KR20220024527A - 생체내 이중 재조합효소-매개된 카세트 교환 (dRMCE)을 위한 시스템 및 방법 그리고 이들의 질환 모델 - Google Patents

생체내 이중 재조합효소-매개된 카세트 교환 (dRMCE)을 위한 시스템 및 방법 그리고 이들의 질환 모델 Download PDF

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KR20220024527A
KR20220024527A KR1020227001180A KR20227001180A KR20220024527A KR 20220024527 A KR20220024527 A KR 20220024527A KR 1020227001180 A KR1020227001180 A KR 1020227001180A KR 20227001180 A KR20227001180 A KR 20227001180A KR 20220024527 A KR20220024527 A KR 20220024527A
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cell
recombinase
promoter
cells
transgene
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조슈아 브레유닉
모이즈 다니엘푸어
기범 김
알베르토 아얄라-사르미엔토
에이미 양
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세다르스-신나이 메디칼 센터
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KR1020227001180A 2019-06-17 2020-06-16 생체내 이중 재조합효소-매개된 카세트 교환 (dRMCE)을 위한 시스템 및 방법 그리고 이들의 질환 모델 Pending KR20220024527A (ko)

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US201962862576P 2019-06-17 2019-06-17
US62/862,576 2019-06-17
PCT/US2020/037946 WO2020257205A1 (en) 2019-06-17 2020-06-16 SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF

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WO2017131926A1 (en) 2016-01-26 2017-08-03 Cedars-Sinai Medical Center SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF
WO2019178550A1 (en) 2018-03-16 2019-09-19 Cedars-Sinai Medical Center Methods and compositions for inducible expression of neurotrophic factors
CN114480457A (zh) * 2021-12-21 2022-05-13 浙江大学 一种基于pCAG-flox-neo载体的高效稳定的定点整合基因敲入方法
CN114438039A (zh) * 2022-04-07 2022-05-06 中国科学院天津工业生物技术研究所 一种哺乳动物细胞疾病模型的高通量构建方法
EP4596686A1 (en) * 2022-09-29 2025-08-06 Keio University Searching method for functional molecule for causing response in cell
CN118460688A (zh) * 2023-02-09 2024-08-09 中国人民解放军军事科学院军事医学研究院 多聚甲醛固定细胞的单细胞转录组及多重靶向蛋白质同时检测方法的建立
CN116463380A (zh) * 2023-03-30 2023-07-21 中国科学院深圳先进技术研究院 一种重组腺相关病毒载体组合物、外源基因表达系统及方法
WO2024243040A2 (en) * 2023-05-19 2024-11-28 The Board Of Trustees Of The Leland Stanford Junior University High-throughput multiomic readout of rna and genomic dna within single cells
IT202300019377A1 (it) * 2023-09-20 2025-03-20 Univ Degli Studi Di Pavia Linee di cellule staminali contenenti proteine endogene marcate con espressione differenziale, metodi di produzione e loro utilizzo per l’identificazione del ciclo cellulare
CN118086394B (zh) * 2024-04-24 2024-07-12 中国农业科学院北京畜牧兽医研究所 猪脂肪组织发育示踪系统及应用

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EP1614755A1 (en) * 2004-07-07 2006-01-11 ARTEMIS Pharmaceuticals GmbH Target transgenesis of short hairpin RNA expression cassette using recombinase mediated cassette exchange
WO2011001247A2 (en) * 2009-06-29 2011-01-06 University Of Basel Methods and kits for high efficiency engineering of conditional mouse alleles
WO2017131926A1 (en) * 2016-01-26 2017-08-03 Cedars-Sinai Medical Center SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF
JP6856919B2 (ja) * 2016-05-10 2021-04-14 大学共同利用機関法人情報・システム研究機構 ベクターシステム、遺伝子発現方法、標的遺伝子ノックアウト方法、標的遺伝子ノックダウン方法、標的遺伝子編集方法、及び遺伝子発現キット

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CN114761035A (zh) 2022-07-15
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CA3143981A1 (en) 2020-12-24
AU2020297427A1 (en) 2022-02-03
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