JP2019535003A5 - - Google Patents
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- Publication number
- JP2019535003A5 JP2019535003A5 JP2019514077A JP2019514077A JP2019535003A5 JP 2019535003 A5 JP2019535003 A5 JP 2019535003A5 JP 2019514077 A JP2019514077 A JP 2019514077A JP 2019514077 A JP2019514077 A JP 2019514077A JP 2019535003 A5 JP2019535003 A5 JP 2019535003A5
- Authority
- JP
- Japan
- Prior art keywords
- beads
- polymer layer
- transparent polymer
- bead
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011324 bead Substances 0.000 claims 40
- 229920000642 polymer Polymers 0.000 claims 26
- 239000010410 layer Substances 0.000 claims 25
- 239000012491 analyte Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 238000003384 imaging method Methods 0.000 claims 9
- 238000003556 assay Methods 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 238000007837 multiplex assay Methods 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000007801 affinity label Substances 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 150000001720 carbohydrates Chemical group 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 239000013047 polymeric layer Substances 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 1
- 108010004729 Phycoerythrin Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000013641 positive control Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662396056P | 2016-09-16 | 2016-09-16 | |
| US62/396,056 | 2016-09-16 | ||
| PCT/US2016/063202 WO2018052464A1 (en) | 2016-09-16 | 2016-11-21 | Methods and systems for multiplex assays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535003A JP2019535003A (ja) | 2019-12-05 |
| JP2019535003A5 true JP2019535003A5 (cg-RX-API-DMAC7.html) | 2020-01-23 |
| JP7062002B2 JP7062002B2 (ja) | 2022-05-02 |
Family
ID=61620090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514077A Active JP7062002B2 (ja) | 2016-09-16 | 2016-11-21 | マルチプレックスアッセイの方法及びシステム |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11796535B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3513186A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7062002B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110073212B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016423082B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018052464A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI737614B (zh) | 2015-06-11 | 2021-09-01 | 博錸生技股份有限公司 | 已編碼微載體及其製造方法以及用以進行多工分析之包含該等已編碼微載體之套件 |
| US10894975B2 (en) | 2016-12-09 | 2021-01-19 | Plexbio Co., Ltd. | Image differentiated multiplex assays for multiplex detection of DNA mutations |
| JP7511344B2 (ja) | 2018-04-20 | 2024-07-05 | イルミナ インコーポレイテッド | 単一細胞を封入する方法、封入された細胞およびその使用 |
| CA3113271A1 (en) * | 2018-10-26 | 2020-04-30 | Illumina, Inc. | Modulating polymer beads for dna processing |
| US11366109B2 (en) * | 2018-12-06 | 2022-06-21 | Winmems Technologies Co., Ltd. | Encoded microflakes |
| ES2974361T3 (es) * | 2019-01-23 | 2024-06-27 | Bgi Shenzhen | Microesfera |
| EP4130272A4 (en) | 2020-03-31 | 2024-05-22 | Denka Company Limited | PRIMER SET AND PROBE FOR DETECTION OF KLEBSIELLA BACTERIA |
| WO2021201072A1 (ja) | 2020-03-31 | 2021-10-07 | デンカ株式会社 | スタフィロコッカス・アルジェンテウスの検出のためのプライマーセット及びプローブ |
| GB202006800D0 (en) * | 2020-05-07 | 2020-06-24 | Cambridge Entpr Ltd | Carrier system and method |
| EP4302087A4 (en) * | 2021-03-02 | 2025-01-08 | IDEXX Laboratories, Inc. | BIOCHEMICAL PROBES ATTACHED TO EPOXY-BASED RESINS |
| WO2022202954A1 (ja) | 2021-03-24 | 2022-09-29 | デンカ株式会社 | 特定のｇｃ含量を有する標的遺伝子の増幅方法 |
| US20250151174A1 (en) * | 2021-03-25 | 2025-05-08 | Uniheat Inc. | Infrared heating and heat transfer and radiation element including nanocomposite |
| US20250277255A1 (en) * | 2021-05-21 | 2025-09-04 | Timo Rapakko | A large capacity clinical assay method |
| JPWO2024204748A1 (cg-RX-API-DMAC7.html) * | 2023-03-30 | 2024-10-03 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677045A (en) | 1984-07-27 | 1987-06-30 | International Business Machines Corporation | Squarylium charge generating dye and electrophotographic photoconductor |
| US5237498A (en) | 1988-07-08 | 1993-08-17 | Hitachi, Ltd. | System and method for computing profits for individual entities of an entity group via use of means to retrieve and process data for specific entities |
| US5354873A (en) | 1991-11-20 | 1994-10-11 | Polaroid Corporation | Squarylium dyes, and processes and intermediates for the preparation thereof |
| GB9521943D0 (en) | 1995-10-26 | 1996-01-03 | Univ Hertfordshire | Coded particles for process sequence tracking in combinatorial compound library preparation |
| US5641634A (en) | 1995-11-30 | 1997-06-24 | Mandecki; Wlodek | Electronically-indexed solid-phase assay for biomolecules |
| US20020150909A1 (en) | 1999-02-09 | 2002-10-17 | Stuelpnagel John R. | Automated information processing in randomly ordered arrays |
| US20030134330A1 (en) | 1999-04-15 | 2003-07-17 | Ilya Ravkin | Chemical-library composition and method |
| AU771517B2 (en) | 1999-04-16 | 2004-03-25 | Mycartis Nv | Encoding of microcarriers |
| DE60040603D1 (de) | 1999-08-17 | 2008-12-04 | Luminex Corp | Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten |
| US6934408B2 (en) | 2000-08-25 | 2005-08-23 | Amnis Corporation | Method and apparatus for reading reporter labeled beads |
| RU2285265C2 (ru) | 2000-10-19 | 2006-10-10 | Тиботек Бвба | Способ и устройство манипулирования микроносителями для их идентификации |
| WO2002057743A2 (en) | 2001-01-17 | 2002-07-25 | Streamline Proteomics, Llc. | Methods of analyzing and sorting one or more analytes |
| US7811768B2 (en) * | 2001-01-26 | 2010-10-12 | Aviva Biosciences Corporation | Microdevice containing photorecognizable coding patterns and methods of using and producing the same |
| US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
| ATE513838T1 (de) | 2002-09-20 | 2011-07-15 | Promega Corp | Auf lumineszenz basierende verfahren und sonden zur messung der cytochrom-p450-aktivität |
| US7960184B2 (en) * | 2002-09-20 | 2011-06-14 | George Mason Intellectual Properties, Inc. | Methods and devices for active bioassay |
| DE10345021A1 (de) | 2003-09-23 | 2005-05-04 | Univ Potsdam | Verfahren zur nichtinvasiven Früherkennung von Dickdarmkrebs und/oder Darmkrebsvorläuferzellen |
| US7456506B2 (en) | 2005-03-14 | 2008-11-25 | Rcd Technology Inc. | Radio frequency identification (RFID) tag lamination process using liner |
| US8232092B2 (en) * | 2005-08-09 | 2012-07-31 | Maxwell Sensors, Inc. | Apparatus and method for digital magnetic beads analysis |
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| US7858307B2 (en) | 2005-08-09 | 2010-12-28 | Maxwell Sensors, Inc. | Light transmitted assay beads |
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| US8697334B2 (en) * | 2005-09-13 | 2014-04-15 | Affymetrix, Inc. | Miniaturized microparticles |
| JP5452922B2 (ja) * | 2005-09-13 | 2014-03-26 | アフィメトリックス・インコーポレーテッド | コード化されたマイクロ粒子 |
| US8586389B2 (en) * | 2005-09-28 | 2013-11-19 | Kent State University | Ligand concentrating, liquid crystal biosensor system |
| WO2007079752A2 (en) | 2006-01-11 | 2007-07-19 | Novo Nordisk A/S | Improved spherical encoded beads |
| US20070238140A1 (en) | 2006-04-07 | 2007-10-11 | Pentoney Stephen L Jr | Method For Multiplex Bead-Based Assays Using Chemiluminescence and Fluorescence |
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| EP1903337B1 (en) | 2006-09-20 | 2015-07-22 | Mycartis N.V. | Coating for microcarriers |
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| EP2755031B1 (en) * | 2007-03-20 | 2017-05-03 | Becton, Dickinson and Company | Assay using surface-enhanced raman spectroscopy (sers)-active particles |
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| EP2367633B1 (en) | 2008-12-23 | 2019-03-27 | MyCartis N.V. | Assay device and method for performing biological assays |
| WO2011006021A1 (en) | 2009-07-08 | 2011-01-13 | Applied Biocode Inc. | Apparatus and method for barcoded magnetic beads analysis |
| AU2010278710A1 (en) | 2009-07-31 | 2012-03-15 | Prognosys Biosciences, Inc. | Assay tools and methods of use |
| EP2312393A1 (en) | 2009-10-14 | 2011-04-20 | Biocartis SA | Method for producing microparticles |
| WO2011156432A2 (en) | 2010-06-07 | 2011-12-15 | Firefly Bioworks, Inc. | Scanning multifunctional particles |
| US20120088691A1 (en) * | 2010-10-08 | 2012-04-12 | Gao Chen | Highly multiplexed real-time pcr using encoded microbeads |
| EP2484447A1 (en) | 2011-02-07 | 2012-08-08 | Biocartis SA | Improved encoded microcarriers, assay system using them and method for performing an assay |
| KR101827849B1 (ko) | 2011-02-09 | 2018-02-12 | 삼성디스플레이 주식회사 | 블랙 매트릭스 레지스트 조성물, 블랙 매트릭스 레지스트 제조 방법, 컬러 필터 표시판 및 그 제조 방법 |
| DK2776833T3 (da) * | 2011-11-11 | 2019-01-02 | Eli N Glezer | Cobinder-understøttet testfremgangsmåde |
| EP2690057A1 (en) | 2012-07-24 | 2014-01-29 | Biocartis SA | Method for producing structured microcarriers |
| CN104884605B (zh) * | 2012-08-24 | 2018-05-18 | 耶鲁大学 | 用于高通量多重检测的系统、装置和方法 |
| US9063044B2 (en) | 2013-02-27 | 2015-06-23 | Plexbio Co. Ltd. | Magnetic aggregating and washing device for in vitro assays and methods of use thereof |
| EP2774997A1 (en) | 2013-03-05 | 2014-09-10 | Bayer Pharma Aktiengesellschaft | Detection of Androgen Receptor (AR) mutations in circulating tumor DNA from plasma samples of castration-resistant prostate cancer patients using locked nucleic acid-clamp PCR |
| US10436778B2 (en) | 2013-03-15 | 2019-10-08 | Plexbio Co., Ltd. | Methods and systems for multiplex assays |
| US10119964B2 (en) * | 2014-12-22 | 2018-11-06 | Digital Biotech, LLC | Multiplex assay strip, beads, device and method |
| TWI737614B (zh) | 2015-06-11 | 2021-09-01 | 博錸生技股份有限公司 | 已編碼微載體及其製造方法以及用以進行多工分析之包含該等已編碼微載體之套件 |
| US10436776B2 (en) | 2015-11-20 | 2019-10-08 | Plexbio Co., Ltd. | Methods and systems for selection of detection area |
| US10019815B2 (en) | 2016-03-17 | 2018-07-10 | Plexbio Co., Ltd. | Methods and systems for image differentiated multiplex assays |
| US20180195113A1 (en) | 2016-12-09 | 2018-07-12 | Plexbio Co., Ltd. | Image differentiated multiplex assays for multiplex detection of dna mutations |
| US10894975B2 (en) | 2016-12-09 | 2021-01-19 | Plexbio Co., Ltd. | Image differentiated multiplex assays for multiplex detection of DNA mutations |
-
2016
- 2016-11-21 US US16/332,271 patent/US11796535B2/en active Active
- 2016-11-21 JP JP2019514077A patent/JP7062002B2/ja active Active
- 2016-11-21 WO PCT/US2016/063202 patent/WO2018052464A1/en not_active Ceased
- 2016-11-21 CN CN201680089213.3A patent/CN110073212B/zh active Active
- 2016-11-21 AU AU2016423082A patent/AU2016423082B2/en active Active
- 2016-11-21 EP EP16916388.8A patent/EP3513186A4/en active Pending
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