CN114761035A - 用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型 - Google Patents
用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型 Download PDFInfo
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- CN114761035A CN114761035A CN202080058251.9A CN202080058251A CN114761035A CN 114761035 A CN114761035 A CN 114761035A CN 202080058251 A CN202080058251 A CN 202080058251A CN 114761035 A CN114761035 A CN 114761035A
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962862576P | 2019-06-17 | 2019-06-17 | |
| US62/862,576 | 2019-06-17 | ||
| PCT/US2020/037946 WO2020257205A1 (en) | 2019-06-17 | 2020-06-16 | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114761035A true CN114761035A (zh) | 2022-07-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080058251.9A Pending CN114761035A (zh) | 2019-06-17 | 2020-06-16 | 用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220304286A1 (enExample) |
| EP (1) | EP3983000A4 (enExample) |
| JP (1) | JP2022536934A (enExample) |
| KR (1) | KR20220024527A (enExample) |
| CN (1) | CN114761035A (enExample) |
| AU (1) | AU2020297427A1 (enExample) |
| CA (1) | CA3143981A1 (enExample) |
| WO (1) | WO2020257205A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118086394A (zh) * | 2024-04-24 | 2024-05-28 | 中国农业科学院北京畜牧兽医研究所 | 猪脂肪组织发育示踪系统及应用 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017131926A1 (en) | 2016-01-26 | 2017-08-03 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
| WO2019178550A1 (en) | 2018-03-16 | 2019-09-19 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
| CN114480457A (zh) * | 2021-12-21 | 2022-05-13 | 浙江大学 | 一种基于pCAG-flox-neo载体的高效稳定的定点整合基因敲入方法 |
| CN114438039A (zh) * | 2022-04-07 | 2022-05-06 | 中国科学院天津工业生物技术研究所 | 一种哺乳动物细胞疾病模型的高通量构建方法 |
| EP4596686A1 (en) * | 2022-09-29 | 2025-08-06 | Keio University | Searching method for functional molecule for causing response in cell |
| CN118460688A (zh) * | 2023-02-09 | 2024-08-09 | 中国人民解放军军事科学院军事医学研究院 | 多聚甲醛固定细胞的单细胞转录组及多重靶向蛋白质同时检测方法的建立 |
| CN116463380A (zh) * | 2023-03-30 | 2023-07-21 | 中国科学院深圳先进技术研究院 | 一种重组腺相关病毒载体组合物、外源基因表达系统及方法 |
| WO2024243040A2 (en) * | 2023-05-19 | 2024-11-28 | The Board Of Trustees Of The Leland Stanford Junior University | High-throughput multiomic readout of rna and genomic dna within single cells |
| IT202300019377A1 (it) * | 2023-09-20 | 2025-03-20 | Univ Degli Studi Di Pavia | Linee di cellule staminali contenenti proteine endogene marcate con espressione differenziale, metodi di produzione e loro utilizzo per l’identificazione del ciclo cellulare |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080313747A1 (en) * | 2004-07-07 | 2008-12-18 | Heidrun Kern | Targeted Transgenesis of Short Hairpin Rna Expression Cassettes Using Recombinase Mediated Cassette Exchange |
| JP2017201975A (ja) * | 2016-05-10 | 2017-11-16 | 大学共同利用機関法人情報・システム研究機構 | ベクターシステム、遺伝子発現方法、標的遺伝子ノックアウト方法、標的遺伝子ノックダウン方法、標的遺伝子編集方法、及び遺伝子発現キット |
| CN108884472A (zh) * | 2016-01-26 | 2018-11-23 | 西达-赛奈医疗中心 | 用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011001247A2 (en) * | 2009-06-29 | 2011-01-06 | University Of Basel | Methods and kits for high efficiency engineering of conditional mouse alleles |
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2020
- 2020-06-16 KR KR1020227001180A patent/KR20220024527A/ko active Pending
- 2020-06-16 JP JP2021574914A patent/JP2022536934A/ja active Pending
- 2020-06-16 CN CN202080058251.9A patent/CN114761035A/zh active Pending
- 2020-06-16 CA CA3143981A patent/CA3143981A1/en active Pending
- 2020-06-16 WO PCT/US2020/037946 patent/WO2020257205A1/en not_active Ceased
- 2020-06-16 US US17/617,878 patent/US20220304286A1/en active Pending
- 2020-06-16 AU AU2020297427A patent/AU2020297427A1/en active Pending
- 2020-06-16 EP EP20827879.6A patent/EP3983000A4/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080313747A1 (en) * | 2004-07-07 | 2008-12-18 | Heidrun Kern | Targeted Transgenesis of Short Hairpin Rna Expression Cassettes Using Recombinase Mediated Cassette Exchange |
| CN108884472A (zh) * | 2016-01-26 | 2018-11-23 | 西达-赛奈医疗中心 | 用于体内双重组酶介导的盒式交换(dRMCE)的系统和方法及其疾病模型 |
| JP2017201975A (ja) * | 2016-05-10 | 2017-11-16 | 大学共同利用機関法人情報・システム研究機構 | ベクターシステム、遺伝子発現方法、標的遺伝子ノックアウト方法、標的遺伝子ノックダウン方法、標的遺伝子編集方法、及び遺伝子発現キット |
Non-Patent Citations (3)
| Title |
|---|
| DORIENM.DEGROOT ET AL.: "In Vivo Induction of Glial Cell Proliferation and Axonal Out growth and Myelination by Brain-Derived Neurotrophic Factor", MOL ENDOCRINOL, vol. 20, no. 11, 30 November 2006 (2006-11-30) * |
| JINJU ZHANG ET AL.: "Human Neural Stem Cells with GDNF Site-Specifc Integration at AAVS1 by Using AAV Vectors Retained Their Stemness", NEUROCHEMICAL RESEARCH, vol. 43, no. 4, 30 April 2018 (2018-04-30) * |
| KARIMOVA ET AL.: "Discovery of Nigri/nox and Panto/pox site-specifc recombinase systems facilitates advanced genome engineering", SCIENTIFIC REPORTS, vol. 6, 22 July 2016 (2016-07-22), pages 2 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118086394A (zh) * | 2024-04-24 | 2024-05-28 | 中国农业科学院北京畜牧兽医研究所 | 猪脂肪组织发育示踪系统及应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220024527A (ko) | 2022-03-03 |
| WO2020257205A1 (en) | 2020-12-24 |
| EP3983000A4 (en) | 2023-10-11 |
| CA3143981A1 (en) | 2020-12-24 |
| AU2020297427A1 (en) | 2022-02-03 |
| US20220304286A1 (en) | 2022-09-29 |
| EP3983000A1 (en) | 2022-04-20 |
| JP2022536934A (ja) | 2022-08-22 |
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