CN108884472A - 用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型 - Google Patents

用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型 Download PDF

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CN108884472A
CN108884472A CN201680084065.6A CN201680084065A CN108884472A CN 108884472 A CN108884472 A CN 108884472A CN 201680084065 A CN201680084065 A CN 201680084065A CN 108884472 A CN108884472 A CN 108884472A
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cells
rna
transgene
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expression
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约施华·布罗尼格
莫伊兹·丹尼尔鲍尔
金基范
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Cedars Sinai Medical Center
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CN201680084065.6A 2016-01-26 2016-12-30 用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型 Pending CN108884472A (zh)

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US201662287197P 2016-01-26 2016-01-26
US62/287,197 2016-01-26
PCT/US2016/069442 WO2017131926A1 (en) 2016-01-26 2016-12-30 SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF

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US (2) US11466290B2 (enExample)
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KR (1) KR102811061B1 (enExample)
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Cited By (5)

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CN109943564A (zh) * 2019-03-28 2019-06-28 上海市中医老年医学研究所 Amh基因定点敲入2A-Cre的杂合子小鼠模型构建方法及其应用
CN114080451A (zh) * 2019-06-19 2022-02-22 豪夫迈·罗氏有限公司 通过使用Cre mRNA进行的靶向整合来产生蛋白质表达细胞的方法
CN114761035A (zh) * 2019-06-17 2022-07-15 西达-赛奈医疗中心 用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型
US11466290B2 (en) 2016-01-26 2022-10-11 Cedars-Sinai Medical Center Systems and methods for in vivo dual recombinase-mediated cassette exchange (dRMCE) and disease models thereof
US12258571B2 (en) 2018-03-16 2025-03-25 Cedars-Sinai Medical Center Methods and compositions for inducible expression of neurotrophic factors

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CN109321599B (zh) * 2018-09-27 2023-08-22 同济大学 人多能干细胞中的谱系示踪系统的构建与应用
WO2023238843A1 (ja) 2022-06-06 2023-12-14 協和発酵バイオ株式会社 ３'－シアリルラクトースの生産性が向上した微生物および３'－シアリルラクトースの製造方法

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11466290B2 (en) 2016-01-26 2022-10-11 Cedars-Sinai Medical Center Systems and methods for in vivo dual recombinase-mediated cassette exchange (dRMCE) and disease models thereof
US12258571B2 (en) 2018-03-16 2025-03-25 Cedars-Sinai Medical Center Methods and compositions for inducible expression of neurotrophic factors
CN109943564A (zh) * 2019-03-28 2019-06-28 上海市中医老年医学研究所 Amh基因定点敲入2A-Cre的杂合子小鼠模型构建方法及其应用
CN109943564B (zh) * 2019-03-28 2022-03-15 上海市中医老年医学研究所 Amh基因定点敲入2A-Cre的杂合子小鼠模型构建方法及其应用
CN114761035A (zh) * 2019-06-17 2022-07-15 西达-赛奈医疗中心 用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型
CN114080451A (zh) * 2019-06-19 2022-02-22 豪夫迈·罗氏有限公司 通过使用Cre mRNA进行的靶向整合来产生蛋白质表达细胞的方法
CN114080451B (zh) * 2019-06-19 2024-03-22 豪夫迈·罗氏有限公司 通过使用Cre mRNA进行的靶向整合来产生蛋白质表达细胞的方法

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KR102811061B1 (ko) 2025-05-21
WO2017131926A1 (en) 2017-08-03
CA3012042A1 (en) 2017-08-03
AU2016389495B2 (en) 2023-03-30
AU2016389495A1 (en) 2018-08-16
JP2022091801A (ja) 2022-06-21
US20190390222A1 (en) 2019-12-26
EP3408396A1 (en) 2018-12-05
EP3408396A4 (en) 2019-10-09
JP2019511243A (ja) 2019-04-25
JP2024063065A (ja) 2024-05-10
KR20180101535A (ko) 2018-09-12
US11466290B2 (en) 2022-10-11

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