JP2019512224A5 - - Google Patents
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- Publication number
- JP2019512224A5 JP2019512224A5 JP2018546669A JP2018546669A JP2019512224A5 JP 2019512224 A5 JP2019512224 A5 JP 2019512224A5 JP 2018546669 A JP2018546669 A JP 2018546669A JP 2018546669 A JP2018546669 A JP 2018546669A JP 2019512224 A5 JP2019512224 A5 JP 2019512224A5
- Authority
- JP
- Japan
- Prior art keywords
- epitope tag
- antibody
- epitope
- seq
- construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 8
- 238000001514 detection method Methods 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 125000006850 spacer group Chemical group 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 239000003593 chromogenic compound Substances 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021156935A JP7174126B2 (ja) | 2016-03-08 | 2021-09-27 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP2022177332A JP2023024990A (ja) | 2016-03-08 | 2022-11-04 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305440P | 2016-03-08 | 2016-03-08 | |
| US62/305,440 | 2016-03-08 | ||
| US201662418667P | 2016-11-07 | 2016-11-07 | |
| US62/418,667 | 2016-11-07 | ||
| US201762461651P | 2017-02-21 | 2017-02-21 | |
| US62/461,651 | 2017-02-21 | ||
| PCT/US2017/021157 WO2017155996A1 (en) | 2016-03-08 | 2017-03-07 | Multiplexed immunohistochemistry using recombinant antibodies with epitope tags |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021156935A Division JP7174126B2 (ja) | 2016-03-08 | 2021-09-27 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512224A JP2019512224A (ja) | 2019-05-16 |
| JP2019512224A5 true JP2019512224A5 (cg-RX-API-DMAC7.html) | 2020-04-16 |
| JP6952706B2 JP6952706B2 (ja) | 2021-10-20 |
Family
ID=58361148
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546669A Active JP6952706B2 (ja) | 2016-03-08 | 2017-03-07 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP2021156935A Active JP7174126B2 (ja) | 2016-03-08 | 2021-09-27 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP2022177332A Pending JP2023024990A (ja) | 2016-03-08 | 2022-11-04 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021156935A Active JP7174126B2 (ja) | 2016-03-08 | 2021-09-27 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP2022177332A Pending JP2023024990A (ja) | 2016-03-08 | 2022-11-04 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11112413B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3426684B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6952706B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017229370B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3016555A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017155996A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA43135A (fr) | 2015-10-30 | 2018-09-05 | Aleta Biotherapeutics Inc | Compositions et méthodes pour le du traitement du cancer |
| BR112018008390A2 (pt) | 2015-10-30 | 2018-11-27 | Aleta Biotherapeutics Inc | composições e métodos para transdução tumoral |
| AU2017229370B2 (en) * | 2016-03-08 | 2021-03-11 | Ventana Medical Systems, Inc. | Multiplexed immunohistochemistry using recombinant antibodies with epitope tags |
| US20210188953A1 (en) * | 2017-11-07 | 2021-06-24 | Trustees Of Tufts College | Heteromultimeric binding molecules for toxin neutralization, compositions and methods thereof |
| WO2020206175A1 (en) * | 2019-04-03 | 2020-10-08 | Access Medical Systems, Ltd. | Method for re-using hapten-coated probe in an immunoassay |
| CN110850094A (zh) * | 2019-11-22 | 2020-02-28 | 西安交通大学 | 一种免疫组化双标单染试剂盒及其使用方法和应用 |
| CN114113616B (zh) * | 2021-12-07 | 2022-08-23 | 深圳裕策生物科技有限公司 | 一种试剂盒及其染色方法 |
| JP7783531B2 (ja) | 2022-02-22 | 2025-12-10 | Ｎｔｔ株式会社 | センサー付きハイドロゲル流路型デバイス |
| EP4590709A1 (en) | 2022-09-22 | 2025-07-30 | Agilent Technologies, Inc. | Anti-human icos antibodies for use in immunohistochemistry (ihc) protocols and for diagnosing cancer |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1564604A (en) | 1925-06-12 | 1925-12-08 | Chas S Hodges | Water wheel |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| CA2320750C (en) | 1998-02-27 | 2004-08-24 | Ventana Medical Systems, Inc. | System and method of aspirating and dispensing reagent |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6670113B2 (en) | 2001-03-30 | 2003-12-30 | Nanoprobes | Enzymatic deposition and alteration of metals |
| JP4648902B2 (ja) | 2003-06-24 | 2011-03-09 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 免疫組織化学的エピトープおよび核酸配列のインサイチュ検出が向上するように酵素の触媒作用で金属を付着 |
| US20060246523A1 (en) | 2005-04-28 | 2006-11-02 | Christopher Bieniarz | Antibody conjugates |
| WO2007062177A2 (en) | 2005-11-23 | 2007-05-31 | Ventana Medical Systems, Inc. | Molecular conjugate |
| CA3069091C (en) | 2006-11-01 | 2021-09-14 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
| EP2167963B1 (en) | 2007-05-23 | 2019-04-17 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
| US20080299555A1 (en) * | 2007-05-30 | 2008-12-04 | Hiroaki Nitta | Multicolor chromogenic detection of biomarkers |
| WO2009111729A1 (en) * | 2008-03-06 | 2009-09-11 | Ventana Medical Systems, Inc. | Anti-dnp antibodies and methods of use |
| AU2009282760B2 (en) | 2008-08-22 | 2013-08-15 | Ventana Medical Systems, Inc. | Method for chromogenic detection of two or more target molecules in a single sample |
| AU2009311233B2 (en) * | 2008-11-06 | 2015-01-15 | University Of Guelph | Methods of improving the therapeutic efficacy and utility of antibody fragments |
| KR101424414B1 (ko) | 2009-10-19 | 2014-08-01 | 벤타나 메디컬 시스템즈, 인코포레이티드 | 현미경 스테이지에 대한 디바이스 |
| WO2011139978A1 (en) | 2010-05-04 | 2011-11-10 | Ventana Medical Systems, Inc. | Moving meniscus rinsing and mixing in cell staining |
| EP2588443A2 (en) | 2010-07-02 | 2013-05-08 | Ventana Medical Systems, Inc. | Hapten conjugates for target detection |
| CN103097412B (zh) * | 2010-07-09 | 2016-08-10 | 克鲁塞尔荷兰公司 | 抗人呼吸道合胞病毒(rsv)抗体以及使用方法 |
| JP6644713B2 (ja) | 2014-02-24 | 2020-02-12 | ヴェンタナ メディカル システムズ， インク． | キノンメチドアナログシグナル増幅 |
| JP7095995B2 (ja) | 2015-04-20 | 2022-07-05 | ベンタナ メディカル システムズ， インコーポレイテッド | 組織学的試料のための試薬のインクジェット沈着 |
| AU2017229370B2 (en) * | 2016-03-08 | 2021-03-11 | Ventana Medical Systems, Inc. | Multiplexed immunohistochemistry using recombinant antibodies with epitope tags |
-
2017
- 2017-03-07 AU AU2017229370A patent/AU2017229370B2/en active Active
- 2017-03-07 CA CA3016555A patent/CA3016555A1/en active Pending
- 2017-03-07 WO PCT/US2017/021157 patent/WO2017155996A1/en not_active Ceased
- 2017-03-07 JP JP2018546669A patent/JP6952706B2/ja active Active
- 2017-03-07 EP EP17712344.5A patent/EP3426684B1/en active Active
-
2018
- 2018-09-06 US US16/123,750 patent/US11112413B2/en active Active
-
2021
- 2021-07-30 US US17/389,757 patent/US11988673B2/en active Active
- 2021-09-27 JP JP2021156935A patent/JP7174126B2/ja active Active
-
2022
- 2022-11-04 JP JP2022177332A patent/JP2023024990A/ja active Pending
-
2024
- 2024-03-26 US US18/617,474 patent/US20240230667A1/en active Pending
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