutics Inc | ORAL FORMULAS |
| GB201003734D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Delayed prolonged drug delivery |
| GB201003731D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Immediate/delayed drug delivery |
| EP2468264A1 (en) * | 2010-12-27 | 2012-06-27 | Laboratorios Liconsa, S.A. | Oral pharmaceutical tablet for controled release of mesalazine and process for obtaining it |
| EP2822542A1 (en) * | 2012-03-07 | 2015-01-14 | Santarus, Inc. | Controlled-release solid dosage forms of mesalamine |
| CN102579388A (zh) * | 2012-03-10 | 2012-07-18 | 吉林化工学院 | 美沙拉秦结肠定位给药缓释片的制备 |
| US20150164920A1 (en) | 2012-03-30 | 2015-06-18 | Laboratorios Del Dr. Esteve S.A. | Controlled release formulation comprising mesalamine |
| ES2859758T3 (es) | 2012-06-15 | 2021-10-04 | Conaris Res Institute Ag | Una composición farmacéutica que contiene ácido nicotínico y/o nicotinamida y/o triptófano para influir positivamente en la microbiota intestinal |
| US20140178468A1 (en) | 2012-12-24 | 2014-06-26 | Ranbaxy Laboratories Limited | Multiparticulate extended-release composition of mesalamine |
| EP2953619A1 (en) * | 2013-03-15 | 2015-12-16 | Warner Chilcott Company, LLC | Mesalamine pharmaceutical composition with multiple dosage elements for reduced delivery variability |
| EP3079704B1 (en) | 2013-12-13 | 2019-01-02 | CONARIS research institute AG | A pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation |
| HUE048488T2 (hu) | 2013-12-13 | 2020-07-28 | Conaris Res Institute Ag | Nikotinsavat és/vagy nikotinamidot tartalmazó gyógyászati készítmény a vérlipid szint jótékony hatású befolyására történõ alkalmazásra a bélrendszeri mikrobióta módosításával |
| US20160045442A1 (en) * | 2014-08-13 | 2016-02-18 | Cadila Healthcare Limited | Stable pharmaceutical compositions of mesalamine |
| CN104257669A (zh) | 2014-09-25 | 2015-01-07 | 合肥平光制药有限公司 | 一种用于向肠道递送水杨酸类药物的口服给药组合物 |
| CN105687158B (zh) * | 2016-01-21 | 2019-06-07 | 贝沃特医药技术(上海)有限公司 | 一种时间依赖释放机制的美沙拉嗪微粒制剂及其制备方法 |
-
2017
- 2017-04-18 TW TW106112907A patent/TW201740932A/zh unknown
- 2017-04-18 RU RU2018137359A patent/RU2744576C2/ru active
- 2017-04-18 CN CN201780031230.6A patent/CN109310642B/zh not_active Expired - Fee Related
- 2017-04-18 JP JP2018554489A patent/JP2019513800A/ja active Pending
- 2017-04-18 EP EP17737401.4A patent/EP3445340A1/en not_active Withdrawn
- 2017-04-18 CA CA3021071A patent/CA3021071A1/en active Pending
- 2017-04-18 BR BR112018071370A patent/BR112018071370A2/pt not_active IP Right Cessation
- 2017-04-18 WO PCT/US2017/028067 patent/WO2017184566A1/en not_active Ceased
- 2017-04-18 AU AU2017252410A patent/AU2017252410A1/en not_active Abandoned
- 2017-04-18 US US16/094,644 patent/US10874617B2/en not_active Expired - Fee Related
- 2017-04-18 KR KR1020187033227A patent/KR102381586B1/ko active Active
- 2017-04-18 AR ARP170100993A patent/AR108231A1/es unknown
- 2017-04-18 MX MX2018012618A patent/MX387731B/es unknown
-
2020
- 2020-12-23 US US17/132,577 patent/US20210220281A1/en not_active Abandoned
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