JP2022536934A5 - - Google Patents
Info
- Publication number
- JP2022536934A5 JP2022536934A5 JP2021574914A JP2021574914A JP2022536934A5 JP 2022536934 A5 JP2022536934 A5 JP 2022536934A5 JP 2021574914 A JP2021574914 A JP 2021574914A JP 2021574914 A JP2021574914 A JP 2021574914A JP 2022536934 A5 JP2022536934 A5 JP 2022536934A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinase
- promoter
- rna
- transgene
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962862576P | 2019-06-17 | 2019-06-17 | |
| US62/862,576 | 2019-06-17 | ||
| PCT/US2020/037946 WO2020257205A1 (en) | 2019-06-17 | 2020-06-16 | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022536934A JP2022536934A (ja) | 2022-08-22 |
| JP2022536934A5 true JP2022536934A5 (enExample) | 2023-06-23 |
Family
ID=74040106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021574914A Pending JP2022536934A (ja) | 2019-06-17 | 2020-06-16 | ｉｎ ｖｉｖｏ二重リコンビナーゼ媒介カセット交換（ｄＲＭＣＥ）のためのシステム及び方法ならびにその疾患モデル |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220304286A1 (enExample) |
| EP (1) | EP3983000A4 (enExample) |
| JP (1) | JP2022536934A (enExample) |
| KR (1) | KR20220024527A (enExample) |
| CN (1) | CN114761035A (enExample) |
| AU (1) | AU2020297427A1 (enExample) |
| CA (1) | CA3143981A1 (enExample) |
| WO (1) | WO2020257205A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017131926A1 (en) | 2016-01-26 | 2017-08-03 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
| WO2019178550A1 (en) | 2018-03-16 | 2019-09-19 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
| CN114480457A (zh) * | 2021-12-21 | 2022-05-13 | 浙江大学 | 一种基于pCAG-flox-neo载体的高效稳定的定点整合基因敲入方法 |
| CN114438039A (zh) * | 2022-04-07 | 2022-05-06 | 中国科学院天津工业生物技术研究所 | 一种哺乳动物细胞疾病模型的高通量构建方法 |
| EP4596686A1 (en) * | 2022-09-29 | 2025-08-06 | Keio University | Searching method for functional molecule for causing response in cell |
| CN118460688A (zh) * | 2023-02-09 | 2024-08-09 | 中国人民解放军军事科学院军事医学研究院 | 多聚甲醛固定细胞的单细胞转录组及多重靶向蛋白质同时检测方法的建立 |
| CN116463380A (zh) * | 2023-03-30 | 2023-07-21 | 中国科学院深圳先进技术研究院 | 一种重组腺相关病毒载体组合物、外源基因表达系统及方法 |
| WO2024243040A2 (en) * | 2023-05-19 | 2024-11-28 | The Board Of Trustees Of The Leland Stanford Junior University | High-throughput multiomic readout of rna and genomic dna within single cells |
| IT202300019377A1 (it) * | 2023-09-20 | 2025-03-20 | Univ Degli Studi Di Pavia | Linee di cellule staminali contenenti proteine endogene marcate con espressione differenziale, metodi di produzione e loro utilizzo per l’identificazione del ciclo cellulare |
| CN118086394B (zh) * | 2024-04-24 | 2024-07-12 | 中国农业科学院北京畜牧兽医研究所 | 猪脂肪组织发育示踪系统及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1614755A1 (en) * | 2004-07-07 | 2006-01-11 | ARTEMIS Pharmaceuticals GmbH | Target transgenesis of short hairpin RNA expression cassette using recombinase mediated cassette exchange |
| WO2011001247A2 (en) * | 2009-06-29 | 2011-01-06 | University Of Basel | Methods and kits for high efficiency engineering of conditional mouse alleles |
| WO2017131926A1 (en) * | 2016-01-26 | 2017-08-03 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
| JP6856919B2 (ja) * | 2016-05-10 | 2021-04-14 | 大学共同利用機関法人情報・システム研究機構 | ベクターシステム、遺伝子発現方法、標的遺伝子ノックアウト方法、標的遺伝子ノックダウン方法、標的遺伝子編集方法、及び遺伝子発現キット |
-
2020
- 2020-06-16 KR KR1020227001180A patent/KR20220024527A/ko active Pending
- 2020-06-16 JP JP2021574914A patent/JP2022536934A/ja active Pending
- 2020-06-16 CN CN202080058251.9A patent/CN114761035A/zh active Pending
- 2020-06-16 CA CA3143981A patent/CA3143981A1/en active Pending
- 2020-06-16 WO PCT/US2020/037946 patent/WO2020257205A1/en not_active Ceased
- 2020-06-16 US US17/617,878 patent/US20220304286A1/en active Pending
- 2020-06-16 AU AU2020297427A patent/AU2020297427A1/en active Pending
- 2020-06-16 EP EP20827879.6A patent/EP3983000A4/en active Pending
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