ES2848575T3 - Composiciones farmacéuticas orales de nicotinamida - Google Patents
Composiciones farmacéuticas orales de nicotinamida Download PDFInfo
- Publication number
- ES2848575T3 ES2848575T3 ES17733604T ES17733604T ES2848575T3 ES 2848575 T3 ES2848575 T3 ES 2848575T3 ES 17733604 T ES17733604 T ES 17733604T ES 17733604 T ES17733604 T ES 17733604T ES 2848575 T3 ES2848575 T3 ES 2848575T3
- Authority
- ES
- Spain
- Prior art keywords
- nicotinamide
- release
- tablets
- mini
- mesalazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title claims abstract description 754
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- 239000011570 nicotinamide Substances 0.000 title claims abstract description 377
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- 238000009505 enteric coating Methods 0.000 claims abstract description 46
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims abstract description 29
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims description 293
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Classifications
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- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
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- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662324415P | 2016-04-19 | 2016-04-19 | |
| PCT/US2017/028063 WO2017184563A1 (en) | 2016-04-19 | 2017-04-18 | Oral pharmaceutical compositions of nicotinamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2848575T3 true ES2848575T3 (es) | 2021-08-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17733604T Active ES2848575T3 (es) | 2016-04-19 | 2017-04-18 | Composiciones farmacéuticas orales de nicotinamida |
Country Status (13)
| Country | Link |
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| US (1) | US11622938B2 (OSRAM) |
| EP (1) | EP3445360B1 (OSRAM) |
| JP (1) | JP7021108B2 (OSRAM) |
| KR (1) | KR20180135020A (OSRAM) |
| CN (1) | CN109152772B (OSRAM) |
| AR (1) | AR108233A1 (OSRAM) |
| AU (1) | AU2017252407A1 (OSRAM) |
| BR (1) | BR112018071363A2 (OSRAM) |
| CA (1) | CA3021066C (OSRAM) |
| ES (1) | ES2848575T3 (OSRAM) |
| RU (1) | RU2738114C2 (OSRAM) |
| TW (1) | TW201739455A (OSRAM) |
| WO (1) | WO2017184563A1 (OSRAM) |
Families Citing this family (4)
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| MX370795B (es) | 2012-06-15 | 2020-01-08 | Conaris Res Institute Ag | Una composición farmacéutica que contiene ácido nicotínico y/o nicotinamida y/o triptófano para influir positivamente en la microbiota intenstinal. |
| EP3079675B1 (en) | 2013-12-13 | 2020-02-12 | CONARIS research institute AG | A pharmaceutical composition containing nicotinic acid and/or nicotinamide for use in beneficially influencing blood lipid levels by modifying the intestinal microbiota |
| US10758552B2 (en) | 2013-12-13 | 2020-09-01 | Conaris Research Institute Ag | Pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation |
| US20210236519A1 (en) * | 2020-01-30 | 2021-08-05 | Atoz Pharmaceuticals Pvt Ltd | Controlled release dosage forms of 5-aminosalicylic acid and process thereof |
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| BE791458A (fr) | 1972-07-31 | 1973-05-16 | Merck & Co Inc | Produit microencapsule |
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| ES2139077T3 (es) | 1994-06-02 | 2000-02-01 | Dan Riga | Medicamento contra el estres, la degeneracion y el envejecimiento y proceso para su fabricacion. |
| AU1075997A (en) | 1996-11-15 | 1998-06-10 | Procter & Gamble Company, The | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
| GB0007419D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Gmbh | Composition |
| IT1318625B1 (it) | 2000-07-14 | 2003-08-27 | Roberto Valducci | Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente. |
| SK287902B6 (sk) | 2001-01-31 | 2012-03-02 | Evonik Rohm Gmbh | Multiparticulate drug form and method for the preparation thereof |
| US8048924B2 (en) | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| US20040185097A1 (en) | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| AR062647A1 (es) * | 2005-01-21 | 2008-11-26 | Pharmanova Inc | Formulaciones farmaceutica y metodos de uso |
| EP1935422A1 (en) | 2006-12-20 | 2008-06-25 | PEJO Iserlohn Heilmittel-und Diät-GmbH & Co.KG | Pharmaceutical composition comprising nicotinamide or nicotinic acid |
| US20080286344A1 (en) | 2007-05-16 | 2008-11-20 | Olivia Darmuzey | Solid form |
| WO2009131537A1 (en) | 2008-04-25 | 2009-10-29 | Karolinska Institutet Innovations Ab | New therapy of treatment of the irritable bowel syndrome. |
| US20110123609A1 (en) | 2008-07-19 | 2011-05-26 | Sunil Shantwan Borude | Multiple unit dosage form of niacin |
| WO2010077908A1 (en) | 2008-12-17 | 2010-07-08 | Altheus Therapeutics, Inc. | Oral formulations |
| US20100159001A1 (en) * | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
| GB201003734D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Delayed prolonged drug delivery |
| GB201003731D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Immediate/delayed drug delivery |
| EP2468264A1 (en) | 2010-12-27 | 2012-06-27 | Laboratorios Liconsa, S.A. | Oral pharmaceutical tablet for controled release of mesalazine and process for obtaining it |
| US10071058B2 (en) * | 2012-03-07 | 2018-09-11 | Santarus, Inc. | Controlled-release solid dosage forms of mesalamine |
| WO2013144176A1 (en) | 2012-03-30 | 2013-10-03 | Laboratorios Del Dr. Esteve, S.A. | Controlled release formulatin comprising mesalamine |
| MX370795B (es) | 2012-06-15 | 2020-01-08 | Conaris Res Institute Ag | Una composición farmacéutica que contiene ácido nicotínico y/o nicotinamida y/o triptófano para influir positivamente en la microbiota intenstinal. |
| US20140178468A1 (en) | 2012-12-24 | 2014-06-26 | Ranbaxy Laboratories Limited | Multiparticulate extended-release composition of mesalamine |
| CN105307644B (zh) | 2013-03-15 | 2019-07-23 | 沃纳奇尔科特有限责任公司 | 用于减少递送变化性的具有多种剂量单元的美沙拉嗪药物组合物 |
| ES2785399T3 (es) | 2013-06-14 | 2020-10-06 | Conaris Res Institute Ag | Formulación de nicotinamida de liberación prolongada |
| US10758552B2 (en) | 2013-12-13 | 2020-09-01 | Conaris Research Institute Ag | Pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation |
| EP3079675B1 (en) | 2013-12-13 | 2020-02-12 | CONARIS research institute AG | A pharmaceutical composition containing nicotinic acid and/or nicotinamide for use in beneficially influencing blood lipid levels by modifying the intestinal microbiota |
| US20170143743A1 (en) | 2014-06-16 | 2017-05-25 | Valpharma International S.P.A. | Formulation for oral administration containing mesalazine |
| US20160045442A1 (en) | 2014-08-13 | 2016-02-18 | Cadila Healthcare Limited | Stable pharmaceutical compositions of mesalamine |
| CN104257669A (zh) | 2014-09-25 | 2015-01-07 | 合肥平光制药有限公司 | 一种用于向肠道递送水杨酸类药物的口服给药组合物 |
| US10874617B2 (en) | 2016-04-19 | 2020-12-29 | Ferring B.V. | Oral pharmaceutical compositions of mesalazine |
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2017
- 2017-04-18 JP JP2018554492A patent/JP7021108B2/ja active Active
- 2017-04-18 CA CA3021066A patent/CA3021066C/en active Active
- 2017-04-18 WO PCT/US2017/028063 patent/WO2017184563A1/en not_active Ceased
- 2017-04-18 BR BR112018071363A patent/BR112018071363A2/pt not_active Application Discontinuation
- 2017-04-18 KR KR1020187033390A patent/KR20180135020A/ko not_active Withdrawn
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- 2017-04-18 US US16/094,654 patent/US11622938B2/en active Active
- 2017-04-18 TW TW106112905A patent/TW201739455A/zh unknown
- 2017-04-18 ES ES17733604T patent/ES2848575T3/es active Active
- 2017-04-18 AR ARP170100995A patent/AR108233A1/es unknown
Also Published As
| Publication number | Publication date |
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| CN109152772A (zh) | 2019-01-04 |
| RU2018137323A (ru) | 2020-05-19 |
| CN109152772B (zh) | 2021-09-28 |
| AR108233A1 (es) | 2018-08-01 |
| JP2019513801A (ja) | 2019-05-30 |
| EP3445360A1 (en) | 2019-02-27 |
| TW201739455A (zh) | 2017-11-16 |
| AU2017252407A1 (en) | 2018-11-01 |
| US20200155461A1 (en) | 2020-05-21 |
| RU2018137323A3 (OSRAM) | 2020-07-13 |
| EP3445360B1 (en) | 2020-11-11 |
| BR112018071363A2 (pt) | 2019-02-05 |
| US11622938B2 (en) | 2023-04-11 |
| CA3021066A1 (en) | 2017-10-26 |
| WO2017184563A1 (en) | 2017-10-26 |
| JP7021108B2 (ja) | 2022-02-16 |
| RU2738114C2 (ru) | 2020-12-08 |
| CA3021066C (en) | 2024-04-09 |
| KR20180135020A (ko) | 2018-12-19 |
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