JP2019511243A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019511243A5 JP2019511243A5 JP2018557283A JP2018557283A JP2019511243A5 JP 2019511243 A5 JP2019511243 A5 JP 2019511243A5 JP 2018557283 A JP2018557283 A JP 2018557283A JP 2018557283 A JP2018557283 A JP 2018557283A JP 2019511243 A5 JP2019511243 A5 JP 2019511243A5
- Authority
- JP
- Japan
- Prior art keywords
- rna
- transgene
- human animal
- nucleic acid
- recombinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022036725A JP2022091801A (ja) | 2016-01-26 | 2022-03-10 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
| JP2024025071A JP2024063065A (ja) | 2016-01-26 | 2024-02-22 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662287197P | 2016-01-26 | 2016-01-26 | |
| US62/287,197 | 2016-01-26 | ||
| PCT/US2016/069442 WO2017131926A1 (en) | 2016-01-26 | 2016-12-30 | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022036725A Division JP2022091801A (ja) | 2016-01-26 | 2022-03-10 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019511243A JP2019511243A (ja) | 2019-04-25 |
| JP2019511243A5 true JP2019511243A5 (enExample) | 2020-02-06 |
Family
ID=59398838
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557283A Pending JP2019511243A (ja) | 2016-01-26 | 2016-12-30 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
| JP2022036725A Pending JP2022091801A (ja) | 2016-01-26 | 2022-03-10 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
| JP2024025071A Pending JP2024063065A (ja) | 2016-01-26 | 2024-02-22 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022036725A Pending JP2022091801A (ja) | 2016-01-26 | 2022-03-10 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
| JP2024025071A Pending JP2024063065A (ja) | 2016-01-26 | 2024-02-22 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11466290B2 (enExample) |
| EP (1) | EP3408396A4 (enExample) |
| JP (3) | JP2019511243A (enExample) |
| KR (1) | KR102811061B1 (enExample) |
| CN (1) | CN108884472A (enExample) |
| AU (1) | AU2016389495B2 (enExample) |
| CA (1) | CA3012042A1 (enExample) |
| WO (1) | WO2017131926A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017131926A1 (en) | 2016-01-26 | 2017-08-03 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
| WO2019178550A1 (en) | 2018-03-16 | 2019-09-19 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
| CN109321599B (zh) * | 2018-09-27 | 2023-08-22 | 同济大学 | 人多能干细胞中的谱系示踪系统的构建与应用 |
| CN109943564B (zh) * | 2019-03-28 | 2022-03-15 | 上海市中医老年医学研究所 | Amh基因定点敲入2A-Cre的杂合子小鼠模型构建方法及其应用 |
| KR20220024527A (ko) * | 2019-06-17 | 2022-03-03 | 세다르스-신나이 메디칼 센터 | 생체내 이중 재조합효소-매개된 카세트 교환 (dRMCE)을 위한 시스템 및 방법 그리고 이들의 질환 모델 |
| BR112021025425A2 (pt) * | 2019-06-19 | 2022-02-01 | Hoffmann La Roche | Método para produzir uma célula de mamífero recombinante e uso de mrna de recombinase cre |
| WO2023238843A1 (ja) | 2022-06-06 | 2023-12-14 | 協和発酵バイオ株式会社 | ３'－シアリルラクトースの生産性が向上した微生物および３'－シアリルラクトースの製造方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7575924B2 (en) * | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
| US20030084468A1 (en) * | 2001-09-05 | 2003-05-01 | Economides Aris N. | Methods of expressing transgenes |
| US20030228295A1 (en) | 2002-04-25 | 2003-12-11 | Svendsen Clive N. | Use of human neural stem cells secreting GDNF for treatment of parkinson's and other neurodegenerative diseases |
| GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
| AU2007337263A1 (en) * | 2006-12-21 | 2008-07-03 | Genentech, Inc. | Compositions and methods for the expression of nucleic acids |
| US8592211B2 (en) | 2009-03-20 | 2013-11-26 | The Rockefeller University | Enhanced PiggyBac transposon and methods for transposon mutagenesis |
| WO2011001247A2 (en) * | 2009-06-29 | 2011-01-06 | University Of Basel | Methods and kits for high efficiency engineering of conditional mouse alleles |
| US9528124B2 (en) * | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| WO2013155222A2 (en) | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Brain-specific enhancers for cell-based therapy |
| EP2961277A4 (en) | 2013-02-15 | 2016-12-28 | Int Stem Cell Corp | USE OF NERVOUS CELLS OBTAINED FROM HUMAN PLURIPOTENTIAL STEM CELLS FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES |
| US10519421B2 (en) | 2013-03-21 | 2019-12-31 | Kyoto University | Induction of motor neurons from pluripotent stem cells |
| WO2014204724A1 (en) * | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
| AU2015234242B2 (en) | 2014-03-21 | 2020-09-24 | Children's Medical Research Institute | Stable gene transfer to proliferating cells |
| DK3119881T3 (da) | 2014-03-21 | 2023-04-03 | Fujifilm Cellular Dynamics Inc | Production of midbrain dopaminergic neurons and methods for the use thereof |
| US20170274048A1 (en) | 2014-03-28 | 2017-09-28 | Buck Institute For Research On Aging | Methods and compositions for modulating the imune system |
| AU2015279552B2 (en) | 2014-06-27 | 2021-01-21 | Angiocrine Bioscience, Inc. | Neural cells expressing adenovirus E4ORF1, and methods of making and using the same |
| CN108368520B (zh) | 2015-11-04 | 2023-01-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
| WO2017131926A1 (en) | 2016-01-26 | 2017-08-03 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
| WO2019178550A1 (en) | 2018-03-16 | 2019-09-19 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
| KR20220024527A (ko) | 2019-06-17 | 2022-03-03 | 세다르스-신나이 메디칼 센터 | 생체내 이중 재조합효소-매개된 카세트 교환 (dRMCE)을 위한 시스템 및 방법 그리고 이들의 질환 모델 |
-
2016
- 2016-12-30 WO PCT/US2016/069442 patent/WO2017131926A1/en not_active Ceased
- 2016-12-30 CN CN201680084065.6A patent/CN108884472A/zh active Pending
- 2016-12-30 JP JP2018557283A patent/JP2019511243A/ja active Pending
- 2016-12-30 AU AU2016389495A patent/AU2016389495B2/en active Active
- 2016-12-30 KR KR1020187023347A patent/KR102811061B1/ko active Active
- 2016-12-30 CA CA3012042A patent/CA3012042A1/en active Pending
- 2016-12-30 EP EP16888589.5A patent/EP3408396A4/en active Pending
- 2016-12-30 US US16/071,407 patent/US11466290B2/en active Active
-
2022
- 2022-03-10 JP JP2022036725A patent/JP2022091801A/ja active Pending
- 2022-09-08 US US17/930,558 patent/US20230084201A1/en active Pending
-
2024
- 2024-02-22 JP JP2024025071A patent/JP2024063065A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Schiwon et al. | One-vector system for multiplexed CRISPR/Cas9 against hepatitis B virus cccDNA utilizing high-capacity adenoviral vectors | |
| Wei et al. | Delivery of tissue-targeted scalpels: opportunities and challenges for in vivo CRISPR/Cas-based genome editing | |
| US20230332185A1 (en) | Methods and compositions for targeted genetic modification using paired guide rnas | |
| Yao et al. | Tild-CRISPR allows for efficient and precise gene knockin in mouse and human cells | |
| Chen et al. | CRISPR-Cas9: from genome editing to cancer research | |
| JP2016528894A5 (enExample) | ||
| JP2012130346A5 (enExample) | ||
| JP2016500262A5 (enExample) | ||
| JP2022536934A5 (enExample) | ||
| US20180371493A1 (en) | Methods of modifying genes in eukaryotic cells | |
| JP2024001075A5 (enExample) | ||
| JP2016504922A5 (enExample) | ||
| JP2016521554A5 (enExample) | ||
| Andries et al. | Synthetic biology devices and circuits for RNA-based ‘smart vaccines’: a propositional review | |
| Zhang et al. | Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration | |
| JP2016063839A5 (enExample) | ||
| Jo et al. | CRISPR/Cas9 system as an innovative genetic engineering tool: Enhancements in sequence specificity and delivery methods | |
| Gentner et al. | Exploiting microRNA regulation for genetic engineering | |
| JP2016539629A5 (enExample) | ||
| ES2947714T9 (es) | Métodos y composiciones para la modificación genética dirigida a través de múltiples direccionamientos en un solo paso | |
| JP2018531013A (ja) | 細胞ゲノムの誘導性改変 | |
| CN102943092A (zh) | 一种通用型PiggyBac转座子转基因载体及其制备方法 | |
| Kaczmarczyk et al. | Manipulating the prion protein gene sequence and expression levels with CRISPR/Cas9 | |
| Moses et al. | Applications of CRISPR systems in respiratory health: entering a new ‘red pen’era in genome editing | |
| JP2017060502A5 (enExample) |