JP2019511243A5 - - Google Patents
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- Publication number
- JP2019511243A5 JP2019511243A5 JP2018557283A JP2018557283A JP2019511243A5 JP 2019511243 A5 JP2019511243 A5 JP 2019511243A5 JP 2018557283 A JP2018557283 A JP 2018557283A JP 2018557283 A JP2018557283 A JP 2018557283A JP 2019511243 A5 JP2019511243 A5 JP 2019511243A5
- Authority
- JP
- Japan
- Prior art keywords
- rna
- transgene
- human animal
- nucleic acid
- recombinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022036725A JP2022091801A (ja) | 2016-01-26 | 2022-03-10 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
| JP2024025071A JP2024063065A (ja) | 2016-01-26 | 2024-02-22 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662287197P | 2016-01-26 | 2016-01-26 | |
| US62/287,197 | 2016-01-26 | ||
| PCT/US2016/069442 WO2017131926A1 (en) | 2016-01-26 | 2016-12-30 | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022036725A Division JP2022091801A (ja) | 2016-01-26 | 2022-03-10 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019511243A JP2019511243A (ja) | 2019-04-25 |
| JP2019511243A5 true JP2019511243A5 (enExample) | 2020-02-06 |
Family
ID=59398838
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557283A Pending JP2019511243A (ja) | 2016-01-26 | 2016-12-30 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
| JP2022036725A Pending JP2022091801A (ja) | 2016-01-26 | 2022-03-10 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
| JP2024025071A Pending JP2024063065A (ja) | 2016-01-26 | 2024-02-22 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022036725A Pending JP2022091801A (ja) | 2016-01-26 | 2022-03-10 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
| JP2024025071A Pending JP2024063065A (ja) | 2016-01-26 | 2024-02-22 | インビボのデュアルリコンビナーゼ媒介性カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11466290B2 (enExample) |
| EP (1) | EP3408396A4 (enExample) |
| JP (3) | JP2019511243A (enExample) |
| KR (1) | KR102811061B1 (enExample) |
| CN (1) | CN108884472A (enExample) |
| AU (1) | AU2016389495B2 (enExample) |
| CA (2) | CA3303511A1 (enExample) |
| WO (1) | WO2017131926A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3303511A1 (en) | 2016-01-26 | 2026-05-13 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
| AU2019236288B2 (en) | 2018-03-16 | 2025-06-05 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
| CN109321599B (zh) * | 2018-09-27 | 2023-08-22 | 同济大学 | 人多能干细胞中的谱系示踪系统的构建与应用 |
| CN109943564B (zh) * | 2019-03-28 | 2022-03-15 | 上海市中医老年医学研究所 | Amh基因定点敲入2A-Cre的杂合子小鼠模型构建方法及其应用 |
| EP3983000A4 (en) * | 2019-06-17 | 2023-10-11 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS OF DOUBLE RECOMBINASE-MEDIATED CASSETTE EXCHANGE (DRMCE) IN VIVO AND ASSOCIATED DISEASE MODELS |
| CA3140297A1 (en) * | 2019-06-19 | 2020-12-24 | Simon Auslaender | Method for the generation of a protein expressing cell by targeted integration using cre mrna |
| CN119301241A (zh) | 2022-06-06 | 2025-01-10 | 协和发酵生化株式会社 | 提高了3'-唾液酸乳糖的生产率的微生物和3'-唾液酸乳糖的制造方法 |
| WO2024218715A1 (en) | 2023-04-19 | 2024-10-24 | Btl Healthcare Technologies A.S. | Culture media based on protein hydrolysate and a process for preparing thereof |
| US12668774B2 (en) | 2023-10-12 | 2026-06-30 | Btl Healthcare Technologies A.S. | Product, system and method of cell cultivation |
| WO2026050378A1 (en) * | 2024-08-28 | 2026-03-05 | Cedars-Sinai Medical Center | Humanized genetically-engineered autochthonous brain tumors compatible with use in immunocompetent rodents |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7575924B2 (en) * | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
| WO2003020743A1 (en) * | 2001-09-05 | 2003-03-13 | Regeneron Pharmaceuticals, Inc. | Methods of expressing transgenes |
| WO2003090689A2 (en) | 2002-04-25 | 2003-11-06 | Wisconsin Alumni Research Foundation | Neurodegenerative disorder treatment using gdnf secreting neural cells |
| GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
| CA2672203A1 (en) * | 2006-12-21 | 2008-07-03 | Genentech, Inc. | Compositions and methods for the expression of nucleic acids |
| US8592211B2 (en) | 2009-03-20 | 2013-11-26 | The Rockefeller University | Enhanced PiggyBac transposon and methods for transposon mutagenesis |
| WO2011001247A2 (en) | 2009-06-29 | 2011-01-06 | University Of Basel | Methods and kits for high efficiency engineering of conditional mouse alleles |
| US9528124B2 (en) * | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| WO2013155222A2 (en) | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Brain-specific enhancers for cell-based therapy |
| WO2014127289A1 (en) | 2013-02-15 | 2014-08-21 | International Stem Cell Corporation | Use of neural cells derived from human pluripotent stem cells for the treatment of neurodegenerative diseases |
| SG11201507829SA (en) | 2013-03-21 | 2015-12-30 | Univ Kyoto | Pluripotent stem cell for neuronal differentiation induction |
| ES2777217T3 (es) * | 2013-06-17 | 2020-08-04 | Broad Inst Inc | Suministro, modificación y optimización de sistemas de guía en tándem, métodos y composiciones para la manipulación de secuencias |
| US9694036B2 (en) | 2014-03-21 | 2017-07-04 | Cellular Dynamics International, Inc. | Production of midbrain dopaminergic neurons and methods for the use thereof |
| WO2015139093A1 (en) | 2014-03-21 | 2015-09-24 | The Sydney Children's Hospitals Network (Randwick And Westmead) (Incorporating The Royal Alexandra Hospital For Children) | Stable gene transfer to proliferating cells |
| EP3122370A1 (en) | 2014-03-28 | 2017-02-01 | Buck Institute for Research on Aging | Methods and compositions for modulating the immune system |
| EP3584312A1 (en) | 2014-06-27 | 2019-12-25 | Angiocrine Bioscience, Inc. | Neural cells expressing adenovirus e4orf1, and methods of making and using the same |
| US12642852B1 (en) | 2015-11-04 | 2026-06-02 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
| CA3303511A1 (en) | 2016-01-26 | 2026-05-13 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
| AU2019236288B2 (en) | 2018-03-16 | 2025-06-05 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
| EP3983000A4 (en) | 2019-06-17 | 2023-10-11 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS OF DOUBLE RECOMBINASE-MEDIATED CASSETTE EXCHANGE (DRMCE) IN VIVO AND ASSOCIATED DISEASE MODELS |
-
2016
- 2016-12-30 CA CA3303511A patent/CA3303511A1/en active Pending
- 2016-12-30 AU AU2016389495A patent/AU2016389495B2/en active Active
- 2016-12-30 WO PCT/US2016/069442 patent/WO2017131926A1/en not_active Ceased
- 2016-12-30 JP JP2018557283A patent/JP2019511243A/ja active Pending
- 2016-12-30 CN CN201680084065.6A patent/CN108884472A/zh active Pending
- 2016-12-30 US US16/071,407 patent/US11466290B2/en active Active
- 2016-12-30 EP EP16888589.5A patent/EP3408396A4/en active Pending
- 2016-12-30 CA CA3012042A patent/CA3012042A1/en active Pending
- 2016-12-30 KR KR1020187023347A patent/KR102811061B1/ko active Active
-
2022
- 2022-03-10 JP JP2022036725A patent/JP2022091801A/ja active Pending
- 2022-09-08 US US17/930,558 patent/US20230084201A1/en active Pending
-
2024
- 2024-02-22 JP JP2024025071A patent/JP2024063065A/ja active Pending
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